Does a Federal Glass Ceiling Have Differential Effects on Female and Male Technology Entrepreneurs?

Glass ceilings are invisible organizational barriers encountered by underrepresented groups in large hierarchies. This chapter empirically investigates the existence and characteristics of an internal, government-wide glass ceiling for female employees using aggregate pay grade and demographic data on nearly 1.5 million U.S. Federal employees between 2001-2011. The external consequences for over 15,000 technology ventures seeking R&D funding from 12 federal agencies is explored. In this context, the researchers analyze over 50,000 grants and find that a unit increase in a novel, government-wide, glass ceiling measure is a meaningful and negative predictor of subsequent Phase II funding outcomes for Phase I grantees. More importantly, the negative external effects of the identified glass ceilings are significantly larger for women technology entrepreneurs when compared to their male counterparts.

Behavioral and postural analyses establish sleep-like states for mosquitoes that can impact interactions with hosts

Sleep is an evolutionarily conserved process that has been described in different animal systems. For insects, sleep characterization has been primarily achieved using behavioral and electrophysiological correlates in a few systems. Sleep in mosquitoes, which are important vectors of disease-causing pathogens, has not been directly examined. This is surprising as circadian rhythms, which have been well studied in mosquitoes, influence sleep in other systems. In this study, we characterized sleep in mosquitoes using body posture analysis and behavioral correlates, and quantified the effect of sleep deprivation on sleep rebound and host landing. Body and appendage position metrics revealed a clear distinction between the posture of mosquitoes in their putative sleep and awake states for multiple species, which correlates with a reduction in responsiveness to host cues. Sleep assessment informed by these posture analyses indicated significantly more sleep during periods of low activity. Nighttime and daytime sleep deprivation resulting from the delivery of vibration stimuli induced sleep rebound in the subsequent phase in day and night active mosquitoes, respectively. Lastly, sleep deprivation suppressed host landing in both laboratory and field settings when mosquitoes would normally be active. These results suggest that quantifiable sleep states occur in mosquitoes, and highlight the potential epidemiological importance of mosquito sleep.

Primary calibration of mechanical sensors with digital output for dynamic applications

This article tackles the challenge of the dynamic calibration of modern sensors with integrated data sampling and purely digital output for the measurement of mechanical quantities like acceleration, angular velocity, force, pressure, or torque. Based on the established calibration methods using sine excitation, it describes an extension of the established methods and devices that yields primary calibration results for the magnitude and phase of the complex transfer function. The system is demonstrated with a focus on primary accelerometer calibrations but can easily be transferred to the other mechanical quantities. Furthermore, it is shown that the method can be used to investigate the quality and characteristics of the timing for the internal sampling of such digital output sensors. Thus, it is able to gain crucial information for any subsequent phase-related measurements with such sensors.

From the Sequence of the Sun-Goddess (bhānavīkrama) to Time-Consumption (kālagrāsa): Some Notes on the Development of the Śākta Doctrine of the Twelve Kālīs

The doctrine of the twelve Kālīs is one of the earliest developments of the Śākta tradition of the Kālīkula/Kālīkrama/Mahānaya and it is well known in the later exegetical works of Abhinavagupta (10th–11th c.), Kṣemarāja (11th c.), and Maheśvarānanda (13th–14th c.). Although the twelve Kālīs have been treated to some extent in secondary literature, a systematic study of the development and reception of this doctrine has not been undertaken yet. This is mainly due to the fact that most of the Kālīkula scriptures are available in manuscript form, and methodical analysis of their contents remains a desideratum. In this article, I intend to examine selected tantric scriptures teaching the doctrine of the twelve Kālīs, focusing on the development of the constituent elements of this doctrine, as they appear in different tantric sources. This article traces the origins of the twelve Kālīs to the esoteric teaching of the Sun-Goddess, linked to the tradition of the Skeleton of Kālī (kālīkaṅkāla/kaṅkāla). It will argue that in the subsequent phase of the doctrine’s development the solar context gradually diminished and an emphasis on the twelve goddesses’ function as the destroyers of time became more and more pronounced. This tendency, in turn, influenced the codification of the twelve Kālīs as the fully-fledged doctrine of time-consumption (kālagrāsa), popular in the Trika and the Trika-inspired Krama sources.

