Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux

2017 ◽  
Vol 131 (6) ◽  
pp. 549-556 ◽  
Author(s):  
N Siupsinskiene ◽  
I Katutiene ◽  
V Jonikiene ◽  
D Janciauskas ◽  
S Vaitkus
Keyword(s):  
Helicobacter Pylori ◽  
Laryngopharyngeal Reflux ◽  
Chronic Tonsillitis ◽  
Control Group ◽  
Tonsillar Hypertrophy ◽  
Posterior Commissure ◽  
Tissue Samples ◽  
Tonsillar Tissue ◽  
Significant Relationships ◽  
H Pylori

AbstractObjective:To identify Helicobacter pylori infection in tonsillar tissue samples from patients undergoing tonsillectomy for chronic tonsillitis versus tonsillar hypertrophy, and to assess the possible relationships between H pylori and patients’ sociodemographic data and laryngopharyngeal reflux.Methods:In this prospective study, 97 patients who underwent tonsillectomy were divided into the following 2 groups: patients with chronic tonsillitis (n = 62) and patients with tonsillar hypertrophy (control group; n = 35). H pylori infection in the tonsillar biopsy samples was identified using histochemical and rapid urease tests.Results:The incidence of H pylori infection was significantly higher in the chronic tonsillitis group (56.5 per cent) compared to the control group (31.4 per cent). Similar findings were obtained for both subgroups of adults (68.6 vs 42.3 per cent) and children (40.7 vs 0.0 per cent). Significant relationships between a positive H pylori finding and laryngopharyngeal reflux related signs of vocal fold oedema, diffuse laryngeal oedema and hypertrophy of the posterior commissure were revealed.Conclusion:H pylori infection may be related to chronic tonsillitis and laryngopharyngeal reflux.

Intranasal Helicobacter pylori infection in patients with chronic rhinosinusitis with polyposis

2018 ◽  
Vol 132 (9) ◽  
pp. 816-821 ◽  
Author(s):  
N Siupsinskiene ◽  
I Katutiene ◽  
V Jonikiene ◽  
D Janciauskas ◽  
S Vaitkus
Keyword(s):  
Helicobacter Pylori ◽  
Chronic Rhinosinusitis ◽  
Laryngopharyngeal Reflux ◽  
Statistical Significance ◽  
Control Group ◽  
Clinical Group ◽  
Posterior Commissure ◽  
Nasal Tissue ◽  
H Pylori ◽  
Nasal Biopsy

AbstractObjectiveTo determine the prevalence of Helicobacter pylori infection in nasal biopsy specimens from patients with chronic rhinosinusitis with polyposis versus control patients, and to assess the correlations between H pylori infection identified in the nasal tissue and patients’ sociodemographic data and reflux-related symptoms and signs.MethodsNasal biopsy samples were taken from 75 adult patients who underwent nasal surgery for chronic rhinosinusitis with polyposis (clinical group, n = 45) and a deviated septum (control group, n = 30). H pylori infection was identified using histochemical and rapid urease tests.ResultsThe prevalence of intranasal H pylori infection was significantly higher in the clinical group (28.9 per cent) compared to the control group (3.3 per cent) (p = 0.005). A significant yet weak association was found between positive H pylori status and laryngopharyngeal reflux related hypertrophy of the posterior commissure of the larynx. No other correlations reached statistical significance.ConclusionH pylori infection is potentially related to chronic rhinosinusitis with polyposis. Further research is needed to clarify the role of H pylori as a risk factor for the development of sinonasal diseases and to examine its link with laryngopharyngeal reflux.

