scholarly journals Proceedings of the Rank Forum on Vitamin D

2010 ◽  
Vol 105 (1) ◽  
pp. 144-156 ◽  
Author(s):  
S. A. Lanham-New ◽  
J. L. Buttriss ◽  
L. M. Miles ◽  
M. Ashwell ◽  
J. L. Berry ◽  
...  
Keyword(s):  
Vitamin D ◽  
Reference Values ◽  
Age Groups ◽  
Vitamin D Status ◽  
Public Health Burden ◽  
Hydroxyvitamin D ◽  
Wide Range ◽  
The Uk ◽  
The University ◽  
Risk Managers

The Rank Forum on Vitamin D was held on 2nd and 3rd July 2009 at the University of Surrey, Guildford, UK. The workshop consisted of a series of scene-setting presentations to address the current issues and challenges concerning vitamin D and health, and included an open discussion focusing on the identification of the concentrations of serum 25-hydroxyvitamin D (25(OH)D) (a marker of vitamin D status) that may be regarded as optimal, and the implications this process may have in the setting of future dietary reference values for vitamin D in the UK. The Forum was in agreement with the fact that it is desirable for all of the population to have a serum 25(OH)D concentration above 25 nmol/l, but it discussed some uncertainty about the strength of evidence for the need to aim for substantially higher concentrations (25(OH)D concentrations>75 nmol/l). Any discussion of ‘optimal’ concentration of serum 25(OH)D needs to define ‘optimal’ with care since it is important to consider the normal distribution of requirements and the vitamin D needs for a wide range of outcomes. Current UK reference values concentrate on the requirements of particular subgroups of the population; this differs from the approaches used in other European countries where a wider range of age groups tend to be covered. With the re-emergence of rickets and the public health burden of low vitamin D status being already apparent, there is a need for urgent action from policy makers and risk managers. The Forum highlighted concerns regarding the failure of implementation of existing strategies in the UK for achieving current vitamin D recommendations.

scholarly journals Implementation Strategies for Improving Vitamin D Status and Increasing Vitamin D Intake in the UK: Current Controversies and Future Perspectives. Proceedings of the 2nd Rank Prize Funds Forum on Vitamin D

2021 ◽  
pp. 1-60
Author(s):  
J.L. Buttriss ◽  
S.A. Lanham-New ◽  
S. Steenson ◽  
L. Levy ◽  
G.E. Swan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Age Groups ◽  
Implementation Strategies ◽  
Vitamin D Status ◽  
Cost Information ◽  
Hydroxyvitamin D ◽  
Minority Ethnic Groups ◽  
Modelling Studies ◽  
Clinical Consequences ◽  
The Uk

Abstract A multi-disciplinary expert group met to discuss vitamin D deficiency in the UK, and strategies for improving population intakes and status. Changes to UK Government advice since the 1st Rank Forum on Vitamin D (2009) were discussed, including rationale for setting a RNI (10µg/day;400IU/day) for adults and children (4+ years). Current UK data show inadequate intakes among all age groups, and high prevalence of low vitamin D status among specific groups (e.g. pregnant women and adolescent males/females). Evidence of widespread deficiency within some minority ethnic groups, resulting in nutritional rickets (particularly among Black and South Asian infants), raised particular concern. It is too early to establish whether population vitamin D status has altered since Government recommendations changed in 2016. Vitamin D food fortification was discussed as a potential strategy to increase population intakes. Data from dose-response and dietary modelling studies indicate dairy products, bread, hens’ eggs and some meats as potential fortification vehicles. Vitamin D3 appears more effective than vitamin D2 for raising serum 25-hydroxyvitamin D concentration, which has implications for choice of fortificant. Other considerations for successful fortification strategies include: i) need for ‘real-world’ cost information for use in modelling work; ii) supportive food legislation; iii) improved consumer and health professional understanding of vitamin D’s importance; iv) clinical consequences of inadequate vitamin D status; v) consistent communication of Government advice across health/social care professions, and via the food industry. These areas urgently require further research to enable universal improvement in vitamin D intakes and status in the UK population.

