Utility of current sialendoscopes in the sinonasal cavity

2015 ◽  
Vol 129 (9) ◽  
pp. 870-873
Author(s):  
C R Kieliszak ◽  
T R Khoury ◽  
A Singh ◽  
A S Joshi
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Paranasal Sinuses ◽  
Sphenoid Sinus ◽  
Mucosal Biopsy ◽  
Before And After ◽  
Invasive Method ◽  
Cannulation Success ◽  
Cadaveric Model ◽  
Sphenoid Sinuses

AbstractObjectives:This study assessed the utility of current sialendoscopes in the paranasal sinuses in a cadaveric model and evaluated novel uses for sialendoscopes.Methods:Currently available sialendoscopes were used for visualisation and performing interventions in the paranasal sinuses. Ten cadaver heads were studied before and after dissection. Outcomes included ostia identification, sinus cannulation, success of mucosal biopsy collection and image clarity.Results:Marchal and Erlangen sialendoscopes were found to be effective for both visualising and cannulating the sphenoid sinuses before and after dissection. Both types demonstrated poor maxillary ostia visualisation without dissection, but did allow treatment after antrostomy. Larger diameter sialendoscopes were associated with the lowest image distortion during maxillary ostia assessment. Mucosal biopsy collection within the sphenoid sinus, but not in the maxillary sinus, was possible before dissection.Conclusion:Sialendoscopes can be used for visualisation and performing interventions in the sinonasal cavity, but their utility is mainly limited to the sphenoid sinus. They may be considered a minimally invasive method for drug delivery and/or biopsy collection in the post-operative setting for all sinuses. Design improvements are suggested.

EVALUATION OF VARIATIONS IN SPHENOID SINUS PNEUMATIZATION USING MULTIDETECTOR COMPUTED TOMOGRAPHY IN PATIENTS ATTENDING TERTIARY CARE HOSPITAL, VISAKHAPATNAM

2021 ◽  
pp. 62-65
Author(s):  
Sonica Sharma ◽  
Bhamidipaty Kanaka Durgaprasad ◽  
Payala Vijayalakshmi
Keyword(s):  
Computed Tomography ◽  
Paranasal Sinuses ◽  
Sphenoid Sinus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Ct Images ◽  
Care Hospital ◽  
Anterior Clinoid Process ◽  
Anterior Extension ◽  
Sphenoid Sinuses

BACKGROUND: The purpose of our study was to assess the prevalence of different patterns of pneumatization in the sphenoid sinuses as detected on the computed tomography (CT) images of paranasal sinuses of the patients presenting with various pathologies. This is a retrospective radiological study of CT im MATERIALS AND METHODS: ages of paranasal sinuses, done at Radio diagnosis department of a Tertiary care hospital. The study comprised CT images of 500 patients in the age range of 18-75years who were referred for CT scan of paranasal sinuses for various pathologies between the period of July 2018 and July 2019. All images of paranasal sinuses had been acquired following a standardized protocol in axial plane. Their reconstructed images in axial, coronal and sagittal planes were evaluated, using Osirix software, for the extent and different patterns of sphenoid sinus pneumatization. The Images of sphenoid sinuses were assessed for the posterior, lateral and anterior extension of their pneumatization The sphenoid sinuses pneumatization patterns in the RESULTS: descending order of prevalence were complete sellar (75.0%), incomplete sellar (22.6%), presellar (2.4%) and conchal (0%). The clival extensions was seen in 75% of patients and lateral extension sides in 49.1% patients. Lateral recesses as assessed on coronal images was seen in 49.1 % of cases with the prevalence in descending order being extension into pterygoid process 59.8 %, greater wing of sphenoid 9.2 %, full lateral 41% and lesser wing (anterior clinoid process) 19.3%. The pure forms were relatively less common and combined forms being more common. A preoperative review of the sphenoid anatomy should allow for safer endo

scholarly journals Interleukin-17A blockade with secukinumab results in decreased neutrophil infiltration in psoriasis: minimally-invasive measurement by tape stripping

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Christian Loesche ◽  
Frank Kolbinger ◽  
Marie-Anne Valentin ◽  
Philip Jarvis ◽  
Melanie Ceci ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Immunohistochemical Analysis ◽  
Neutrophil Infiltration ◽  
Skin Lesions ◽  
Psoriatic Skin ◽  
Tape Stripping ◽  
Neutrophil Accumulation ◽  
Interleukin 17A ◽  
Before And After ◽  
Invasive Method

