scholarly journals Amelioration of hyperglycaemia and its associated complications by finger millet (Eleusine coracanaL.) seed coat matter in streptozotocin-induced diabetic rats

2010 ◽  
Vol 104 (12) ◽  
pp. 1787-1795 ◽  
Author(s):  
Shanmugam Shobana ◽  
Mysore R. Harsha ◽  
Kalpana Platel ◽  
Krishnapura Srinivasan ◽  
Nagappa G. Malleshi
Keyword(s):  
Seed Coat ◽  
Finger Millet ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Tubular Structures ◽  
Glycation End Products ◽  
Body Weights ◽  
Millet Seed ◽  
Effect Of Feeding ◽  
Partial Reversal

Finger millet (Eleusine coracana) is extensively cultivated and consumed in India and Africa. The millet seed coat is a rich source of dietary fibre and phenolic compounds. The effect of feeding a diet containing 20 % finger millet seed coat matter (SCM) was examined in streptozotocin-induced diabetic rats. Diabetic rats maintained on the millet SCM diet (diabetic experimental (DE) group) for 6 weeks exhibited a lesser degree of fasting hyperglycaemia and partial reversal of abnormalities in serum albumin, urea and creatinine compared with the diabetic control (DC) group. The DE group of rats excreted comparatively lesser amounts of glucose, protein, urea and creatinine and was accompanied by improved body weights compared with their corresponding controls. Hypercholesterolaemia and hypertriacylglycerolaemia associated with diabetes were also notably reversed in the DE group. Slit lamp examination of the eye lens revealed an immature subcapsular cataract with mild lenticular opacity in the DE group of rats compared to the mature cataract with significant lenticular opacity and corneal vascularisation in the DC group. Lower activity of lens aldose reductase, serum advanced glycation end products and blood glycosylated Hb levels were observed in the DE group. The millet SCM feeding showed pronounced ameliorating effects on kidney pathology as reflected by near normal glomerular and tubular structures and lower glomerular filtration rate compared with the shrunken glomerulus, tubular vacuolations in the DC group. Thus, the present animal study evidenced the hypoglycaemic, hypocholesterolaemic, nephroprotective and anti-cataractogenic properties of finger millet SCM, suggesting its utility as a functional ingredient in diets for diabetics.

Quality characteristics of biscuits prepared from finger millet seed coat based composite flour

2011 ◽  
Vol 129 (2) ◽  
pp. 499-506 ◽  
Author(s):  
Rateesh Krishnan ◽  
Usha Dharmaraj ◽  
R. Sai Manohar ◽  
N.G. Malleshi
Keyword(s):  
Seed Coat ◽  
Finger Millet ◽  
Quality Characteristics ◽  
Composite Flour ◽  
Millet Seed

Effects of Nigerian black finger millet (Eleusine coracana L. Gaertn.) seed coat supplementation on streptozotocin-induced diabetic rats

2015 ◽  
Vol 8 (2) ◽  
pp. 93-100 ◽  
Author(s):  
Onyike Elewechi ◽  
Okoyomoh Kingsley ◽  
Ndidi Uche Samuel ◽  
Olowoniyi Olufunsho Dayo ◽  
Adejo Godwin Ojochogu ◽  
...  
Keyword(s):  
Seed Coat ◽  
Finger Millet ◽  
Diabetic Rats ◽  
Eleusine Coracana

Evaluation of Exogenous Laccase Enzyme Treated Finger Millet Straw on Body Weight Gain, DM Intake and Nutrient Digestibility in Heifers

2021 ◽  
Author(s):  
Vidya Pradeep Kumar ◽  
Ramya G. Rao ◽  
A. Dhali ◽  
Vandana Thammiaha ◽  
Manpal Sridhar
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Finger Millet ◽  
Body Weight Gain ◽  
Test Group ◽  
Nutrient Digestibility ◽  
Control Group ◽  
Widespread Application ◽  
Body Weights ◽  
Effect Of Feeding