scholarly journals Vitamin D Status and Seasonal Variation among Danish Children and Adults: A Descriptive Study

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1801 ◽  
Author(s):  
Louise Hansen ◽  
Anne Tjønneland ◽  
Brian Køster ◽  
Christine Brot ◽  
Rikke Andersen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Seasonal Variation ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Supplement Use ◽  
Wide Range ◽  
Adults And Children ◽  
25 Hydroxyvitamin D ◽  
Vitamin D Supplement ◽  
Very High

The aim of the present study was to describe vitamin D status and seasonal variation in the general Danish population. In this study, 3092 persons aged 2 to 69 years (2565 adults, 527 children) had blood drawn twice (spring and autumn) between 2012 and 2014. A sub-sample of participants had blood samples taken monthly over a year. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured by liquid chromatography mass spectrometry, and information on supplement use was assessed from questionnaires. Seasonal variations in 25(OH)D concentrations were evaluated graphically and descriptively, and status according to age, sex, and supplement use was described. It was found that 86% of both adults and children were vitamin D-sufficient in either spring and or/autumn; however, many had a spring concentration below 50 nmol/L. A wide range of 25(OH)D concentrations were found in spring and autumn, with very low and very high values in both seasons. Among adults, women in general had higher median 25(OH)D concentrations than men. Furthermore, vitamin D supplement use was substantial and affected the median concentrations markedly, more so during spring than autumn. Seasonal variation was thus found to be substantial, and bi-seasonal measurements are vital in order to capture the sizable fluctuations in vitamin D status in this Nordic population.

scholarly journals Vitamin D Levels of Out-Patients in Lithuania: Deficiency and Hypervitaminosis

Medicina ◽  
2018 ◽  
Vol 54 (2) ◽  
pp. 25 ◽  
Author(s):  
Andrius Bleizgys ◽  
Jevgenij Kurovskij
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
High Performance ◽  
Age Groups ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
The Mean ◽  
Almost All

Aim: Data on the prevalence of vitamin D deficiency in Lithuania are scarce. The aim was to assess the reserves of vitamin D in different age groups of out-patients, regarding the season of the year. Methods: Data on serum 25-hydroxyvitamin D (25(OH)D) levels from blood tests made in 2012–2014 were obtained from one laboratory, and a retrospective cross-sectional analysis was performed. Results: A total of 9581 subjects were included. The mean age of the participants was 33 ± 23 years. The mean levels of vitamin D were higher in males than in females (p < 0.001). The highest mean 25(OH)D levels were in 0–9-year-old group, the lowest were in the 10–19-year-old group and in the group of participants that were 70 years and older (p < 0.001). The lowest vitamin D status was found in January, February, March, and April. The highest status was found in August and September. Overall, vitamin D deficiency, sufficiency, and hypervitaminosis were detected in 67%, 21%, and 12% of cases, respectively. Most cases with hypervitaminosis were in the group of children up to 2 years of age. Conclusion: Vitamin D status demonstrated clear seasonality. Significant sex-related differences of vitamin D statuses were also determined. Vitamin D deficiency was very prevalent in almost all age groups. Young children (aged up to 2 years) are of special interest for further research involving other types of 25(OH)D assays, such as those based on high-performance liquid chromatography (HPLC), since the real prevalence of “true” vitamin D hypervitaminosis in Lithuania’s children is still to be determined.

scholarly journals Does vitamin D status track through adolescence?

