The Role of VLBI in the Establishment of Coordinate Systems

1975 ◽  
Vol 26 ◽  
pp. 293-295 ◽  
Author(s):  
I. Zhongolovitch
Keyword(s):  
General Solution ◽  
Future Development ◽  
Rational Approach ◽  
Radio Telescopes ◽  
Coordinate Systems ◽  
Tectonic Plates ◽  
Astronomical Observations ◽  
Optical Instruments ◽  
Fundamental Polyhedron

Considering the future development and general solution of the problem under consideration and also the high precision attainable by astronomical observations, the following procedure may be the most rational approach:1. On the main tectonic plates of the Earth’s crust, powerful movable radio telescopes should be mounted at the same points where standard optical instruments are installed. There should be two stations separated by a distance of about 6 to 8000 kilometers on each plate. Thus, we obtain a fundamental polyhedron embracing the whole Earth with about 10 to 12 apexes, and with its sides represented by VLBI.

A Comparative Study of 1D Descriptors Supported CoMFA and CoMSIA QSAR Models to Gain Novel Insights into 1,2,4-Triazoles Acting As Antitubercular Agents

2020 ◽  
Vol 16 ◽  
Author(s):  
Rajdeep Ray ◽  
Gautham Shenoy ◽  
N V Ganesh Kumar Tummalapalli
Keyword(s):  
External Validation ◽  
Antitubercular Activity ◽  
New Drugs ◽  
Rational Approach ◽  
Antitubercular Drugs ◽  
Comfa Model ◽  
Qsar Models ◽  
Structural Insights ◽  
The Way

: Tuberculosis is one of the leading cause for deaths due to infectious disease worldwide. There is an urgent need for developing new drugs due to the rising incidents of drug resistance. Triazoles have previously been reported to show antitubercular activity. Various computational tools pave the way for a rational approach in understanding the structural importance of these compounds in inhibiting Mycobacterium tuberculosis growth. The aim of this study is to develop and compare two different QSAR models based on a set of previously reported molecules and use the best one for gaining structural insights in to the Triazole molecules. In the current study, two separate models were generated with CoMFA and CoMSIA descriptors respectively based on a dataset of triazole molecules showing antitubercular activity. Several one dimensional (1D) descriptors were added to each of the models and the validation results and the contour data generated from them were compared. The best model was studied to give a detailed understanding of the triazole molecules and their role in the antitubercular activity.The r2, q2, predicted r2 and SEP (Standard error of prediction) for the CoMFA model were 0.866, 0.573, 0.119 and 0.736 respectively and for the CoMSIA model the r2, q2, predicted r2 and SEP were calculated to be 0.998, 0.634, 0.013 and 0.869 respectively. Although both the QSAR models produced acceptable internal and external validation scores but the CoMSIA results were significantly better. The CoMSIA contours also provided a better match than CoMFA with most of the features of the active compound 30b. Hence, the CoMSIA model was chosen and its contours were explored for gaining structural insights on the triazole molecules. The CoMSIA contours helped us to understand the role of several atoms and groups of the triazole molecules in their biological activity. The possibilities for substitution in the triazole compounds that would enhance the activity were also analysed. Thus, this study paves the way for designing new antitubercular drugs in future.

THE INFLUENCE OF TANEYEV’S STYLISTIC PRINCIPLES ON RUSSIAN CHORAL MUSIC OF THE XXTH CENTURY

2020 ◽  
Vol 1 (2) ◽  
pp. 75-80
Author(s):  
V. P. Tereshchenko ◽  
Keyword(s):  
Choral Music ◽  
Compositional Style ◽  
Rational Approach ◽  
A Cappella ◽  
Unique Combination ◽  
Xxth Century ◽  
Leading Role ◽  
Baroque Music ◽  
Special Area

The article touches upon the unique combination of Taneyev’s stylistic principles, which consists in an organic synthesis of protective and innovative features. Taneyev consciously turns to the polyphony of strictly writing, Baroque music and Viennese classicism in forming his own individual compositional style. The paradox is that Taneyev acted as an innovator who foresaw a vision for the future of music through the prism of the distant past. Stylistic principles such as historicism of thinking, rational approach to creativity and leading role of counterpoint forms became the basis of new trends in music art of the XXth century. A special area of the composer's innovative achievements is choral music. Taneyev founded of a number of genre trends that developed in the XXth century, among them a lyrical-philosophical cantata, "spiritual concert" vocal-instrumental and symphonic music, a choral a cappella cycle to secular text.

scholarly journals THE ROLE OF INLAND WATERWAY NAVIGATION IN A SUSTAINABLE TRANSPORT SYSTEM

Transport ◽  
2007 ◽  
Vol 22 (3) ◽  
pp. 148-153 ◽  
Author(s):  
József Rohács ◽  
Győző Simongáti
Keyword(s):  
Sustainable Development ◽  
Future Development ◽  
Great Part ◽  
Road Transport ◽  
Sustainable Transport ◽  
Modal Shift ◽  
Guiding Principle ◽  
Inland Waterway ◽  
Total Transport

Sustainable development has become a guiding principle of human activities nowadays. Sustainable transport can take a great part in future development. Today this is not the case, and road transport contributes to this above all. For sustainable transport development the necessity of modal shift is inevitable and the inland waterway navigation should get the higher share of the total transport where there is an alternative. This presentation shows the reasons why the inland waterway navigation can increase the level of sustainability.

