The relationship between famine exposure during early life and ascending aorta dilatation in adults

2021 ◽  
pp. 1-29
Author(s):  
Yu-qing Huang ◽  
Lin Liu ◽  
Kenneth Lo ◽  
Yu-ling Yu ◽  
Chao-lei Chen ◽  
...  
Keyword(s):  
Early Life ◽  
Chinese Population ◽  
Ascending Aorta ◽  
Late Childhood ◽  
Cardiac Ultrasound ◽  
Multivariate Logistic Regression ◽  
Fetal Period ◽  
Famine Exposure ◽  
Aorta Dilatation ◽  
The Relationship

Abstract Background and aims: The relationship between exposure to famine in early life and the risk of ascending aorta dilatation (AAD) in adulthood is still unclear, therefore we aimed to examine the association in a Chinese population. Methods and results: We investigated the data of 2,598 adults that were born between 1,952 and 1,964 in Guangdong, China. All enrolled subjects were categorized into five groups: not exposed to famine, exposed during fetal period, and exposed during early, mid or late childhood. AAD was assessed by cardiac ultrasound. Multivariate logistic regression and interaction tests were performed to estimate the odds ratio (OR) and confidence interval (CI) on the association between famine exposure and AAD. There were 2,598 (943 male, mean age 58.3 ± 3.68 years) participants were enrolled, and 270 (10.4%) subjects with AAD. We found that famine exposure (OR=2.266, 95% CI: 1.477, 3.477, P=0.013) associated with elevated AAD after adjusting for multiple confounders. In addition, compared with the non-exposure group, the adjusted ORs for famine exposure during fetal period, early, mid or late childhood were 1.374 (95% CI: 0.794, 2.364, P=0.251), 1.976 (95% CI: 1.243, 3.181, P=0.004), 1.929 (95% CI: 1.237, 3.058, P=0.004) and 2.227 (95% CI: 1.433, 3.524, P<0.001), respectively. Subgroup analysis showed that the effect of famine exposure on the association with AAD was more pronounced in female, current smokers, people with BMI ≥24 kg/m2 and hypertensive patients. Conclusion: We observed that exposure to famine during early life was linked to AAD in adulthood.

scholarly journals The relationship between famine exposure in early life and ascending aorta dilatation in adulthood

2020 ◽  
Author(s):  
Yu-qing HUANG ◽  
Lin LIU ◽  
Kenneth Lo ◽  
Yu-ling YU ◽  
Chao-lei CHEN ◽  
...  
Keyword(s):  
Early Life ◽  
Ascending Aorta ◽  
Exposed Group ◽  
Late Childhood ◽  
Cardiac Ultrasound ◽  
Multivariate Logistic Regression ◽  
Famine Exposure ◽  
Aorta Dilatation ◽  
Stratified Analysis ◽  
The Relationship

Abstract BackgroundThe relationship between malnutrition and ascending aorta dilatation (AAD) is still unclear. Therefore, the aim of this study was to examine the association of exposure to the Chinese famine during early life with AAD in adulthood.MethodsWe investigated data of 2598 adults born between 1952 and 1964 from Guangdong, China. All enrolled subjects were divided into five groups: no exposed, fetal exposed, early, mid and late childhood exposed. AAD was assessed by cardiac ultrasound. Multivariate logistic regression and interaction tests were used to estimate the odds ratio (OR) and confidence interval (CI) between famine exposure and AAD.ResultsThere were 2598 (943 male, mean age 59.1 ± 3.65 years) participants were enrolled, among them consist of 270 (10.4%) subjects with AAD. Compared with no exposed group, the adjusted ORs for AAD widening from fetal-exposed, early, mid to late childhood exposed were 1.374 (95% CI: 0.794, 2.364, P = 0.251), 1.976 (95% CI: 1.243, 3.181, P = 0.004), 1.929 (95% CI: 1.237, 3.058, P = 0.004) and 2.227 (95% CI: 1.433, 3.524, P < 0.001), respectively. Stratified analysis showed that the effect of famine exposure on AAD was more pronounced in female, smokers, BMI ≥ 24 kg/m2 and hypertensive patients.ConclusionsWe observed that exposure to famine during early life was an independent risk factor for AAD in adulthood; this effect was not modified by gender, BMI, smoking, hypertension and diabetes.Yu-qing HUANG and Lin LIU are equally to this paper.