Helicobacter pylori siedelt gerne auf Mandel-Gewebe

2017 ◽  
Vol 96 (12) ◽  
pp. 822-823
Author(s):  
Kai J. Lorenz
Keyword(s):  
Helicobacter Pylori ◽  
Laryngopharyngeal Reflux ◽  
Chronic Tonsillitis ◽  
Tonsillar Tissue ◽  
H Pylori

Siupsinskiene N et al. Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux. J Laryngol Otol 2017; 131: 549–55 Wie häufig finden sich Helicobacter pylori Infektionen in den Gaumenmandeln und welcher Zusammenhang besteht zwischen H. pylori, den soziodemografischen Patientendaten und dem laryngopharyngealen Reflux?

scholarly journals Overview of Helicobacter pylori Detection Using Rapid Urease Test and Giemsa Modification Staining in Chronic Tonsillitis Patients

2020 ◽  
Vol 8 (B) ◽  
pp. 1105-1109
Author(s):  
Ade Asyari ◽  
Ferdy Azman ◽  
Novialdi Novialdi ◽  
Aziz Djamal ◽  
Hafni Bachtiar ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Descriptive Study ◽  
Chronic Tonsillitis ◽  
Rapid Urease Test ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Tonsillar Tissue ◽  
Urease Test ◽  
Tonsil Tissue ◽  
H Pylori

BACKGROUND: Helicobacter pylori (H. pylori) is a Gram-negative bacteria and has been known for its role in causing gastric infection aused diseases such as gastric ulcer. H. pylori also implied to play a role in chronic tonsillitis, but this theory remains controversial. Many researches have different and contradictory results due to difficulty to accurately detect H. pylori in tonsillar tissue. There is still no appropriate method that able to detect H. pylori in tonsil tissue. AIM: The aim of the study was to detect H. pylori colonization in chronic tonsillitis and understand some of the methods of examination that can be done to detect H. pylori in tonsillar tissue. METHODS: This study is a descriptive study conducted on 25 respondents. Each sample was taken from patients with chronic tonsillitis who underwent tonsillectomy. Then, the rapid urease test (RUT) and the Giemsa modification staining were carried out to determine the presence of H. pylori. RESULTS: There were 19 people (76%) positive and 6 people (24%) negative for H. pylori using RUT. On examination with Giemsa modification staining obtained 19 people (76%) positive and 6 people (24%) negative for H. pylori. CONCLUSION: H. pylori can be found in most of chronic tonsillitis. Combination RUT and Giemsa modification staining examination can be a good option in detecting H. pylori in chronic tonsillitis.

scholarly journals A Correlative Study between Chronic Tonsillitis and Helicobacter Pylori

2019 ◽  
Vol 27 (1) ◽  
pp. 60-64
Author(s):  
Abhishek Singh ◽  
Santosh Uttarkar Pandurangarao ◽  
Aravind Darga Ramchandra ◽  
Sridurga Janarthanan
Keyword(s):  
Helicobacter Pylori ◽  
Acute Infection ◽  
Chronic Tonsillitis ◽  
Common Finding ◽  
Rapid Urease Test ◽  
Palatine Tonsils ◽  
Regular Treatment ◽  
Tonsillar Tissue ◽  
Urease Test ◽  
H Pylori

Introduction : Chronic tonsillitis is characterized by persistent inflammation of the palatine tonsils and seen commonly in patients attending ENT OPD. Bacterial infection is usually the cause but anaerobes and viruses may also be implicated. The possibility that tonsillar tissue possesses Helicobacter pylori or that H. pylori can colonize the palatine tonsils is explored. Materials and Methods : Hundred patients aged between 5-50 years of either sex diagnosed with chronic tonsillitis undergoing elective tonsillectomy and willing to participate in the study were selected. Informed and written consent was taken from all the patients (in case of minor patients, consent was taken from parents). Specimen (tonsillar tissue) was harvested from the surgically removed tonsils  and put through Rapid urease test. The results were analysed statistically using Chi square test and Unpaired t test and inference was drawn. Results : Amongst 100 patients, 61 (61%) patients were females and 39 (39%) patients were males. Helicobacter pylori could be detected in Chronic Tonsillitis in 64 (64%) patients. Conclusion : According to our study, Helicobacter pylori was found to be a common finding in cases of chronic tonsillitis. Even after regular treatment with antibiotics, the chances of getting acute  infection in chronic tonsillitis still persist. We can try treatment for H. pylori and look for changes in recurrence of tonsillitis and also it can be tried in patients who are not willing/fit to undergo tonsillectomy.

