scholarly journals Three-dimensional viscoelastic instabilities in microchannels

2019 ◽  
Vol 870 ◽  
pp. 1-4 ◽  
Author(s):  
R. J. Poole
Keyword(s):  
Elastic Waves ◽  
Single Phase ◽  
Characteristic Length ◽  
Three Dimensional ◽  
Newtonian Fluids ◽  
Small Scale ◽  
Dilute Polymer Solutions ◽  
Propagation Effects ◽  
Microfluidic Flows ◽  
Elastic Fluids

Whereas the flow of simple single-phase Newtonian fluids tends to become more complex as the characteristic length scale in the problem (and hence the Reynolds number) increases, for complex elastic fluids such as dilute polymer solutions the opposite holds true. Thus small-scale, so-called ‘microfluidic’ flows of complex fluids can exhibit rich dynamics in situations where the ‘equivalent’ flow of Newtonian fluids remains linear and predictable. In the recent study of Qin et al. (J. Fluid Mech., vol. 864, 2019, R2) of the flow of a dilute polymeric fluid past a $50~\unicode[STIX]{x03BC}\text{m}$ cylinder (in a $100\times 60~\unicode[STIX]{x03BC}\text{m}$ channel), a novel 3-D holographic particle velocimetry technique reveals the underlying complexity of the flow, including inherent three-dimensionality and symmetry breaking as well as strong upstream propagation effects via elastic waves.

Extrusion-Based 3D Printing for Pharmaceuticals: Contemporary Research and Applications

2019 ◽  
Vol 24 (42) ◽  
pp. 4991-5008 ◽  
Author(s):  
Mohammed S. Algahtani ◽  
Abdul Aleem Mohammed ◽  
Javed Ahmad
Keyword(s):  
Cosmetic Surgery ◽  
Fused Deposition Modeling ◽  
Personalised Medicine ◽  
Organ Transplant ◽  
Three Dimensional ◽  
Dosage Forms ◽  
Release Profile ◽  
Small Scale ◽  
Drug Release Profile ◽  
Fused Deposition

Three-dimensional printing (3DP) has a significant impact on organ transplant, cosmetic surgery, surgical planning, prosthetics and other medical fields. Recently, 3 DP attracted the attention as a promising method for the production of small-scale drug production. The knowledge expansion about the population differences in metabolism and genetics grows the need for personalised medicine substantially. In personalised medicine, the patient receives a tailored dose and the release profile is based on his pharmacokinetics data. 3 DP is expected to be one of the leading solutions for the personalisation of the drug dispensing. This technology can fabricate a drug-device with complicated geometries and fillings to obtain the needed drug release profile. The extrusionbased 3 DP is the most explored method for investigating the feasibility of the technology to produce a novel dosage form with properties that are difficult to achieve using the conventional industrial methods. Extrusionbased 3 DP is divided into two techniques, the semi-solid extrusion (SSE) and the fused deposition modeling (FDM). This review aims to explain the extrusion principles behind the two techniques and discuss their capabilities to fabricate novel dosage forms. The advantages and limitations observed through the application of SSE and FDM for fabrication of drug dosage forms were discussed in this review. Further exploration and development are required to implement this technology in the healthcare frontline for more effective and personalised treatment.

scholarly journals Quantification of Measurement and Model Effects in Monopile Foundation Scour Protection Experiments

2021 ◽  
Vol 9 (6) ◽  
pp. 585
Author(s):  
Minghao Wu ◽  
Leen De Vos ◽  
Carlos Emilio Arboleda Chavez ◽  
Vasiliki Stratigaki ◽  
Maximilian Streicher ◽  
...  
Keyword(s):  
Standard Deviation ◽  
Flow Field ◽  
Three Dimensional ◽  
Small Scale ◽  
Maximum Wave Height ◽  
Chaotic Flow ◽  
The Mean ◽  
Scour Protection ◽  
Damage Number ◽  
Measurement Effects

The present work introduces an analysis of the measurement and model effects that exist in monopile scour protection experiments with repeated small scale tests. The damage erosion is calculated using the three dimensional global damage number S3D and subarea damage number S3D,i. Results show that the standard deviation of the global damage number σ(S3D)=0.257 and is approximately 20% of the mean S3D, and the standard deviation of the subarea damage number σ(S3D,i)=0.42 which can be up to 33% of the mean S3D. The irreproducible maximum wave height, chaotic flow field and non-repeatable armour layer construction are regarded as the main reasons for the occurrence of strong model effects. The measurement effects are limited to σ(S3D)=0.039 and σ(S3D,i)=0.083, which are minor compared to the model effects.

scholarly journals Experimental and Numerical Investigation about Small Clearance Journal Bearings under Static Load Conditions

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Carlo Alberto Niccolini Marmont Du Haut Champ ◽  
Fabrizio Stefani ◽  
Paolo Silvestri
Keyword(s):  
Three Dimensional ◽  
Journal Bearings ◽  
Radial Clearance ◽  
Small Scale ◽  
Test Rig ◽  
Small Clearance ◽  
Dimensional Simulation ◽  
Dynamic Loading Conditions ◽  
Static And Dynamic Loading ◽  
Good Agreement