scholarly journals Famine Exposure During Early Life Increased the Risk of Ascending Aorta Dilatation in Adults

2020 ◽  
Author(s):  
Yu-qing HUANG ◽  
Lin LIU ◽  
Kenneth Lo ◽  
Yu-ling YU ◽  
Chao-lei CHEN ◽  
...  
Keyword(s):  
Risk Factor ◽  
Early Life ◽  
Independent Risk Factor ◽  
Ascending Aorta ◽  
Late Childhood ◽  
Multivariate Logistic Regression ◽  
Famine Exposure ◽  
Aorta Dilatation ◽  
Stratified Analysis ◽  
The Relationship

Abstract Background: The relationship between malnutrition and ascending aorta dilatation (AAD) is still unclear. Therefore, the aim of this study was to examine the association of exposure to the Chinese famine during early life with AAD in adulthood. Methods: We investigated data of 2598 adults born between 1952 and 1964 from Guangdong, China. All enrolled subjects were divided into five groups: no exposed, fetal exposed, early, mid and late childhood exposed. AAD was assessed by cardiac ultrasound. Multivariate logistic regression and interaction tests were used to estimate the odds ratio (OR) and confidence interval (CI) between famine exposure and AAD. Results: There were 2598 (943 male, mean age 59.1 ± 3.65 years) participants were enrolled, among them consist of 270 (10.4%) subjects with AAD. We found that famine exposure (OR=2.266, 95% CI: 1.477, 3.477, P=0.013), age, smoking, hypertension, elevated SBP, elevated BMI was an independent risk factor for AAD. In addition, compared with no exposed group, the adjusted ORs for AAD widening from fetal-exposed, early, mid to late childhood exposed were 1.374 (95% CI: 0.794, 2.364, P=0.251), 1.976 (95% CI: 1.243, 3.181, P=0.004), 1.929 (95% CI: 1.237, 3.058, P=0.004) and 2.227 (95% CI: 1.433, 3.524, P<0.001), respectively. Stratified analysis showed that the effect of famine exposure on AAD was more pronounced in female, smokers, BMI ≥24 kg/m2 and hypertensive patients. Conclusions: We observed that exposure to famine during early life was an independent risk factor for AAD in adulthood; this effect was not modified by gender, BMI, smoking, hypertension and diabetes.

scholarly journals Exposure to Chinese famine in early life and the risk of sensory impairment in adulthood

2020 ◽  
pp. jech-2020-213775
Author(s):  
Hongguo Rong ◽  
Xiaozhen Lai ◽  
Elham Mahmoudi ◽  
Hai Fang
Keyword(s):  
Early Life ◽  
Late Childhood ◽  
Sensory Impairment ◽  
Fetal Period ◽  
Unexposed Group ◽  
Multi Stage ◽  
Sensory Impairments ◽  
Negative Effect ◽  
Famine Exposure ◽  
The Relationship

BackgroundStudies have shown that malnutrition in early life has a negative effect on midlife cognitive functions. Little is known, however, about the relationship between early-life malnutrition and visual, hearing or dual sensory impairments in adulthood. This study aims to investigate the association between exposure to the 1959–1961 Chinese famine in early life and sensory impairments in adulthood.MethodsA total of 6347 adults born between 1952 and 1964 surveyed in the 2015 China Health and Retirement Longitudinal Study were included in this study. The presence of sensory impairments was identified by self-reported assessment of visual and hearing functions. The associations between multi-stage early-life famine exposure and sensory functions were estimated using the multiple generalised linear model.ResultsCompared with the unexposed group, respondents exposed to famine in the fetal period and late childhood had a significantly higher risk of hearing impairment (OR 1.54, 95% CI 1.06 to 2.24; OR 1.75, 95% CI 1.23 to 2.50) and dual sensory impairments (OR 1.45, 95% CI 1.00 to 2.11; OR 1.55, 95% CI 1.09 to 2.21), respectively. Furthermore, in severely famine-affected areas, the early, mid and late childhood-exposed groups were more likely to have hearing and dual sensory impairments than the unexposed group. Those associations were not observed in less famine-affected areas. However, no significant association was found between famine exposure and visual impairment in early-life famine-exposed group.ConclusionExposure to Chinese famine in the fetal period and late childhood was linked to hearing and dual sensory impairments in adulthood.