Decay of baryon inhomogeneities in an expanding universe

Baryon inhomogeneities are generated early in the universe. These inhomogeneities affect the phase transition dynamics of subsequent phase transitions, they also affect the nucleosynthesis calculations. We study the decay of the inhomogeneities in the early universe using the diffusion equation in the Friedmann–Lemaître–Robertson–Walker metric. We calculate the interaction cross section of the quarks with the neutrinos, the electrons and the muons and obtain the diffusion coefficients. The diffusion coefficients are temperature dependent. We find that the expansion of the universe causes the inhomogeneities to decay at a faster rate. We find that the baryon inhomogeneities generated at the electroweak epoch have low amplitudes at the time of the quark hadron transition and hence will not affect the phase transition dynamics unless they are generated with a amplitude greater than $$10^{5}$$ 10 5 times the background density. After the quark hadron transition, we include the interaction of the muons with the hadrons till 100 MeV. We find that large density inhomogeneities generated during the quark hadron transition with sizes of the order of 1 km must have amplitudes greater than $$10^{5} $$ 10 5 times the background density to survive upto the nucleosynthesis epoch. This puts constraints on any models that generate these inhomogeneities

A Neural Network Approach to Value R&D Compound American Exchange Option

In this paper we show as the neural network methodology, coupled with the Least Squares Monte Carlo approach, can be very helpful in valuing R&D investment opportunities. As it is well known, R&D projects are made in a phased manner, with the commencement of subsequent phase being dependent on the successful completion of the preceding phase. This is known as a sequential investment and therefore R&D projects can be considered as compound options. In addition, R&D investments often involve considerable cost uncertainty so that they can be viewed as an exchange option, i.e. a swap of an uncertain investment cost for an uncertain gross project value. Finally, the production investment can be realized at any time before the maturity date, after that the effects of R&D disappear. Consequently, an R&D project can be considered as a compound American exchange option. In this context, the Least Squares Monte Carlo method is a powerful and flexible tool for capital budgeting decisions and for valuing American-type options. But, using the simulated values as “targets”, the implementation of a neural network allows to extend the results for any R&D valuation and to abate the waiting time of Least Squares Monte Carlo simulation.

Effects of Recirculating Aquaculture System Wastewater on Anammox Performance and Community Structure

Recirculating aquaculture systems (RAS) are good candidates for the sustainable development of the aquaculture sector. A current limitation of RAS is the production and accumulation of nitrogenous waste, which could affect fish health. We investigated the potential of the anaerobic ammonia oxidation (anammox) process to treat marine wastewater from a cold-water RAS. We show that the marine anammox bacteria Candidatus Scalindua is a promising candidate. However, its activity was affected by unknown compounds in the RAS wastewater and/or the sub-optimum of essential trace elements (TEs). Anammox activity dropped to 2% and 13% in NH4+ and NO2- removal, respectively, when nitrate-rich RAS wastewater was used as a medium in the absence of TE supplementation. A TE supplementation was added to the RAS wastewater in a subsequent phase, and a recovery in anammox activity was shown (25% and 24% in NH4+ and NO2- removal, respectively). Future studies need to identify the unknown factor and determine the specific needs regarding TE for optimal RAS wastewater treatment by Candidatus Scalindua.

Ethical limits to placebo use and access to Covid-19 vaccines as a human right

The world is currently facing another severe pandemic, Covid-19, just four decades after the start of AIDS, and the still increasing incidence of HIV infection continues to be one of the greatest global health challenges. The way the latter was confronted is of fundamental importance for a serious discussion on global health, ethics and human rights, and this experience could and can still be applied to Covid-19. The Covid-19 pandemic has specific characteristics and these will be discussed, in relation to vaccine research and especially to the global right to equal access to products proven to be safe and effective. The article focusses primarily on issues related to Covid-19 vaccines, especially the appropriate use and limits on placebo, the right to post-trial access to placebo arm participants, and the use of an active control for subsequent Phase-3 trials after the approval of other safe and efficacious vaccines. Most importantly, it will emphasise that access to Covid-19 vaccines is a human right, which presupposes the establishment of appropriate ethical standards to ensure universal, equal, and affordable access to healthcare and to vaccines for all, and the imperative need for suspension of patents for products developed for Covid-19. It will consider the role of social determinants that contribute to the severity of Covid-19 and that must be addressed to effectively curb the current syndemic.

