scholarly journals Depression, violence and cortisol awakening response: a 3-year longitudinal study in adolescents

2018 ◽  
Vol 49 (6) ◽  
pp. 997-1004 ◽  
Author(s):  
Rongqin Yu ◽  
Susan Branje ◽  
Wim Meeus ◽  
Philip Cowen ◽  
Seena Fazel
Keyword(s):  
Depressive Symptoms ◽  
Stressful Life Events ◽  
Community Sample ◽  
Area Under The Curve ◽  
Biological Marker ◽  
Cortisol Awakening Response ◽  
Cortisol Reactivity ◽  
Two Measures ◽  
Time Invariant ◽  
Invariant Factors

AbstractBackgroundDespite evidence of links between depression and violent outcomes, potential moderators of this association remain unknown. The current study tested whether a biological marker, cortisol, moderated this association in a longitudinal sample of adolescents.MethodsParticipants were 358 Dutch adolescents (205 boys) with a mean age of 15 years at the first measurement. Depressive symptoms, the cortisol awakening response (CAR) and violent outcomes were measured annually across 3 years. The CAR was assessed by two measures: waking cortisol activity (CAR area under the curve ground) and waking cortisol reactivity (CAR area under the curve increase). Within-individual regression models were adopted to test the interaction effects between depressive symptoms and CAR on violent outcomes, which accounted for all time-invariant factors such as genetic factors and early environments. We additionally adjusted for time-varying factors including alcohol drinking, substance use and stressful life events.ResultsIn this community sample, 24% of adolescents perpetrated violent behaviours over 3 years. We found that CAR moderated the effects of depressive symptoms on adolescent violent outcomes (βs ranged from −0.12 to −0.28). In particular, when the CAR was low, depressive symptoms were positively associated with violent outcomes in within-individual models, whereas the associations were reversed when the CAR was high.ConclusionsOur findings suggest that the CAR should be investigated further as a potential biological marker for violence in adolescents with high levels of depressive symptoms.

Interpersonal Stress Generation—A Girl Problem? The Role of Depressive Symptoms, Dysfunctional Attitudes, and Gender in Early Adolescent Stress Generation

2017 ◽  
Vol 39 (1) ◽  
pp. 41-66 ◽  
Author(s):  
Susanne Meiser ◽  
Günter Esser
Keyword(s):  
Depressive Symptoms ◽  
Stressful Life Events ◽  
Depressive Symptomatology ◽  
Community Sample ◽  
Dysfunctional Attitudes ◽  
Stress Generation ◽  
Interpersonal Stress ◽  
German Children ◽  
And Gender

To provide further insight into stress generation patterns in boys and girls around puberty, this study investigated longitudinal reciprocal relations between depressive symptoms, dysfunctional attitudes, and stress generation, the process by which individuals contribute to the occurrence of stress in interpersonal contexts (e.g., problematic social interactions) or in noninterpersonal contexts (e.g., achievement problems). A community sample of N = 924 German children and early adolescents (51.8% male) completed depressive symptoms and dysfunctional attitudes measures at T1 and again 20 months later (T2). Stressful life events were reported at T2. Dysfunctional attitudes were unrelated to stress generation. Interpersonal, but not noninterpersonal, dependent stress partially mediated the relationship between initial and later depressive symptoms, with girls being more likely to generate interpersonal stress in response to depressive symptoms. Findings underscore the role of interpersonal stress generation in the early development of depressive symptomatology, and in the gender difference in depression prevalence emerging around puberty.

scholarly journals Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls

2015 ◽  
Vol 28 (1) ◽  
pp. 97-109 ◽  
Author(s):  
Lucy Riglin ◽  
Stephan Collishaw ◽  
Katherine H. Shelton ◽  
I. C. McManus ◽  
Terry Ng-Knight ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Cognitive Ability ◽  
Cognitive Processing ◽  
Stressful Life Events ◽  
Depressive Symptomatology ◽  
Causal Effect ◽  
Community Sample ◽  
Familial Risk ◽  
Data Sets ◽  
Cognitive Operations