Psoriasis is a well characterized interleukin (IL)-17A-driven skin disease with neutrophil infiltration and epidermal hyperkeratosis. Several biomarkers, most prominently β-defensin-2 (BD-2), have been identified using local and systemic invasive measurements as responsive markers of IL-17A-driven skin pathology. We sought to determine whether measurements of epidermal proteins by tape stripping could offer a minimally-invasive method to assess treatment responses. We compared the expression of 170 proteins in the epidermis (tape stripping) and dermis (open flow microperfusion) of 8 psoriatic subjects before and after administration of a single dose of subcutaneous (s.c.) antiIL-17A mAb secukinumab. Proteomic analyses of tape strips revealed a >3-fold decrease in 32 epidermal and inflammatory cell proteins in response to secukinumab. The epidermal proteins with the largest (>10-fold) decreases were: matrix metalloproteinase-8 (MMP-8, 15.68-fold, p<0.05); myeloperoxidase (MPO, 14.72-fold, p<0.005); IL-8 (11.93-fold, p<0.05); MMP-9 (10.81-fold, p<0.005); and IL-1β (10.35-fold, p<0.05). For these proteins, greater-fold protein changes were detected in the epidermis compared to dermis. Immunohistochemical analysis confirmed that neutrophils are the predominant cell type in psoriatic skin lesions that express MPO, MMP-8 and MMP-9, and that secukinumab treatment dramatically decreases neutrophil accumulation. Thus, tape stripping may be used to assess epidermal neutrophils, and protein biomarker responses to anti-IL-17A therapy in psoriasis.

Proximal Femoral Nail - A Minimally Invasive Method for Stabilization of Subtrochanteric Femoral Fractures

2012 ◽  
Vol 3 (1) ◽  
pp. 20-22
Author(s):  
Dr. Dhaval J Patel ◽  
◽  
Dr. Bipin B Chhajed ◽  
Dr. Dhaval R Modi ◽  
Dr. Nirav P Trivedi ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Femoral Fractures ◽  
Proximal Femoral Nail ◽  
Femoral Nail ◽  
Invasive Method

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Lumbar periarticular cysts of arcorray joint

2020 ◽  
pp. 47-57
Author(s):  
Anton Yarikov ◽  
Maxim Shpagin ◽  
Iliya Nazmeev ◽  
Sergey Gorelov ◽  
Olga Perlmutter
Keyword(s):  
Minimally Invasive ◽  
Severe Pain ◽  
Pain Syndrome ◽  
Long Term Results ◽  
Lumbar Region ◽  
Results Of Treatment ◽  
Invasive Method ◽  
Facet Syndrome

The immediate and long-term results of treatment of 30 patients with severe pain syndrome of the lumbar region, who underwent operations on denervation of DOS, were studied. The aim of the study was to evaluate the effectiveness of minimally invasive technologies for the treatment of pain in the lumbar region (denervation of DOS), to study the near and distant results of these treatment methods. Denervation DOS is an effective minimally invasive method for the treatment of facet syndrome caused by spondylarthrosis. It allows in the early and distant postoperative periods to significantly reduce the pain syndrome and improve the quality of life of patients.

scholarly journals CT perfusion in peripheral arterial disease—hemodynamic differences before and after revascularisation

2021 ◽  
Author(s):  
Patrick Veit-Haibach ◽  
Martin W. Huellner ◽  
Martin Banyai ◽  
Sebastian Mafeld ◽  
Johannes Heverhagen ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Ct Perfusion ◽  
Arterial Disease ◽  
Lower Leg ◽  
Therapy Control ◽  
Non Invasive ◽  
Before And After ◽  
Invasive Method ◽  
The Mean ◽  
Peripheral Arterial

Abstract Objectives The purpose of this study was the assessment of volumetric CT perfusion (CTP) of the lower leg musculature in patients with symptomatic peripheral arterial disease (PAD) before and after interventional revascularisation. Methods Twenty-nine consecutive patients with symptomatic PAD of the lower extremities requiring interventional revascularisation were assessed prospectively. All patients underwent a CTP scan of the lower leg, and hemodynamic and angiographic assessment, before and after intervention. Ankle-brachial pressure index (ABI) was determined. CTP parameters were calculated with a perfusion software, acting on a no outflow assumption. A sequential two-compartment model was used. Differences in CTP parameters were assessed with non-parametric tests. Results The cohort consisted of 24 subjects with an occlusion, and five with a high-grade stenosis. The mean blood flow before/after (BFpre and BFpost, respectively) was 7.42 ± 2.66 and 10.95 ± 6.64 ml/100 ml*min−1. The mean blood volume before/after (BVpre and BVpost, respectively) was 0.71 ± 0.35 and 1.25 ± 1.07 ml/100 ml. BFpost and BVpost were significantly higher than BFpre and BVpre in the treated limb (p = 0.003 and 0.02, respectively), but not in the untreated limb (p = 0.641 and 0.719, respectively). Conclusions CTP seems feasible for assessing hemodynamic differences in calf muscles before and after revascularisation in patients with symptomatic PAD. We could show that CTP parameters BF and BV are significantly increased after revascularisation of the symptomatic limb. In the future, this quantitative method might serve as a non-invasive method for surveillance and therapy control of patients with peripheral arterial disease. Key Points • CTP imaging of the lower limb in patients with symptomatic PAD seems feasible for assessing hemodynamic differences before and after revascularisation in PAD patients. • This quantitative method might serve as a non-invasive method, for surveillance and therapy control of patients with PAD.

