Experimental production of hypomagnesaemia in ewes and its control by small magnesium supplements

1962 ◽  
Vol 58 (3) ◽  
pp. 399-404 ◽  
Author(s):  
N. S. Ritchie ◽  
R. G. Hemingway ◽  
J. S. S. Inglis ◽  
R. M. Peacock
Keyword(s):  
Magnesium Level ◽  
Barley Straw ◽  
Experimental Production ◽  
Lower Plasma ◽  
Preliminary Trial ◽  
Low Magnesium ◽  
Winter Grazing ◽  
Plasma Magnesium ◽  
Magnesium Supplement

1. A low magnesium diet is described, consisting of barley straw, sucrose and casein, which induced hypomagnesaemia and one case of clinical tetany in non-pregnant, non-lactating ewes.2. On the above diet a daily drench of 0·25 g. MgO maintained plasma magnesium levels at 1·60–1·80 mg./100 ml. which was significantly higher than the plasma magnesium level of 1·09–1·20 mg./100 ml. for the unsupplemented group.3. An experimental formulation of a magnesium heavy pellet is described and its use as a method of supplementation was investigated. On the above diet it was found that two or four heavy pellets also maintained plasma magnesium values at 1·601–80 mg./100 ml. which was significantly higher (P = 0·01) than the level of the unsupplemented group.4. Five sheep out of the forty ewes used in this experiment were found to have consistently lower plasma magnesium values than the remaining thirty-five.5. A preliminary trial of the use of heavy pellets as a magnesium supplement in non-pregnant, non-lactating ewes on winter grazing is described. The results of the trial under these conditions were encouraging.

Effects of conventional daily magnesium supplementation, breed of ewe and continued potassium fertilizer applications on plasma magnesium and calcium levels of ewes

1963 ◽  
Vol 61 (3) ◽  
pp. 411-415 ◽  
Author(s):  
N. S. Ritchie ◽  
R. G. Hemingway
Keyword(s):  
Magnesium Level ◽  
Plasma Calcium ◽  
Potassium Fertilizer ◽  
Lower Plasma ◽  
Magnesium Supplementation ◽  
Before And After ◽  
The Mean ◽  
Calcium And Magnesium ◽  
Plasma Magnesium ◽  
Muriate Of Potash

1. Muriate of potash applied at rates of 0, 1 and 2 cwt./acre to herbage which had also received similar treatments in the previous year did not influence plasma magnesium or calcium values in lactating ewes.2. 24 Cheviot ewes had slightly lower plasma calcium and magnesium levels than 24 Half-bred ewes of the same age both before and after lambing.3. 6·6 g. of magnesium oxide given as a daily drench did not increase plasma magnesium values as measured by blood samples taken 24 hr. after drenching. Values were however increased by 0·5 mg. Mg/100 ml. four hours after drenching.4. No clinical cases of hypomagnesaemic tetany occurred, even although the mean plasma magnesium level of all the ewes in the experiment was only about 1·0 mg./lOO ml.5. Plasma magnesium values of ewes before lambing were significantly (P < 0·001) correlated with post-lambing levels. Values for the ewes during 1962 were equally significantly correlated with levels for the same sheep at comparable dates in 1961.

EFFECT OF SUPPLEMENTAL RATION ON CHANGES IN BLOOD COMPONENTS OF STEERS GIVEN ACCESS TO LUSH PASTURE

1971 ◽  
Vol 51 (1) ◽  
pp. 179-186 ◽  
Author(s):  
E. E. LISTER ◽  
W. SZEPESI ◽  
K. A. WINTER ◽  
H. F. JEFFERS ◽  
V. S. LOGAN
Keyword(s):  
Lactic Acid ◽  
Rumen Fluid ◽  
Plasma Calcium ◽  
Lactic Acid Concentration ◽  
Lower Plasma ◽  
Supplemental Feed ◽  
Glucose Levels ◽  
Subsequent Effect ◽  
Calcium And Magnesium ◽  
Plasma Magnesium

Prepasture feeding of low quality hay versus hay and grain had no subsequent effect on rumen fluid ammonia, blood urea, or plasma calcium, glucose and lactic acid concentration in steers turned out on lush pasture. Steers previously fed hay and grain had lower plasma magnesium levels on the first day on unsupplemented pasture than those fed hay prior to pasture. Supplemental feed on pasture partly alleviated the depression in plasma magnesium on the first day on pasture. Feeding supplemental hay with pasture tended to lower rumen fluid ammonia, blood urea and plasma lactic acid compared with feeding no supplement during the initial days on pasture, indicating the desirability of hay feeding during this time. A hay and grain supplement with pasture had a similar effect to the hay supplement on rumen-fluid ammonia, and plasma lactic acid, but a lesser effect on blood urea concentration. Neither supplemental hay nor hay plus grain affected plasma calcium or glucose levels. All steers showed an increase in rumen fluid ammonia, blood urea and plasma lactic acid on the first day and a decrease in plasma calcium and magnesium on the second day on pasture. Blood urea, plasma magnesium and plasma calcium concentrations had not returned to prepasture levels by 21 days on pasture.

