P300 waveform and dopamine transporter availability: a controlled EEG and SPECT study in medication-naive patients with schizophrenia and a meta-analysis

2013 ◽  
Vol 44 (10) ◽  
pp. 2151-2162 ◽  
Author(s):  
K. C. Chen ◽  
I. H. Lee ◽  
Y. K. Yang ◽  
S. Landau ◽  
W. H. Chang ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Meta Analysis ◽  
Gender Effect ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Healthy Controls ◽  
Local Study ◽  
Significant Difference ◽  
Drug Naïve

BackgroundReduced P300 event-related potential (ERP) amplitude and latency prolongation have been reported in patients with schizophrenia compared to healthy controls. However, the influence of antipsychotics (and dopamine) on ERP measures are poorly understood and medication confounding remains a possibility.MethodWe explored ERP differences between 36 drug-naive patients with schizophrenia and 138 healthy controls and examined whether P300 performance was related to dopamine transporter (DAT) availability, both without the confounding effects of medication. We also conducted a random effects meta-analysis of the available literature, synthesizing the results of three comparable published articles and our local study.ResultsNo overall significant difference was found in mean P300 ERP between patients and controls in latency or in amplitude. There was a significant gender effect, with females showing greater P300 amplitude than males. A difference between patients and controls in P300 latency was evident with ageing, with latency increasing faster in patients. No effect of DAT availability on P300 latency or amplitude was detected. The meta-analysis computed the latency pooled standardized effect size (PSES; Cohen's d) of −0.13 and the amplitude PSES (Cohen's d) of 0.48, with patients showing a significant reduction in amplitude.ConclusionsOur findings suggest the P300 ERP is not altered in the early stages of schizophrenia before medication is introduced, and the DAT availability does not influence the P300 ERP amplitude or latency. P300 ERP amplitude reduction could be an indicator of the progression of illness and chronicity.

Sleep quality and its effect on event related potential P300 in adolescents with and without sleep disturbances

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Anam Aseem ◽  
Mohammed Ejaz Hussain
Keyword(s):  
Sleep Quality ◽  
Sleep Disturbance ◽  
Sleep Disturbances ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Healthy Controls ◽  
Cortical Arousal ◽  
Previous Night ◽  
Significant Difference

Abstract Objectives The present study aimed: (i) to investigate the sleep quality and cortical arousal (ERP P300) in adolescents with and without sleep disturbances, and (ii) to examine whether P300 vary as a function of quality of the previous night’s sleep in sleep disturbed adolescents and to compare the findings with healthy controls. Methods Fifteen sleep disturbed adolescents and 15 age-matched controls were recruited. Participants filled 10 days of sleep logs to identify their good (GN) and bad nights (BN). GN and BN were scored as a measure of sleep efficiency (SE), with nights having greater SE defined as GN and nights with lower SE scores labelled as BN. Afterwards, subjects were summoned to the lab for recording ERP P300 once after a night of good sleep (GN) and once after a night of bad sleep (BN). Results The findings demonstrate that sleep disturbed adolescents exhibited poorer quality of sleep than controls. The ERP P300 also revealed significant difference in participants with and without sleep disturbance. Moreover, the P300 amplitude was higher and the latency was shorter after a GN in sleep disturbed as well as in controls, however, the values were better for adolescents without disturbed sleep. Similarly, amplitude and latency of P300 was lower and longer, respectively, after a BN in both the groups, however, participants with sleep disturbance demonstrated very penurious scores for amplitude and latency than the controls. Conclusion Adolescents with sleep disturbance have poorer sleep quality and ERP characteristics than their healthy counterparts. Moreover, the quality of the previous night sleep determines cortical arousal in both sleep disturbed and healthy controls.

scholarly journals The Role of Butyric Acid in Treatment Response in Drug-Naïve First Episode Schizophrenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Xue Li ◽  
Xiaoduo Fan ◽  
Xiuxia Yuan ◽  
Lijuan Pang ◽  
Shaohua Hu ◽  
...  
Keyword(s):  
Treatment Response ◽  
Butyric Acid ◽  
Serum Levels ◽  
First Episode ◽  
Healthy Controls ◽  
Significant Difference ◽  
Drug Naïve ◽  
First Episode Schizophrenia ◽  
Risperidone Treatment

