Effects of conventional daily magnesium supplementation, breed of ewe and continued potassium fertilizer applications on plasma magnesium and calcium levels of ewes

1963 ◽  
Vol 61 (3) ◽  
pp. 411-415 ◽  
Author(s):  
N. S. Ritchie ◽  
R. G. Hemingway

1. Muriate of potash applied at rates of 0, 1 and 2 cwt./acre to herbage which had also received similar treatments in the previous year did not influence plasma magnesium or calcium values in lactating ewes.2. 24 Cheviot ewes had slightly lower plasma calcium and magnesium levels than 24 Half-bred ewes of the same age both before and after lambing.3. 6·6 g. of magnesium oxide given as a daily drench did not increase plasma magnesium values as measured by blood samples taken 24 hr. after drenching. Values were however increased by 0·5 mg. Mg/100 ml. four hours after drenching.4. No clinical cases of hypomagnesaemic tetany occurred, even although the mean plasma magnesium level of all the ewes in the experiment was only about 1·0 mg./lOO ml.5. Plasma magnesium values of ewes before lambing were significantly (P < 0·001) correlated with post-lambing levels. Values for the ewes during 1962 were equally significantly correlated with levels for the same sheep at comparable dates in 1961.

1963 ◽  
Vol 60 (3) ◽  
pp. 307-312 ◽  
Author(s):  
R. G. Hemingway ◽  
N. S. Ritchie ◽  
A. R. Rutherford ◽  
G. M. Jolly

1. An experiment is described which investigated the effects of potassium fertilizer, age of ewe, and a small magnesium supplement, on the plasma magnesium and calcium levels of ewes shortly after lambing.2. Three potassium treatments (0, 1, and 2 cwt. muriate of potash/acre) were used, each being replicated six times, which gave a total of eighteen plots. Each plot was grazed by two old and two young ewes. One ewe of each age in every plot was given supplementary magnesium in the form of two magnesium heavy pellets, which released a total of 150 mg. Mg/day.3. 22% of the ewes had plasma magnesium values below 1·0 mg. Mg/100 ml. on at least one sampling occasion during the experimental period. There was only one clinical case of tetany.4. Neither potassium fertilizer use, nor magnesium supplementation influenced plasma magnesium and calcium levels of the ewes. Old ewes had greater temporary falls in plasma magnesium values and had consistently lower plasma calcium values.5. Attention is drawn to the large individual variation between animals and the consequent need for providing adequate statistical analysis of experiments of this type.


1971 ◽  
Vol 51 (1) ◽  
pp. 179-186 ◽  
Author(s):  
E. E. LISTER ◽  
W. SZEPESI ◽  
K. A. WINTER ◽  
H. F. JEFFERS ◽  
V. S. LOGAN

Prepasture feeding of low quality hay versus hay and grain had no subsequent effect on rumen fluid ammonia, blood urea, or plasma calcium, glucose and lactic acid concentration in steers turned out on lush pasture. Steers previously fed hay and grain had lower plasma magnesium levels on the first day on unsupplemented pasture than those fed hay prior to pasture. Supplemental feed on pasture partly alleviated the depression in plasma magnesium on the first day on pasture. Feeding supplemental hay with pasture tended to lower rumen fluid ammonia, blood urea and plasma lactic acid compared with feeding no supplement during the initial days on pasture, indicating the desirability of hay feeding during this time. A hay and grain supplement with pasture had a similar effect to the hay supplement on rumen-fluid ammonia, and plasma lactic acid, but a lesser effect on blood urea concentration. Neither supplemental hay nor hay plus grain affected plasma calcium or glucose levels. All steers showed an increase in rumen fluid ammonia, blood urea and plasma lactic acid on the first day and a decrease in plasma calcium and magnesium on the second day on pasture. Blood urea, plasma magnesium and plasma calcium concentrations had not returned to prepasture levels by 21 days on pasture.