Nonsurgical Rhinoplasty: A Technical Note

2021 ◽  
pp. 074880682199015
Author(s):  
Ian S. Lehrer ◽  
Joe Niamtu
Keyword(s):  
Hyaluronic Acid ◽  
Minimally Invasive ◽  
Cosmetic Surgery ◽  
Recovery Time ◽  
Technical Note ◽  
Dermal Fillers ◽  
Facial Surgery ◽  
Before And After ◽  
Application Potential ◽  
Invasive Techniques

Cosmetic facial surgery procedures and therapies have continued to evolve with an emphasis on minimally invasive techniques with a shorter recovery time. We present a how-to guide for nonsurgical rhinoplasty including the use of different hyaluronic acid fillers. We provide examples of before and after patient photos as well as photos demonstrating our technique. This technical note highlights the popular concept of minimally invasive nasal contouring using dermal fillers. As such, we provide a brief overview of different dermal fillers that can be used for this application, potential problems and complications, as well as remedies. Dermal fillers have become an entry point into cosmetic surgery for many patients. Our technique of nasal contouring with hyaluronic acid fillers in particular yields safe, effective, and repeatable results.

scholarly journals Minimally invasive debridement and drainage using intraoperative CT-Guide in multilevel spondylodiscitis: a long‐term follow‐up study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jianbiao Xu ◽  
Leiming Zhang ◽  
Rongqiang Bu ◽  
Yankang Liu ◽  
Kai-Uwe Lewandrowski ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Clinical Manifestations ◽  
Operation Time ◽  
Intervertebral Discs ◽  
Intraoperative Ct ◽  
Long Term Follow Up ◽  
Invasive Method ◽  
Vertebral Bodies ◽  
Adjacent Segments

Abstract Background Spondylodiscitis is an unusual infectious disease, which usually originates as a pathogenic infection of intervertebral discs and then spreads to neighboring vertebral bodies. The objective of this study is to evaluate percutaneous debridement and drainage using intraoperative CT-Guide in multilevel spondylodiscitis. Methods From January 2002 to May 2017, 23 patients with multilevel spondylodiscitis were treated with minimally invasive debridement and drainage procedures in our department. The clinical manifestations, evolution, and minimally invasive debridement and drainage treatment of this refractory vertebral infection were investigated. Results Of the enrolled patients, the operation time ranged from 30 minutes to 124 minutes every level with an average of 48 minutes. Intraoperative hemorrhage was minimal. The postoperative follow-up period ranged from 12 months to 6.5 years with an average of 3.7 years. There was no reactivation of infection in the treated vertebral segment during follow-up, but two patients with fungal spinal infection continued to progress by affecting adjacent segments prior to final resolution. According to the classification system of Macnab, one patient had a good outcome at the final follow-up, and the rest were excellent. Conclusions Minimally invasive percutaneous debridement and irrigation using intraoperative CT-Guide is an effective minimally invasive method for the treatment of multilevel spondylodiscitis.

scholarly journals Image-guided Percutaneous Drainage in the Pediatric Population: A Primer for Radiologists

2011 ◽  
Vol 1 ◽  
pp. 31 ◽  
Author(s):  
Keerthi Arani ◽  
Kiran Nandalur ◽  
Christina M Tucker ◽  
David A Bloom
Keyword(s):  
Minimally Invasive ◽  
Patient Outcomes ◽  
Percutaneous Drainage ◽  
Pediatric Population ◽  
Infectious Complications ◽  
Image Guided ◽  
Pictorial Essay ◽  
Invasive Method ◽  
Patient Preparation ◽  
The Common

Image-guided percutaneous drainage is an excellent minimally invasive method for dealing with infectious complications in the pediatric population. A thorough understanding of drainage procedures in children can often lead to improved patient outcomes. Indications for percutaneous drainage will be reviewed, including abscesses related to appendicitis, post-surgical abscess formation, and abscesses related to Crohn's disease. This pictorial essay will help the radiologist better understand the common etiologies of abscesses in children that may require percutaneous drainage, the special considerations for catheter placement, patient preparation, and anesthesia or sedation issues unique to the pediatric population.

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