Drug use is associated with lower plasma magnesium levels in geriatric outpatients; possible clinical relevance

2019 ◽  
Vol 38 (6) ◽  
pp. 2668-2676 ◽  
Author(s):  
A.C.B. van Orten-Luiten ◽  
A. Janse ◽  
E. Verspoor ◽  
E.M. Brouwer-Brolsma ◽  
R.F. Witkamp
Keyword(s):  
Drug Use ◽  
Clinical Relevance ◽  
Lower Plasma ◽  
Plasma Magnesium

THE EFFECTS OF CALCITONIN AND PARATHORMONE ON PLASMA MAGNESIUM LEVELS BEFORE AND AFTER BIRTH IN THE RAT

1974 ◽  
Vol 61 (1) ◽  
pp. 1-13 ◽  
Author(s):  
J. M. GAREL ◽  
J. P. BARLET
Keyword(s):  
Parathyroid Hormone ◽  
Salmon Calcitonin ◽  
Magnesium Level ◽  
Plasma Calcium ◽  
Parathyroid Glands ◽  
Small Decrease ◽  
Newborn Rats ◽  
Newborn Rat ◽  
Before And After ◽  
Plasma Magnesium

SUMMARY Plasma magnesium levels measured in rats from 16·5 to 21·5 days of gestation and during the first week after birth proved to be invariably higher in the foetus than in the mother. The highest level observed was in the 16·5-day-old foetus. A small decrease occurred between 16·5 and 17·5 days of gestation; thereafter the plasma magnesium level did not change until 19·5 days and then decreased between 19·5 and 21·5 days. After birth an increase in plasma magnesium occurred with suckling but then remained constant during the first week of life. Parathyroid hormone (0·25 USP unit/g) injected into 21·5-day-old foetuses had no effect on plasma magnesium levels from 0·5 to 24 h after injection. This dose was found to be very potent in raising plasma calcium values 4 h after injection. In the 3-day-old newborn rat this dose was similarly ineffective. Removal of the foetal parathyroid glands by decapitation at 17·5 days of gestation was followed by a decrease in plasma magnesium at 21·5 days of gestation. Parathyroid hormone (0·25 USP unit/g) injected into decapitated foetuses did not change the level of magnesium in the plasma. Salmon calcitonin (S-CT) at two doses (0·4 and 4 ng/g) produced no effect on plasma magnesium concentrations in 3-day-old newborn rats 3 h after injection; whereas at both doses, marked diminutions in plasma calcium and phosphate concentrations were observed. After injection of 40 ng S-CT/g, plasma magnesium decreased in 3-day-old newborn rats 3 h after injection. This dose was found to decrease plasma magnesium in the 19·5-day-old foetus and in the 20·5-day-old foetus. Before 19·5 days of gestation no effect was observed.

scholarly journals The relationship between blood pressure and plasma magnesium level in hypertensive patients

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 2) ◽  
pp. P241
Author(s):  
A Bayir ◽  
B Cander ◽  
A Ak ◽  
S Girisgin
Keyword(s):  
Blood Pressure ◽  
Magnesium Level ◽  
Hypertensive Patients ◽  
Plasma Magnesium ◽  
The Relationship

Admission Low Magnesium Level Is Associated with In-Hospital Mortality in Acute Ischemic Stroke Patients

2017 ◽  
Vol 44 (1-2) ◽  
pp. 35-42 ◽  
Author(s):  
Shoujiang You ◽  
Chongke Zhong ◽  
Huaping Du ◽  
Yu Zhang ◽  
Danni Zheng ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Hospital Mortality ◽  
Hospital Admission ◽  
Acute Ischemic Stroke ◽  
Serum Magnesium ◽  
Fold Increase ◽  
Magnesium Level ◽  
Low Magnesium ◽  
Cox Proportional Hazard ◽  
Suzhou City

Background: Low magnesium levels are associated with an elevated risk of stroke. In this study, we investigated the association between magnesium levels on hospital admission and in-hospital mortality in acute ischemic stroke (AIS) patients. Methods: A total of 2,485 AIS patients, enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city, were included in this study. The patients were divided into 4 groups according to their level of admission magnesium: Q1 (<0.82 mmol/L), Q2 (0.82-0.89 mmol/L), Q3 (0.89-0.98 mmol/L), and Q4 (≥0.98 mmol/L). Cox proportional hazard model was used to estimate the effect of magnesium on all-cause in-hospital mortality in AIS patients. Results: During hospitalization, 92 patients (3.7%) died from all causes. The lowest serum magnesium level (Q1) was associated with a 2.66-fold increase in the risk of in-hospital mortality in comparison to Q4 (hazard ratio [HR] 2.66; 95% CI 1.55-4.56; p-trend < 0.001). After adjusting for age, sex, time from onset to hospital admission, baseline National Institutes of Health Stroke Scale score, and other potential covariates, HR for Q1 was 2.03 (95% CI 1.11-3.70; p-trend = 0.014). Sensitivity and subgroup analyses further confirmed a significant association between lower magnesium levels and a high risk of in-hospital mortality. Conclusions: Decreased serum magnesium levels at admission were independently associated with in-hospital mortality in AIS patients.

