scholarly journals Associations between obesity candidate gene polymorphisms (fat mass and obesity-associated (FTO), melanocortin-4 receptor (MC4R), leptin (LEP) and leptin receptor (LEPR)) and dietary intake in pregnant women

2018 ◽  
Vol 120 (4) ◽  
pp. 454-463 ◽  
Author(s):  
Maisa C. Martins ◽  
Janet Trujillo ◽  
Ana Amélia Freitas-Vilela ◽  
Dayana R. Farias ◽  
Eliane L. Rosado ◽  
...  

AbstractGenetic variants associated with dietary intake may be important as factors underlying the development of obesity. We investigated the associations between the obesity candidate genes (fat mass and obesity-associated (FTO), melanocortin-4 receptor (MC4R), leptin (LEP) and leptin receptor) and total energy intake and percentage of energy from macronutrients and ultra-processed foods before and during pregnancy. A sample of 149 pregnant women was followed up in a prospective cohort in Rio de Janeiro, Brazil. A FFQ was administered at 5–13 and 30–36 weeks of gestation. Genotyping was performed using real-time PCR. Associations between polymorphisms and the outcomes were investigated through multiple linear regression and ANCOVA having pre-pregnancy dietary intake as a covariate. The A-allele of FTO-rs9939609 was associated with a −6·5 % (95 % CI −12·3, −0·4) decrease in the percentage of energy from protein and positively associated with the percentage of energy from carbohydrates before pregnancy (β=2·6; 95 % CI 0·5, 4·8) and with a 13·3 % (95 % CI 0·7, 27·5) increase in the total energy intake during pregnancy. The C-allele of MC4R-rs17782313 was associated with a −7·6 % (95 % CI −13·8, −1·0) decrease in the percentage of energy from protein, and positively associated with the percentage of energy from ultra-processed foods (β=5·4; 95 % CI 1·1, 9·8) during pregnancy. ANCOVA results revealed changes in dietary intake from pre-pregnancy to pregnancy for FTO-rs9939609 (percentage of energy from ultra-processed foods, P=0·03), MC4R-rs17782313 (total energy intake, P=0·02) and LEP-rs7799039 (total energy intake, P=0·04; percentage of energy from protein, P=0·04). These findings suggest significant associations between FTO-rs9939609, MC4R-rs17782313 and LEP-rs7799039 genes and the components of dietary intake in pregnant women.

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1665 ◽  
Author(s):  
Cheng-Chieh Lin ◽  
Chiu-Shong Liu ◽  
Chia-Ing Li ◽  
Chih-Hsueh Lin ◽  
Wen-Yuan Lin ◽  
...  

The best macronutrient percentages of dietary intake supporting longevity remains unclear. The strength of association between dietary intake and mortality in patients with type 2 diabetes (T2DM) should be quantified as a basis for dietary recommendations. Our study cohort consisted of 15,289 type 2 diabetic patients aged 30 years and older in Taiwan during 2001–2014 and was followed up through 2016. Percentages of macronutrient intakes were calculated as dietary energy intake contributed by carbohydrate, protein, and fat, divided by the total energy intake using a 24 h food diary recall approach. Cox proportional hazard models were applied to examine the temporal relation of macronutrient intakes with all-cause and cause-specific mortality. The average follow-up time was 7.4 years, during which 2784 adults with T2DM died. After multivariable adjustment, people with fourth and fifth quintiles of total energy, second and third quintiles of carbohydrate, and fourth quintiles of protein intakes were likely to have lower risks of all-cause and expanded cardiovascular disease (CVD) mortality. People with fifth quintiles of total energy intake were likely to have decreased non-expanded CVD mortality. We found a significant interaction between gender and fat intake on all-cause and expanded CVD mortality. Fat intake was associated with all-cause, expanded and non-expanded CVD mortality among males with T2DM. Total energy, carbohydrate, and protein intakes were associated with lower risks of all-cause and expanded CVD mortality, with minimal risks observed at ≥1673 Kcal total energy, 43–52% carbohydrate intake, and 15–16% protein intake among people with T2DM.