2015 ◽  
Vol 102 (5) ◽  
pp. 1025-1029 ◽  
Author(s):  
Machuene A Poopedi ◽  
Shane A Norris ◽  
Lisa K Micklesfield ◽  
John M Pettifor
Keyword(s):  
Vitamin D ◽  
Age Groups ◽  
Vitamin D Status ◽  
Hydroxyvitamin D ◽  
Disease States ◽  
Cast Doubt ◽  
Z Scores ◽  
The Individual ◽  
Time Point

ABSTRACT Background: To our knowledge, no studies have reported on the long-term variability of vitamin D status in adolescents. Objective: To determine whether tracking of vitamin D status occurs in healthy adolescents, we assessed the variability of 25-hydroxyvitamin D [25(OH)D] every 2 y over a 10-y period in a longitudinal cohort of adolescents living in Johannesburg, South Africa (latitude 26°S). Design: Healthy adolescents who had blood samples available on ≥3 occasions between 11 and 20 y of age were included in the study. Of the cohort of 504 children, 99 met the criteria. The mean 25(OH)D concentration at each time point was measured, and the individual 25(OH)D z scores based on year 11 values were used as the reference. All 25(OH)D concentrations for a subject were measured in a single assay. Results: No significant correlation was found between 25(OH)D in the earlier and later years of adolescence, although significant correlations were found between year 11 and year 13 (r = 0.71, P < 0.0001) and between years 15, 17, and 20 (r ≥ 0.65, P < 0.0001). The percentage of adolescents whose 25(OH)D concentration changed by >20 nmol/L from year 11 was calculated for all age groups: 12% of the cohort had a change of >20 nmol/L at 13 y of age compared with 46% at 20 y of age. Just more than one-half (53%) of the cohort changed their category of vitamin D status between the ages of 11 and 20 y, and one-third of adolescents changed from being replete to insufficient over the same period. Conclusions: The data suggest that the measurement of 25(OH)D at a single time point does not reflect the long-term vitamin D status of an adolescent. These findings may cast doubt on the veracity of those studies that suggest an association of vitamin D status with various disease states in which vitamin D status was measured only once.

scholarly journals Prospective associations between vitamin D and depression in middle-aged adults: findings from the UK Biobank cohort

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Amy Ronaldson ◽  
Jorge Arias de la Torre ◽  
Fiona Gaughran ◽  
Ioannis Bakolis ◽  
Stephani L. Hatch ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Vitamin D Status ◽  
Uk Biobank ◽  
Middle Aged ◽  
Wide Range ◽  
The Uk ◽  
Middle Aged Adults ◽  
New Onset

Abstract Background A possible role of vitamin D in the pathophysiology of depression is currently speculative, with more rigorous research needed to assess this association in large adult populations. The current study assesses prospective associations between vitamin D status and depression in middle-aged adults enrolled in the UK Biobank. Methods We assessed prospective associations between vitamin D status at the baseline assessment (2006–2010) and depression measured at the follow-up assessment (2016) in 139 128 adults registered with the UK Biobank. Results Amongst participants with no depression at baseline (n = 127 244), logistic regression revealed that those with vitamin D insufficiency [adjusted odds ratio (aOR) = 1.14, 95% confidence interval (CI) = 1.07–1.22] and those with vitamin D deficiency (aOR = 1.24, 95% CI 1.13–1.36) were more likely to develop new-onset depression at follow-up compared with those with optimal vitamin D levels after adjustment for a wide range of relevant covariates. Similar prospective associations were reported for those with depression at baseline (n = 11 884) (insufficiency: aOR = 1.11, 95% CI 1.00–1.23; deficiency: aOR = 1.30, 95% CI 1.13–1.50). Conclusions The prospective associations found between vitamin D status and depression suggest that both vitamin D deficiency and insufficiency might be risk factors for the development of new-onset depression in middle-aged adults. Moreover, vitamin D deficiency (and to a lesser extent insufficiency) might be a predictor of sustained depressive symptoms in those who are already depressed. Vitamin D deficiency and insufficiency is very common, meaning that these findings have significant implications for public health.

scholarly journals UK Food Standards Agency Workshop Consensus Report: the choice of method for measuring 25-hydroxyvitamin D to estimate vitamin D status for the UK National Diet and Nutrition Survey

