Validation and calibration of the Eating Assessment in Toddlers FFQ (EAT FFQ) for children, used in the Growing Up Milk – Lite (GUMLi) randomised controlled trial

2020 ◽  
Vol 125 (2) ◽  
pp. 183-193
Author(s):  
Amy L. Lovell ◽  
Peter S. W. Davies ◽  
Rebecca J. Hill ◽  
Tania Milne ◽  
Misa Matsuyama ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Weighted Kappa ◽  
Randomised Control Trial ◽  
Growing Up ◽  
Linear Regression Models ◽  
Nutrient Intakes ◽  
Good Reliability ◽  
Randomised Controlled

AbstractThe Eating Assessment in Toddlers FFQ (EAT FFQ) has been shown to have good reliability and comparative validity for ranking nutrient intakes in young children. With the addition of food items (n 4), we aimed to re-assess the validity of the EAT FFQ and estimate calibration factors in a sub-sample of children (n 97) participating in the Growing Up Milk – Lite (GUMLi) randomised control trial (2015–2017). Participants completed the ninety-nine-item GUMLi EAT FFQ and record-assisted 24-h recalls (24HR) on two occasions. Energy and nutrient intakes were assessed at months 9 and 12 post-randomisation and calibration factors calculated to determine predicted estimates from the GUMLi EAT FFQ. Validity was assessed using Pearson correlation coefficients, weighted kappa (κ) and exact quartile categorisation. Calibration was calculated using linear regression models on 24HR, adjusted for sex and treatment group. Nutrient intakes were significantly correlated between the GUMLi EAT FFQ and 24HR at both time points. Energy-adjusted, de-attenuated Pearson correlations ranged from 0·3 (fibre) to 0·8 (Fe) at 9 months and from 0·3 (Ca) to 0·7 (Fe) at 12 months. Weighted κ for the quartiles ranged from 0·2 (Zn) to 0·6 (Fe) at 9 months and from 0·1 (total fat) to 0·5 (Fe) at 12 months. Exact agreement ranged from 30 to 74 %. Calibration factors predicted up to 56 % of the variation in the 24HR at 9 months and 44 % at 12 months. The GUMLi EAT FFQ remained a useful tool for ranking nutrient intakes with similar estimated validity compared with other FFQ used in children under 2 years.

scholarly journals FFQ for the adult population of the capital of Ecuador (FFQ-Quito): development, reliability and validity

2015 ◽  
Vol 18 (14) ◽  
pp. 2540-2549 ◽  
Author(s):  
Katherine M Silva-Jaramillo ◽  
Marilda B Neutzling ◽  
Michele Drehmer
Keyword(s):  
Correlation Coefficient ◽  
Nutrient Intake ◽  
Communicable Disease ◽  
Pearson Correlation ◽  
Adult Population ◽  
Reliability And Validity ◽  
Correlation Coefficients ◽  
Weighted Kappa ◽  
Nutrient Intakes ◽  
Relative Validity

AbstractObjectiveTo assess the reliability and validity of a semi-quantitative FFQ designed to evaluate the usual nutrient intake of adults in Quito, Ecuador.DesignDietary data using 24 h recalls (24hR) were used to design a list of commonly consumed foods. The relative validity of a 111-item FFQ was evaluated by comparing nutrient intakes against three non-consecutive 24hR. All nutrients were energy-adjusted. Reliability was assessed using two FFQ (FFQ1 and FFQ2) and assessed by the intra-class correlation coefficient. The comparisons between the FFQ and the 24hR were assessed by the de-attenuated Pearson correlation coefficient, weighted kappa and by Bland–Altman plots.SettingQuito, Ecuador.SubjectsOverall, 345 adults were enrolled in the present study. Two hundred and fifty participated in FFQ development and ninety-five participated in the FFQ validity and reliability.ResultsThe FFQ produced higher energy and nutrient intakes. Reliability correlation coefficients after adjusting for energy ranged from 0·62 to 0·88 for protein and Ca, respectively. For the validity study, energy-adjusted and de-attenuated correlation coefficients between the questionnaire and the 24hR ranged from 0·21 for fat to 0·65 for Ca. Only 4 % of the participants were grossly misclassified and 46 % had weighted kappa higher than 0·42. The Bland–Altman plot showed a constant bias with a tendency to increase according to the intake level.ConclusionsThe FFQ showed reasonably good relative validity and reliable measurements, especially for nutrients considered protective and risk markers of non-communicable disease, and can be used to assess usual nutrient intake in this population.