Background: Fungal laccases have widespread application in a number of biotechnological processes including the biodegradation of lignin. Their low yield in the native state limits their practical use in the deconstruction of lignocellulosic biomass for feeding ruminants. Enzymes in bulk quantities are required to treat biomass which has got greater product consistency and less lot to lot variations. The present study was an attempt to evaluate the effect of feeding finger millet straw treated with exogenous laccases in heifers.Methods: The effect of feeding exogenous laccases obtained from immobilized Schizophyllum commune (MTCC 11893) on body weight gain, dry matter intake and nutrient digestibility in heifers was evaluated in three groups of heifers (4-each) with body weights ranging between 275 ± 47.12 to 276.75 ± 64.48kg. The control group received ad lib. finger millet straw treated with only production media (GI). Test group 1 (GII) received ad lib. straw treated with laccase rich media in a 3:5 (w/v) ratio, while test group 2 (GIII) received ad lib. straw treated in a 4:5 (w/v) ratio. Result: After 14- days of feeding, gain in body weights for GI, GII and GIII were 277.9 ± 68.47; 277.50 ± 46.43 and 278.85 ± 37.22 respectively with an overall increase of 1.15, 4.25 and 3.60 kgs. No significant variation (P greater than 0.05) was observed with regard to DMD (%) between the groups which was 46 ± 5.8 for the control animals and 41±13.0 and 41± 3.4 in G2 and G3 groups. Though significant variations were observed digestibility studies proved inconclusive. Though preliminary results indicate that applying lignin degrading enzymes as feed supplements could enhance digestibility of crop residues in ruminants.

scholarly journals EFFECT OF GYMNEMA SYLVESTRE METHANOLIC EXTRACT ON PANCREATIC PUTRESCINE LEVELS AGAINST ALLOXAN-INDUCED DIABETIC RATS

2019 ◽  
Vol 12 (1) ◽  
pp. 253
Author(s):  
Jothi Muniyandi M ◽  
Benno Susai Vijayakumar A
Keyword(s):  
High Performance ◽  
Liver Glycogen ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Phytochemical Analysis ◽  
Gymnema Sylvestre ◽  
Standard Drug ◽  
Beneficial Effects ◽  
Body Weights

Objective: Gymnema sylvestre, a rare herb with significant medicinal values widely used as a naturopathic treatment for diabetes. This study demonstrates the antidiabetic potential and changes in the levels of pancreatic putrescine in G. sylvestre treated experimental rat models.Methods: Phytochemical analysis was carried out for methanolic leaf extract of G. sylvestre (GSME). Further, antidiabetic property and putrescine levels in alloxan-induced diabetic Wister albino rats were analyzed by high-performance liquid chromatography method.Results: The GSME (500 mg/kg b/w) was administered daily up to 15 days in diabetic rats against standard drug metformin (500 mg/kg b/w). At the end of the experiments, the increased body weights were noted in the diabetic control groups, while there was reduction in blood glucose level, total protein, liver glycogen, glutathione, glutathione peroxidase, and blood catalase, respectively.Conclusion: GSME at the dose of (500 mg/kg b/w) brings about significant beneficial effects in various physiological parameters and level of putrescine altered during diabetic manifestations, and these effects are quite comparable with the standard drug, metformin.

