Development of the testis and epididymis of the Clun Forest ram

1971 ◽  
Vol 76 (3) ◽  
pp. 433-441 ◽  
Author(s):  
R. J. Colyer
Keyword(s):  
Body Weight ◽  
Rate Of Increase ◽  
Wide Range ◽  
Body Weights ◽  
Close Relationship ◽  
Subsequent Phase ◽  
Dimensional Growth ◽  
Left And Right ◽  
Ram Lambs

SUMMARYObservations were made on the development of the testes and epididymides of thirty-two Clun Forest ram lambs. There were no significant differences between the weights and volumes of the left and right testes and epididymides.The rate of increase in testicular and epididymal weights was linear up to a body weight of 46 lb (20·9 kg) followed subsequently by a significantly greater rate of increase at higher body weights. Similar patterns of growth occurred in relation to age, although at a given age there was a wide range of testicular and epididymal weights. There was a close relationship between the development of the testis and the epididymis at body weights greater than 46 lb (20·9 kg).There were two distinct phases in the dimensional growth of the testis. Increases in testicular length and breadth proceeded at much the same rate at testis weights of below 20 g. During the subsequent phase testicular length increased at a significantly greater rate than testis breadth.

Clinical pharmacokinetics (PK) of BMS-936558, a fully human anti-PD-1 monoclonal antibody.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. TPS2622-TPS2622 ◽  
Author(s):  
Shruti Agrawal ◽  
Yan Feng ◽  
Georgia Kollia ◽  
Sally Saeger ◽  
Martin Ullmann ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Body Weight ◽  
Half Life ◽  
Dose Range ◽  
Volume Of Distribution ◽  
Wide Range ◽  
Body Weights ◽  
Clinically Significant ◽  
Potentially Clinically Significant ◽  
Dose Proportional

TPS2622 Background: BMS-936558 is a fully human IgG4 monoclonal antibody targeted against human Programed Death-1 (PD1) receptor on activated T and B lymphocytes. Blocking of PD-1 prevents these activated cells from becoming anergic, thereby maintaining anti-tumor immunologic activity. Methods: The PK of BMS-936558 was characterized with data from a single ascending dose (SAD) and a multiple ascending dose (MAD) study in subjects with advanced solid malignancies. Subjects received a single IV infusion of 0.3 to 10 mg/kg BMS-936558 in the SAD study (MDX-1106-01 Study) and 0.1 to 10 mg/kg BMS-936558 every two weeks in the MAD study (MDX-1106-03/CA209003 Study). The PK of BMS-936558 was characterized by non-compartmental analysis of intensively sampled PK data from a SAD study, as well as by population PK analysis of available intensive and sparse PK data from the SAD and MAD studies, respectively. Results: The PK of BMS-936558 is linear in the studied dose range with dose-proportional increase in Cmax and AUC with low to moderate (20-44%) inter-subject variability. Geometric mean clearance ranged from 0.13 - 0.19 mL/h/kg, whereas mean volume of distribution ranged from 83 -113 mL/kg. The range of mean terminal elimination half-life of BMS-936558 is 17 to 25 days which is consistent with half-life of endogenous IgG4. BMS-936558 PK was adequately described by a linear two-compartment model, and there was no evidence of a contribution of target mediated drug disposition to drug elimination within tested dose range. Body weight and gender are potentially clinically significant covariate for both clearance and volume of distribution (> 20% effect); and baseline CRP, LDH, and albumin are potentially clinically significant covariates for CL. The body weight normalized dosing employed produces trough concentrations that are approximately constant over a wide range of body weights. Conclusions: The pharmacokinetics of BMS-936558 is dose-proportional and body weight normalized dosing is appropriate to ensure consistent exposure over a wide range of body weights.