Background: Butyric acid, a major short-chain fatty acid (SCFA), has an important role in the microbiota–gut–brain axis and brain function. This study investigated the role of butyric acid in treatment response in drug-naïve first episode schizophrenia.Methods: The study recruited 56 Chinese Han schizophrenia inpatients with normal body weight and 35 healthy controls. Serum levels of butyric acid were measured using Gas Chromatography-Mass Spectrometer (GC-MS) analysis at baseline (for all participants) and 24 weeks after risperidone treatment (for patients). Clinical symptoms were measured using the Positive and Negative Syndrome Scale (PANSS) for patients at both time points.Results: At baseline, there was no significant difference in serum levels of butyric acid between patients and healthy controls (p = 0.206). However, there was a significant increase in serum levels of butyric acid in schizophrenia patients after 24-week risperidone treatment (p = 0.030). The PANSS total and subscale scores were decreased significantly after 24-week risperidone treatment (p's < 0.001). There were positive associations between baseline serum levels of butyric acid and the reduction ratio of the PANSS total and subscale scores after controlling for age, sex, education, and duration of illness (p's < 0.05). Further, there was a positive association between the increase in serum levels of butyric acid and the reduction of the PANSS positive symptoms subscale scores (r = 0.38, p = 0.019) after controlling for potential confounding factors.Conclusions: Increased serum levels of butyric acid might be associated with a favorable treatment response in drug-naïve, first episode schizophrenia. The clinical implications of our findings were discussed.

scholarly journals Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Kaat Hebbrecht ◽  
Katrien Skorobogatov ◽  
Erik J. Giltay ◽  
Violette Coppens ◽  
Livia De Picker ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cerebrospinal Fluid ◽  
Methodological Quality ◽  
Meta Analysis ◽  
Random Effect ◽  
Healthy Controls ◽  
Significant Difference ◽  
Subgroup Analyses ◽  
Tryptophan Catabolites

ObjectiveTryptophan catabolites (TRYCATs) are implicated in the pathophysiology of mood disorders by mediating immune-inflammation and neurodegenerative processes. We performed a meta-analysis of TRYCAT levels in bipolar disorder (BD) patients compared to healthy controls.MethodsA systematic literature search in seven electronic databases (PubMed, Embase, Web of Science, Cochrane, Emcare, PsycINFO, Academic Search Premier) was conducted on TRYCAT levels in cerebrospinal fluid or peripheral blood according to the PRISMA statement. A minimum of three studies per TRYCAT was required for inclusion. Standardized mean differences (SMD) were computed using random effect models. Subgroup analyses were performed for BD patients in a different mood state (depressed, manic). The methodological quality of the studies was rated using the modified Newcastle-Ottawa Quality assessment Scale.ResultsTwenty-one eligible studies were identified. Peripheral levels of tryptophan (SMD = -0.44; p < 0.001), kynurenine (SMD = - 0.3; p = 0.001) and kynurenic acid (SMD = -.45; p = < 0.001) were lower in BD patients versus healthy controls. In the only three eligible studies investigating TRP in cerebrospinal fluid, tryptophan was not significantly different between BD and healthy controls. The methodological quality of the studies was moderate. Subgroup analyses revealed no significant difference in TRP and KYN values between manic and depressed BD patients, but these results were based on a limited number of studies.ConclusionThe TRYCAT pathway appears to be downregulated in BD patients. There is a need for more and high-quality studies of peripheral and central TRYCAT levels, preferably using longitudinal designs.

scholarly journals Emotional Substrates in Neuroticism: The Reactions to Arousal-evoking Stimuli of Various Strengths

2020 ◽  
Vol 19 (2) ◽  
pp. 262-267
Author(s):  
Nasir Yusoff ◽  
Faruque Reza ◽  
Nik NurAzhani Anuar ◽  
Roslee Ahmad
Keyword(s):  
Significant Interaction ◽  
Medical Condition ◽  
Medical Science ◽  
Visual Stimuli ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Significant Interaction Effect ◽  
Mean Values ◽  
Emotional Pictures