Inhibition of lipid oxidation in mayonnaise by finger millet seed coat polyphenols

2021 ◽  
Author(s):  
Geetha Velur Balasubramaniam ◽  
Sathvika Sukumar ◽  
Meena Alagarsamy ◽  
Pon Sharmila Devi Velpandi ◽  
Ayyappan Palaniappan ◽  
...  
Keyword(s):  
Lipid Oxidation ◽  
Seed Coat ◽  
Finger Millet ◽  
Millet Seed

scholarly journals EFFECT OF GYMNEMA SYLVESTRE METHANOLIC EXTRACT ON PANCREATIC PUTRESCINE LEVELS AGAINST ALLOXAN-INDUCED DIABETIC RATS

2019 ◽  
Vol 12 (1) ◽  
pp. 253
Author(s):  
Jothi Muniyandi M ◽  
Benno Susai Vijayakumar A
Keyword(s):  
High Performance ◽  
Liver Glycogen ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Phytochemical Analysis ◽  
Gymnema Sylvestre ◽  
Standard Drug ◽  
Beneficial Effects ◽  
Body Weights

Objective: Gymnema sylvestre, a rare herb with significant medicinal values widely used as a naturopathic treatment for diabetes. This study demonstrates the antidiabetic potential and changes in the levels of pancreatic putrescine in G. sylvestre treated experimental rat models.Methods: Phytochemical analysis was carried out for methanolic leaf extract of G. sylvestre (GSME). Further, antidiabetic property and putrescine levels in alloxan-induced diabetic Wister albino rats were analyzed by high-performance liquid chromatography method.Results: The GSME (500 mg/kg b/w) was administered daily up to 15 days in diabetic rats against standard drug metformin (500 mg/kg b/w). At the end of the experiments, the increased body weights were noted in the diabetic control groups, while there was reduction in blood glucose level, total protein, liver glycogen, glutathione, glutathione peroxidase, and blood catalase, respectively.Conclusion: GSME at the dose of (500 mg/kg b/w) brings about significant beneficial effects in various physiological parameters and level of putrescine altered during diabetic manifestations, and these effects are quite comparable with the standard drug, metformin.

Prebiotic potential of xylooligosaccharides derived from finger millet seed coat

2017 ◽  
Vol 31 (4) ◽  
pp. 264-280 ◽  
Author(s):  
Ayyappan Palaniappan ◽  
V. Geetha Balasubramaniam ◽  
Usha Antony
Keyword(s):  
Seed Coat ◽  
Finger Millet ◽  
Millet Seed

scholarly journals Normoglycaemic, Normolipidaemic and Antioxidant Effects of Ethanolic Extract of Acacia ataxacantha Root in Streptozotocin - induced Diabetic Rats

2016 ◽  
Vol 8 (2) ◽  
pp. 144-150
Author(s):  
Rotimi Olusanya ARISE ◽  
Tosan AKAPA ◽  
Moshood A. ADIGUN ◽  
Abeeb Abiodun YEKEEN ◽  
Oluwafemi O. OGUNTIBEJU
Keyword(s):  
Low Density Lipoprotein ◽  
Antioxidant Properties ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Body Weights ◽  
Repeated Doses ◽  
Phytochemical Constituents

The antidiabetic, normolipidaemic, antioxidant and safety evaluations of ethanolic extract of Acacia ataxacantha roots (EEAAR) were investigated in streptozotocin - induced diabetic rats, to verify its use in traditional African medicine and as alternative to synthetic normoglycaemic agents in diabetic treatments. Thirty albino rats (Rattus novergicus) were randomized into six groups - control, diabetic control, EEAAR-treated at 125 mg/kg, 250 mg/kg, 500 mg/kg body weights (b.wts.) and metformin groups, respectively. Phytochemical screening showed the presence of alkaloids, polyphenols, flavonoid, saponins, tannins and terpenoid. Blood glucose was significantly reduced (p < 0.05) especially after 7 days of oral administration of EEAAR at 125 mg/kg b.wt with values (110.01 ± 9.64 mg/dl) similar to that of the control (106.33 ± 4.13 mg/dl). There was an increase (p < 0.05) in the ALT and AST activities of the liver and serum of rats in all the groups except in those that received 125 mg/kg b.wt. Serum total cholesterol, low density lipoprotein cholesterol and triglyceride were decreased (p < 0.05) upon administration of the extract and metformin. There was no difference (p > 0.05) in malondialdehyde concentration of rats administered with 125 mg/kg b.wt. of extract and metformin. Superoxide dismutase activity was elevated (p < 0.05) in all groups and compared favourably with the control in each of the tissues. This study revealed the antidiabetic and hypolipidaemic effects of EEAAR, which may be due to the antioxidant properties of some of the phytochemical constituents. However, the extract may not be safe at large and repeated doses.