Avian Egg Morphometrics - Allometric Models of Egg Volume, Clutch Volume and Shape

1994 ◽  
Vol 42 (3) ◽  
pp. 307 ◽  
Author(s):  
PD Olsen ◽  
RB Cunningham ◽  
CF Donnelly
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Sexual Dimorphism ◽  
Clutch Size ◽  
Egg Volume ◽  
Simple Power ◽  
Wide Range ◽  
Body Weights ◽  
Body Sizes ◽  
Simple Power Function

This paper describes three comprehensive new models of the allometric relationships between egg volume, clutch volume and shape, and body weight. Mean egg dimensions, clutch sizes and adult body weights were obtained for 326 species, mainly of four bird types: raptors (including owls), shorebirds, frogmouths (including nightjars), and storks (including the New World vultures). These are groups in which there is a wide range of body sizes and of sexual dimorphism in body size (in direction and degree). Female body weight alone accounted for 92% of the variation in egg volume. Sexual dimorphism in body size, phylogenetic relationship, and clutch size were significant contributors to the model of egg volume; their addition increased the explained variance to over 98%. The model was curvilinear (quadratic) in form, rather than linear as assumed in previous models. Larger species laid smaller eggs than expected under a simple power function. For the fitted model, within bird types, generic groupings had parallel curvilinear slopes but differing intercepts. Between bird types, the slopes differed. Clutch volume was scaled to body weight; all the bird types had a common slope, which was curvilinear. Body weight and dimorphism accounted for 89.5% of the variation in clutch volume. For all bird types, eggs became proportionally longer in shape as body weight increased, according to a simple power law. The relevance of these relationships to hypotheses on the evolution and adaptive significance of sexual dimorphism and to the trade-off between egg size and clutch size is discussed briefly.

scholarly journals PUBERAL DEVELOPMENT IN THE NIGERIAN DWARF SHEEP

2021 ◽  
Vol 7 (1) ◽  
pp. 71-76
Author(s):  
B. I. Orji ◽  
J. Steinbach
Keyword(s):  
Body Weight ◽  
Reproductive Tract ◽  
Age Groups ◽  
Reproductive Organs ◽  
The Body ◽  
Endocrine Function ◽  
Physiological Age ◽  
Body Weights ◽  
Pituitary Glands ◽  
Ram Lambs

Eleven ram lambs, all born between June and July (rainy season) were slaughtered at four age groups — 75, 100, 125 and 150 days. The body weights of animals prior to slaughter, the weights of the testes, the epididymis, the vesicular glands, the ampullae, the adrenals, the thyroids and the pituitary glands were determined and subjected to a step-wise multiple regression analysis using age or body weight as the independent variable. The weights of the reproductive organs – testes, epididymides, ampullae, vesicular glands - showed significantly higher correlation with the body weight than with the age, thus emphasizing the greater importance of the physiological age over the chronological age in the development of the body organs. The highest growth rate of the organs of the reproductive tract occurred during puberty and thus coincided with the enhanced endocrine function observed in ram lambs at this stage.

Work performance of trained rats as affected by corticoadrenal steroids and by adrenalectomy

1960 ◽  
Vol 199 (5) ◽  
pp. 863-866
Author(s):  
Charles A. Winter ◽  
Lars Flataker
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Adrenal Insufficiency ◽  
Work Performance ◽  
Skeletal Muscle Mass ◽  
Food Reward ◽  
Narrow Range ◽  
Wide Range ◽  
Body Weights ◽  
Fasted Rats

Fasted rats trained to climb a rope for a food reward were capable of carrying added weights approximately equal to their own body weights. The logclimbing time in seconds was linearly related to the total weight of the animal plus added load within a narrow range of body weight. When correction was made for skeletal muscle mass, the rate of work performance in gram-meters per long second per gram muscle was essentially the same over a wide range of body weights and of added load. Work performance as measured by this preparation was sensitive to changes in glucocorticoid levels, and was increased by cortisone or hydrocortisone in either intact or adrenalectomized animals, and was decreased by adrenal insufficiency.

scholarly journals Some Gastrointestinal Tract Characteristics of Karayaka Ram Lambs Slaughtered at Different Weights

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Arda Yıldırım ◽  
Yüksel Aksoy ◽  
Nuh Ocak ◽  
Zafer Ulutaş
Keyword(s):  
Body Weight ◽  
Gastrointestinal Tract ◽  
Weight Ratio ◽  
The Body ◽  
Steady Growth ◽  
Linear Relationships ◽  
Intestinal Length ◽  
Body Weights ◽  
Intestine Length ◽  
Ram Lambs

