scholarly journals Ageing and vitamin D deficiency: effects on calcium homeostasis and considerations for vitamin D supplementation

2009 ◽  
Vol 101 (11) ◽  
pp. 1597-1606 ◽  
Author(s):  
Christian Oudshoorn ◽  
Tischa J. M. van der Cammen ◽  
Marion E. T. McMurdo ◽  
Johannes P. T. M. van Leeuwen ◽  
Edgar M. Colin
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Calcium Homeostasis ◽  
Human Body ◽  
Steroid Hormone ◽  
Endocrine System ◽  
Vitamin D Supplementation ◽  
Multiple Systems ◽  
Almost All ◽  
Ca Homeostasis

Vitamin D is a fat-soluble, seco-steroid hormone. In man, the vitamin D receptor is expressed in almost all tissues, enabling effects in multiple systems of the human body. These effects can be endocrine, paracrine and autocrine. The present review summarises the effects of ageing on the vitamin D endocrine system and on Ca homeostasis. Furthermore, consequences for vitamin D supplementation are discussed.

scholarly journals The effectiveness of nutritional vitamin D supplementation and selective vitamin D receptor agonists treatment on secondary hyperparathyroidism in chronic kidney diseases patients

2018 ◽  
Vol 21 (2) ◽  
pp. 12-22 ◽  
Author(s):  
Lilit V. Egshatyan ◽  
Natalya G. Mokrisheva
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Receptor ◽  
Vitamin D Supplementation ◽  
Target Range ◽  
Receptor Agonists ◽  
Stage 4 ◽  
Calcium Phosphorus ◽  
Phosphorus Levels

Background: secondary hyperparathyroidism (SHPT) is an early complication of chronic kidney disease (CKD). Maintaining the level of 25(OH)D and parathyroid hormone concentrations in the target range reduce its associated complications (fractures and cardiovascular calcification). Aims: to examine the effectiveness of vitamin D supplementation and selective vitamin D receptor agonists treatment on SHPT in CKD. Material and methods: prospective observational study to evaluate the efficacy and safety of vitamin D therapy SHPT in 54 in patients with CKD. The first phase (24 weeks) – treatment of suboptimal 25-hydroxycalciferol (25(OH)D) levels. The second (16 weeks) – treatment colecalciferol-resistant SHPT by combination of cholecalciferol with paricalcitol. Blood samples were taken to assess parathyroid hormone (PTH), 25(OH)D, creatinine, calcium, phosphorus levels and calcium excretion. Results: After 8 weeks of cholecalciferol treatment all patients achieved 25(OH)D levels above 20 ng/ml, however 78% of patients still had SHPT. After 16 weeks, the decrease of PTH was achieved in all patients, but significantly only in patients with CKD 2 (19.2%, p< 0.01) and 3 (31%, p <0.05), compared with CKD 4 (17%, p >0.05). After 24 weeks of therapy, PTH normalized in all patients with CKD 2, in 15 (79%) with CKD 3 and in 9 (50%) patients with CKD 4. Cholecalciferol treatment resulted in a substantial increase in 25(OH)D levels with minimal or no impact on calcium, phosphorus levels and kidney function. After 24 weeks we initiated combination therapy (cholecalciferol and paricalcitol) for patients with colecalciferol-resistant SHPT (n=13). PTH levels decreased from 149.1±13.4 to 118.2±14.1 pg/ml at 8 weeks, and to 93.1±9.7 pg/ml (p <0.05) at 16 weeks of treatment. No significant differences in serum calcium, phosphorus or urinary calcium levels. Normalization of PTH was achieved in all patients with CKD 3 and in 8 patients with stage 4. One patient with CKD 4 needed an increase in paricalcitol dose. Conclusion: Cholecalciferol can be used in correcting vitamin D deficiency in patients with all stages of CKD, however, its effectiveness in reducing PTH in stage 4 is limited. Selective analogs, such as paricalcitol, were well-tolerated and effectively decreased PTH levels.

