Association of older paternal age with earlier onset among co-affected schizophrenia sib-pairs

2015 ◽  
Vol 45 (10) ◽  
pp. 2205-2213 ◽  
Author(s):  
S. H. Wang ◽  
C. M. Liu ◽  
H. G. Hwu ◽  
C. K. Hsiao ◽  
W. J. Chen
Keyword(s):  
Diagnostic Interview ◽  
Paternal Age ◽  
Hierarchical Regression ◽  
Trend Test ◽  
Advanced Paternal Age ◽  
Familial Predisposition ◽  
Hierarchical Regression Model ◽  
Increased Risk ◽  
Familial Dependence ◽  
Sib Pairs

BackgroundAdvanced paternal age is associated with increased risk of schizophrenia. This study aimed to explore whether older paternal age is associated with earlier onset among co-affected schizophrenia sib-pairs with the same familial predisposition.MethodA total of 1297 patients with schizophrenia from 630 families, which were ascertained to have at least two siblings affected, throughout Taiwan were interviewed using the Diagnostic Interview for Genetic Studies. Both inter-family comparisons, a hierarchical regression model allowing for familial dependence and adjusting for confounders, and within-family comparisons, examining the consistency between onset order and birth order, were performed.ResultsAn inverted U shape was observed between paternal age and onset of schizophrenia. Affected offspring with paternal age of 20–24 years had the oldest onset. As paternal age increased over 25 years, older paternal age exhibited a linear decrease in the onset of schizophrenia. On average, the onset was lowered by 1.5 years for paternal age of 25–29 years and by 5.5 years for paternal age ⩾50 years (p = 0.04; trend test). The proportion of younger siblings with earlier onset (58%) was larger than that of older siblings with earlier onset (42%) (p = 0.0002).ConclusionsThese findings indicate that paternal age older than 25 years and younger than 20 years were both associated with earlier onset among familial schizophrenia cases. The associations of advanced paternal age with both increased susceptibility to schizophrenia and earlier onset of schizophrenia are consistent with the rate of increases in spontaneous mutations in sperm as men age.

Understanding the association between advanced paternal age and schizophrenia and bipolar disorder

2019 ◽  
Vol 50 (3) ◽  
pp. 431-437 ◽  
Author(s):  
Mark Weiser ◽  
Daphna Fenchel ◽  
Or Frenkel ◽  
Eyal Fruchter ◽  
Shimon Burshtein ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
De Novo ◽  
Psychiatric Hospitalization ◽  
Population Based ◽  
Paternal Age ◽  
Social Characteristics ◽  
Advanced Paternal Age ◽  
First Child ◽  
Increased Risk ◽  
Age At Birth

AbstractBackgroundPrevious studies reported an association between advanced paternal age at birth and increased risk for schizophrenia and bipolar disorder. While some hypothesize that this association is caused by de-novo mutations in paternal spermatozoa, others cite factors associated with psycho-social characteristics of fathers who have children at a late age. This study aims to test these hypotheses.MethodsA historical-prospective, population-based cohort study, performed by linking the Israeli Draft Board Registry and the Israeli National Psychiatric Hospitalization Registry (N = 916 439; 4488 with schizophrenia, 883 with bipolar disorder). Odds ratios (OR) and two-sided 95% confidence intervals (CI) were calculated by logistic regression models, using paternal age as predictor and risk for later hospitalizations for schizophrenia or bipolar disorder as outcome measure. Models were first fitted unadjusted, then adjusted for paternal age at birth of the first child.ResultsIn the unadjusted model, offspring of fathers aged 45 and above at birth had increased risk of schizophrenia (OR = 1.71, 95% CI 1.49–1.99) and bipolar disorder (OR = 1.63, 95% CI 1.16–2.24). However, taking into account paternal age at birth of first child, advanced paternal age was no longer associated with increased risk of schizophrenia (OR = 0.60, 95% CI 0.48–0.79) or bipolar disorder (OR = 1.03, 95% CI 0.56–1.90).ConclusionsControlling for paternal age at birth of the first offspring, advanced paternal age does not predict increased risk for schizophrenia or bipolar disorder. These data indicate that the association between advanced paternal age and having an offspring with schizophrenia and bipolar disorder is likely due to psychos-social factors, or common genetic variation associated with delayed initial fatherhood.