scholarly journals Study on the immunogenicity of pcDNA3.1(+)-cagT recombinant vector against Helicobacter pylori in BALB/c mice

2020 ◽  
Vol 22 (4) ◽  
pp. 159-166
Author(s):  
Armita Balash ◽  
Abbas Doosti
Keyword(s):  
Helicobacter Pylori ◽  
Immune System ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Chitosan Nanoparticles ◽  
Interleukin 4 ◽  
Control Group ◽  
Tissue Samples ◽  
H Pylori ◽  
Tgf Β1

Background and aims: The role of Helicobacter pylori in the development of gastric ulcer and gastrointestinal cancer was identified in this study. More precisely, the study focused on the creation of a DNA vaccine based on the cagT gene of this bacterium and the investigation of its immunogenicity against H. pylori in infused BALB/c mice. Materials and Methods: To this end, the pcDNA3.1(+)-cagT was prepared and transformed into Escherichia coli. Then, animals were injected with recombinant pcDNA3.1(+)-cagT plasmid, pcDNA3.1(+)-cagT + nanoparticles, and pcDNA3.1(+). After the plasmid purification and confirmation of the transformation by digestion and polymerase chain reaction (PCR), chitosan nanoparticles were synthesized using the ionic gelation method. Next, the animals were classified into three groups each including 21 mice. The injectable solutions including pcDNA3.1(+)-cagT, pcDNA3.1(+)-cagT + nanoparticles, or empty pCDNA3.1 (as a control group) were injected into the quadriceps muscle of mice, separately. Finally, the blood and tissue samples of each mouse were collected 15, 30, and 45 days after the last injection, and the expression levels of transforming growth factor-beta (TGF-β1), interleukin-4 (IL-4), and interferon-gamma (IFNγ) were evaluated by real-time PCR. Results: The IFNγ and TGF-β1 expression increased in the infused mice (P<0.01) while the IL4 expression represented a significant decrease (P<0.01). Moreover, the IFNγ and IL4 expression level in pcDNA3.1(+)-cagT + nanoparticle significantly altered (P<0.01) compared to the pcDNA3.1(+)-cagT group although the TGF-β1 expression was not significantly different (P=0.075). Contrarily, the cagT gene expression in the tissue samples of both groups was significantly different 15, 30, and 45 days after the last injection (P<0.01). Eventually, the expression of the cagT gene in the infused mice by pcDNA3.1(+)-cagT and in the nanoparticle group was not significantly different 45 days after the last injection (P=0.105). Conclusion: In general, the decrease of IL-4 expression was observed in the injected mice by pcDNA3.1(+)-cagT and indicated that the immune system work by a Th1 pattern. The findings showed that a pcDNA3.1(+)-cagT construct combined with chitosan nanoparticles can increase the stimulation of the immune system in an animal model and thus it can be used as an appropriate method for controlling H. pylori infection.

scholarly journals Prevalence of Helicobacter pylori colonisation in tonsillar tissue in cases of chronic tonsillitis: a prospective study

2018 ◽  
Vol 4 (3) ◽  
pp. 738
Author(s):  
Vellamparambil Sreejaraj ◽  
Paul Vazhapilly Sumam ◽  
Verghese Nevil ◽  
Karuthedath Sridevi ◽  
Ariyamparampil Rajagopalan Vinayakumar
Keyword(s):  
Helicobacter Pylori ◽  
Tertiary Hospital ◽  
Chronic Tonsillitis ◽  
Rapid Urease Test ◽  
Recurrent Tonsillitis ◽  
Cross Sectional ◽  
Female Ratio ◽  
Tonsillar Tissue ◽  
Urease Test ◽  
H Pylori

