scholarly journals Relationship between enlarged perivascular space in hippocampus and P300 event-related potential in patients with acute lacunar stroke

2021 ◽  
Author(s):  
Shan Huang ◽  
Zhixiang Zhang ◽  
Yuqing Mei ◽  
Kuankuan Huang ◽  
Yiping Feng ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Roc Curve ◽  
Verbal Fluency ◽  
Perivascular Space ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Lacunar Stroke ◽  
The Relationship ◽  
P300 Event Related Potential

Abstract Background This study aimed to investigate the relationship between enlarged perivascular space in hippocampus (H-EPVS) and P300 event-related potential (ERP) in patients with acute lacunar stroke. Methods Patients with acute lacunar stroke hospitalized in Changzhou No.2 people's Hospital from February 2019 to July 2020 were collected. All the patients performed the P300 auditory oddball task and a full set of cognitive function tests. We recorded P300 latency and amplitude by EMG evoked potential instrument. H-EPVS showed round, oval and linear structures on MRI T2-weighted images of hippocampus, with clear boundaries and consistency in the direction of the perforating arterioles. Dividing the total number of H-EPVS ≥ 7 into extensive H-EPVS group (n = 61) and non-extensive H-EPVS group (n = 53). ROC curve was used to analyze the relationship between P300 ERP and cognitive function of extensive H-EPVS in patients with acute lacunar stroke. Results A total of 114 patients with acute lacunar stroke were included, and 61 (53.5%) patients were found to have extensive H-EPVS. The P300 latency in patients with extensive H-EPVS( mean and SD, 393.61 ± 30.36) was significantly higher than in non-extensive H-EPVS (mean and SD, 356.4 ± 19.59 ms, t = -7.870, P < 0.01). There was no significant difference in P300 amplitude between the two groups (P > 0.05). In addition, The cognitive function (the field of verbal fluency) in patients with extensive H-EPVS (mean and SD, -0.41 ± 0.50) was significantly lower than in non-extensive H-EPVS (mean and SD, 0.47 ± 0.54, t = 9.017, P < 0.01). Further analysis shows that in patients with acute lacunar stroke, P300 latency was positively associated with H-EPVS counts (r = 0.726, P = 0.000). H-EPVS counts was negatively associated with cognitive function score (the field of verbal fluency) (r=-0.705, P = 0.000). ROC curve analysis showed that the index of cognitive impairment diagnosed by P300 in patients with acute lacunar stoke was 0.796. Conclusion Extensive H-EPVS has a high incidence in patients with acute lacunar stroke. The P300 latency may be used as an early indicator to evaluate the verbal fluency function of extensive H-EPVS patients with acute lacunar stroke.

scholarly journals Emotional Substrates in Neuroticism: The Reactions to Arousal-evoking Stimuli of Various Strengths

2020 ◽  
Vol 19 (2) ◽  
pp. 262-267
Author(s):  
Nasir Yusoff ◽  
Faruque Reza ◽  
Nik NurAzhani Anuar ◽  
Roslee Ahmad
Keyword(s):  
Significant Interaction ◽  
Medical Condition ◽  
Medical Science ◽  
Visual Stimuli ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Significant Interaction Effect ◽  
Mean Values ◽  
Emotional Pictures

Objective: Neuroticism is a medical condition associated with negative affect and is considered to predispose one to mental disorders. This study examined the effectsof arousal-evoking stimuli of various strengths on the severity of neuroticism. Materials and Methods: In the Event Related Potential (ERP)/electroencephalograph (EEG) recording session that was held at the Clinical Neuroscience Laboratory at a local hospital, Electroencephalogram was recorded in 58 participants (N=29 for moderate neuroticism and 29 for mild neuroticism) after they were screened for the severity of the neurotic trait. Universal emotional pictures were chosen randomly from the International Affective Picture System (IAPS) and were used as visual stimuli in the experiment. Visual stimuli weredivided into three categories (high, moderate, low) based on the IAPS normative mean values of arousal. Results: The significant interaction effect of P300 latency between neuroticism and arousal strength was found in the mid-frontal region. Meanwhile, independent of neuroticism, the main effects of arousal strength of the P300 (amplitude and latency) and N200 (latency) were observed in the mid-central region. Conclusion: There is a significant interaction between the severity of neuroticism and the emotional arousal strength, thus, points to the implication of the emotion process in the brain rewards system especially among individuals with neuroticism. Bangladesh Journal of Medical Science Vol.19(2) 2020 p.262-267