The aim of the present research is to characterize both experimentally and numerically journal bearings with low radial clearances for rotors in small-scale applications (e.g., microgas turbines); their diameter is in the order of ten millimetres, leading to very small dimensional clearances when the typical relative ones (order of 1/1000) are employed; investigating this particular class of journal bearings under static and dynamic loading conditions represents something unexplored. To this goal, a suitable test rig was designed and the performance of its bearings was investigated under steady load. For the sake of comparison, numerical simulations of the lubrication were also performed by means of a simplified model. The original test rig adopted is a commercial rotor kit (RK), but substantial modifications were carried out in order to allow significant measurements. Indeed, the relative radial clearance of RK4 RK bearings is about 2/100, while it is around 1/1000 in industrial bearings. Therefore, the same original RK bearings are employed in this new test rig, but a new shaft was designed to reduce their original clearance. The new custom shaft allows to study bearing behaviour for different clearances, since it is equipped with interchangeable journals. Experimental data obtained by this test rig are then compared with further results of more sophisticated simulations. They were carried out by means of an in-house developed finite element (FEM) code, suitable for thermoelasto-hydrodynamic (TEHD) analysis of journal bearings both in static and dynamic conditions. In this paper, bearing static performances are studied to assess the reliability of the experimental journal location predictions by comparing them with the ones coming from already validated numerical codes. Such comparisons are presented both for large and small clearance bearings of original and modified RKs, respectively. Good agreement is found only for the modified RK equipped with small clearance bearings (relative radial clearance 8/1000), as expected. In comparison with two-dimensional lubrication analysis, three-dimensional simulation improves prediction of journal location and correlation with experimental results.

scholarly journals Nonlinear effects of locally heterogeneous hydraulic conductivity fields on regional stream–aquifer exchanges

2015 ◽  
Vol 19 (11) ◽  
pp. 4531-4545 ◽  
Author(s):  
J. Zhu ◽  
C. L. Winter ◽  
Z. Wang
Keyword(s):  
Groundwater Flow ◽  
Effective Conductivity ◽  
Model Simulation ◽  
Three Dimensional ◽  
Small Scale ◽  
Heihe River ◽  
Effective Parameters ◽  
Aquifer Systems ◽  
Basin Scale ◽  
Local Grid

Abstract. Computational experiments are performed to evaluate the effects of locally heterogeneous conductivity fields on regional exchanges of water between stream and aquifer systems in the Middle Heihe River basin (MHRB) of northwestern China. The effects are found to be nonlinear in the sense that simulated discharges from aquifers to streams are systematically lower than discharges produced by a base model parameterized with relatively coarse effective conductivity. A similar, but weaker, effect is observed for stream leakage. The study is organized around three hypotheses: (H1) small-scale spatial variations of conductivity significantly affect regional exchanges of water between streams and aquifers in river basins, (H2) aggregating small-scale heterogeneities into regional effective parameters systematically biases estimates of stream–aquifer exchanges, and (H3) the biases result from slow paths in groundwater flow that emerge due to small-scale heterogeneities. The hypotheses are evaluated by comparing stream–aquifer fluxes produced by the base model to fluxes simulated using realizations of the MHRB characterized by local (grid-scale) heterogeneity. Levels of local heterogeneity are manipulated as control variables by adjusting coefficients of variation. All models are implemented using the MODFLOW (Modular Three-dimensional Finite-difference Groundwater Flow Model) simulation environment, and the PEST (parameter estimation) tool is used to calibrate effective conductivities defined over 16 zones within the MHRB. The effective parameters are also used as expected values to develop lognormally distributed conductivity (K) fields on local grid scales. Stream–aquifer exchanges are simulated with K fields at both scales and then compared. Results show that the effects of small-scale heterogeneities significantly influence exchanges with simulations based on local-scale heterogeneities always producing discharges that are less than those produced by the base model. Although aquifer heterogeneities are uncorrelated at local scales, they appear to induce coherent slow paths in groundwater fluxes that in turn reduce aquifer–stream exchanges. Since surface water–groundwater exchanges are critical hydrologic processes in basin-scale water budgets, these results also have implications for water resources management.

Analysis of Single- and Two-Phase Flows in Turbopump Inducers

1967 ◽  
Vol 89 (4) ◽  
pp. 577-586 ◽  
Author(s):  
P. Cooper
Keyword(s):  
Equation Of State ◽  
Flow Field ◽  
Thermal Effects ◽  
Single Phase ◽  
Fluid Pressure ◽  
Three Dimensional ◽  
Pressure Rise ◽  
Recent Theory ◽  
Two Phase ◽  
Overall Efficiency

A model is developed for analytically determining pump inducer performance in both the single-phase and cavitating flow regimes. An equation of state for vaporizing flow is used in an approximate, three-dimensional analysis of the flow field. The method accounts for losses and yields internal distributions of fluid pressure, velocity, and density together with the resulting overall efficiency and pressure rise. The results of calculated performance of two sample inducers are presented. Comparison with recent theory for fluid thermal effects on suction head requirements is made with the aid of a resulting dimensionless vaporization parameter.

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