1974 ◽  
Vol 61 (1) ◽  
pp. 1-13 ◽  
Author(s):  
J. M. GAREL ◽  
J. P. BARLET

SUMMARY Plasma magnesium levels measured in rats from 16·5 to 21·5 days of gestation and during the first week after birth proved to be invariably higher in the foetus than in the mother. The highest level observed was in the 16·5-day-old foetus. A small decrease occurred between 16·5 and 17·5 days of gestation; thereafter the plasma magnesium level did not change until 19·5 days and then decreased between 19·5 and 21·5 days. After birth an increase in plasma magnesium occurred with suckling but then remained constant during the first week of life. Parathyroid hormone (0·25 USP unit/g) injected into 21·5-day-old foetuses had no effect on plasma magnesium levels from 0·5 to 24 h after injection. This dose was found to be very potent in raising plasma calcium values 4 h after injection. In the 3-day-old newborn rat this dose was similarly ineffective. Removal of the foetal parathyroid glands by decapitation at 17·5 days of gestation was followed by a decrease in plasma magnesium at 21·5 days of gestation. Parathyroid hormone (0·25 USP unit/g) injected into decapitated foetuses did not change the level of magnesium in the plasma. Salmon calcitonin (S-CT) at two doses (0·4 and 4 ng/g) produced no effect on plasma magnesium concentrations in 3-day-old newborn rats 3 h after injection; whereas at both doses, marked diminutions in plasma calcium and phosphate concentrations were observed. After injection of 40 ng S-CT/g, plasma magnesium decreased in 3-day-old newborn rats 3 h after injection. This dose was found to decrease plasma magnesium in the 19·5-day-old foetus and in the 20·5-day-old foetus. Before 19·5 days of gestation no effect was observed.


1969 ◽  
Vol 115 (529) ◽  
pp. 1375-1377 ◽  
Author(s):  
D. Frizel ◽  
Alec Coppen ◽  
V. Marks

Recent investigations suggest that there may be an abnormality of calcium and magnesium in depressive illness. Flach (1964) followed the urinary excretion of calcium in depressed patients maintained on a constant intake of calcium before and during recovery. Those patients that recovered showed a significant decrease in the excretion of calcium. Coiraultet al.(1959) reported an increase in ionized calcium and a decrease in total plasma calcium on recovery from depression. Cade (1964) reported considerably raised total plasma magnesium levels in depressed patients both before and after recovery. A connection between affective disorders and calcium metabolism is suggested by the common occurrence of such states in both hypo- and hypercalcaemia (Denco and Kaelbling, 1962; Rookus and Speelman, 1961). The present paper reports an investigation into total and ionized plasma calcium and magnesium in a group of depressed patients both before and after recovery. The effects of lithium carbonate, a compound used in the treatment and prophylaxis of affective disorders (Baastrup and Schou, 1967; Schou, 1963) on plasma concentrations of magnesium and calcium was also investigated.


2020 ◽  
pp. 107815522094859
Author(s):  
So Jung Uhm ◽  
Elizabeth Meszaros ◽  
Kendall Hammonds ◽  
Ina Patel ◽  
Jon D Herrington

Background Cisplatin-associated electrolyte dysregulation is a prevalent therapy-related adverse effect. There are numerous electrolyte-supplemented hydration regimens that have been evaluated, however these studies focused on the development of nephrotoxicity. The objective of this study was to characterize the impact of magnesium and potassium-supplemented hydration during cisplatin administration on subsequent magnesium and potassium imbalances. Methods A single-region retrospective study from central Texas at Baylor Scott & White Cancer Clinics who were treated with two or more cycles of cisplatin were included. Standard hydration for this study was defined as normal saline before and after cisplatin along with potassium chloride 10 mEq and magnesium sulfate 1 g added to the cisplatin bag. Results A total of 477 patients were included in the study with376 patients receiving the standard hydration. Overall, 17 percent of patients experienced a potassium level below 3.5 mEq/L, but no major depletion was observed. Thirty-three percent of the patients experienced a magnesium level below 1.8 mg/dL, and time to first rescue magnesium supplementation was 4 weeks. Conclusion Our study demonstrated despite routine magnesium and potassium supplementation in hydration, magnesium imbalances were observed. Potassium levels post cisplatin administration were maintained with minimal routine supplementation in hydration.