Sensory Gating Capacity and Attentional Function in Adults With ADHD: A Preliminary Neurophysiological and Neuropsychological Study

2016 ◽  
Vol 23 (10) ◽  
pp. 1199-1209 ◽  
Author(s):  
Jean-Arthur Micoulaud-Franchi ◽  
Régis Lopez ◽  
Michel Cermolacce ◽  
Florence Vaillant ◽  
Pauline Péri ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Sensory Input ◽  
Neuropsychological Test ◽  
Sensory Gating ◽  
Adult Patients ◽  
P300 Amplitude ◽  
Oddball Paradigm ◽  
Protective Mechanism ◽  
The Relationship ◽  
The Brain

Objective: The inability to filter sensory input correctly may impair higher cognitive function in ADHD. However, this relationship remains largely elusive. The objectives of the present study is to investigate the relationship between sensory input processing and cognitive function in adult patients with ADHD. Method: This study investigated the relationship between deficit in sensory gating capacity (P50 amplitude changes in a double-click conditioning-testing paradigm and perceptual abnormalities related to sensory gating deficit with the Sensory Gating Inventory [SGI]) and attentional and executive function (P300 amplitude in an oddball paradigm and attentional and executive performances with a neuropsychological test) in 24 adult patients with ADHD. Results: The lower the sensory gating capacity of the brain and the higher the distractibility related to sensory gating inability that the patients reported, the lower the P300 amplitude. Conclusion: The capacity of the brain to gate the response to irrelevant incoming sensory input may be a fundamental protective mechanism that prevents the flooding of higher brain structures with irrelevant information in adult patients with ADHD.

P300 event-related potential and serotonin-1A activity in depression

1999 ◽  
Vol 14 (3) ◽  
pp. 143-147 ◽  
Author(s):  
M Hansenne ◽  
M Ansseau
Keyword(s):  
Critical Role ◽  
Brain Structures ◽  
Significant Negative Correlation ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Endocrine Response ◽  
Major Depressive ◽  
Serotonergic Activity ◽  
The Brain

SummaryThe identification of the brain structures and neurotransmitters responsible for the generation and/or modulation of P300 could lead to important clinical implications. Since serotonin disturbances seem to play a critical role in depression, the aim of the study was to assess the possible relationships between the P300 event-related brain potential and serotonergic activity in depression. The study was conducted among 45 major depressive inpatients, and serotonergic activity was assessed by prolactin (PRL) response to flesinoxan (a 5-HT1A agonist). Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = –0.40, P = 0.007 at Cz; r = –0.47, P = 0.001 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin-1A in the neurobiological modulation of P300 amplitude.

scholarly journals Relationship between cognitive processing, language and verbal fluency among elderly individuals

2019 ◽  
Vol 13 (3) ◽  
pp. 299-304
Author(s):  
Helen Capeleto Francisco ◽  
Allan Gustavo Brigola ◽  
Ana Carolina Ottaviani ◽  
Ariene Angelini dos Santos-Orlandi ◽  
Fabiana de Souza Orlandi ◽  
...  
Keyword(s):  
Cognitive Processing ◽  
Negative Correlation ◽  
Verbal Fluency ◽  
Healthcare Services ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Cross Sectional ◽  
Elderly Individuals ◽  
Positive Correlation ◽  
Processing Language