<p class="abstract"><strong>Background:</strong> Human stomach is not the only reservoir of <em>Helicobacter pylori</em> but it has been detected in dental plaques, oral lesions and saliva. It could play role in the pathogenesis of various otorhinolaryngologic problems and remains debatable. This study was aimed to find out the prevalence of <em>H. pylori</em> in tonsillar tissue of patients with chronic tonsillitis by rapid urease test in a tertiary hospital in Kerala.</p><p class="abstract"><strong>Methods:</strong> Prospective cross sectional study was done in patients who attended the outpatient department of ENT with a history suggestive of chronic tonsillitis. The patient satisfied the criteria for chronic recurrent tonsillitis were subsequently posted for tonsillectomy. Each specimen was subjected to rapid urease test.  </p><p class="abstract"><strong>Results:</strong> Total 228 patients were included in this study with age ranging between 3 and 31 years (10.0±7.1), with most common age being &lt;10 years in 159 patients (69.7%). Male to female ratio was 1.4:1. Among these, the presence of <em>H. pylori</em> was seen in only 6/228 patients.</p><p class="abstract"><strong>Conclusions:</strong> The possibility of tonsillar tissue acting as a reservoir for <em>H. pylori </em>infection is very low.</p>

Helicobacter Pylori Infection in Sjögren’s Syndrome: Co-incidence or Causality?

2019 ◽  
Vol 15 (3) ◽  
pp. 238-241
Author(s):  
Massoud Saghafi ◽  
Nafiseh Abdolahi ◽  
Reza Orang ◽  
Mohammad Reza Hatef ◽  
Mohammad Hadi Molseghi
Keyword(s):  
Helicobacter Pylori ◽  
Serum Level ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Control Group ◽  
P Value ◽  
H Pylori ◽  
Sjögren‘S Syndrome

Background and Aim: Lymphoid cell infiltration and destruction of exocrine glands, specifically lacrimal and salivary glands are characteristics of Sjogren’s syndrome (SS). An etiological role has been proposed for Helicobacter pylori (H. pylori), interacting in the clinical course and complications of SS (including gastric cancer and lymphoma). The aim of this study was to identify the probable correlation between H. pylori infection and Sjogren’s syndrome (SS). Methods: In this case-control study, ELISA method was used to determine serum level of IgA and IgM anti H. pylori antibody in 43 subjects with SS according to the international criteria and 95 healthy subjects as control. SPSS-17 was used to analyze data with t-test. P value <.05 were considered significant. Results: Serum level of IgM (34.9% vs. 10.5%, p-value= 0.001) and IgA (67.4% vs. 46.3% p value= 0.021) anti H. pylori antibody were significantly higher in SS patients compared to the control group. There was a positive correlation between age and H. pylori infection (r=0.2, Pvalue= 0.05). Conclusion: Patients with SS had a higher prevalence of H. pylori infection compared to the normal population. Eradication of H. pylori is recommended particularly in older patients with SS.

The evaluation of nasal mucociliary clearance in patients with Helicobacter pylori infection

2019 ◽  
Vol 133 (03) ◽  
pp. 220-223
Author(s):  
S Üstün Bezgin ◽  
T Çakabay ◽  
K Irak ◽  
M Koçyiğit ◽  
B Serin Keskineğe ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Mucociliary Clearance ◽  
Endoscopic Examination ◽  
Control Group ◽  
Clearance Time ◽  
Saccharine Test ◽  
Significant Difference ◽  
And Gender ◽  
H Pylori ◽  
Nasal Mucociliary Clearance

AbstractObjectiveThis study aimed to examine nasal mucociliary clearance time in patients with Helicobacter pylori infection.MethodsFifty patients who were newly diagnosed with H pylori infection using gastric biopsy in the gastroenterology out-patient clinic, and 50 age- and gender-matched healthy adults who were admitted to the otorhinolaryngology out-patient clinic, were included in this study. After an otorhinolaryngological examination (anterior rhinoscopy and nasal endoscopic examination), the nasal mucociliary clearance time of each subject was calculated using the saccharine test.ResultsThe mean mucociliary clearance time was 06:29 ± 3:31 minutes (range, 00:55–15:19 minutes) in the control group and 10:12 ± 06:09 minutes (range, 01:28–32:00 minutes) in the study group. Comparisons of the two groups revealed a statistically significant difference (p = 0.002).ConclusionNasal mucociliary clearance time was significantly increased in patients with H pylori infection. The results suggest that H pylori infection may have an unfavourable effect on nasal mucociliary clearance.