scholarly journals Relative validity of an FFQ to estimate daily food and nutrient intakes for Chilean adults

2012 ◽  
Vol 16 (10) ◽  
pp. 1782-1788 ◽  
Author(s):  
Mahshid Dehghan ◽  
Solange Martinez ◽  
Xiaohe Zhang ◽  
Pamela Seron ◽  
Fernando Lanas ◽  
...  
Keyword(s):  
Pearson Correlation ◽  
Dietary Assessment ◽  
Correlation Coefficients ◽  
Weighted Kappa ◽  
Epidemiological Studies ◽  
Food Groups ◽  
Nutrient Intakes ◽  
Dietary Assessment Methods ◽  
Daily Food ◽  
Almost All

AbstractObjectiveFFQ are commonly used to rank individuals by their food and nutrient intakes in large epidemiological studies. The purpose of the present study was to develop and validate an FFQ to rank individuals participating in an ongoing Prospective Urban and Rural Epidemiological (PURE) study in Chile.DesignAn FFQ and four 24 h dietary recalls were completed over 1 year. Pearson correlation coefficients, energy-adjusted and de-attenuated correlations and weighted kappa were computed between the dietary recalls and the FFQ. The level of agreement between the two dietary assessment methods was evaluated by Bland–Altman analysis.SettingTemuco, Chile.SubjectsOverall, 166 women and men enrolled in the present study. One hundred men and women participated in FFQ development and sixty-six individuals participated in FFQ validation.ResultsThe FFQ consisted of 109 food items. For nutrients, the crude correlation coefficients between the dietary recalls and FFQ varied from 0·14 (protein) to 0·44 (fat). Energy adjustment and de-attenuation improved correlation coefficients and almost all correlation coefficients exceeded 0·40. Similar correlation coefficients were observed for food groups; the highest de-attenuated energy-adjusted correlation coefficient was found for margarine and butter (0·75) and the lowest for potatoes (0·12).ConclusionsThe FFQ showed moderate to high agreement for most nutrients and food groups, and can be used to rank individuals based on energy, nutrient and food intakes. The validation study was conducted in a unique setting and indicated that the tool is valid for use by adults in Chile.

scholarly journals A comparison of the effect of a Growing Up Milk – Lite (GUMLi) v. cows’ milk on longitudinal dietary patterns and nutrient intakes in children aged 12–23 months: the GUMLi randomised controlled trial

2019 ◽  
Vol 121 (6) ◽  
pp. 678-687 ◽  
Author(s):  
Amy L. Lovell ◽  
Peter S. W. Davies ◽  
Rebecca J. Hill ◽  
Tania Milne ◽  
Misa Matsuyama ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Breast Milk ◽  
Dietary Patterns ◽  
Controlled Trial ◽  
Milk Formula ◽  
Growing Up ◽  
Nutrient Intakes ◽  
Lower Protein ◽  
Randomised Controlled ◽  
Post Randomisation