ABSTRACT Some cognitive dimensions, such as attention, memory and executive functions, may decline with age, while other functions remain intact or even improve due to greater life experience. Objective: to analyze the relationship between cognitive processing, language and verbal fluency among elderly individuals seen by primary healthcare services located in a city in the interior of São Paulo, Brazil. Methods: a cross-sectional study with a quantitative method was conducted. A total of 149 elderly individuals were assessed through previously scheduled interviews. Data collection included a questionnaire on sociodemographic data and the Addenbrooke's Cognitive Examination - Revised (ACE-R). Cognitive processing (P300) was assessed using a device that captures potentials elicited in auditory tasks. Descriptive analysis and Spearman's correlation were performed with the level of significance established at 5%. Results: a negative correlation was found between language and P300 latency, while a positive correlation was found between verbal fluency and P300 amplitude. Comprehension and naming tasks showed a negative correlation with latency. The repetition task revealed a positive correlation with P300 amplitude. Conclusion: although more extensive testing is needed, these findings suggest that language correlates with P300 latency, whereas verbal fluency correlates with P300 amplitude.

scholarly journals P300 and decision-making in neuromarketing

2021 ◽  
Vol 4 (3) ◽  
pp. 21-26
Author(s):  
Aida Azlina Mansor ◽  
Salmi Mohd Isa ◽  
Syaharudin Shah Mohd Noor
Keyword(s):  
Decision Making ◽  
Test Methods ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Decision Making Process ◽  
Related Research ◽  
P300 Wave ◽  
Human Event ◽  
Marketing Methods

Neuromarketing provides insights into consumers' decision-making that traditional marketing test methods cannot offer. The foundation in the process of decision-making is P300. Thus, the P300 wave is a potential Event-Related Component (ERP) used to measure consumers' decision-making process. The P300 wave represents a positive transition in human event-related potential. Therefore, the P300 is determined by measuring the amplitude and latency of the consumers. A higher P300 amplitude indicates greater confidence in the decision-making process, while a longer P300 latency indicates lower attentiveness. Thus, P300 in neuroscience, which investigates customers' responses in-depth, cannot be accomplished by typical marketing methods. For many years, P300 components such as attitudes, preferences, and information-based decision-making have been examined extensively in marketing-related research. However, a review of an ERP in neuromarketing method is fewer reported. This mini review describes some analysis on P300 and decision-making by several researchers.

P300 waveform and dopamine transporter availability: a controlled EEG and SPECT study in medication-naive patients with schizophrenia and a meta-analysis

2013 ◽  
Vol 44 (10) ◽  
pp. 2151-2162 ◽  
Author(s):  
K. C. Chen ◽  
I. H. Lee ◽  
Y. K. Yang ◽  
S. Landau ◽  
W. H. Chang ◽  
...  
Keyword(s):  
Dopamine Transporter ◽  
Meta Analysis ◽  
Gender Effect ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
P300 Latency ◽  
Healthy Controls ◽  
Local Study ◽  
Significant Difference ◽  
Drug Naïve

BackgroundReduced P300 event-related potential (ERP) amplitude and latency prolongation have been reported in patients with schizophrenia compared to healthy controls. However, the influence of antipsychotics (and dopamine) on ERP measures are poorly understood and medication confounding remains a possibility.MethodWe explored ERP differences between 36 drug-naive patients with schizophrenia and 138 healthy controls and examined whether P300 performance was related to dopamine transporter (DAT) availability, both without the confounding effects of medication. We also conducted a random effects meta-analysis of the available literature, synthesizing the results of three comparable published articles and our local study.ResultsNo overall significant difference was found in mean P300 ERP between patients and controls in latency or in amplitude. There was a significant gender effect, with females showing greater P300 amplitude than males. A difference between patients and controls in P300 latency was evident with ageing, with latency increasing faster in patients. No effect of DAT availability on P300 latency or amplitude was detected. The meta-analysis computed the latency pooled standardized effect size (PSES; Cohen's d) of −0.13 and the amplitude PSES (Cohen's d) of 0.48, with patients showing a significant reduction in amplitude.ConclusionsOur findings suggest the P300 ERP is not altered in the early stages of schizophrenia before medication is introduced, and the DAT availability does not influence the P300 ERP amplitude or latency. P300 ERP amplitude reduction could be an indicator of the progression of illness and chronicity.