scholarly journals The association between primary open-angle glaucoma and helicobacter pylori infection

2021 ◽  
pp. 036-042
Author(s):  
Raji Mohammad Mehdi
Keyword(s):  
Helicobacter Pylori ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Helicobacter Pylori Infection ◽  
Control Group ◽  
Case Group ◽  
Open Angle ◽  
Practical Applications ◽  
Ocular Pressure ◽  
H Pylori

Background: Primary Open-Angle Glaucoma (POAG) the most common form of glaucoma is a neurodegenerative disease, which is the third most common cause of blindness worldwide. It is estimated that 60 million people in the world are affected by this disease and 8.4 million are bilaterally blind. Among the various factors that have been implicated in the pathophysiology of this disease is infection with Helicobacter pylori (HP), a Gram-negative bacterium that is commonly found in stomach and present in approximately one-half of the world’s population. Establishment of such a causal correlation will probably have important practical applications as the eradication of H. pylori might lead to developments in the treatment of glaucoma. Objectives: To investigate the association between Primary Open-Angle Glaucoma (POAG) and Helicobacter Pylori infection and to observe fluctuations in intra ocular pressure after Helicobacter Pylori infection eradication. Design: Duration based, prospective observational study. Participants: 50 patients with documented Primary Open-Angle Glaucoma (POAG) as case group and 50 non-glaucoma participants as control group. Methods: Upper gastrointestinal endoscopy was performed to evaluate macroscopic abnormalities, and gastric mucosal biopsy specimens were obtained for the presence of H. pylori infection tested by Rapid Urease Test (RUT). All subjects underwent detailed ocular examinations including visual acuity, slit-lamp examination, fundoscopy, intra-ocular pressure recording, gonioscopy, GHT to assess visual fields and OCT of optic nerve head. Results: In 90% of POAG patients of case group and in 68% of non-glaucoma participants of control group Helicobacter pylori infection was detected by RUT (P-Value=0.007). Conclusion: H. pylori infection is more frequent in glaucoma patients, perhaps more so in those of Indian ethnicity. It may play a role as a secondary aggravating factor or even may be the primary cause. The establishment of such a causal relationship will probably have important practical applications as the eradication of H. pylori might lead to developments in the treatment of glaucoma.

scholarly journals 3-Pentylcatechol, a Non-Allergenic Urushiol Derivative, Displays Anti-Helicobacter pylori Activity In Vivo

2020 ◽  
Vol 13 (11) ◽  
pp. 384
Author(s):  
Hang Yeon Jeong ◽  
Tae Ho Lee ◽  
Ju Gyeong Kim ◽  
Sueun Lee ◽  
Changjong Moon ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Triple Therapy ◽  
Inflammatory Cells ◽  
Control Group ◽  
Vitro Assay ◽  
Low Concentrations ◽  
H Pylori ◽  
Stomach Mucous Membrane

We previously reported that 3-pentylcatechol (PC), a synthetic non-allergenic urushiol derivative, inhibited the growth of Helicobacter pylori in an in vitro assay using nutrient agar and broth. In this study, we aimed to investigate the in vivo antimicrobial activity of PC against H. pylori growing in the stomach mucous membrane. Four-week-old male C57BL/6 mice (n = 4) were orally inoculated with H. pylori Sydney Strain-1 (SS-1) for 8 weeks. Thereafter, the mice received PC (1, 5, and 15 mg/kg) and triple therapy (omeprazole, 0.7 mg/kg; metronidazole, 16.7 mg/kg; clarithromycin, 16.7 mg/kg, reference groups) once daily for 10 days. Infiltration of inflammatory cells in gastric tissue was greater in the H. pylori-infected group compared with the control group and lower in both the triple therapy- and PC-treated groups. In addition, upregulation of cytokine mRNA was reversed after infection, upon administration of triple therapy and PC. Interestingly, PC was more effective than triple therapy at all doses, even at 1/15th the dose of triple therapy. In addition, PC demonstrated synergism with triple therapy, even at low concentrations. The results suggest that PC may be more effective against H. pylori than established antibiotics.

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