Thirty-one Karayaka ram lambs were slaughtered at different body weights (30n=7, 35n=6, 40n=7, 45n=6, and 50n=5 kg of body weight at fast) to evaluate the growth of their gastrointestinal tract (GIT) characteristics, to determine the relationship among slaughter body weight (SBW) and empty body weight (EBW), whole GIT and segments, and the influence of slaughter weight on the pH of rumen, jejunum, and cecal contents. The effects of the SBW on GIT weightP<0.05, stomachP<0.001, and intestineP<0.05, the body lengthP<0.001and caecumP<0.05, and the relative weights of GITP<0.05, stomachP<0.001, and intestineP<0.001were linear whereas that for the length of intestine were quadratic. The effect of SBW were quadraticP<0.05on ratios of stomach to GIT weight and intestine length to intestine weight and rumen pH while, for the intestine to GIT weight ratioP<0.001and caecum pHP<0.05, this effect was linear. The results indicated that for all parameters studied, with the exception of intestinal length and cecal pH, linear relationships were observed with SBW indicating steady growth rates for these tissues.

A note on mating ability in clun forest ram lambs

1972 ◽  
Vol 14 (2) ◽  
pp. 259-262 ◽  
Author(s):  
Ó. R. Dýrmundsson ◽  
J. L. Lees
Keyword(s):  
Body Weight ◽  
Sexual Development ◽  
Mating Behaviour ◽  
Late Summer ◽  
Seasonal Influence ◽  
Mating Ability ◽  
Breeding Activity ◽  
Wide Range ◽  
Ram Lambs

SUMMARYSome aspects of sexual development and mating behaviour in Clun Forest ram lambs having a wide range of birth dates were studied during two seasons. The 61 ram lambs studied were introduced individually to Clun ewes in oestrus, for short periods at fortnightly intervals during late summer and autumn. Complete matings, i.e. intromission and ejaculation, were first achieved at a mean age of 6 months (range 142–223 days) and a mean body weight of 35 kg (range 24–49 kg). The attainment of physiological puberty preceded the first copulation, often by several weeks. A few individuals had abnormal testes and were partly or completely sterile, but exhibited normal mating behaviour. Early-born lambs tended to complete their first matings at a higher age and heavier body weight than late-born lambs, which suggests a possible seasonal influence on the development of breeding activity in the ram lamb.

scholarly journals Energy expenditure during heavy work and its interaction with body weight

1997 ◽  
Vol 77 (3) ◽  
pp. 359-373 ◽  
Author(s):  
P. Haggarty ◽  
M. E. Valencia ◽  
G. McNeill ◽  
N. L. Gonzales ◽  
S. Y. Moya ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Expenditure ◽  
Time Allocation ◽  
Theoretical Calculations ◽  
Metabolic Adaptation ◽  
Energy Costs ◽  
Work Activities ◽  
Discretionary Time ◽  
Wide Range ◽  
Body Weights

The present study was designed to investigate the interaction between body weight and energy expenditure in well-nourished individuals. Energy expenditure was determined during a 10 d highly controlled work programme in apparently well-nourished adult male construction workers with a wide range of body weights (mean weight: 63·9 (SD 11·0, range 46·7-80·1) kg, mean BMI: 22·5 (SD 3·8, range 16·7-28·9) kg/m2). Total energy expenditure (mean: 12·68 (SE 0·73) MJ/d or 1·78 (SE 0·07) x BMR) was determined using doubly-labelled water and the energy costs of work activities by Oxylog. The energy expenditure during work (mean: 5·75 (SE 0·29) MJ/day or 3·48 (SE 0·09) x BMR) was estimated from the energy costs of individual tasks and the time spent in those tasks. The energy expenditure during discretionary time (mean: 4·37 (SE 0·58) MJ/d or 1·49 (SE 0·17) x BMR) was calculated by subtracting occupation and sleep expenditure (taken as1 x BMR) from total expenditure. Food intake and discretionary time allocation were recorded by the subjects. The energy expenditure in the programmed work activities (expressed as a multiple of BMR) showed a significant increase (P=0·035) with increasing body weight, suggesting that the assumed constancy of BMR multiples across a wide range of body weights may not be valid. This assertion was supported by theoretical calculations based on empirically derived equations. In order to avoid errors which could be interpreted as metabolic ‘adaptation’ it may be necessary to take account of body weight when using the BMR-multiple approach to estimate energy requirements at low body weights.