AbstractStress has been shown to have a causal effect on risk for depression. We investigated the role of cognitive ability as a moderator of the effect of stressful life events on depressive symptoms and whether this varied by gender. Data were analyzed in two adolescent data sets: one representative community sample aged 11–12 years (n = 460) and one at increased familial risk of depression aged 9–17 years (n = 335). In both data sets, a three-way interaction was found whereby for girls, but not boys, higher cognitive ability buffered the association between stress and greater depressive symptoms. The interaction was replicated when the outcome was a diagnosis of major depressive disorder. This buffering effect in girls was not attributable to coping efficacy. However, a small proportion of the variance was accounted for by sensitivity to environmental stressors. Results suggest that this moderating effect of cognitive ability in girls is largely attributable to greater available resources for cognitive operations that offer protection against stress-induced reductions in cognitive processing and cognitive control which in turn reduces the likelihood of depressive symptomatology.

Neuroticism, social network, stressful life events: Association with mood disorders, depressive symptoms and suicidal ideation in a community sample of women

2015 ◽  
Vol 226 (1) ◽  
pp. 38-44 ◽  
Author(s):  
Laura Mandelli ◽  
Finiki A. Nearchou ◽  
Chrysostomos Vaiopoulos ◽  
Costas N. Stefanis ◽  
Silia Vitoratou ◽  
...  
Keyword(s):  
Social Network ◽  
Depressive Symptoms ◽  
Suicidal Ideation ◽  
Mood Disorders ◽  
Life Events ◽  
Stressful Life Events ◽  
Community Sample ◽  
Stressful Life

scholarly journals Examining associations between internalizing behaviour, cortisol reactivity, and physiological coordination, in two differentially potent challenges

2021 ◽  
Author(s):  
Jennifer Khoury
Keyword(s):  
Depressive Symptoms ◽  
Hierarchical Linear Modeling ◽  
Internalizing Problems ◽  
Allostatic Load ◽  
Child Behavior Checklist ◽  
Stress Test ◽  
Community Sample ◽  
Trier Social Stress Test ◽  
Cortisol Reactivity ◽  
The Impact

Background: Research examining associations between child internalizing behaviours and cortisol reactivity is equivocal, with studies suggesting positive, negative and non-significant associations. The present study assessed three primary confounds that contribute to these inconsistencies: 1) the differential effectiveness of laboratory challenges in eliciting cortisol reactivity; 2) the impact of coordination between the Hypothalamic-Pituitary-Adrenal axis and the Sympathetic-Adrenal-Medullary system (assessed via salivary alpha-amylase (sAA)); and 3) variation in the measurement of internalizing behaviour, specifically, parent versus child ratings. The primary aims of this study were to assess internalizing behaviours in relation to both cortisol reactivity and coordination between cortisol and sAA, measured in two distinct challenges. Method: A community sample of 8-10 year olds (N= 52) participated in two laboratory challenges, across two study sessions: 1) the Trier Social Stress Test-Child Version (TSST-C), a potent social-evaluative challenge, and 2) a less-potent competition challenge, composed of a puzzle and mirror-tracing task. Saliva was collected at several time points before and after each challenge. Saliva was later assayed to extract cortisol and sAA. Child-reported depressive symptoms were assessed using the Child Depression Inventory, and maternal-reported internalizing problems were assessed using the Child Behavior Checklist. Multilevel modelling was conducted using Hierarchical Linear Modeling. Results: In the TSST-C, child-reported depressive symptoms were significantly associated with a declining cortisol trajectory. Maternal-reported internalizing problems were not associated with cortisol and internalizing behaviour did not moderate the impact of sAA levels on cortisol levels (i.e., coordination) in the TSST-C. With regards to the competition challenge, maternal-reported internalizing behaviours predicted cortisol-sAA coordination, such that children with more internalizing behaviours who experienced higher sAA levels also had higher cortisol reactivity. However, there were no significant associations between child-reported depressive symptoms, cortisol reactivity, or coordination between sAA and cortisol reactivity in the competition challenge. Conclusions: Results are discussed in the context of allostatic load and in relation to theories of physiological coordination. These findings underscore the importance of differential stressor contexts, physiological coordination, and the informant of internalizing behaviours moderating associations between internalizing behaviour and cortisol reactivity. Future research should integrate these factors in models of physiological stress and developmental psychopathology.