scholarly journals Exposure to Famine During Early Life and Abdominal Obesity in Adulthood: Findings from the Great Chinese Famine During 1959–1961

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 903 ◽  
Author(s):  
Dan Liu ◽  
Dong-mei Yu ◽  
Li-yun Zhao ◽  
Hong-yun Fang ◽  
Jian Zhang ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Urban Areas ◽  
Early Life ◽  
Healthy Lifestyle ◽  
Positive Association ◽  
Fetal Life ◽  
Cross Sectional ◽  
Famine Exposure ◽  
Nationally Representative ◽  
The Relationship

Undernutrition during early life may lead to obesity in adulthood. This study was conducted to examine the relationship between famine exposure during early life and the risk of abdominal obesity in adulthood. A total of 18,984 and 16,594 adults were surveyed in 2002 and 2010–2012 in two nationally representative cross-sectional surveys, namely China Nutrition and Health Survey, respectively. The risk of abdominal obesity was evaluated for participants born during 1956–1961 and compared with that of participants born during 1962–1964. The overall prevalence of abdominal obesity in adulthood showed a positive association with famine exposure during early life. The odds ratios of famine exposure were 1.31 (1.19–1.44) and 1.28 (1.17–1.40) in 2002 during fetal life and infancy and 1.09 (1.00–1.19) in 2012 during fetal life, respectively. The relationships between famine exposure and abdominal obesity across the famine exposure groups were distinct among females and those who lived in urban areas and were physical inactive (p < 0.05). Exposure to famine during early life was associated with increased risks of abdominal obesity in adulthood, which was partially alleviated by healthy lifestyle factors (e.g., physical activity).

Association of Exposure to Chinese Famine in Early Life with the Risk of Metabolic Syndrome in Adulthood

2020 ◽  
Vol 76 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Yue Peng ◽  
Miaomiao Hai ◽  
Pengcheng Li ◽  
Yongjie Chen
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Early Childhood ◽  
Early Life ◽  
Lower Risk ◽  
Late Childhood ◽  
Fetal Life ◽  
Childhood Exposure ◽  
Study Results ◽  
Famine Exposure

Objective: To explore the association of famine exposure in early life with the risk of metabolic syndrome (MS) in the ­Chinese adults. Methods: Data were obtained from the wave 2009 of the China Health and Nutrition Survey. MS was identified when 3 or more of the following components happened: (1) waist circumference >90 cm in males or >85 cm in females; (2) fasting glucose ≥6.1 mmol/L; (3) systolic blood pressure ≥130 mm Hg/diabolic blood pressure ≥85 mm Hg; (4) fasting triglyceride ≥1.70 mmol/L; and (5) high-density lipids cholesterol <1.04 mmol/L. All participants were divided into 5 groups: no exposure, born after 1961; fetal life exposure, between 1959 and 1961; early childhood exposure, between 1956 and 1958; mid-childhood exposure, between 1953 and 1955; and late childhood exposure, between 1949 and 1952. A total of 2,080 subjects were included in this study. Results: In rural, famine exposure in fetal life and early childhood was associated with the lower risk of MS (p = 0.0491 and 0.0245; OR 0.583 and 0.703; and OR, 95% CI 0.341–0.998 and 0.517–0.956, respectively). But famine exposure in late childhood was associated with the higher risk of MS (p = 0.0140; OR 3.096; and OR, 95% CI 1.257–7.625). Famine exposure in early childhood was associated with the lower risk of MS (p = 0.0120; OR 0.633; and OR, 95% CI 0.443–0.904) in males. Conclusions: Famine exposure in mid- and late-childhood was associated with the higher risk of MS, especially in rural, males, and severe famine areas.

scholarly journals Empirically derived dietary patterns and constipation among a middle-aged population from China, 2016–2018

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Li Li ◽  
Ai-Ping Huang ◽  
Li-Qin Wang ◽  
Xiao-Long Yu
Keyword(s):  
Dietary Patterns ◽  
Chinese Population ◽  
Multivariate Logistic Regression ◽  
Middle Aged ◽  
Food Frequency ◽  
Rome Ii Criteria ◽  
Southern Chinese ◽  
Confounding Variables ◽  
Study Population ◽  
The Relationship