2010 ◽  
Vol 104 (4) ◽  
pp. 612-619 ◽  
Author(s):  
Anne de la Hunty ◽  
A. Michael Wallace ◽  
Sigrid Gibson ◽  
Heli Viljakainen ◽  
Christel Lamberg-Allardt ◽  
...  
Keyword(s):  
Vitamin D ◽  
Expert Panel ◽  
Detailed Knowledge ◽  
Vitamin D Status ◽  
Nutrition Survey ◽  
Hydroxyvitamin D ◽  
Young Infants ◽  
Food Standards ◽  
25 Hydroxyvitamin D ◽  
The Uk

The consensus workshop, organised on behalf of the Food Standards Agency, was convened to recommend the most appropriate and secure method for measuring vitamin D status in the UK. Workshop participants (the Expert Panel) were invited on the basis of expertise in current 25-hydroxyvitamin D (25OHD) assays, or expertise in vitamin D nutrition and metabolism or detailed knowledge and experience in the National Diet and Nutrition Survey (NDNS). A decision support matrix, which set out the particular criteria by which the different options were scored and evaluated, was used to structure the discussion. The Expert Panel agreed that five methods for measuring 25OHD should be evaluated according to eleven criteria, selected on the basis of their relevance to the NDNS. All three of the evaluating subgroups of the Expert Panel produced similar total scores over the eleven criteria for the different methods; they scored LC–MS/MS and HPLC-UV similarly highly, while the scores for the immunoassay methods were lower. The Expert Panel recommended that an LC–MS/MS method should be the preferred method for the NDNS. A detailed specification for the method will be required to ensure comparability between NDNS and the National Health and Nutrition Examination Survey in the US facilitating future comparisons. The Expert Panel also recommended that the method should be carried out in a laboratory with appropriate expertise, competency and history of records of good performance. The method should be standardised against the National Institute of Standards and Technology SRM 972. If the recommended LC–MS/MS is adopted, the Expert Panel indicated that the method should be able to discriminate the C-3 epimer of 25OHD3, especially if used to measure 25OHD in young infants in the forthcoming Diet and Nutrition Survey of Infants and Young Children, who are known to have high circulating concentrations of the C-3 epimer.

scholarly journals Study on Association between BMI and Vitamin D Levels in South Indian Rural Population

2021 ◽  
Vol 9 (4) ◽  
pp. 213-218
Author(s):  
Dr. A Ponnambalam ◽  
◽  
Dr. M Arun ◽  
Dr. G Prabhu ◽  
◽  
...  
Keyword(s):  
Vitamin D ◽  
Age Groups ◽  
Sun Exposure ◽  
Research Centre ◽  
Vitamin D Status ◽  
College Hospital ◽  
Hydroxyvitamin D ◽  
Medical College ◽  
South Indian ◽  
Vitamin D Levels

Introduction: Vitamin D deficiency is a global health problem worldwide and is considered to be apandemic with implications for compromised bone health and other chronic diseases. A few studieshave examined the association between vitamin D status and body mass index (BMI). However,prospective data using the biomarker serum 25-hydroxyvitamin D 25(OH) D3 are limited andtherefore examined in the present study. Methods: Participants were selected from subjectsattending to Medicine Outpatient Department (OPD) in Sri Venkateshwara Medical College Hospital &Research Centre (SVMCH & RC) willing to participate in the present study between Jan 2020 to Dec2020. Anthropometric measurements, personal, medical history questionnaire, food frequencyquestionnaire (FFQ) for vitamin D, and sun exposure questionnaire were collected from all theparticipants in the present study, blood samples for serum 25(OH)D3 were collected from allsubjects. Results: Our study showed that the majority of healthy individual cases of the study i.e.,68.0% have a deficiency in vitamin D status, while 68.0% have ≤20 ng/dl in vitamin D, and 32.0%in >20 ng/dl. Moreover, the study showed a negative association between the level of circulating25(OH) D3 and BMI. Conclusion: This study demonstrated that the association between BMI and25(OH)D concentrations in populations from south India can be seen across different age groups andin both men and women. The study also exemplified that higher BMI leads to lower vitamin D status,providing evidence for the role of obesity as a causal risk factor for the development of vitamin Ddeficiency.