2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 841-841
Author(s):  
Daniel Hoffman ◽  
Paula dos Leffa ◽  
Caroline Sangalli ◽  
Julia Valmórbida ◽  
André Dornelles ◽  
...  

Abstract Objectives Poor diet quality is a major risk factor for the development of anemia. An increased consumption of fortified ultra-processed food (UPF) among children presents a new contributor to micronutrient intake, one that could potentially improve anemia biomarkers despite having a concomitantly low diet quality. Our objective was to investigate the impact of fortified UPF consumption on the prevalence of anemia and diet quality among children from low-income families in Brazil. Methods A cross-sectional analyses from a randomized field trial of children at 3 years of age (n = 432) from Porto Alegre, Brazil. Capillary blood samples were taken to measure hemoglobin concentration (Hb) and used to determine anemia status. Dietary data was assessed using two multiple-pass 24-h recalls and the consumption of UPF was classified according to the NOVA system. Results UPF account for 42.6% of total energy intake. Children in the highest tertile of UPF consumption had significantly lower risk of anemia (Hb < 110 g/L) compared to those in the lowest tertile (tertile 3 vs. tertile 1; OR 0.56 95% CI 0.39 to 0.82). Similarly, a 10% increase in the consumption of UPF was associated with a 22% lower risk of anemia (95% CI 0.64 to 0.94). Conversely, consumption of UPF was negatively associated with consumption of unprocessed/minimally processed foods. Finally, as the contribution of UPF to total energy intake increased, the intake of added sugars, total fats, and sodium increased, whereas the intake of proteins, fiber, and calcium decreased. Conclusions The consumption of fortified UPF was associated with a lower risk of anemia and a poor diet quality in children from a low-income community in Brazil. The co-existence of normal Hb with poor diet quality suggests the need for a more nuanced assessment of dietary patterns in low-income settings to best address this paradoxical situation as the prevalence of the double burden of disease continues to increase throughout the world. Funding Sources Coordination for the Improvement of Higher Education Personnel (CAPES).


2019 ◽  
Vol 37 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Camila Silva Ferreira ◽  
Dyene Aparecida Silva ◽  
Cristiana Araújo Gontijo ◽  
Ana Elisa Madalena Rinaldi

ABSTRACT Objective: To compare and analyze the consumption of minimally processed and ultra-processed foods among students from public and private schools. Methods: Study conducted in Uberlândia, MG, with fifth-grade students from three private and six public schools, selected by stratified cluster sampling. We collected data on food consumption using the 24-hour recall. Foods were classified into four groups (G) according to extent and purpose of processing: fresh/minimally processed foods (G1) culinary ingredients (G2), processed foods (G3), and ultra-processed foods (G4). Total energy intake (kcal) of each group, amount of sugar (g), sodium (mg), and fiber (g) were quantified and compared according to administrative affiliation (private or public). Results: Percentage of total energy intake was: G1 - 52%; G2 - 12%; G3 - 5%; e G4 - 31%. Energy intake from G1 (53 vs. 47%), G2 (12 vs. 9%), and G3 (6.0 vs. 0.1%), and amount of sodium (3,293 vs. 2,724 mg) and fiber (23 vs. 18 g) were higher among students from public schools. Energy intake from G4 (36 vs. 28%) and amount of sugar (20 vs. 14%) were higher among students from private schools. The consumption of foods from G1 in the school environment was higher among students from public schools (40 vs. 9%). Conclusions: Foods from G1 represent the highest percentage of total energy intake, while those from G4 constitute a third of calories consumed. Processed juice, sandwich cookie, processed cake, and breakfast cereals are more frequent among private school students; snacks and juice powder are more common for students from public schools.


2017 ◽  
Vol 21 (1) ◽  
pp. 125-133 ◽  
Author(s):  
Gustavo Cediel ◽  
Marcela Reyes ◽  
Maria Laura da Costa Louzada ◽  
Euridice Martinez Steele ◽  
Carlos A Monteiro ◽  
...  