Fictitious but Not Utopian

This chapter traces the conversion of feudal land tenures into private agricultural property in the immediate post-Independence period, a subsequent phase of agricultural corporatism, and the recent subsumption of agrarian land into the current regime of urban rent-seeking. It clarifies the meaning and defends the utility of Karl Polanyi's conception of land as a fictitious commodity. Drawing on historical and ethnographic research into processes of land commodification and dispossession in rural northwest India, the chapter argues that Polanyi's conception of land as a fictitious commodity helps to explain why state action — including but not limited to dispossession — is an important mechanism for transforming land into a commodity. The chapter then reveals different configurations of state force were required to disembed land, first, from a feudal regime, then from the joint family, and finally from regulated agricultural developmentalism. Underlying each of these transformations were particular narratives of land's social function — as symbol of sovereign power, as grounds for productivist nation building, and ultimately as a source of foreign investment. The chapter employs this historical analysis to offer a sociological reconstruction of Polanyi's concept of fictitiousness, elucidating the unique challenges of commodifying land and the crucial role of extra-economic forces in the process.

A phaseⅠ/Ⅱa clinical study of cetuximab combined with fruquintinib in the third-line treatment of RAS/BRAF wild-type colorectal cancer.

TPS151 Background: The standard third-line treatment of mCRC is regofenib, fruquintinib or TAS-102. However, the efficacy was not satisfied. Because VEGF and EGFR share the downstream signal pathway, targeting these two pathways may have synergistic efficacy. Preclinical studies have confirmed the effect of the combination of regorafenib and cetuximab. The subsequent phase Ⅰb study in advanced cancer showed the combination is effective. Fruquintinib is the same anti-VEGF drugs and was approved in China. Our department has treated one patient of advanced colorectal cancer, no standard regimen after third-line treatment. The efficacy is SD and PFS time exceeded 6 months. Therefore this study explores the safety and efficacy of fruquintinib combined with cetuximab. Methods: This is a single-center, non-random, prospective, open exploratory study. Eligible pts were diagnosed as advanced RAS/BRAF wild-type colorectal cancer and had received at least two prior regimens of standard therapies. The purpose of phase Ⅰ is to confirm the safety and the appropriate dose of fruquintinib combined with cetuximab. The phase Ⅱa investigate the safety and the efficacy of fruquintinib combined with cetuximab. Phase I: The dose of cetuximab is 500mg/m2 every two weeks which is clinically tolerable, so the dose need not be adjusted. fruquintinib is taken once daily for the first 21 days of each 28-day cycle and the dose adjustment is required due to the side effects. The standard dose of fruquintinib is 5mg/d, but the side effects are serious. The dose of 3mg/d is the minimum effective dose, therefore the initial dose of fruquintinib starts from 4mg, and three patients are enrolled. If DLT appeared in less than three patients, the dose elevated to 5mg/d. Three patients were enrolled in the 5mg/d dose group. If DLT appeared in less than three patients, the right dose of fruquintinib was 5mg/d. If DLT appeared in all three patients of the 5mg/d, fruquintinib was declined to 4mg/d combined with cetuximab to carry out a phase Ⅱa study. Fruquintinib initial dose is 4mg/d. If DLT was present in all three patients, the dose was reduced to 3mg/d. The standard dose of fruquintinib (3mg/d) was determined to be MDT, and the subsequent phase Ⅱa study was conducted by giving fruquintinib 3mg/d. The phase Ⅱa study is cetuximab 500mg/m2 biweekly combined with fruquintinib according to the confirmed dose in phase Ⅰ, taking it once daily for the first 21 days of each 28-day cycle. The number of cases is 20.Response assessment via CT/MRI is to be done q8 wks (RECIST 1.1). Continue until disease progression or unacceptable toxicity. The primary objective is to estimate safety, grade 3/4 adverse, and DLT. Secondary objectives include ORR, PFS, and OS. Final analysis to be done 6 mo after enrollment of the final pt. Clinical trial information: ChiCTR2000038227 . Research Sponsor: None