scholarly journals Profile of 25-Hydroxyvitamin D in Individuals Attending Armed Forces Institute of Pathology (AFIP), Dhaka

2018 ◽  
Vol 8 (1) ◽  
pp. 35-40
Author(s):  
Mimi Parvin ◽  
Mreenal Kanti Sarkar ◽  
Debashis Saha
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Skin Pigmentation ◽  
Age Groups ◽  
Armed Forces ◽  
Automated System ◽  
Vitamin D Status ◽  
Female Ratio ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

Background: In the last two decades, there has been increasing interest in the biology of vitamin D and a growing recognition is that vitamin D deficiency is common in tropical countries despite having ample sunshine. Myth of ‘routine exposure to sunshine does not require extra vitamin D’ results in severe asymptomatic vitamin D deficiency. Several factors like socio-economic condition, dietary insufficiency, inadequate exposure to sunlight due to use of sun-screen, clothes, environmental pollution, skin pigmentation may contribute to vitamin D deficiency.Objective: The study was designed to evaluate the vitamin D status of patients of different age groups reporting to Armed Forces Institute of Pathology (AFIP), Dhaka.Materials and Methods: This crosssectional, observational study was conducted from October 2015 to March 2017, using serum 25-hydroxyvitamin D (25-OHD) levels to classify patients of different age groups into deficient, insufficient and sufficient categories. Individuals up to 70 years of age of all religions, genders and occupations who gave blood specimens at AFIP were included in the study. Patients with chronic renal failure, primary hyperparathyroidism, on vitamin D supplementation with established diagnosis of osteomalacia and rickets, taking phenytoin or glucocorticoids were excluded. Total 25-OH vitamin D level in serum was estimated by electro-chemiluminescence on Cobas Elecsys e411 fully automated system on the day of collection. This method has been standardized against LC-MS/MS which in turn has been standardized to the NIST (National Institute of Standards and Technology, USA). The functional sensitivity was determined to be 4.01 ng/mL (CV 18.5%). Vitamin D deficiency is defined as 25(OH) D <50 nmol/L, insufficiency as 50–75 nmol/L and sufficiency as ≥75 nmol/L and toxicity >375 nmol/L. The definition of vitamin D status was based on the recommendation of the US Institute of Medicine (IOM) for vitamin D.Results: A total of 2867 specimens were enrolled in the study, comprising 1949 (67.98%) female and 918 (32.02%) male. Maximum number (1270) was in the age range of 41−60 years. According to vitamin D status 1640 (57.20%) out of 2867 were found deficient, among which female were 1175 (71.65%) and male 465 (28.35%) with 1:2.5 male and female ratio. There were 255 male (37.83%) and 419 (62.17%) female in the insufficient group with 1:1.64 male-female ratio. Lowest value of <7.5 nmol/L was found in 36 subjects where 80.55% were female. Female were also found to be predominant (62.75%) in highest concentration of vitamin D (>175 nmol/L). Female in all age groups predominated in both deficiency and insufficiency groups. No toxic values were found in any age group among male or female.Conclusion: Vitamin D deficiency is pandemic; it has been assumed that one billion people worldwide have vitamin D deficiency or insufficiency. Laboratory professionals are confronted with substantial increase in laboratory testing due to growing clinical interest in vitamin D status. At the same time avoidance of overscreening of vitamin D by physicians should also be considered.J Enam Med Col 2018; 8(1): 35-40

Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in a Large Cohort: Results From the UK Biobank

2020 ◽  
Vol 105 (10) ◽  
pp. e3606-e3619 ◽  
Author(s):  
Xikang Fan ◽  
Jiayu Wang ◽  
Mingyang Song ◽  
Edward L Giovannucci ◽  
Hongxia Ma ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cancer Mortality ◽  
Lower Risk ◽  
Premature Death ◽  
Inverse Association ◽  
Vitamin D Status ◽  
Uk Biobank ◽  
Hydroxyvitamin D ◽  
Specific Mortality ◽  
The Uk