Characterization of xylan from rice bran and finger millet seed coat for functional food applications

2017 ◽  
Vol 75 ◽  
pp. 296-305 ◽  
Author(s):  
Ayyappan Palaniappan ◽  
Shanmuga Sundharam Yuvaraj ◽  
Saravanan Sonaimuthu ◽  
Usha Antony
Keyword(s):  
Rice Bran ◽  
Seed Coat ◽  
Functional Food ◽  
Finger Millet ◽  
Millet Seed ◽  
Food Applications

scholarly journals Antidiabetic and Hypolipidaemic Action of Finger Millet (Eleusine coracana)-Enriched Probiotic Fermented Milk

2020 ◽  
Vol 58 (2) ◽  
pp. 192-202
Author(s):  
Jinal Kesharbhai Chaudhary ◽  
Sreeja Mudgal
Keyword(s):  
Body Mass ◽  
Finger Millet ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Fermented Milk ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Eleusine Coracana ◽  
Lactobacillus Helveticus ◽  
Enriched Milk

Research background. Diabetes is a chronic multi-system disease having long term consequences to the health of people suffering from it. This study investigates the role of finger millet (Eleusine coracana)-enriched probiotic fermented milk in alleviating the diabetic complications in streptozotocin-induced diabetic rats. Experimental approach. The probiotic strain used in the study was Lactobacillus helveticus MTCC 5463. Study comprised six groups each containing 6 Sprague Dawley rats: two controls (nondiabetic and diabetic), and four diabetic groups fed finger millet-enriched probiotic fermented milk, probiotic fermented milk, finger millet flour or metformin (standard drug). Samples were administered orally for four weeks, and parameters associated with diabetic disorders were studied. Results and conclusions. Oral administration of finger millet-enriched milk significantly (p&lt;0.001) decreased (64.26 %) the fasting blood glucose level of diabetic rats compared to metformin (56.43 %) and diabetic groups receiving the probiotic fermented milk (18.88 %) and finger millet flour (47.14 %) after four weeks of treatment. The finger millet-enriched milk significantly ameliorated the diabetic symptoms polyphagia and polydipsia and improved body mass. In diabetic control group, body mass was reduced up to 15.60 % at the end of experiment, while in the group receiving the probiotic fermented milk, body mass significantly (p&lt;0.0001) increased by about 5-30 %. Significant (p&lt;0.0001) reduction in total cholesterol, triglyceride levels in the groups treated with finger millet flour, finger millet-enriched probiotic fermented milk and probiotic fermented milk was observed compared to diabetic control rats. The probiotic fermented milk enriched with finger millet caused significant (p&lt;0.05) decrease in low-density lipoprotein and very-low-density lipoprotein levels (p&lt;0.0001) and insignificant increase in high-density lipoprotein level. A reversal of altered activities of hepatic marker enzymes aspartate transaminase and alanine transaminase was observed in the group receiving the probiotic milk enriched with finger millet. Histological observations of pancreatic tissues and liver showed that the enriched milk prevents more severe changes in the acinar cells and ameliorated the inflammation and alteration in the liver structure to some extent. Therefore, the finger millet-enriched probiotic fermented milk can be a potential functional food in the management of diabetes. Novelty and scientific contribution. This is the only paper reporting about the antidiabetic potential of finger millet-enriched milk fermented using probiotic Lactobacillus helveticus MTCC 5463 and Streptococcus thermophilus MTCC 5460. It also shows the synergistic antidiabetic effect of milk and finger millet used in combination, thus offering a novel functional food.

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