Effects of Self-Evaluation on the P300 Event-Related Potential

2005 ◽  
Vol 100 (2) ◽  
pp. 409-420
Author(s):  
Joel E. Alexander ◽  
Ben Crowson ◽  
Kelly Machan ◽  
Denesa Lockwood ◽  
Ronald G. Alexander ◽  
...  
Keyword(s):  
Cognitive Task ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Sensory Discrimination ◽  
Self Evaluation ◽  
Auditory Oddball ◽  
Cognitive Readiness ◽  
Oddball Task ◽  
Secondary Stimulus ◽  
P300 Event Related Potential

The effects of self evaluation on the P300 event-related potential (ERP) were explored with 56 participants (16 men, 40 women; M age = 23.4 yr., SD = 1.2) across three conditions. The conditions included (1) a standard ERP auditory oddball discrimination between a random target (15% occurrence) and standard stimuli (85% occurrence), (2) the oddball task followed by the additional cognitive task of maintaining a mental count of the target tones, and (3) the oddball task followed by the additional cognitive task of self-evaluating whether they felt surprised by the current occurrence of the target tone. The added cognitive requirements for Conditions 2 and 3 required the subjects to maintain a cognitive readiness for the secondary stimulus-related task during their sensory discrimination response for the standard oddball task. During the self-evaluation condition, the P300 amplitude was significantly larger across all recording locations than the regular oddball condition and the cognitive count condition.

scholarly journals Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1

2021 ◽  
Author(s):  
Gorana Pobric ◽  
Jason R. Taylor ◽  
Hemavathy M. Ramalingam ◽  
Emily Pye ◽  
Louise Robinson ◽  
...  
Keyword(s):  
Working Memory ◽  
Single Gene ◽  
Neurofibromatosis Type ◽  
Event Related Potential ◽  
P300 Amplitude ◽  
Group Differences ◽  
Control Group ◽  
P300 Latency ◽  
Memory Impairments

AbstractNeurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed poorer performance on measures of WM as compared to the control group. No group differences were observed in P300 amplitude at Pz, but P300 latency was shorter in the NF1 group. Topographic analyses of P300 amplitude showed group differences indicating neural processing differences in the NF1 group relative to controls, which possibly contribute to the cognitive deficits seen in this population.

scholarly journals MON-636 The Relationship Between Glucose Control & Cognitive Function in People with Diabetes After a Lacunar Stroke

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Tali Cukierman-Yaffe ◽  
Leslie McClure ◽  
Thomas Risoli ◽  
Jackie Bosch ◽  
Hertzel C Gerstein ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Function ◽  
Cognitive Dysfunction ◽  
Glucose Control ◽  
High Risk Population ◽  
Z Score ◽  
Lacunar Stroke ◽  
The Relationship ◽  
Over Time

Abstract Background & Objective Both lacunar strokes and diabetes are risk factors for dementia and cognitive dysfunction. Thus, elucidating modifiable risk factors for cognitive dysfunction in people with type 2 diabetes who experienced a lacunar infarct has large public health implications. One such factor may be glycemic status, as measured by glycosylated hemoglobin (A1C). Thus, the aim of this study was to assess the relationship between A1C and cognitive function in people with diabetes after a lacunar stroke. Research Design & Methods The effect of baseline and follow-up A1C on the baseline and the change in Cognitive Assessment Screening Instrument (CASI) score over time among participants with a median of 2 cognitive assessments (range 1-5) was examined in of 942 individuals with diabetes and a lacunar stroke who participated in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial (ClinicalTrials.gov number, NCT00059306). Results Every 1 % higher baseline A1C was associated with a 0.06 lower standardized CASI z-score (95% CI -0.101, -0.018). Higher baseline A1C values were associated with lower CASI z-score over time (p for interaction=0.037). A 1% increase in A1C over time, corresponded with a CASI score decrease of 0.021 (95% CI -0.0043, -0.038) during follow-up. All these remained statistically significant after adjustment for age, sex, education, race, depression, hypertension, hyperlipidemia, BMI, CVD, OSA, diabetic retinopathy, nephropathy insulin use and White Matter Abnormalities. Conclusion This analysis of 942 individuals with diabetes after a lacunar stroke demonstrates a relationship between A1C and change in cognitive scores over time. Intervention studies are needed in order to delineate if better glucose control could slow the rate of cognitive decline in this high risk population.

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