scholarly journals Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis

2020 ◽  
Vol 26 (5) ◽  
pp. 650-669 ◽  
Author(s):  
Nadia A du Fossé ◽  
Marie-Louise P van der Hoorn ◽  
Jan M M van Lith ◽  
Saskia le Cessie ◽  
Eileen E L O Lashley
Keyword(s):  
Systematic Review ◽  
Maternal Age ◽  
Meta Analysis ◽  
Advanced Maternal Age ◽  
Paternal Age ◽  
Free Text ◽  
Advanced Paternal Age ◽  
Spontaneous Miscarriage ◽  
Risk Estimates ◽  
Increased Risk

Abstract BACKGROUND Although spontaneous miscarriage is the most common complication of human pregnancy, potential contributing factors are not fully understood. Advanced maternal age has long been recognised as a major risk factor for miscarriage, being strongly related with fetal chromosomal abnormalities. The relation between paternal age and the risk of miscarriage is less evident, yet it is biologically plausible that an increasing number of genetic and epigenetic sperm abnormalities in older males may contribute to miscarriage. Previous meta-analyses showed associations between advanced paternal age and a broad spectrum of perinatal and paediatric outcomes. This is the first systematic review and meta-analysis on paternal age and spontaneous miscarriage. OBJECTIVE AND RATIONALE The aim of this systematic review and meta-analysis is to evaluate the effect of paternal age on the risk of spontaneous miscarriage. SEARCH METHODS PubMed, Embase and Cochrane databases were searched to identify relevant studies up to August 2019. The following free text and MeSH terms were used: paternal age, father’s age, male age, husband’s age, spontaneous abortion, spontaneous miscarriage, abortion, miscarriage, pregnancy loss, fetal loss and fetal death. PRISMA guidelines for systematic reviews and meta-analysis were followed. Original research articles in English language addressing the relation between paternal age and spontaneous miscarriage were included. Exclusion criteria were studies that solely focused on pregnancy outcomes following artificial reproductive technology (ART) and studies that did not adjust their effect estimates for at least maternal age. Risk of bias was qualitatively described for three domains: bias due to confounding, information bias and selection bias. OUTCOMES The search resulted in 975 original articles. Ten studies met the inclusion criteria and were included in the qualitative synthesis. Nine of these studies were included in the quantitative synthesis (meta-analysis). Advanced paternal age was found to be associated with an increased risk of miscarriage. Pooled risk estimates for miscarriage for age categories 30–34, 35–39, 40–44 and ≥45 years of age were 1.04 (95% CI 0.90, 1.21), 1.15 (0.92, 1.43), 1.23 (1.06, 1.43) and 1.43 (1.13, 1.81) respectively (reference category 25–29 years). A second meta-analysis was performed for the subgroup of studies investigating first trimester miscarriage. This showed similar pooled risk estimates for the first three age categories and a slightly higher pooled risk estimate for age category ≥45 years (1.74; 95% CI 1.26, 2.41). WIDER IMPLICATIONS Over the last decades, childbearing at later ages has become more common. It is known that frequencies of adverse reproductive outcomes, including spontaneous miscarriage, are higher in women with advanced age. We show that advanced paternal age is also associated with an increased risk of spontaneous miscarriage. Although the paternal age effect is less pronounced than that observed with advanced maternal age and residual confounding by maternal age cannot be excluded, it may have implications for preconception counselling of couples comprising an older aged male.

scholarly journals Advanced paternal age is associated with an increased risk for segmental aberrations in embryos derived from young oocyte donors