AbstractThe second year of life is a period of nutritional vulnerability. We aimed to investigate the dietary patterns and nutrient intakes from 1 to 2 years of age during the 12-month follow-up period of the Growing Up Milk – Lite (GUMLi) trial. The GUMLi trial was a multi-centre, double-blinded, randomised controlled trial of 160 healthy 1-year-old children in Auckland, New Zealand and Brisbane, Australia. Dietary intakes were collected at baseline, 3, 6, 9 and 12 months post-randomisation, using a validated FFQ. Dietary patterns were identified using principal component analysis of the frequency of food item consumption per d. The effect of the intervention on dietary patterns and intake of eleven nutrients over the duration of the trial were investigated using random effects mixed models. A total of three dietary patterns were identified at baseline: ‘junk/snack foods’, ‘healthy/guideline foods’ and ‘breast milk/formula’. A significant group difference was observed in ‘breast milk/formula’ dietary pattern z scores at 12 months post-randomisation, where those in the GUMLi group loaded more positively on this pattern, suggesting more frequent consumption of breast milk. No difference was seen in the other two dietary patterns. Significant intervention effects were seen on nutrient intake between the GUMLi (intervention) and cows’ milk (control) groups, with lower protein and vitamin B12, and higher Fe, vitamin D, vitamin C and Zn intake in the GUMLi (intervention) group. The consumption of GUMLi did not affect dietary patterns, however, GUMLi participants had lower protein intake and higher Fe, vitamins D and C and Zn intake at 2 years of age.

scholarly journals Correlations Between Clinical Trial Outcomes Based on Symptoms, Functional Impairments, and Quality of Life in Children and Adolescents With ADHD

2017 ◽  
Vol 23 (13) ◽  
pp. 1578-1591 ◽  
Author(s):  
David R. Coghill ◽  
Alain Joseph ◽  
Vanja Sikirica ◽  
Mark Kosinski ◽  
Caleb Bliss ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Rating Scale ◽  
Controlled Trial ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Parent Report ◽  
Functional Impairments ◽  
Risk Avoidance

Objective: To assess relationships between treatment-associated changes in measures of ADHD symptoms, functional impairments, and health-related quality of life in children and adolescents with ADHD. Method: Pearson correlation coefficients were calculated post hoc for changes from baseline to endpoint in outcomes of one randomized, placebo- and active-controlled trial of lisdexamfetamine (osmotic-release methylphenidate reference) and one of guanfacine extended-release (atomoxetine reference). Results: Changes in ADHD Rating Scale IV (ADHD-RS-IV) total score generally correlated moderately with changes in Child Health and Illness Profile−Child Edition: Parent Report Form (CHIP-CE:PRF) Achievement and Risk Avoidance ( r ≈ .4), but weakly with Resilience, Satisfaction, and Comfort ( r ≈ .2); and moderately with Weiss Functional Impairment Rating Scale–Parent (WFIRS-P) total score ( r ≈ .5). CHIP-CE:PRF Achievement and Risk Avoidance correlated moderately to strongly with WFIRS-P total score ( r ≈ .6). Conclusion: The ADHD-RS-IV, CHIP-CE:PRF, and WFIRS-P capture distinct but interconnected aspects of treatment response in individuals with ADHD.

scholarly journals Recruitment And Retention Of Participants From Socioeconomically Deprived Communities: Lessons From The Awareness And Beliefs About Cancer (ABACus3) Randomised Controlled Trial

2020 ◽  
Author(s):  
Vasiliki Kolovou ◽  
Yvonne Moriarty ◽  
Stephanie Gilbert ◽  
Harriet Quinn-Scoggins ◽  
Julia Townson ◽  
...  
Keyword(s):  
Financial Incentives ◽  
Controlled Trial ◽  
Qualitative Interviews ◽  
Randomised Control Trial ◽  
Trial Participant ◽  
Community Settings ◽  
Research Strategies ◽  
Healthcare Settings ◽  
Randomised Controlled ◽  
Deprived Areas