scholarly journals Childhood adversity moderates the influence of proximal episodic stress on the cortisol awakening response and depressive symptoms in adolescents

2017 ◽  
Vol 29 (5) ◽  
pp. 1877-1893 ◽  
Author(s):  
Lisa R. Starr ◽  
Kimberly Dienes ◽  
Catherine B. Stroud ◽  
Zoey A. Shaw ◽  
Y. Irina Li ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Life Stress ◽  
Allostatic Load ◽  
Area Under The Curve ◽  
Childhood Adversity ◽  
Cortisol Awakening Response ◽  
Cortisol Secretion ◽  
Depression Risk ◽  
Episodic Stress ◽  
Pituitary Adrenal Axis

AbstractChildhood adversity (CA) is known to predict sensitization to proximal stressors. Researchers have suggested that disruptions in hypothalamus–pituitary–adrenal axis functioning may be a biological mechanism. If so, CA may predict altered associations between proximal life stress and markers of cortisol secretion. We examined whether CA moderates associations between recent episodic stress and (a) the cortisol awakening response (CAR), and (b) depressive symptoms, in 241 adolescents aged 14–17 years (cortisoln= 196). Salivary cortisol was sampled at 0, 30, and 60 min postawakening for 2 days. The CAR was calculated as the area under the curve with respect to increase and waking cortisol. CA and episodic stress were assessed using contextual-threat-method-coded objective interviews. CA significantly interacted with episodic stress to predict both the CAR and depression. Among those with low CA, episodic stress predicted increased CAR but did not predict depression. For adolescents with high CA, episodic stress predicted lower CAR and higher depression. These interactions were found only for independent (uncontrollable, fateful) events, and not for dependent (self-generated) stress. Increased allostatic load resulting from CA exposure may interfere with adolescents' ability to optimally regulate their CAR in relation to recent stress, contributing to increased depression risk.

scholarly journals Examining associations between internalizing behaviour, cortisol reactivity, and physiological coordination, in two differentially potent challenges

2021 ◽  
Author(s):  
Jennifer Khoury
Keyword(s):  
Depressive Symptoms ◽  
Hierarchical Linear Modeling ◽  
Internalizing Problems ◽  
Allostatic Load ◽  
Child Behavior Checklist ◽  
Stress Test ◽  
Community Sample ◽  
Trier Social Stress Test ◽  
Cortisol Reactivity ◽  
The Impact

Background: Research examining associations between child internalizing behaviours and cortisol reactivity is equivocal, with studies suggesting positive, negative and non-significant associations. The present study assessed three primary confounds that contribute to these inconsistencies: 1) the differential effectiveness of laboratory challenges in eliciting cortisol reactivity; 2) the impact of coordination between the Hypothalamic-Pituitary-Adrenal axis and the Sympathetic-Adrenal-Medullary system (assessed via salivary alpha-amylase (sAA)); and 3) variation in the measurement of internalizing behaviour, specifically, parent versus child ratings. The primary aims of this study were to assess internalizing behaviours in relation to both cortisol reactivity and coordination between cortisol and sAA, measured in two distinct challenges. Method: A community sample of 8-10 year olds (N= 52) participated in two laboratory challenges, across two study sessions: 1) the Trier Social Stress Test-Child Version (TSST-C), a potent social-evaluative challenge, and 2) a less-potent competition challenge, composed of a puzzle and mirror-tracing task. Saliva was collected at several time points before and after each challenge. Saliva was later assayed to extract cortisol and sAA. Child-reported depressive symptoms were assessed using the Child Depression Inventory, and maternal-reported internalizing problems were assessed using the Child Behavior Checklist. Multilevel modelling was conducted using Hierarchical Linear Modeling. Results: In the TSST-C, child-reported depressive symptoms were significantly associated with a declining cortisol trajectory. Maternal-reported internalizing problems were not associated with cortisol and internalizing behaviour did not moderate the impact of sAA levels on cortisol levels (i.e., coordination) in the TSST-C. With regards to the competition challenge, maternal-reported internalizing behaviours predicted cortisol-sAA coordination, such that children with more internalizing behaviours who experienced higher sAA levels also had higher cortisol reactivity. However, there were no significant associations between child-reported depressive symptoms, cortisol reactivity, or coordination between sAA and cortisol reactivity in the competition challenge. Conclusions: Results are discussed in the context of allostatic load and in relation to theories of physiological coordination. These findings underscore the importance of differential stressor contexts, physiological coordination, and the informant of internalizing behaviours moderating associations between internalizing behaviour and cortisol reactivity. Future research should integrate these factors in models of physiological stress and developmental psychopathology.