Objective: Neuroticism is a medical condition associated with negative affect and is considered to predispose one to mental disorders. This study examined the effectsof arousal-evoking stimuli of various strengths on the severity of neuroticism. Materials and Methods: In the Event Related Potential (ERP)/electroencephalograph (EEG) recording session that was held at the Clinical Neuroscience Laboratory at a local hospital, Electroencephalogram was recorded in 58 participants (N=29 for moderate neuroticism and 29 for mild neuroticism) after they were screened for the severity of the neurotic trait. Universal emotional pictures were chosen randomly from the International Affective Picture System (IAPS) and were used as visual stimuli in the experiment. Visual stimuli weredivided into three categories (high, moderate, low) based on the IAPS normative mean values of arousal. Results: The significant interaction effect of P300 latency between neuroticism and arousal strength was found in the mid-frontal region. Meanwhile, independent of neuroticism, the main effects of arousal strength of the P300 (amplitude and latency) and N200 (latency) were observed in the mid-central region. Conclusion: There is a significant interaction between the severity of neuroticism and the emotional arousal strength, thus, points to the implication of the emotion process in the brain rewards system especially among individuals with neuroticism. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.262-267

scholarly journals Selenium Level in Patients with Vitiligo: A Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Ting Dai ◽  
Sun Xiaoying ◽  
Xin Li ◽  
Li Hongjin ◽  
Zhou Yaqiong ◽  
...  
Keyword(s):  
Subgroup Analysis ◽  
Meta Analysis ◽  
Selenium Level ◽  
Serum Selenium ◽  
Healthy Controls ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Significant Difference ◽  
Comprehensive Search ◽  
Caucasian Patients

Background. It has been reported that deficiency of selenium can cause autoimmune disease. This meta-analysis was aimed at evaluating whether there exits an association between selenium level and vitiligo. Methods. A comprehensive search was conducted on PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Med Online, and China VIP databases from the inception to February 12, 2019. The main outcome was the standardized mean difference (SMD) with 95% confidence interval (CI) in serum selenium level between vitiligo patients and healthy controls. Results. A total of 8 studies with 305 vitiligo patients and 6156 healthy controls were included in this meta-analysis. The results showed that there was no significant difference in selenium level between vitiligo patients and healthy controls (SMD=0.481, 95%CI=−0.642 to 1.604, Z=0.840, P>0.05). Further subgroup analysis stratified by area revealed that Asian vitiligo patients had decreased selenium level, while that finding was not observed in Caucasian patients (Asian: SMD=−0.303, 95%CI=−0.603 to −0.004, P<0.05; Caucasian: SMD=0.957, 95%CI=−0.752 to 2.665, P>0.05). Conclusions. Although overall selenium level was similar between vitiligo patients and health controls, subgroup analysis showed decreased levels of selenium in Asian vitiligo patients. It may suggest a clinical tailored administration of selenium supplementation in Asian vitiligo patients.

scholarly journals Changes in face and face pareidolia processing in patients with migraine: an ERP study

2020 ◽  
Vol 123 (3) ◽  
pp. 876-884 ◽  
Author(s):  
Gülsüm Akdeniz ◽  
Sadiye Gumusyayla ◽  
Gonul Vural ◽  
Hesna Bektas ◽  
Orhan Deniz
Keyword(s):  
Migraine With Aura ◽  
Migraine Without Aura ◽  
Cortical Excitability ◽  
Event Related Potentials ◽  
Event Related Potential ◽  
Healthy Controls ◽  
Positive Potential ◽  
Cortical Hyperexcitability ◽  
Significant Difference ◽  
Related Potentials