Abstract Background Recruitment of research participants poses challenges in socioeconomically deprived areas. The Awareness and Beliefs About Cancer (ABACus) phase 3 Randomised Control Trial recruited adult participants from socioeconomically deprived areas using a combined healthcare/community engagement model. We report the strategies used to successfully recruit and retain our trial participant sample. Methods Community and healthcare settings in areas of high socioeconomic deprivation were identified by lay advisors who recruited participants opportunistically or by appointment. Follow-up was done by telephone or post at 2-weeks and 6-months after recruitment, and all participants were offered financial incentives. Qualitative interviews were conducted with lay advisors regarding their experience and reflections. Results The lay advisors identified and contacted 107 potential recruitment venues across South and West Yorkshire and South East Wales of which 41.1% (n = 42) were opened for recruitment. A total of 234 participants were recruited, with 91% (n = 212) retention at 2-weeks and 85% (n = 199) at 6-months. Community settings yielded 75% (n = 176) of participants. Participants had a mean age of 61.3 years and 63.3% (n = 148) were female, with 66% (n = 154) resident in the most deprived geographical areas. Lay advisors described recruitment as intensive, although engaging participants was easier in community settings. Conclusions The ABACus3 trial achieved recruitment and high retention with a population that is often “hard to reach” or entirely missed in health research. Strategies were specifically tailored to engage the venues and adult residents of highly deprived areas. Future studies recruiting adults living in the most deprived areas might benefit from community recruitment and from collaborating with local gatekeepers who are key to engagement.

scholarly journals Improving chronic pain management with eHealth and mHealth: study protocol for a randomised controlled trial

BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e033586 ◽  
Author(s):  
Irene Jaén ◽  
Carlos Suso-Ribera ◽  
Diana Castilla ◽  
Irene Zaragoza ◽  
Azucena García-Palacios ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Web Application ◽  
Controlled Trial ◽  
Repeated Measure ◽  
Health Concern ◽  
Randomised Control Trial ◽  
Treatment As Usual ◽  
Use Of Technology ◽  
Public Costs ◽  
Randomised Controlled

IntroductionChronic pain has become a matter of public health concern due to its high prevalence and because public costs associated with treatment and disability increase each year. Research suggests that limitations in the traditional assessment of chronic pain patients limit the effectiveness of current medical treatments. The use of technology might serve change patient traditional monitoring into ecological momentary assessments, which might be visualised by physicians live. This study describes a randomised control trial designed to test the utility of a technology-based solution for pain telemonitoring consisting of a smartphone app for patients and a web application for physicians. The goal of this study will be to explore whether this combination of eHealth and mHealth improves the effectiveness of existing pain treatments.Methods and analysisParticipants will be 250 patients randomly assigned to one of these two conditions: treatment-as-usual (TAU) and TAU +app+ web. All participants will receive the usual treatment for their pain. Only the TAU +app+ web group use Pain Monitor app, which generates alarms that are sent to the physicians in the face of previously established undesired events. Physicians will be able to monitor app reports using a web application, which might result in an adjustment of treatment. We anticipate that the use of Pain Monitor plus the therapist web will result in a reduction of pain intensity and side effects of the medication. Improvements on secondary outcomes, namely fatigue, mood, pain interference, rescue medication use and quality of life, are also expected. Mixed repeated-measure multivariate analyses of variances will be conducted to investigate whether there are differences between preassessment and postassessment scores as a function of the experimental condition.Ethics and disseminationEthical approval from the Hospital General Universitari de Castellon was obtained. The findings will be published in peer-reviewed journals.Trial registration numberNCT03606265

scholarly journals Validity and reliability of an FFQ for use with adolescents in Ho Chi Minh City, Vietnam

2009 ◽  
Vol 13 (3) ◽  
pp. 368-375 ◽  
Author(s):  
Tang K Hong ◽  
Michael J Dibley ◽  
David Sibbritt
Keyword(s):  
Nutrient Intake ◽  
Reliability And Validity ◽  
Correlation Coefficients ◽  
Weighted Kappa ◽  
Ho Chi Minh City ◽  
Kappa Statistics ◽  
Validity And Reliability ◽  
Nutrient Intakes ◽  
The Mean

