scholarly journals Mosquito-borne infections in Fiji: III. Filariasis in northern Fiji: epidemiological evidence regarding the mechanisms of pathogenesis

1971 ◽  
Vol 69 (2) ◽  
pp. 297-306 ◽  
Author(s):  
J. U. Mataika ◽  
B. C. Dando ◽  
G. F. S. Spears ◽  
F. N. Macnamara

SUMMARYDuring a filariasis survey conducted in northern Fiji in 1968–9 examinations were made for microfilaraemia, enlarged lymph nodes and elephantiasis. Analysis of the microfilarial densities at different ages and the number of anatomical sites showing lymph gland enlargement or elephantiasis have been used to provide evidence on the clustering of infections and pathogenesis.Although there is no evidence of clustering of risk of infection, there is evidence favouring the clustering of adult filariae in individuals. Nevertheless the number of sites of lymph node enlargement do not correspond with this finding and statistical evidence suggests that lymph-node enlargement is not necessarily associated with the near presence in the body of adult filariae, whether dead or alive.Males of Indian ethnic origin showed a higher prevalence of elephantiasis than males of Fijian ethnic origin, but women of either ethnic race showed prevalences lower than those of men.The onset of elephantiasis at a site does not directly reflect the number of infections sustained in the local area, but it appears that filariasis first induces for a limited period a proneness to elephantiasis. During this period a random and discrete event may induce the onset of elephantiasis. The nature of the event is unknown, but it probably is not trauma.

1971 ◽  
Vol 69 (2) ◽  
pp. 273-286 ◽  
Author(s):  
J. U. Mataika ◽  
B. C. Dando ◽  
G. F. S. Spears ◽  
F. N. Macnamara

SUMMARYA survey of microfilaraemia among the population of Vanua Levu, Taveuni and Koro islands in northern Fiji was conducted in 1968 and 1969 as a prelude to a campaign of mass treatment with diethylcarbamazine.The prevalences of microfilaraemia were found in the more moist conditions of Taveuni and Koro and on the windward southern side of Vanua Levu to be higher than on the drier northern side of Vanua Levu. On both sides of Vanua Levu prevalences were lower inland than near the coast.Under apparently similar environmental conditions those of Fijian ethnic origin exhibited a higher prevalence of microfilaraemia than that shown by Indians. This ethnic difference and a difference between the prevalences in male and female Fijians are considered to be due more to higher rates of recovery from microfilaraemia in Indians and Fijian women than to diminished exposure to mosquitoes. Mathematical models have been used as an aid to the interpretation of the data, and, where appropriate, comparison has been made with the prevalence of antibodies to dengue, an arbovirus having the same vectors.Household infections were analysed by computer techniques. Infections in large households were not proportionately higher than in small households, indicating that transmission was not intrafamilial. The clustering of infections within households, though present, was not marked. Among the occupants of outlying settlements the prevalence of microfilaraemia was relatively low indicating a lower risk of infection due to isolation.


2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S488-S488
Author(s):  
Constantine Vassalos ◽  
Dimitrios Papaventsis ◽  
Ioannis Koutelekos ◽  
Marina Panagi ◽  
Evangelos Vogiatzakis ◽  
...  

Abstract Background Although the most common site of tuberculosis (TB) is the lungs, spreading may occur to any part of the body, resulting in extrapulmonary tuberculosis (EPTB). We conducted a study to describe the clinical and epidemiological features of EPTB in Greece, a low TB burden country (<50 TB cases/million), in which immigrants from high TB burden countries make up >7% of the population. Methods We retrieved data for adults presenting with signs/symptoms consistent with EPTB from 2014 to 2015 registries of the Athens Chest Disease Hospital. EPTB was clinically, histologically or microbiologically diagnosed. We recorded age, gender, immigrant, or native status, site of disease, history of diabetes, smoking, and immunological status. Proportion ratios (PR) and 95% confidence interval (CI) were calculated to estimate risk factors for developing EPTB. Results We identified 277 (153 males) adult patients, 254 (91.7%) natives, and 23 (8.3%) immigrants, with signs/symptoms consistent with EPTB. Of 118/277 (42.6%) EPTB cases, 67 (57.6%) were males. No association with gender, diabetes, or smoking was shown between EPTB cases and non-cases. Immigrants were twice as likely to develop EPTB as natives (PR = 1.86 95% CI: 1.38–2.51 P < 0.001). Immigrants from high TB burden countries were 2 times as likely to develop nodal, pericardial, or pleural TB as the native population (Tables 1 and 2). Native patients > 60 years of age presenting with lymph node enlargement or with a pleural effusion were 3 times as likely to have TB disease as those aged <60 years (Table 2). In contrast, all immigrants with lymph node enlargement were EPTB cases (Table 1) and were <45 years old. Impaired immunological status increased the risk of developing EPTB by 62% in the native population (PR = 1.62 95% CI: 1.20–2.33 P < 0.001). Conclusion In a low TB burden country, EPTB is associated with old age and weak immune system due to possible extrapulmonary dissemination of latent TB. Considered to be at high-risk for developing EPTB, immigrants from high TB burden countries with signs and/or symptoms consistent with EPTB, albeit not transmitting the disease, need to be priority-wise tested for TB in order to be adequately treated. Disclosures All authors: No reported disclosures.