1977 ◽  
Vol 55 (2) ◽  
pp. 206-211 ◽  
Author(s):  
Yukio Komatsu ◽  
George Constantopoulos ◽  
Jolanta Gutkowska ◽  
Jose-Manuel Rojo-Ortega ◽  
Jacques Genest

Six adult male mongrel dogs were treated orally with reserpine (0.03 mg/kg) for 6 weeks, after which time the arterial tissue content of water, cations (sodium, potassium, magnesium, and calcium), and norepinephrine was determined and compared with those of six untreated dogs. Reserpine administration resulted in sustained decreases in the mean arterial blood pressure and heart rate, and the arterial tissues of the treated dogs contained less potassium, calcium, and magnesium, the last-named being affected most, but the sodium remained the same. Arterial norepinephrine content was significantly decreased. There was a slight but significant increase in plasma magnesium, without any noticeable changes in other plasma cations. The reduction in the arterial magnesium by reserpine may help to regulate vascular tone and (or) vascular reactivity.


Author(s):  
K. B. Vala ◽  
A. J. Dhami ◽  
F. S. Kavani ◽  
S. C. Parmar ◽  
M. M. Pathan

This investigation was undertaken on 40 transitional Jaffarabadi buffaloes with the objective to evaluate the effect of peripartum nutritional (multiminerals and bypass fat) supplementation without and with micro-minerals (Inj. Stimvet) and oral ecbolic (Boli Exapar) on uterine involution and postpartum fertility including plasma minerals profile. The animals of treatment group (n=20) received additional oral supplements daily with 50 g of chelated mineral mixture and 150 g of bypass fat along with concentrates for 6 weeks prepartum and 2 weeks postpartum over the control farm fed group (n=20). Ten buffaloes in each control and treatment group further received Inj. Stimvet 5 ml (micro-minerals) around day 45 prepartum and on day of calving. Half of these Stimvet treated and control subgroups also received Exapar (n=5) 2 boli/day for 4 consecutive days postpartum. Blood samples were obtained on day –45, –30, –7 and 0 (day of calving), 7, 15, 30, 45, 60 peripartum for estimation of minerals profile. Animals were followed for puerperal events, uterine involution and intervals for postpartum first estrus and conception. The feeding of bypass fat and chelated minerals had significant effect on the time required for expulsion of placenta (3.93±0.24 vs 7.18±0.72 hrs; p Lass Than 0.01), uterine involution (32.75±0.57 vs 37.00±0.56 days; p Lass Than 0.05), intervals for first estrus postpartum (79.05±3.82 vs 100.55±3.47 days; p Lass Than 0.05) and service period (107.10±4.43 vs 133.65±6.04 days; p Lass Than 0.05). The prepartum mean plasma calcium and inorganic phosphorus levels in the buffaloes of both control and treatment groups decreased significantly on the day of calving, and then gradually increased during the days postpartum, again reaching at par with prepartum levels at around day 15-30 postpartum. The mean plasma calcium levels were observed to be higher in treatment than control group at most of the intervals. The mean plasma inorganic phosphorus values on periods closer to calving were apparently higher in treatment group than the control group. Further, the levels during close peripartum period were observed to be apparently higher in untreated subgroup as compared to Stimvet and Exapar alone or its combination subgroups. The mean plasma magnesium concentrations were found to be almost consistent during entire peripartum period studied in both the groups with apparently higher values in treatment than control group at most of the intervals. Very similar trend was also found in subgroups treated with Stimvet and oral Exapar alone or in combination, being little higher in Stimvet injected subgroup.