Influence of manufacturing conditions on the bioavailability of magnesium in calcined magnesites measured in vivo and in vitro

1996 ◽  
Vol 127 (3) ◽  
pp. 377-385 ◽  
Author(s):  
C. L. Adam ◽  
R. G. Hemingway ◽  
N. S. Ritchie
Keyword(s):  
Urinary Output ◽  
Magnesium Concentration ◽  
Particle Sizes ◽  
Calcination Temperatures ◽  
Low Magnesium ◽  
Veterinary School ◽  
Grade Material ◽  
Plasma Magnesium

SUMMARYDietary calcined magnesite supplements of different particle sizes and temperatures of calcination were examined at Glasgow University Veterinary School in 1981. Balance experiments with wether sheep revealed that particle sizes < 75, 75–150, 150–250 and 500–1000 μm diameter of a feed-grade calcined magnesite all increased urinary output of magnesium to a similar extent but the apparent magnesium availability coefficient for the 500–1000 μm diameter fraction (0·03) was significantly less than for fractions of smaller diameter (0·17–0·23) (P < 0·01). A 1000–2000 μm fraction of fertilizer-grade material had an apparent availability of 0·18 but had the least effect on urinary magnesium output. Calcination temperatures of 800, 900 and 1100 °C significantly increased apparent availability (c. 0·46)compared with that for temperatures of 500 and 650 °C (c. 0·12) (P < 0·01), and significantly increased urinary output of magnesium. Losses of magnesium from these supplements incubated in the rumen of cows at grass in 24 μm mesh nylon bags showed some correlations with their apparent availability and urinary magnesium output. Solubility in molar ammonium nitrate showed some good correlations with urinary magnesium output but not with magnesium availability. Supplementation of a low magnesium diet given to lactating ewes with fine particle (< 75μm) calcined magnesite resulted in significantly greater increases in plasma magnesium concentration than when coarse particle material (500–1000 μm) was given (P < 0·05), but magnesites calcined at 650 and 800 °C induced similar changes in plasma magnesium.

Omeprazole suppressed plasma magnesium level and duodenal magnesium absorption in male Sprague-Dawley rats

2016 ◽  
Vol 468 (11-12) ◽  
pp. 1809-1821 ◽  
Author(s):  
Narongrit Thongon ◽  
Jirawat Penguy ◽  
Sasikan Kulwong ◽  
Kanyanat Khongmueang ◽  
Matthana Thongma
Keyword(s):  
Magnesium Level ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Plasma Magnesium

Effects of potassium fertilizers, age of ewe, and small magnesium supplementation on blood magnesium and calcium levels of lactating ewes

1963 ◽  
Vol 60 (3) ◽  
pp. 307-312 ◽  
Author(s):  
R. G. Hemingway ◽  
N. S. Ritchie ◽  
A. R. Rutherford ◽  
G. M. Jolly
Keyword(s):  
Clinical Case ◽  
Experimental Period ◽  
Plasma Calcium ◽  
Large Individual ◽  
Potassium Fertilizer ◽  
Lower Plasma ◽  
Magnesium Supplementation ◽  
Fertilizer Use ◽  
Plasma Magnesium ◽  
Muriate Of Potash

1. An experiment is described which investigated the effects of potassium fertilizer, age of ewe, and a small magnesium supplement, on the plasma magnesium and calcium levels of ewes shortly after lambing.2. Three potassium treatments (0, 1, and 2 cwt. muriate of potash/acre) were used, each being replicated six times, which gave a total of eighteen plots. Each plot was grazed by two old and two young ewes. One ewe of each age in every plot was given supplementary magnesium in the form of two magnesium heavy pellets, which released a total of 150 mg. Mg/day.3. 22% of the ewes had plasma magnesium values below 1·0 mg. Mg/100 ml. on at least one sampling occasion during the experimental period. There was only one clinical case of tetany.4. Neither potassium fertilizer use, nor magnesium supplementation influenced plasma magnesium and calcium levels of the ewes. Old ewes had greater temporary falls in plasma magnesium values and had consistently lower plasma calcium values.5. Attention is drawn to the large individual variation between animals and the consequent need for providing adequate statistical analysis of experiments of this type.

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