Abstract Context Although an inverse association between vitamin D status and mortality has been reported in observational studies, the precise association shape and optimal vitamin D status remain undetermined. Objective To investigate the association between vitamin D status and risk of all-cause and cause-specific mortality and estimate optimal serum 25-hydroxyvitamin D [25(OH)D] concentrations. Design Prospective cohort study. Setting UK Biobank. Participants 365 530 participants who had serum 25(OH)D measurements and no history of cardiovascular disease (CVD), cancer, or diabetes at baseline (2006-2010). Main outcome measures All-cause and cause-specific mortality. Results During a median follow-up of 8.9 (interquartile range: 8.3-9.5) years, 10 175 deaths occurred, including 1841 (18.1%) due to CVD and 5737 (56.4%) due to cancer. The multivariate analyses revealed nonlinear inverse associations, with a decrease in mortality risk appearing to level off at 60 nmol/L of 25(OH)D for all-cause and CVD deaths and at 45 nmol/L for cancer deaths. Compared to participants with 25(OH)D concentrations below the cutoffs, those with higher concentrations had a 17% lower risk for all-cause mortality (hazard ratio [HR]: 0.83, 95% confidence interval [CI]: 0.79-0.86), 23% lower risk for CVD mortality (HR: 0.77, 95% CI: 0.68-0.86), and 11% lower risk for cancer mortality (HR: 0.89, 95% CI: 0.84-0.95). Conclusions Higher 25(OH)D concentrations are nonlinearly associated with lower risk of all-cause, CVD, and cancer mortality. The thresholds of 45 to 60 nmol/L might represent an intervention target to reduce the overall risk of premature death, which needs further confirmation in large clinical trials.

scholarly journals Comparison of Vitamin D and 25-Hydroxyvitamin D Concentrations in Human Breast Milk between 1989 and 2016–2017

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 573
Author(s):  
Naoko Tsugawa ◽  
Mayu Nishino ◽  
Akiko Kuwabara ◽  
Honami Ogasawara ◽  
Maya Kamao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Breast Milk ◽  
Sun Exposure ◽  
Stepwise Multiple Regression ◽  
Human Breast Milk ◽  
Vitamin D Status ◽  
Human Breast ◽  
Hydroxyvitamin D ◽  
Lactating Mothers ◽  
25 Hydroxyvitamin D

Background: Breast milk is considered the optimal source of nutrition during infancy. Although the vitamin D concentration in human breast milk is generally considered poor for infants, vitamin D in breast milk is an important source for exclusively breastfed infants. Increases in vitamin D insufficiency and deficiency in lactating mothers may reduce vitamin D concentrations in breast milk. This study aimed to compare vitamin D and 25-hydroxyvitamin D (25OHD) concentrations in breast milk collected in 1989 and 2016–2017 and simultaneously analyze them with liquid chromatography-tandem mass spectrometry (LC-MS/MS); the association between the lifestyle of recent lactating mothers (2016–2017) and vitamin D status in human breast milk was also evaluated. Method: Lactating mothers were recruited from three regions of Japan in 1989 (n = 72) and 2016–2017 (n = 90), and milk from 3–4 months was collected in summer and winter. The samples were strictly sealed and stored at −80℃ until measurement. Breast milk vitamin D and 25OHD concentrations were analyzed by LC-MS/MS. Vitamin D intake, sun exposure, and sunscreen use of the lactating mothers in 2016–2017 were assessed. Results: Both vitamin D and 25OHD concentrations in breast milk were higher in the summer regardless of the survey year. Significantly lower vitamin D and 25OHD concentrations were observed in 2016–2017 compared with 1989 in summer, but no survey year difference was observed in winter. The stepwise multiple regression analyses identified season, daily outdoor activity, and suntan in the last 12 months as independent factors associated with vitamin D3 concentrations. Conclusion: The results suggest that low vitamin D status in recent lactating mothers may have decreased vitamin D and 25OHD concentrations in breast milk compared with the 1980s. These results are helpful for developing public health strategies to improve vitamin D status in lactating mothers and infants.

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