Regulation of aromatase expression by 1α,25(OH)2 vitamin D3 in rat testicular cells

2011 ◽  
Vol 23 (5) ◽  
pp. 725 ◽  
Author(s):  
Leila Zanatta ◽  
Hélène Bouraïma-Lelong ◽  
Christelle Delalande ◽  
Fátima R. M. B. Silva ◽  
Serge Carreau
Keyword(s):  
Gene Expression ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Sertoli Cells ◽  
Endocrine System ◽  
Aromatase Gene ◽  
Testicular Cells ◽  
Pka Pathway ◽  
Aromatase Gene Expression

It is well known that the vitamin D endocrine system is involved in physiological and biochemical events in numerous tissues, especially gut, bone and kidney but also testis. Therefore, in this study the effect and mechanisms of action of 1α,25(OH)2 vitamin D3 (1,25D) on aromatase gene expression in immature rat Sertoli cells were evaluated. Vitamin D receptor transcripts were present in immature Sertoli cells as well as in adult testicular germ cells and somatic cells. The treatment of immature Sertoli cells with 100 nM 1,25D increased the amount of aromatase transcript, mainly in 30-day-old rats. The protein kinase A (PKA) blocker, H89, partially inhibited the 1,25D effect. The stimulation of aromatase gene expression in 30-day-old Sertoli cells by the agonist 1α,25(OH)2 lumisterol3, and the suppression of the 1,25D effect by the antagonists 1β,25(OH)2 vitamin D3 and (23S)-25-dehydro-1α (OH)-vitamin D3-26,23-lactone suggested, besides a genomic effect of 1,25D, the existence of non-genomic activation of the membrane-bound vitamin D receptor involving the PKA pathway.

scholarly journals Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Nasser M. Al-Daghri ◽  
Abdul Khader Mohammed ◽  
Omar S. Al-Attas ◽  
Mohammed Ghouse Ahmed Ansari ◽  
Kaiser Wani ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Supplementation ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms

scholarly journals Controversial problems of Vitamin D receptor genetic polymorphism in patients with bronchial asthma

2020 ◽  
Vol 10 (4) ◽  
pp. 174-180
Author(s):  
Olha Yakovleva ◽  
Olha Nikolova
Keyword(s):  
Vitamin D ◽  
Genetic Polymorphism ◽  
Bronchial Asthma ◽  
Vitamin D Receptor ◽  
Vitamin D Supplementation ◽  
Cochrane Library ◽  
Russian Science ◽  
Russian Science Citation Index ◽  
The World ◽  
The Individual

The review presents information on variants of Vitamin D receptor’s genetic polymorphism, ensuring the direct physiolo­gical effects of the Vitamin via stimulation of nuclear cellular me­chanisms. The article was aimed at raising awareness of the glo­bal scientific advances in the field of Vitamin D receptor’s genetic polymorphism and its association with bronchopulmonary patho­logy in various regions of the planet. The search of scientific refe­rences was carried out in the Scopus, Web of Science, The Cochrane Library, Pubmed, ResearchGate, Russian Science Citation Index (RINC) information databases. The regulatory potential of the Vitamin D active hormonal effects in the bronchopulmonary patho­logy, especially in bronchial asthma (BA), remains unclear in terms of its pathogenetic links. Individual alleles inherent in the receptor genetics were studied, primarily in children with BA across the world. The results were compared as to levels of Vitamin D supplementation, BA symptoms and course The divergences were found in the four variants of alleles: Fok1, Apal, BsmI, TaqI. Those divergences prevail in the individual ethnic populations, limiting our capacities of drawing unambiguous conclusions, although the relationship between the course of BA and the deficient Vitamin’s status remains predominant. It is necessary to widen the database prospectively, to clarify the genetic variants of all the components involved in the metabolism and the Vitamin’s effects (transporter proteins, cytochrome P450 and vitamin D receptor) while the research geography is also expanding in the world.

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