AbstractObjectiveTo assess the consumption of ultra-processed foods and analyse its association with the content of added sugars in the Chilean diet.DesignCross-sectional study of national dietary data obtained through 24 h recalls and classified into food groups according to the extent and purpose of food processing (NOVA classification).SettingChile.SubjectsA probabilistic sample of 4920 individuals (aged 2 years or above) studied in 2010 by a national dietary survey (Encuesta Nacional de Consumo Alimentario).ResultsUltra-processed foods represented 28·6 (se 0·5) % of total energy intake and 58·6 (se 0·9) % of added sugars intake. The mean percentage of energy from added sugars increased from 7·7 (se 0·3) to 19·7 (se 0·5) % across quintiles of the dietary share of ultra-processed foods. After adjusting for several potential sociodemographic confounders, a 5 percentage point increase in the dietary share of ultra-processed foods determined a 1 percentage point increase in the dietary content of added sugars. Individuals in the highest quintile were three times more likely (OR=2·9; 95 % CI 2·4, 3·4) to exceed the 10 % upper limit for added sugars recommended by the WHO compared with those in the lowest quintile, after adjusting for sociodemographic variables. This association was strongest among individuals aged 2–19 years (OR=3·9; 95 % CI 2·7, 5·9).ConclusionsIn Chile, ultra-processed foods are important contributors to total energy intake and to the consumption of added sugars. Actions aimed at limiting consumption of ultra-processed foods are being implemented as effective ways to achieve WHO dietary recommendations to limit added sugars and processed foods, especially for children and adolescents.


2021 ◽  
pp. 1-24
Author(s):  
Jackie Shinwell ◽  
Melissa Bateson ◽  
Daniel Nettle ◽  
Gillian V. Pepper

Abstract The aim of this study was to identify the dietary-intake correlates of food insecurity in UK adults. We recruited groups of low-income participants who were classified as food insecure (n = 196) or food secure (n = 198). Participants completed up to five 24h dietary recalls. There was no difference in total energy intake by food insecurity status (βFI = −0.06, 95% CI −0.25 to 0.13). Food insecure participants consumed a less diverse diet, as evidenced by fewer distinct foods per meal (βFI = −0.27, 95% CI −0.47 to −0.07), and had more variable time gaps between meals (βFI = 0.21, 95% CI 0.01 to 0.41). These associations corresponded closely to those found in a recent U.S. study using similar measures, suggesting that the dietary intake signature of food insecurity generalizes across populations. The findings suggest that the consequences of food insecurity for weight gain and health are not due to increased energy intake. We suggest that there may be important health and metabolic effects of temporal irregularity in dietary intake, which appears to be an important component of food insecurity.


2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yong Zhu ◽  
Jessica Smith ◽  
Vipra Vanage ◽  
Neha Jain ◽  
Mitesh Sharma ◽  
...  

Abstract Objectives To understand consumption pattern of ready to eat cereal (RTEC) in the Hispanic population in the United States and investigate associations between RTEC consumption and dietary intake as well as diet quality in this population. Methods Children aged between 2–17 years old (N = 899) and adults aged 18 years or older (N = 1593) who were Mexican American or other Hispanics from the National Health and Nutrition Examination Survey 2015–2016 were included in the study. Day 1 dietary data were used to determine RTEC consumption status, energy intake, nutrient and food group intake. Diet quality was measured as the Healthy Eating Index 2015 (HEI-2015). Multiple linear regression analyses for surveys were conducted to estimate covariates-adjusted associations between RTEC consumption and dietary intake, as well as diet quality. Results About 40% of Hispanic children reported RTEC consumption whereas only 14% of Hispanic adults were RTEC eaters. RTEC eaters were more likely from lower income families. Compared to non-eaters, both children and adults who reported RTEC consumption had significantly higher intake of whole grains, dairy products, and vitamins and minerals such as calcium, iron, zinc, folate, thiamin, riboflavin, niacin, vitamin B12, vitamin B6, vitamin A, vitamin D; as well as significantly lower intake of sodium and dietary cholesterol (P < 0.05 for all). Total energy intake and added sugar intake did not differ by RTEC consumption status in both age groups. HEI-2015 total score was significantly higher in RTEC eaters than non-eaters in both Hispanic children and adults (P < 0.05 for both). Conclusions Consumption of RTEC is associated with improved diet quality including higher intake of whole grain and dairy products, as well as several vitamins and minerals in both Hispanic children and adults. Consumption of RTEC is not associated with total energy intake or added sugar in the Hispanic population. Funding Sources The study was funded by General Mills, Inc.