2019 ◽  
Vol 112 (3) ◽  
pp. e143
Author(s):  
Michal Dviri ◽  
Svetlana Madjunkova ◽  
Ran Antes ◽  
Rina Abramov ◽  
Jordana Mashiach ◽  
...  
Keyword(s):  
Paternal Age ◽  
Advanced Paternal Age ◽  
Increased Risk ◽  
Oocyte Donors

scholarly journals Paternal age at birth and high-functioning autistic-spectrum disorder in offspring

2008 ◽  
Vol 193 (4) ◽  
pp. 316-321 ◽  
Author(s):  
Kenji J. Tsuchiya ◽  
Kaori Matsumoto ◽  
Taishi Miyachi ◽  
Masatsugu Tsujii ◽  
Kazuhiko Nakamura ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Autistic Spectrum Disorder ◽  
Fold Increase ◽  
Spectrum Disorder ◽  
Paternal Age ◽  
Autistic Spectrum ◽  
Advanced Paternal Age ◽  
High Functioning ◽  
Increased Risk ◽  
Age At Birth

BackgroundPrevious studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability.AimsTo test whether an association between advanced paternal age at birth is found in offspring with high-functioning autistic-spectrum disorder (i.e. offspring without intellectual disability).MethodA case–control study was conducted in Japan. The participants consisted of individuals with full-scale IQ ⩾ 70, with a DSM–IV autistic disorder or related diagnosis. Unrelated healthy volunteers were recruited as controls. Parental ages were divided into tertiles (i.e. three age classes). Odds ratios and 95% confidence intervals were estimated using logistic regression analyses, with an adjustment for age, gender and birth order.ResultsEighty-four individuals with autistic-spectrum disorder but without intellectual disability and 208 healthy controls were enrolled. Increased paternal, but not maternal, age was associated with an elevated risk of high-functioning autistic-spectrum disorder. A one-level advance in paternal age class corresponded to a 1.8-fold increase in risk, after adjustment for covariates.ConclusionsAdvanced paternal age is associated with an increased risk for high-functioning autistic-spectrum disorder.

scholarly journals Paternal age at childbirth and eating disorders in offspring

2016 ◽  
Vol 47 (3) ◽  
pp. 576-584 ◽  
Author(s):  
K. N. Javaras ◽  
M. E. Rickert ◽  
L. M. Thornton ◽  
C. M. Peat ◽  
J. H. Baker ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Maternal Age ◽  
Parental Education ◽  
Large Population ◽  
Population Based ◽  
Criminal History ◽  
Education Level ◽  
Paternal Age ◽  
Advanced Paternal Age ◽  
Increased Risk

BackgroundAdvanced paternal age at childbirth is associated with psychiatric disorders in offspring, including schizophrenia, bipolar disorder and autism. However, few studies have investigated paternal age's relationship with eating disorders in offspring. In a large, population-based cohort, we examined the association between paternal age and offspring eating disorders, and whether that association remains after adjustment for potential confounders (e.g. parental education level) that may be related to late/early selection into fatherhood and to eating disorder incidence.MethodData for 2 276 809 individuals born in Sweden 1979–2001 were extracted from Swedish population and healthcare registers. The authors used Cox proportional hazards models to examine the effect of paternal age on the first incidence of healthcare-recorded anorexia nervosa (AN) and all eating disorders (AED) occurring 1987–2009. Models were adjusted for sex, birth order, maternal age at childbirth, and maternal and paternal covariates including country of birth, highest education level, and lifetime psychiatric and criminal history.ResultsEven after adjustment for covariates including maternal age, advanced paternal age was associated with increased risk, and younger paternal age with decreased risk, of AN and AED. For example, the fully adjusted hazard ratio for the 45+ years (v. the 25–29 years) paternal age category was 1.32 [95% confidence interval (CI) 1.14–1.53] for AN and 1.26 (95% CI 1.13–1.40) for AED.ConclusionsIn this large, population-based cohort, paternal age at childbirth was positively associated with eating disorders in offspring, even after adjustment for potential confounders. Future research should further explore potential explanations for the association, including de novo mutations in the paternal germline.