AbstractObjectiveThe present study evaluates the reliability and validity of an FFQ designed for use with adolescents in urban Vietnam.DesignA cohort study was conducted between December 2003 and June 2004. The FFQ was administered three times over a 6-month period (FFQ 1–3) and nutrient intakes were compared to those obtained from four 24 h recalls collected over the same period (24 h recalls 1–4) using crude, energy-adjusted and de-attenuated correlation coefficients. The level of agreement between the two measurements was also evaluated with Bland–Altman analysis. The percentage of nutrient intakes classified within one quintile, as well as quadratic-weighted kappa statistics, were calculated.SettingHo Chi Minh City, Vietnam.SubjectsA total of 180 students were recruited in three junior high schools.ResultsCoefficients ranged from 0·22 for retinol to 0·78 for fibre for short-term reliability, and from 0·30 for retinol to 0·81 for zinc for long-term reliability. Coefficients for nutrient intakes between the mean of the three FFQ and mean of four 24 h recalls were mostly around 0·40, but higher for energy-adjusted nutrients. After allowing for within-person variation, the mean coefficient was 0·52 for macronutrients and 0·46 for micronutrients. There were a relatively high proportion of nutrient intakes classified within one quintile and a small number grossly misclassified. Kappa values shows ‘fair’ to ‘good’ agreement for all food/nutrient categories, while the Bland–Altman plots indicated that the FFQ is accurate in assessing nutrient intake at a group level.ConclusionsThis newly developed FFQ is a valid tool for measuring nutrient intake in adolescents in urban Vietnam.

scholarly journals Reproducibility and validity of a food-frequency questionnaire for use among low-income Brazilian workers

2003 ◽  
Vol 6 (8) ◽  
pp. 821-827 ◽  
Author(s):  
Nélida Schmid Fornés ◽  
Maria Luiza Ferreira Stringhini ◽  
Berenice Müller Elias
Keyword(s):  
Vitamin C ◽  
Total Energy ◽  
Low Income ◽  
Food Frequency Questionnaire ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Reference Method ◽  
Nutrient Intakes ◽  
Low Literacy ◽  
Food Frequency

AbstractObjectives:To assess the reproducibility and validity a 127-item, habitual intake, food-frequency questionnaire (FFQ), developed for low-income and low-literacy Brazilian workers, by comparison with a 24-hour dietary recall (24-HDR).Design:The FFQ and 24-HDR were interviewer-administered at the local workplace to each subject twice, with a period of 6 months between estimates; and four 24-HDRs were conducted during the 4-month period between the two FFQs (FFQ1 and FFQ2). Reproducibility was tested by comparing mean nutrient intakes from the two FFQs. Validity was determined by comparing the mean nutrient intakes from the FFQs with the corresponding averages of the six 24-HDRs (reference method).Setting:Goiânia City, in Central West Brazil.Subjects:The study was based on 104 (62 women and 42 men) subjects, aged 18 to 60 years, who were randomly selected.Results:Dietary intake from the FFQ was higher than from the 24-HDR. Reproducibility was assessed by Pearson correlation coefficients for nutrients from FFQ1 and FFQ2, and ranged from 0.23 for retinol to 0.69 for total energy (mean 0.52). Intra-class coefficients for nutrients averaged by the 24-HDRs ranged from 0.29 for vitamin C to 0.76 for total energy; retinol was not significant. In the validation study, correlation between the FFQ and the 24-HDR ranged between 0.21 for vitamin C and 0.70 for total energy (mean 0.50). Adjusting for total energy lowered the coefficients, except for calcium, retinol and vitamin C. Coefficients increased with attenuation, ranging from 0.35 for carbohydrate to 0.65 for calcium.Conclusions:Results indicate that this questionnaire had satisfactory reproducibility and reasonable validity.

scholarly journals Recruitment And Retention Of Participants From Socioeconomically Deprived Communities: Lessons From The Awareness And Beliefs About Cancer (ABACus3) Randomised Controlled Trial.