scholarly journals Anti-Human Trafficking Campaigns

2018 ◽  
Vol 24 (2) ◽  
pp. 104-122 ◽  
Author(s):  
Natalia Szablewska ◽  
Krzysztof Kubacki
Keyword(s):  
Literature Review ◽  
Human Trafficking ◽  
Social Marketing ◽  
Systematic Literature Review ◽  
Thematic Analysis ◽  
Future Development ◽  
Evidence Base ◽  
Vulnerable Groups ◽  
The Future

This study aims to systematically identify and review studies on anti-human trafficking campaigns published in peer-reviewed journals to determine the extent to which such campaigns have been critically and rigorously evaluated so as to guide future policies and practice in this area and to identify the main characteristics, problems, and challenges associated with the campaigns in the identified studies. This systematic literature review identified 16 studies that have assessed anti-human trafficking campaigns but found that none of these included outcome, process, or impact evaluations. As identified in our study, anti-human trafficking campaigns tend to rely on advertising techniques to target vulnerable groups and the wider public, with the primary aim of informing and educating. Further, a thematic analysis of the studies identified problems in eight areas that require attention in the future development of anti-human trafficking campaigns: stereotyping, compounding human trafficking with migration, conflating prostitution with human trafficking, sexualization/erotization of women, victimization, role of anti-human trafficking organizations, data shortcomings, and oversimplification of human trafficking. Studies presenting the results of evaluations of social marketing anti-human trafficking campaigns are urgently needed to show which social marketing tools work and to provide an evidence base for future campaigns.

scholarly journals Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications

Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 892 ◽  
Author(s):  
Iva Hoffmanová ◽  
Daniel Sánchez ◽  
Ludmila Tučková ◽  
Helena Tlaskalová-Hogenová
Keyword(s):  
Celiac Disease ◽  
Liver Diseases ◽  
Tissue Transglutaminase ◽  
Intestinal Barrier ◽  
Rational Approach ◽  
Liver Disorders ◽  
Tissue Transglutaminase Antibodies ◽  
Elevated Transaminases ◽  
Made In

Immunologically mediated liver diseases belong to the common extraintestinal manifestations of celiac disease. We have reviewed the current literature that addresses the association between celiac disease and liver disorders. We searched relevant articles on MEDLINE/PubMed up to 15 June 2018. The objective of the article is to provide a comprehensive and up-to-date review on the latest hypotheses explaining the pathogenetic relationship between celiac disease and liver injury. Besides the involvement of gut–liver axis, tissue transglutaminase antibodies, and impairment of intestinal barrier, we integrate the latest achievements made in elucidation of the role of gut microbiota in celiac disease and liver disorders, that has not yet been sufficiently discussed in the literature in this context. The further objective is to provide a complete clinical overview on the types of liver diseases frequently found in celiac disease. In conclusion, the review highlights the clinical implication, recommend a rational approach for managing elevated transaminases in celiac patients, and underscore the importance of screening for celiac disease in patients with associated liver disease.

Stresses in Marine Propellers

1974 ◽  
Vol 18 (04) ◽  
pp. 252-264 ◽  
Author(s):  
James H. Ma
Keyword(s):  
Finite Element ◽  
General Solution ◽  
Arbitrary Shape ◽  
Rational Approach ◽  
Experimental Stress ◽  
Structural Configuration ◽  
Marine Propellers ◽  
Present Procedure ◽  
Plate And Shell ◽  
Displacement Model

A rational approach to the general solution of the propeller strength problem is established. A finite-element displacement model is utilized to predict the behavior of an elastic body having an arbitrary shape and subjected to prescribed loading. Solid elements in their general form are adopted. This formulation bypasses the constraints of simplified assumptions commonly employed by many classical plate and shell theories, and allows a more realistic approximation to the true structural configuration than is possible by most other conventional approaches. The application of the present procedure is simple and straight-forward. Good agreements with measured displacements and experimental stress data were obtained for a highly skewed blade as well as a supercavitating blade.

scholarly journals Interplay between Peptidoglycan Biology and Virulence in Gram-Negative Pathogens

2018 ◽  
Vol 82 (4) ◽  
Author(s):  
Carlos Juan ◽  
Gabriel Torrens ◽  
Isabel Maria Barceló ◽  
Antonio Oliver
Keyword(s):  
Antimicrobial Resistance ◽  
Future Development ◽  
Essential Role ◽  
Therapeutic Options ◽  
Multiple Perspectives ◽  
Weak Point ◽  
Gram Negative ◽  
Severe Infections ◽  
Previous Step

SUMMARYThe clinical and epidemiological threat of the growing antimicrobial resistance in Gram-negative pathogens, particularly for β-lactams, the most frequently used and relevant antibiotics, urges research to find new therapeutic weapons to combat the infections caused by these microorganisms. An essential previous step in the development of these therapeutic solutions is to identify their potential targets in the biology of the pathogen. This is precisely what we sought to do in this review specifically regarding the barely exploited field analyzing the interplay among the biology of the peptidoglycan and related processes, such as β-lactamase regulation and virulence. Hence, here we gather, analyze, and integrate the knowledge derived from published works that provide information on the topic, starting with those dealing with the historically neglected essential role of the Gram-negative peptidoglycan in virulence, including structural, biogenesis, remodeling, and recycling aspects, in addition to proinflammatory and other interactions with the host. We also review the complex link between intrinsic β-lactamase production and peptidoglycan metabolism, as well as the biological costs potentially associated with the expression of horizontally acquired β-lactamases. Finally, we analyze the existing evidence from multiple perspectives to provide useful clues for identifying targets enabling the future development of therapeutic options attacking the peptidoglycan-virulence interconnection as a key weak point of the Gram-negative pathogens to be used, if not to kill the bacteria, to mitigate their capacity to produce severe infections.

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