The Effect of Paternal Age on Fetal Birth Outcomes

2012 ◽  
Vol 6 (5) ◽  
pp. 427-435 ◽  
Author(s):  
Amina P. Alio ◽  
Hamisu M. Salihu ◽  
Cheri McIntosh ◽  
Euna M. August ◽  
Hanna Weldeselasse ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Birth Outcomes ◽  
Age Groups ◽  
Estimating Equation ◽  
Population Based ◽  
Adverse Outcomes ◽  
Paternal Age ◽  
Data Set ◽  
Advanced Paternal Age ◽  
Increased Risk

Research investigating the role of paternal age in adverse birth outcomes is limited. This population-based retrospective cohort study used the Missouri maternally linked data set from 1989 to 2005 to assess whether paternal age affects fetal birth outcomes: low birth weight (LBW), preterm birth (PTB), stillbirth, and small size for gestational age (SGA). We examined these outcomes among infants across seven paternal age-groups (<20, 20-24, 25-29, 30-34, 35-39, 40-45, and >45 years) using the generalized estimating equation framework. Compared with infants born to younger fathers (25-29 years), infants born to fathers aged 40 to 45 years had a 24% increased risk of stillbirth but a reduced risk of SGA. A 48% increased risk of late stillbirth was observed in infants born to advanced paternal age (>45 years). Moreover, advanced paternal age (>45 years) was observed to result in a 19%, 13%, and 29% greater risk for LBW, PTB, and VPTB (very preterm birth) infants, respectively. Infants born to fathers aged 30 to 39 years had a lower risk of LBW, PTB, and SGA, whereas those born to fathers aged 24 years or younger had an elevated likelihood of experiencing these same adverse outcomes. These findings demonstrate that paternal age influences birth outcomes and warrants further investigation.

scholarly journals Association Between Paternal Age and Birth Weight in Preterm and Full-Term Birth: A Retrospective Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Yiting Mao ◽  
Chen Zhang ◽  
Yinyu Wang ◽  
Yicong Meng ◽  
Lei Chen ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Birth Weight ◽  
Preterm Infants ◽  
Gestational Age ◽  
Paternal Age ◽  
Large For Gestational Age ◽  
Term Infants ◽  
Advanced Paternal Age ◽  
Increased Risk ◽  
Infant Birth

PurposeWhile it is well documented that maternal adverse exposures contribute to a series defects on offspring health according to the Developmental Origins of Health and Disease (DOHaD) theory, paternal evidence is still insufficient. Advanced paternal age is associated with multiple metabolism and psychiatric disorders. Birth weight is the most direct marker to evaluate fetal growth. Therefore, we designed this study to explore the association between paternal age and birth weight among infants born at term and preterm (&lt;37 weeks gestation).MethodsA large retrospective study was conducted using population-based hospital data from January 2015 to December 2019 that included 69,964 cases of singleton infant births with complete paternal age data. The primary outcome was infant birth weight stratified by sex and gestational age including small for gestational age (SGA, 10th percentile) and large for gestational age (LGA, 90th percentile). Birth weight percentiles by gestational age were based on those published in the INTERGROWTH-21st neonatal weight-for gestational-age standard. Logistic regression analysis and linear regression model were used to estimate the association between paternal age and infant birth weight.ResultsAdvanced paternal age was associated with a higher risk for a preterm birth [35–44 years: adjusted odds ratio (OR) = 1.13, 95%CI (1.03 to 1.24); &gt;44 years: OR = 1.36, 95%CI (1.09 to 1.70)]. Paternal age exerted an opposite effect on birth weight with an increased risk of SGA among preterm infants (35–44years: OR = 1.85, 95%CI (1.18 to 2.89) and a decreased risk among term infant (35–44years: OR = 0.81, 95%CI (0.68 to 0.98); &gt;44 years: OR = 0.50, 95%CI (0.26 to 0.94). U-shaped associations were found in that LGA risk among term infants was higher in both younger (&lt;25 years) (OR = 1.32; 95%CI, 1.07 to 1.62) and older (35–44 years) (OR = 1.07; 95% CI, 1.01 to 1.14) fathers in comparison to those who were 25 to 34 years old at the time of delivery.ConclusionsOur study found advanced paternal age increased the risk of SGA among preterm infants and for LGA among term infants. These findings likely reflect a pathophysiology etiology and have important preconception care implications and suggest the need for antenatal monitoring.