2020 ◽  
Author(s):  
Vasiliki Kolovou ◽  
Yvonne Moriarty ◽  
Stephanie Gilbert ◽  
Harriet Quinn-Scoggins ◽  
Julia Townson ◽  
...  
Keyword(s):  
Financial Incentives ◽  
Controlled Trial ◽  
Qualitative Interviews ◽  
Randomised Control Trial ◽  
Trial Participant ◽  
Community Settings ◽  
Research Strategies ◽  
Healthcare Settings ◽  
Randomised Controlled ◽  
Deprived Areas

Abstract Background: Recruitment of research participants poses challenges in socioeconomically deprived areas. The Awareness and Beliefs About Cancer (ABACus) phase 3 Randomised Control Trial recruited adult participants from socioeconomically deprived areas using a combined healthcare/community engagement model. We report the strategies used to successfully recruit and retain our trial participant sample.Methods: Community and healthcare settings in areas of high socioeconomic deprivation were identified by lay advisors who recruited participants opportunistically or by appointment. Follow-up was done by telephone or post at 2-weeks and 6-months after recruitment, and all participants were offered financial incentives. Qualitative interviews were conducted with lay advisors regarding their experience and reflections.Results: The lay advisors identified and contacted 107 potential recruitment venues across South and West Yorkshire and South East Wales of which 41.1% (n= 42) were opened for recruitment. A total of 234 participants were recruited, with 91% (n= 212) retention at 2-weeks and 85% (n= 199) at 6-months. Community settings yielded 75% (n= 176) of participants. Participants had a mean age of 61.3 years and 63.3% (n= 148) were female, with 66% (n= 154) resident in the most deprived geographical areas. Lay advisors described recruitment as intensive, although engaging participants was easier in community settings.Conclusions: The ABACus3 trial achieved recruitment and high retention with a population that is often “hard to reach” or entirely missed in health research. Strategies were specifically tailored to engage the venues and adult residents of highly deprived areas. Future studies recruiting adults living in the most deprived areas might benefit from community recruitment and from collaborating with local gatekeepers who are key to engagement.This study adheres to CONSORT guidelines.Trial Registration: Retrospectively registered with ISRCTN (http://www.isrctn.com/ISRCTN16872545) on 12.01.2018.

scholarly journals 127 A Student Pilot For A Feasibility Study of the Theoretical 3S Trial (SPFT3S): Patient Questionnaire and Demographics

2021 ◽  
Vol 50 (Supplement_1) ◽  
pp. i12-i42
Author(s):  
R Foster ◽  
M Dodd ◽  
L Brown ◽  
K Awonaya ◽  
T McCormack
Keyword(s):  
Feasibility Study ◽  
Controlled Trial ◽  
Demographic Data ◽  
Randomised Control Trial ◽  
Patient Questionnaire ◽  
Willingness To Participate ◽  
The Media ◽  
Current Guidance ◽  
Randomised Controlled ◽  
The Uk

Abstract Introduction There is conflicting evidence on the benefit of statins for primary prevention of cardiovascular disease (CVD) in non-diabetics over 75. Emerging evidence shows they may be ineffective, yet current guidance supports their use in those up to 85. The objectives of this study were to assess patients’ understanding of statins, willingness to participate in a theoretical randomised controlled trial (RCT), where they would be randomised to stop their statin and to compare the trial population with national data. Methods The survey took place in 8 GP practices with 4 students involved in questionnaire distribution. A patient search identified those over 75 and on a statin. Patients were excluded if they had a history of CVD or diabetes. 36 patients were identified and completed questionnaires, 5 were removed because they reported exclusion criteria. Demographic data was compared to the UK population from the 2011 census. Results Of 31 participants, 71% understood why they took statins, most were unconcerned about side effects and only 1 patient stopped statins due to the media. Opinions on the theoretical “stopping statins trial” were varied. 35% of people responded positively. 29% would not want to take part and 36% of people were unsure. Comparison of our trial population against the national population shows that 903,505 people would be eligible for a UK trial. Conclusions The purpose of this exercise was to see if patients would be willing to participate in a trial where 50% stopped taking their statin. Approximately a third said yes and only a third said no. As there are nearly a million people in this population, it suggests a fully funded, larger-scale feasibility study of this theoretical randomised control trial is warranted.

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