Migraine is a multifactorial brain disorder characterized by recurrent disabling headache attacks. One of the possible mechanisms in the pathogenesis of migraine may be a decrease in inhibitory cortical stimuli in the primary visual cortex attributable to cortical hyperexcitability. The aim of this study was to investigate the neural correlates underlying face and face pareidolia processing in terms of the event-related potential (ERP) components, N170, vertex positive potential (VPP), and N250, in patients with migraine. In total, 40 patients with migraine without aura, 23 patients with migraine and aura, and 30 healthy controls were enrolled. We recorded ERPs during the presentation of face and face pareidolia images. N170, VPP, and N250 mean amplitudes and latencies were examined. N170 was significantly greater in patients with migraine with aura than in healthy controls. VPP amplitude was significantly greater in patients with migraine without aura than in healthy controls. The face stimuli evoked significantly earlier VPP responses to faces (168.7 ms, SE = 1.46) than pareidolias (173.4 ms, SE = 1.41) in patients with migraine with aura. We did not find a significant difference between N250 amplitude for face and face pareidolia processing. A significant difference was observed between the groups for pareidolia in terms of N170 [F(2,86) = 14,75, P < 0.001] and VPP [F(2,86) = 16.43, P < 0.001] amplitudes. Early ERPs are a valuable tool to study the neural processing of face processing in patients with migraine to demonstrate visual cortical hyperexcitability. NEW & NOTEWORTHY Event-related potentials (ERPs) are important for understanding face and face pareidolia processing in patients with migraine. N170, vertex positive potential (VPP), and N250 ERPs were investigated. N170 was revealed as a potential component of cortical excitability for face and face pareidolia processing in patients with migraine.

P300 event-related potential and serotonin-1A activity in depression

1999 ◽  
Vol 14 (3) ◽  
pp. 143-147 ◽  
Author(s):  
M Hansenne ◽  
M Ansseau
Keyword(s):  
Critical Role ◽  
Brain Structures ◽  
Significant Negative Correlation ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Endocrine Response ◽  
Major Depressive ◽  
Serotonergic Activity ◽  
The Brain

SummaryThe identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = –0.40, P = 0.007 at Cz; r = –0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude.

scholarly journals P300 and decision-making in neuromarketing

2021 ◽  
Vol 4 (3) ◽  
pp. 21-26
Author(s):  
Aida Azlina Mansor ◽  
Salmi Mohd Isa ◽  
Syaharudin Shah Mohd Noor
Keyword(s):  
Decision Making ◽  
Test Methods ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Decision Making Process ◽  
Related Research ◽  
P300 Wave ◽  
Human Event ◽  
Marketing Methods

Neuromarketing provides insights into consumers' decision-making that traditional marketing test methods cannot offer. The foundation in the process of decision-making is P300. Thus, the P300 wave is a potential Event-Related Component (ERP) used to measure consumers' decision-making process. The P300 wave represents a positive transition in human event-related potential. Therefore, the P300 is determined by measuring the amplitude and latency of the consumers. A higher P300 amplitude indicates greater confidence in the decision-making process, while a longer P300 latency indicates lower attentiveness. Thus, P300 in neuroscience, which investigates customers' responses in-depth, cannot be accomplished by typical marketing methods. For many years, P300 components such as attitudes, preferences, and information-based decision-making have been examined extensively in marketing-related research. However, a review of an ERP in neuromarketing method is fewer reported. This mini review describes some analysis on P300 and decision-making by several researchers.

scholarly journals Relationship between enlarged perivascular space in hippocampus and P300 event-related potential in patients with acute lacunar stroke

2021 ◽  
Author(s):  
Shan Huang ◽  
Zhixiang Zhang ◽  
Yuqing Mei ◽  
Kuankuan Huang ◽  
Yiping Feng ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Roc Curve ◽  
Verbal Fluency ◽  
Perivascular Space ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Lacunar Stroke ◽  
The Relationship ◽  
P300 Event Related Potential