scholarly journals Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence

2019 ◽  
Vol 50 (9) ◽  
pp. 1548-1555 ◽  
Author(s):  
Brandon L. Goldstein ◽  
Ellen M. Kessel ◽  
Autumn Kujawa ◽  
Megan C. Finsaas ◽  
Joanne Davila ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Life Events ◽  
Stressful Life Events ◽  
Community Sample ◽  
Reward Processing ◽  
Event Related Potential ◽  
Self Report ◽  
Stressful Life ◽  
Depression Symptoms

AbstractBackgroundReward processing deficits have been implicated in the etiology of depression. A blunted reward positivity (RewP), an event-related potential elicited by feedback to monetary gain relative to loss, predicts new onsets and increases in depression symptoms. Etiological models of depression also highlight stressful life events. However, no studies have examined whether stressful life events moderate the effect of the RewP on subsequent depression symptoms. We examined this question during the key developmental transition from childhood to adolescence.MethodsA community sample of 369 children (mean age of 9) completed a self-report measure of depression symptoms. The RewP to winning v. losing was elicited using a monetary reward task. Three years later, we assessed stressful life events occurring in the year prior to the follow-up. Youth depressive symptoms were rated by the children and their parents at baseline and follow-up.ResultsStressful life events moderated the effect of the RewP on depression symptoms at follow-up such that a blunted RewP predicted higher depression symptoms in individuals with higher levels of stressful life events. This effect was also evident when events that were independent of the youth's behavior were examined separately.ConclusionsThese results suggest that the RewP reflects a vulnerability for depression that is activated by stress.

scholarly journals Low levels of morning salivary α-amylase activity predict higher number of depressive symptoms in a community sample of children

2018 ◽  
Vol 34 (2) ◽  
pp. 224
Author(s):  
Enrique Francisco Maldonado Montero ◽  
María Eugenia Fernández Martín ◽  
María Victoria Trianes Torres ◽  
Carmen Ortiz García ◽  
Alfredo Engüix ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Depressive Disorders ◽  
Community Sample ◽  
Biological Marker ◽  
Depressive Illness ◽  
First Episode ◽  
Morning Cortisol ◽  
Teacher’S Report Form ◽  
Low Levels ◽  
Depressive Episodes

<p>Models of the etiology of depressive disorders suggest that the onset of a depressive episode is the result of a complex phenomenon based on the interaction between genetic background, critical environmental factors such as life stressors and traumatic events, and the effects of neuroendocrine changes associated with the stress response. Numerous studies have highlighted the usefulness of morning cortisol (C) as a potential predictor of depressive episodes. The aim of this study was to compare the effectiveness of C, salivary alpha-amylase (sAA) activity/output, and the sAA/C ratio in predicting depressive symptoms in a community sample of 99 children aged 8-11 years old. Two saliva samples were obtained in the morning on two different school days. Teachers described their pupils' behavior by using the internalizing problems scales of the <em>Teacher’s Report Form</em> (TRF) questionnaire. Our results indicate that, regardless of gender, the best predictor of depressive/withdrawal scores and overall internalizing scores on the TRF was lower mean morning levels of sAA activity. Hence, sAA could be proposed as a biological marker for the risk of developing a first episode of depressive illness in child samples. </p>

scholarly journals Inflammation and the Association of Vitamin D and Depressive Symptomatology