Abstract Background The association of dietary patterns with constipation is not well established, particularly in Chinese population. Therefore, the present study aimed to determine the relationship between dietary patterns and the risk of constipation in a middle-aged Chinese population. Methods A total of 2267 participants aged 45–59 years were recruited in Hangzhou city, the capital of Zhejiang Province, east China from August 2016 to October 2018. Dietary intake was estimated using a semi-quantitative food frequency questionnaire (FFQ) containing 138 food items. Constipation was defined using the Rome II criteria. Multivariate logistic regression was used to examine the association between dietary patterns and the risk of constipation. Results Three major dietary patterns were extracted by factor analysis and labeled as the traditional southern Chinese, Western and grains-vegetables patterns. The prevalence of constipation in our study population was 13.28%. Compared with the participants in the lowest quartile, the participants in the highest quartile of the traditional southern Chinese pattern were associated with reduced odds of constipation (odd ratios (OR) = 0.79; 95%confidence interval (CI): 0.626–0.981; P < 0.05), after adjusting for confounding variables. In contrast, we found no significant associations between the Western and grains-vegetables patterns and the risk of constipation (P > 0.05). Conclusions Our study demonstrated that the traditional southern Chinese pattern was associated with a reduced risk of constipation. Further longitudinal studies are needed to confirm our findings.

scholarly journals The relationship between famine exposure during early life and body mass index in adulthood: A systematic review and meta-analysis

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192212 ◽  
Author(s):  
Jielin Zhou ◽  
Liangjian Zhang ◽  
Peng Xuan ◽  
Yong Fan ◽  
Linsheng Yang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Mass Index ◽  
Body Mass ◽  
Early Life ◽  
Meta Analysis ◽  
Famine Exposure ◽  
The Relationship

scholarly journals (A85) Analysis of Health Risk Perception and Behavior Changes during Elevated Temperatures for an Urban Chinese Population

2011 ◽  
Vol 26 (S1) ◽  
pp. s24-s24 ◽  
Author(s):  
E.Y.Y. Chan ◽  
J.H. Kim ◽  
P.P.Y. Lee ◽  
C.L.Y. Lin
Keyword(s):  
Climate Change ◽  
Hong Kong ◽  
Heat Wave ◽  
Chinese Population ◽  
Behavioral Responses ◽  
Behavioral Changes ◽  
Multivariate Logistic Regression ◽  
The Public ◽  
Hot Weather ◽  
The Relationship

BackgroundLimited research has been conducted to understand the relationship between heat wave warnings with public awareness and behavioral changes in the Asian population. The Hong Kong Observatory introduced the “very hot weather warning” in 2000 to alert the public of heatstroke and sunburn in Hong Kong. However, the population's behavioral responses to these weather alerts is unclear. Moreover, the relationship between perceived health risks and behavioral changes has not been examined. The goal of this study is to examine the health risk perceptions and behavioral changes following public heat wave warnings in Hong Kong.MethodsA cross-sectional, population-based, telephone survey, using the last-birthday method was conducted within two weeks following a heat wave warning in 2009. A heat warning and a health study instrument, based on Intergovernmental Panel on Climate Change (IPCC) guidelines and related literature was developed and validated. Descriptive and multivariate logistic regression analyses were conducted.ResultsThe questionnaire was completed by 1,123 individuals whose socio-demographic characteristics were comparable to 2009 Hong Kong population census data. Of respondents, 83.6% were aware of the heat wave weather warning. Multivariate logistic regression of socio-demographic factors indicated that being female, those in middle age groups, and those with higher educational attainment was significantly associated with heat wave warning awareness. Among those aware of the public warning, the majority were unconcerned about potential adverse health effects, < 40% were aware of the community heat-related preparedness plans, and < 50% changed their behavior to mitigate the potential adverse health impacts of hot weather.ConclusionThis is the first study to examine climate change and health behavioral responses in an urban Chinese population. Future research direction should further investigate correlations between awareness and health protective actions, as well as the drivers for health behavioral changes that mitigate the impact of climate change.

The relationship between famine exposure during early life and carotid plaque in adulthood

2020 ◽  
Author(s):  
Yu-qing Huang ◽  
Lin Liu ◽  
Yu-ling Yu ◽  
Chao-lei Chen ◽  
Jia-yi Huang ◽  
...  
Keyword(s):  
Early Life ◽  
Carotid Plaque ◽  
Famine Exposure ◽  
The Relationship
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