Author(s):  
O. Faroon ◽  
F. Al-Bagdadi ◽  
T. G. Snider ◽  
C. Titkemeyer

The lymphatic system is very important in the immunological activities of the body. Clinicians confirm the diagnosis of infectious diseases by palpating the involved cutaneous lymph node for changes in size, heat, and consistency. Clinical pathologists diagnose systemic diseases through biopsies of superficial lymph nodes. In many parts of the world the goat is considered as an important source of milk and meat products.The lymphatic system has been studied extensively. These studies lack precise information on the natural morphology of the lymph nodes and their vascular and cellular constituent. This is due to using improper technique for such studies. A few studies used the SEM, conducted by cutting the lymph node with a blade. The morphological data collected by this method are artificial and do not reflect the normal three dimensional surface of the examined area of the lymph node. SEM has been used to study the lymph vessels and lymph nodes of different animals. No information on the cutaneous lymph nodes of the goat has ever been collected using the scanning electron microscope.


Somatechnics ◽  
2011 ◽  
Vol 1 (1) ◽  
pp. 87-123 ◽  
Author(s):  
Sherene H. Razack

Paul Alphonse, a 67 year-old Aboriginal died in hospital while in police custody. A significant contributing factor to his death was that he was stomped on so hard that there was a boot print on his chest and several ribs were broken. His family alleged police brutality. The inquest into the death of Paul Alphonse offers an opportunity to explore the contemporary relationship between Aboriginal people and Canadian society and, significantly, how law operates as a site for managing that relationship. I suggest that we consider the boot print on Alphonse's chest and its significance at the inquest in these two different ways. First, although it cannot be traced to the boot of the arresting officer, we can examine the boot print as an event around which swirls Aboriginal/police relations in Williams Lake, both the specific relation between the arresting officer and Alphonse, and the wider relations between the Aboriginal community and the police. Second, the response to the boot print at the inquest sheds light on how law is a site for obscuring the violence in Aboriginal people's lives. A boot print on the chest of an Aboriginal man, a clear sign of violence, comes to mean little because Aboriginal bodies are considered violable – both prone to violence, and bodies that can be violated with impunity. Law, in this instance in the form of an inquest, stages Aboriginal abjection, installing Aboriginal bodies as too damaged to be helped and, simultaneously to harm. In this sense, the Aboriginal body is homo sacer, the body that maybe killed but not murdered. I propose that the construction of the Aboriginal body as inherently violable is required in order for settlers to become owners of the land.


2020 ◽  
Vol 1 (2) ◽  
pp. 93-113
Author(s):  
Obert Bernard Mlambo ◽  

This article examined attitudes, knowledge, behavior and practices of men and society on Gender bias in sports. The paper examined how the African female body was made into an object of contest between African patriarchy and the colonial system and also shows how the battle for the female body eventually extended into the sporting field. It also explored the postcolonial period and the effects on Zimbabwean society of the colonial ideals of the Victorian culture of morality. The study focused on school sports and the participation of the girl child in sports such as netball, volleyball and football. Reference was made to other sports but emphasis was given to where women were affected. It is in this case where reference to the senior women soccer team was made to provide a case study for purposes of illustration. Selected rural community and urban schools were served as case references for ethnographic accounts which provided the qualitative data used in the analysis. In terms of methodology and theoretical framework, the paper adopted the political economy of the female body as an analytical viewing point in order to examine the body of the girl child and of women in action on the sporting field in Zimbabwe. In this context, the female body is viewed as deeply contested and as a medium that functions as a site for the redirection, profusion and transvaluation of gender ideals. Using the concept of embodiment, involving demeanor, body shape and perceptions of the female body in its social context, the paper attempted to establish a connection between gender ideologies and embodied practice. The results of the study showed the prevalence of condescending attitudes towards girls and women participation in sports.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tong-Hui Xie ◽  
Peng Su ◽  
Jian-Guo Hong ◽  
Hui Zhang

Abstract Background Colorectal cancer is a very common malignant tumor worldwide. The clinical manifestations of advanced colorectal cancer include the changes in bowel habits, hematochezia, diarrhea, local abdominal pain and other symptoms. However, the colorectal cancer with an initial symptom of cervical lymph node enlargement is extremely rare. In this article, we report a case of rectal cancer presenting with cervical lymph nodes enlargement as the initial symptom. Case presentation A 57-year-old woman was admitted to our hospital for cervical lymph node enlargement which was accidentally detected during physical examination. Computed tomography scan revealed multiple enlarged lymph nodes in the neck. Cervical ultrasound showed normal thyroid gland and multiple left supraclavicular lymph nodes enlargement. The patient underwent lymph nodes biopsy and pathologic results showed metastatic adenocarcinoma. The subsequent lower gastrointestinal endoscopy revealed a mucosal bulge lesion located at rectus and biopsy revealed adenocarcinoma. The patient underwent rectal cancer resection. She is alive with no evidence of recurrence or new tumors 2 years after surgery. Conclusions Cervical lymph node metastasis is a rare metastatic way in colorectal cancer. This is the first case of rectal cancer presenting with cervical lymph nodes metastases as the initial symptom. Surgical resection combined with postoperative chemotherapy improved long-term prognosis of the patient. This rare metastatic way of rectal cancer should be paid attention for clinicians.