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1972
Author(s):  
Ezgi Dogan-Sander ◽  
Roland Mergl ◽  
Anja Willenberg ◽  
Ronny Baber ◽  
Kerstin Wirkner ◽  
...  
Keyword(s):  
Vitamin D ◽  
Depressive Symptoms ◽  
Inflammatory Markers ◽  
Depressive Symptomatology ◽  
Community Sample ◽  
Significant Negative Correlation ◽  
Vitamin D Supplementation ◽  
Complex Relationship ◽  
Moderation Effect ◽  
Mediation Analyses

Depression and vitamin D deficiency are major public health problems. The existing literature indicates the complex relationship between depression and vitamin D. The purpose of this study was to examine whether this relationship is moderated or mediated by inflammation. A community sample (n = 7162) from the LIFE-Adult-Study was investigated, for whom depressive symptoms were assessed via the German version of CES-D scale and serum 25-hydroxyvitamin D (25(OH)D) levels and inflammatory markers (IL-6 and CRP levels, WBC count) were quantified. Mediation analyses were performed using Hayes’ PROCESS macro and regression analyses were conducted to test moderation effects. There was a significant negative correlation between CES-D and 25(OH)D, and positive associations between inflammatory markers and CES-D scores. Only WBC partially mediated the association between 25(OH)D levels and depressive symptoms both in a simple mediation model (ab: −0.0042) and a model including covariates (ab: −0.0011). None of the inflammatory markers showed a moderation effect on the association between 25(OH)D levels and depressive symptoms. This present work highlighted the complex relationship between vitamin D, depressive symptoms and inflammation. Future studies are needed to examine the effect of vitamin D supplementation on inflammation and depressive symptomatology for causality assessment.

scholarly journals The role of environmental sensitivity in the development of rumination and depressive symptoms in childhood: a longitudinal study

2021 ◽  
Author(s):  
Francesca Lionetti ◽  
Daniel N. Klein ◽  
Massimiliano Pastore ◽  
Elaine N. Aron ◽  
Arthur Aron ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Parenting Style ◽  
Middle Childhood ◽  
Internalizing Problems ◽  
Depressive Symptomatology ◽  
Community Sample ◽  
Healthy Children ◽  
Environmental Sensitivity ◽  
Permissive Parenting

AbstractSome children are more affected than others by their upbringing due to their increased sensitivity to the environment. More sensitive children are at heightened risk for the development of internalizing problems, particularly when experiencing unsupportive parenting. However, little is known about how the interplay between children’s sensitivity and parenting leads to higher levels of depressive symptoms. In the current study, we investigated the interaction between early parenting and children’s sensitivity on levels of depressive symptomatology in middle childhood, exploring the role of rumination as a possible mediator in a community sample. Participants included 196 USA resident families, from a middle class and mostly European–American background, and their healthy children, followed up from age 3 until 9 and 12 years. Environmental sensitivity was assessed observationally when children were 3 years old. Parenting style was based on parent-report at the age of 3 years. When children were nine, they completed questionnaires on rumination and depressive symptoms (repeated at 12 years). Analyses were run applying a Bayesian approach. Children’s sensitivity interacted with permissive parenting in predicting rumination at age 9. Rumination, in turn, was associated with depressive symptoms at age 9 and, to a lesser extent, at age 12. No relevant interactions emerged for authoritative and authoritarian parenting. Sensitive children may be at heightened risk for internalizing problems when exposed to a permissive parenting style. Permissive parenting was associated with increased ruminative coping strategies in sensitive children which, in turn, predicted higher levels of depression. Hence, rumination emerged as an important cognitive risk factor for the development of depressive symptoms in sensitive children.

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