Studies of the effects of the gene N on body growth and fleece development of the New Zealand Romney. I. The body growth of the N type lamb

1959 ◽  
Vol 10 (3) ◽  
pp. 387 ◽  
Author(s):  
F Cockrem ◽  
AL Rae
Keyword(s):  
Body Weight ◽  
New Zealand ◽  
Body Growth ◽  
The Body ◽  
Environment Interaction ◽  
Lower Body ◽  
Initial Weight ◽  
Ewe Lambs ◽  
Body Weights ◽  
Ram Lambs

A study has been made of the pleiotropic effects of the gene N on the body growth and the carcass of the Sew Zealand Romney lamb. Measurements of body weight and height at withers were taken from birth to about 5 months of age for lambs born in 1952 and 1953 from matings of N/+ x +/+, N/N x N/N, N/N x N/+, and N/+ x N/+ parents. In 1952, +/+ lambs grew faster than N/+ or N/N lambs and this was shown in the greater body weight of the +/+ lambs at 30 days of age. The differences in weight gains corrected for initial weight were greater for single lambs than for twin lambs. The differences in the height at withers were proportional to those in body weight except for the N/N lambs. The N/N lambs had a greater height at withers for their body weight but this could have been the result of factors other than the gene N which were associated with the N–type flock. N–type ewe lambs kept up to 18 months of age maintained lower body weights than +/+ lambs. In 1953 no differences between N/+ and +/+ lambs were found in body growth. It is suggested that a genetic-environment interaction exists for body growth and that the environmental factor is possibly one of climate. No differences were found between the carcass measurements of N/+ and +/+ ram lambs which could not be attributed to the previous differences in body growth.

The influence of the poll gene and of castration on production characters of male Merino sheep

1963 ◽  
Vol 3 (11) ◽  
pp. 262 ◽  
Author(s):  
RB Dun
Keyword(s):  
Body Weight ◽  
Merino Sheep ◽  
Wool Production ◽  
Body Weights ◽  
Ram Lambs ◽  
Fleece Weight ◽  
Marking Time ◽  
Staple Length

Two drops of lambs were produced in spring 1959 and 1961 by mating poll rams (Pp) to knobbed ewes (pp). At marking time (1-4 wk), a random half of ram lambs of the Pp group and of the pp group were castrated. The rams and wethers were grown together and the following measurements were made-greasy fleece weight, clean scoured yield, clean fleece weight, staple length, crimps per inch, fold score, body weights at weaning and 17 months, and mortality to 17 months. The analyses showed no evidence of significant poll-genotype x sex interactions caused by superiority of Pp rams and pp wethers. It was concluded that segregation of the poll gene had no influence on any of the production characters studied. Rams cut six per cent more clean wool than wethers, but due to the large difference in size, clean wool production per lb body weight favoured wethers by 19 per cent. The ram's wool showed six per cent finer crimping than the wethers' fleece.

Maximucinus muirheadae, gen. et sp. nov. (Thylacinidae : Marsupialia), from the Miocene of Riversleigh, north-western Queensland, with estimates of body weights for fossil thylacinids

2001 ◽  
Vol 49 (6) ◽  
pp. 603 ◽  
Author(s):  
S. Wroe
Keyword(s):  
Body Weight ◽  
Late Miocene ◽  
Early Miocene ◽  
New Taxon ◽  
Wide Range ◽  
The Family ◽  
Body Weights ◽  
Average Size ◽  
North Western ◽  
Terrestrial Carnivore

An eighth genus and twelfth species of Tertiary thylacinid is described. This new taxon represents the seventh member of the family from the fossiliferous Carl Creek limestones of Riversleigh, north-western Queensland. Although plesiomorphic within Thylacinidae regarding most features and lacking synapomorphies that unambiguously unite it with specialised taxa within the family, it possesses two autapomorphies. With an estimated body weight of around 18 kg it is also larger than any previously known thylacinid predating the late Miocene. Body-weight estimates for remaining fossil Thylacinidae span a wide range from just over 1 kg to almost 60 kg. While the smallest species is comparable to the extant Dasyurus viverrinus in size, most (i.e. 9 of 12 taxa) are at least twice the average size of the living Dasyurus maculatus. These results suggest that trophic diversity among thylacinids is even greater than previously thought and detract from the argument that reptiles have dominated large terrestrial carnivore niches in Australia since at least early Miocene times.

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