Author(s):  
Matthias Grot ◽  
Tristan Becker ◽  
Pia Mareike Steenweg ◽  
Brigitte Werners

AbstractIn order to allocate limited resources in emergency medical services (EMS) networks, mathematical models are used to select sites and their capacities. Many existing standard models are based on simplifying assumptions, including site independency and a similar system-wide busyness of ambulances. In practice, when a site is busy, a call is forwarded to another site. Thus, the busyness of each site depends not only on the rate of calls in the surrounding area, but also on interactions with other facilities. If the demand varies across the urban area, assuming an average system-wide server busy fraction may lead to an overestimation of the actual coverage. We show that site interdependencies can be integrated into the well-known Maximum Expected Covering Location Problem (MEXCLP) by introducing an upper bound for the busyness of each site. We apply our new mathematical formulation to the case of a local EMS provider. To evaluate the solution quality, we use a discrete event simulation based on anonymized real-world call data. Results of our simulation-optimization approach indicate that the coverage can be improved in most cases by taking site interdependencies into account, leading to an improved ambulance allocation and a faster emergency care.


2020 ◽  
pp. 1-15
Author(s):  
Kenneth W. Yu

How to inculcate virtue in the citizens of Magnesia by means of the dance component of choreia constitutes one of the principal concerns in the Laws (= Leg.), revealing Plato's evolving ideas about the expediency of music and paideia for the construction of his ideal city since the Republic. Indeed, a steady stream of monographs and articles on the Laws has enriched our understanding of how Plato theorizes the body as a site of intervention and choral dance as instrumental in solidifying social relations and in conditioning the ethical and political self. As one scholar has aptly put it: ‘a city and its sociopolitical character [are] effectively danced into existence.’ Drawing on this recent work, I focus on an enigmatic passage in Laws Book 7 that merits more attention than it has received, in which Plato curiously singles out Bacchic dances from those that are ‘without controversy’ (815b7–d4): τὴν τοίνυν ἀμφισβητουμένην ὄρχησιν δεῖ πρῶτον χωρὶς τῆς ἀναμφισβητήτου διατεμεῖν. τίς οὖν αὕτη, καὶ πῇ δεῖ χωρὶς τέμνειν ἑκατέραν; ὅση μὲν βακχεία τ᾽ ἐστὶν καὶ τῶν ταύταις ἑπομένων, ἃς Νύμφας τε καὶ Πᾶνας καὶ Σειληνοὺς καὶ Σατύρους ἐπονομάζοντες, ὥς φασιν, μιμοῦνται κατῳνωμένους, περὶ καθαρμούς τε καὶ τελετάς τινας ἀποτελούντων, σύμπαν τοῦτο τῆς ὀρχήσεως τὸ γένος οὔθ᾽ ὡς εἰρηνικὸν οὔθ᾽ ὡς πολεμικὸν οὔθ᾽ ὅτι ποτὲ βούλεται ῥᾴδιον ἀφορίσασθαι: διορίσασθαι μήν μοι ταύτῃ δοκεῖ σχεδὸν ὀρθότατον αὐτὸ εἶναι, χωρὶς μὲν πολεμικοῦ, χωρὶς δὲ εἰρηνικοῦ θέντας, εἰπεῖν ὡς οὐκ ἔστι πολιτικὸν τοῦτο τῆς ὀρχήσεως τὸ γένος, ἐνταῦθα δὲ κείμενον ἐάσαντας κεῖσθαι, νῦν ἐπὶ τὸ πολεμικὸν ἅμα καὶ εἰρηνικὸν ὡς ἀναμφισβητήτως ἡμέτερον ὂν ἐπανιέναι. So, first of all, we should separate questionable dancing far from dancing that is without controversy. Which is the controversial kind, and how are the two to be distinguished? All the dancing that is of a Bacchic kind and cultivated by those who indulge in intoxicated imitations of Nymphs, Pans, Sileni and Satyrs (as they name them), when performing certain rites of expiation and initiation—this entire class of dancing cannot easily be marked off either as pacific or as warlike, nor as of any one particular kind. The most correct way of defining it appears to me to be this—to place it away from both pacific and warlike dancing, and to pronounce that this type of dancing is οὐ πολιτικόν; having thus set aside and dismissed it, we will now return to the warlike and pacific types, which without controversy belong to us.


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