2013 ◽  
Vol 17 (3) ◽  
pp. 479-485 ◽  
Author(s):  
Daisy Abreu ◽  
Isabel Cardoso ◽  
Jean-Michel Gaspoz ◽  
Idris Guessous ◽  
Pedro Marques-Vidal

AbstractObjectiveTo assess nutrition trends of the Geneva population for the period 1999–2009.DesignBus Santé Geneva study, which conducts annual health surveys in random samples of the Geneva population. Dietary intake was assessed using a validated FFQ and trends were assessed by linear regression.SettingPopulation-based survey.SubjectsData from 9283 participants (50 % women, mean age 51·5 (sd10·8) years) were analysed.ResultsIn both genders total energy intake decreased from 1999 to 2009, by 2·9 % in men and by 6·3 % in women (both trendsP< 0·005). Vegetable protein and total carbohydrate intakes, expressed as a percentage of total energy intake, increased in women. MUFA intake increased while SFA, PUFA and alcohol intakes decreased in both genders. Intakes of Ca, Fe and carotene decreased in both genders. No changes in fibre, vitamin D and vitamin A intakes were found. Similar findings were obtained after excluding participants with extreme dietary intakes, except that the decreases in SFA, vegetable protein and carbohydrate were no longer significant in women.ConclusionsBetween 1999 and 2009, a small decrease in total energy intake was noted in the Geneva population. Although the decrease in alcohol and SFA intakes is of interest, the decrease in Ca and Fe intakes may have adverse health effects in the future.


Author(s):  
Daniel Afrifa ◽  
Kwabena Nsiah ◽  
Collins Afriyie Appiah ◽  
Omoniyi Monday Moses

Background: It has been well documented that adequate body composition characteristics and good nutrition practices play significant roles in maintaining good health, proper immune functioning, muscle growth and repair, and delaying fatigue in continuously intense athletic performance. It would be incumbent, however, to support imported information with local data to enhance effective implementation. Objectives: To examine dietary intake and body composition characteristics of National Football League Players in the Ashanti region of Ghana. Methods: Cross-sectional study was used. 95 football players from the premier, 1st and 2nd divisions of the Ghana National Football League were recruited. A 24-hour dietary recall was used to assess the dietary intake of the players. Body composition characteristics of body mass index, percentage (%) body fat, visceral fat and percentage (%) muscle mass were measured. Results: There were 8 (9.3%) goalkeepers, 29 (33.7%) defenders, 34 (39.5%) midfielders and 15 (17.4%) strikers. 42 (44.2%) of the players ate twice per day. Players within age group of 20 - 25 (49, 51.6%) had the highest mean total energy intake (2342.96 ± 848.18), carbohydrates (324.18 ± 106.35), proteins (75.54 ± 23.94) and fats (83.00 ± 50.76). Midfield players had the highest mean total energy intake (2216.26 ± 803.87), carbohydrates (315.74 ± 121.02), proteins (74.23 ± 26.35) and fats (71.59 ± 34.32). 82 (86.3%) had normal weight, 79 (83.2%) normal % body fat, 45 (47.4%) had very high % muscle mass. Conclusions: The sample in this study has low total energy intake compared to other studies. Insufficient nutritional diets could suggest the reason for the low energy intake. If low energy intake persists, the players might be at high risk of chronic cardiovascular diseases and diabetes conditions.