Effects of Violence on Trauma among Immigrant Women from Central America

2020 ◽  
Author(s):  
Arlette Vila ◽  
Elizabeth C Pomeroy
Keyword(s):  
Central America ◽  
Low Socioeconomic Status ◽  
Immigrant Women ◽  
Country Of Origin ◽  
The United States ◽  
Hierarchical Regression ◽  
Trauma Symptoms ◽  
Low Socioeconomic ◽  
Hierarchical Regression Model ◽  
Effects Of Violence

Abstract The purpose of the study was to explore the effects of violence on trauma among forced-immigrant women from the northern triangle of Central America (NTCA) resulting from direct and indirect violence in their country of origin and during the migratory journey through Mexico. In trauma theory the concept of compounding stressors is an important framework for understanding aspects of human development, especially among low-socioeconomic-status and oppressed populations. Authors hypothesized that violence would have an impact on trauma and conducted interviews with 108 women ages 18 to 65 from the NTCA who traveled by land across Mexico before entering the United States. A survey instrument captured demographic information and types of violence experienced in the home country and during the migratory journey. A standardized screening tool was used to measure trauma symptoms. A hierarchical regression model for trauma was entered in the following order: (a) demographics and (b) violence. Violence was found to be a significant predictor for trauma. Findings suggest that having experienced violence in the country of origin and through the migratory journey had a powerful role in predicting trauma symptoms among immigrant women from the NTCA.

scholarly journals Swedish intrauterine growth reference ranges for estimated fetal weight

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Linda Lindström ◽  
Mårten Ageheim ◽  
Ove Axelsson ◽  
Laith Hussain-Alkhateeb ◽  
Alkistis Skalkidou ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Postnatal Growth ◽  
Fetal Weight ◽  
Hierarchical Regression ◽  
Reference Ranges ◽  
Hierarchical Regression Model ◽  
Gestational Week ◽  
Prospective Longitudinal ◽  
Estimate Fetal Weight ◽  
Estimated Fetal Weight

AbstractFetal growth restriction is a strong risk factor for perinatal morbidity and mortality. Reliable standards are indispensable, both to assess fetal growth and to evaluate birthweight and early postnatal growth in infants born preterm. The aim of this study was to create updated Swedish reference ranges for estimated fetal weight (EFW) from gestational week 12–42. This prospective longitudinal multicentre study included 583 women without known conditions causing aberrant fetal growth. Each woman was assigned a randomly selected protocol of five ultrasound scans from gestational week 12 + 3 to 41 + 6. Hadlock’s 3rd formula was used to estimate fetal weight. A two-level hierarchical regression model was employed to calculate the expected median and variance, expressed in standard deviations and percentiles, for EFW. EFW was higher for males than females. The reference ranges were compared with the presently used Swedish, and international reference ranges. Our reference ranges had higher EFW than the presently used Swedish reference ranges from gestational week 33, and higher median, 2.5th and 97.5th percentiles from gestational week 24 compared with INTERGROWTH-21st. The new reference ranges can be used both for assessment of intrauterine fetal weight and growth, and early postnatal growth in children born preterm.

Sign in / Sign up

Export Citation Format

Share Document