Reproduction ◽  
2000 ◽  
pp. 85-94 ◽  
Author(s):  
JJ Dufour ◽  
Y Cognie ◽  
P Mermillod ◽  
JC Mariana ◽  
RF Romain

Endocrine control of follicular growth was studied in mature Romanov ewes carrying (RF+) or not carrying (R+2) the Booroola Fec gene during an oestrous cycle after gonadotrophin-dependent follicles were suppressed by treatment with an antagonist of GnRH (Antarelix, 0.5 mg per day) and superovulatory treatment was administered. The left ovary was removed after 10 days of treatment (saline or Antarelix) and the right ovary was removed at the end of the superovulatory treatment. Ewes of both genotypes treated with Antarelix had lower plasma LH concentrations than did controls from day 0 to day 10. The inhibitory effect of Antarelix on LH concentration increased with day of treatment. The variability in FSH concentrations during the initial 10 days was reduced by Antarelix treatment in both genotypes. Plasma FSH concentrations were higher in RF+ ewes than in R+2 ewes. In both genotypes, FSH concentrations varied significantly with day of treatment, with the lowest concentrations at day 8 and the highest concentrations at day 5. RF+ ewes had a greater total and atretic number of antral follicles 0.62-1.12, 1.12-2.00 and 2.00-3.00 mm in diameter (classes 2, 3 and 4) than did R+2 ewes before and after superovulatory treatment. After superovulatory treatment, the total number of atretic and non-atretic follicles > 3.00 mm in diameter (class 5) increased in both genotypes. Superovulatory treatment also increased the number of total and atretic class 4 follicles in RF+ only. Conversely, superovulatory treatment decreased the mean number of class 3 follicles in both genotypes, while the number of atretic follicles was decreased only in R+2 ewes. Antarelix treatment significantly reduced the percentage of follicles > 2.00 mm in diameter in RF+ but not in R+2 ewes. Antarelix treatment before superovulatory treatment increased the total number of class 4 follicles in both genotypes but the increase was more significant in RF+ than in R+2 ewes. These results indicate that Antarelix pretreatment favours a greater superovulatory response in Romanov ewes carrying the Fec gene because ovulatory follicles are recruited from a wider range of follicular size classes.


1972 ◽  
Vol 120 (559) ◽  
pp. 683-684 ◽  
Author(s):  
G. J. Naylor ◽  
Laura W. Fleming ◽  
W. K. Stewart ◽  
H. B. McNamee ◽  
D. Le Poidevin

There have been reports of the association of alterations in the divalent cation content of plasma with depressive illness. Coirault and colleagues (1959) found increased ionized calcium levels despite decreased total plasma calcium concentration in patients recovered from depression. More recently, Frizel and colleagues (1969) have reported normal plasma ionized and total calcium levels both before and after recovery from depression.


1962 ◽  
Vol 58 (3) ◽  
pp. 399-404 ◽  
Author(s):  
N. S. Ritchie ◽  
R. G. Hemingway ◽  
J. S. S. Inglis ◽  
R. M. Peacock

1. A low magnesium diet is described, consisting of barley straw, sucrose and casein, which induced hypomagnesaemia and one case of clinical tetany in non-pregnant, non-lactating ewes.2. On the above diet a daily drench of 0·25 g. MgO maintained plasma magnesium levels at 1·60–1·80 mg./100 ml. which was significantly higher than the plasma magnesium level of 1·09–1·20 mg./100 ml. for the unsupplemented group.3. An experimental formulation of a magnesium heavy pellet is described and its use as a method of supplementation was investigated. On the above diet it was found that two or four heavy pellets also maintained plasma magnesium values at 1·601–80 mg./100 ml. which was significantly higher (P = 0·01) than the level of the unsupplemented group.4. Five sheep out of the forty ewes used in this experiment were found to have consistently lower plasma magnesium values than the remaining thirty-five.5. A preliminary trial of the use of heavy pellets as a magnesium supplement in non-pregnant, non-lactating ewes on winter grazing is described. The results of the trial under these conditions were encouraging.


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