2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yong Zhu ◽  
Jessica Smith ◽  
Neha Jain ◽  
Vipra Vanage ◽  
Mitesh Sharma ◽  
...  

Abstract Objectives Studies have shown ready to eat cereal (RTEC) eaters had better dietary intake than non-eaters, however, little is known about within-subject differences by RTEC consumption. The study was conducted to compare differences in dietary intake and diet quality between the day with and without RTEC consumption in adults from the United States. Methods Data from the National Health and Nutrition Examination Survey 2013–2014 and 2015–2016 were used in the study. The sample comprised of 1818 adults aged 18 years or older who reported consumption of RTEC in one day but not the other day based on two 24-hour dietary recalls. Energy and nutrient intake were obtained from the dietary data, whereas intake of whole grains and added sugar were estimated using Food Patterns Equivalent Database. Diet quality was measured by Healthy Eating Index 2015 (HEI-2015). Multiple linear regression analyses for surveys were conducted to estimate within-subject differences in each outcome by RTEC consumption while adjusting for recall day, recall method, as well as a separate fixed effect of each person to control for demographic characteristics. Results Subjects had significantly higher intake of vitamin A, vitamin D, vitamin B12, vitamin B6, thiamin, riboflavin, niacin, folate, calcium, magnesium, iron, zinc, potassium, phosphorus, carbohydrate, as well as dietary fiber and whole grains, together with significantly lower intake of total fat and sodium, on the day when they consumed RTEC than the day when RTEC was not consumed (P < 0.05 for all). Total energy intake, intake of protein and total sugar as well as added sugar did not differ significantly between the day with and without RTEC consumption. On days when RTEC was consumed, HEI-2015 total score, as well as sub scores for adequacy components including whole fruits, whole grains, dairy, and moderation components including saturated fat, added sugar, and sodium, were significantly higher (P < 0.05 for all). Conclusions When adults consumed RTEC on a given day, they had a healthier diet with higher daily intake of dietary fiber, whole grains, as well as many key vitamins and minerals than the day when they did not consume RTEC. RTEC consumption is not associated with total energy intake and intake of total sugar or added sugar. Funding Sources The study was funded by General Mills, Inc.


2018 ◽  
Vol 21 (12) ◽  
pp. 2271-2279 ◽  
Author(s):  
Fernanda Marcelina Silva ◽  
Luana Giatti ◽  
Roberta Carvalho de Figueiredo ◽  
Maria del Carmen Bisi Molina ◽  
Letícia de Oliveira Cardoso ◽  
...  

AbstractObjectiveTo verify if the intake of ultra-processed foods is associated with higher BMI and waist circumference (WC) among participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohort.DesignCross-sectional analysis of the ELSA-Brasil baseline (2008–2010). Dietary information obtained through an FFQ was classified according to characteristics of food processing (NOVA) and used to estimate the percentage energy contribution from ultra-processed foods (i.e. industrial formulations, elaborated from food processing, synthetic constituents and food additives) to individuals’ total energy intake. BMI and WC and their respective cut-off points served as response variables. Associations were estimated through linear and multinomial logistic regression models, after adjusting for confounders and total energy intake.SettingSix Brazilian capital cities, 2008–2010.SubjectsActive and retired civil servants, aged 35–64 years, from universities and research organizations (n8977).ResultsUltra-processed foods accounted for 22·7 % of total energy intake. After adjustments, individuals in the fourth quartile of percentage energy contribution from ultra-processed foods presented (β; 95 % CI) a higher BMI (0·80; CI 0·53, 1·07 kg/m2) and WC (1·71; 1·02, 2·40 cm), and higher chances (OR; 95 % CI) of being overweight (1·31; 1·13, 1·51), obese (1·41; 1·18, 1·69) and having significantly increased WC (1·41; 1·20, 1·66), compared with those in the first quartile. All associations suggest a dose–response gradient.ConclusionsResults indicate the existence of associations between greater energy contribution from ultra-processed foods and higher BMI and WC, which are independent of total energy intake. These findings corroborate public policies designed to reduce the intake of this type of food.


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