Abstract Background This study aimed to investigate the relationship between enlarged perivascular space in hippocampus (H-EPVS) and P300 event-related potential (ERP) in patients with acute lacunar stroke. Methods Patients with acute lacunar stroke hospitalized in Changzhou No.2 people's Hospital from February 2019 to July 2020 were collected. All the patients performed the P300 auditory oddball task and a full set of cognitive function tests. We recorded P300 latency and amplitude by EMG evoked potential instrument. H-EPVS showed round, oval and linear structures on MRI T2-weighted images of hippocampus, with clear boundaries and consistency in the direction of the perforating arterioles. Dividing the total number of H-EPVS ≥ 7 into extensive H-EPVS group (n = 61) and non-extensive H-EPVS group (n = 53). ROC curve was used to analyze the relationship between P300 ERP and cognitive function of extensive H-EPVS in patients with acute lacunar stroke. Results A total of 114 patients with acute lacunar stroke were included, and 61 (53.5%) patients were found to have extensive H-EPVS. The P300 latency in patients with extensive H-EPVS( mean and SD, 393.61 ± 30.36) was significantly higher than in non-extensive H-EPVS (mean and SD, 356.4 ± 19.59 ms, t = -7.870, P < 0.01). There was no significant difference in P300 amplitude between the two groups (P > 0.05). In addition, The cognitive function (the field of verbal fluency) in patients with extensive H-EPVS (mean and SD, -0.41 ± 0.50) was significantly lower than in non-extensive H-EPVS (mean and SD, 0.47 ± 0.54, t = 9.017, P < 0.01). Further analysis shows that in patients with acute lacunar stroke, P300 latency was positively associated with H-EPVS counts (r = 0.726, P = 0.000). H-EPVS counts was negatively associated with cognitive function score (the field of verbal fluency) (r=-0.705, P = 0.000). ROC curve analysis showed that the index of cognitive impairment diagnosed by P300 in patients with acute lacunar stoke was 0.796. Conclusion Extensive H-EPVS has a high incidence in patients with acute lacunar stroke. The P300 latency may be used as an early indicator to evaluate the verbal fluency function of extensive H-EPVS patients with acute lacunar stroke.

scholarly journals Increased Serum Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) Levels in FSGS: A Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Jiwon M. Lee ◽  
Jae Won Yang ◽  
Andreas Kronbichler ◽  
Michael Eisenhut ◽  
Gaeun Kim ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Minimal Change Disease ◽  
Meta Analysis ◽  
Minimal Change ◽  
Adult Patients ◽  
Healthy Controls ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Significant Difference ◽  
Plasminogen Activator Receptor

Introduction. The soluble urokinase-type plasminogen activator receptor (suPAR) has been found to be elevated in primary focal segmental glomerulosclerosis (pFSGS). However, its usefulness as a biomarker for FSGS remains controversial. We conducted a meta-analysis aiming at investigating the significance of suPAR in diagnosing pFSGS. Methods. Electronic databases (PubMed and EMBASE) were searched to identify studies comparing suPAR levels in FSGS patients and controls, from the earliest available date to May 1, 2018. A random-effects model with standardized mean difference (SMD) was used for meta-analyses. Risk of bias was assessed using the Newcastle-Ottawa quality assessment scale. Results. A total of 187 articles were screened, and the final analysis included 13 articles. In comparison to healthy controls, serum suPAR levels were significantly increased in pFSGS patients (SMD, 1.07, 95% confidence interval (CI) 0.65 to 1.48; participants=814; studies=9, I2=85%). Higher suPAR levels were also found in patients with pFSGS compared to those with minimal change disease (SMD 0.53, 95% CI 0.22 to 0.84). Of note, such a difference was not found in pediatric groups (SMD 0.42, 95% CI -0.13 to 0.96) while it was more evidently noted in adult patients (SMD 1.32, 95% CI 0.90 to 1.74). Serum suPAR levels did not differ between pFSGS patients in remission compared to those in active proteinuric state (SMD 0.29, 95% CI -0.30 to 0.88). Comparison with membranous nephropathy and IgA nephropathy showed no significant difference. Conclusions. Our meta-analysis demonstrated that, in comparison to both healthy controls and controls with minimal change disease, suPAR levels were significantly higher in adult patients with pFSGS. suPAR levels did not differ between pFSGS patients during the initial period of diagnosis and those in remission.

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