Association of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis

Abstract Hypertension is a common comorbidity in COVID-19 patients. However, the association of hypertension with the severity and fatality of COVID-19 remain unclear. In the present meta-analysis, relevant studies reported the impacts of hypertension on SARS-CoV-2 infection were identified by searching PubMed, Elsevier Science Direct, Web of Science, Wiley Online Library, Embase and CNKI up to 20 March 2020. As the results shown, 12 publications with 2389 COVID-19 patients (674 severe cases) were included for the analysis of disease severity. The severity rate of COVID-19 in hypertensive patients was much higher than in non-hypertensive cases (37.58% vs 19.73%, pooled OR: 2.27, 95% CI: 1.80–2.86). Moreover, the pooled ORs of COVID-19 severity for hypertension vs. non-hypertension was 2.21 (95% CI: 1.58–3.10) and 2.32 (95% CI: 1.70–3.17) in age <50 years and ⩾50 years patients, respectively. Additionally, six studies with 151 deaths of 2116 COVID-19 cases were included for the analysis of disease fatality. The results showed that hypertensive patients carried a nearly 3.48-fold higher risk of dying from COVID-19 (95% CI: 1.72–7.08). Meanwhile, the pooled ORs of COVID-19 fatality for hypertension vs. non-hypertension was 6.43 (95% CI: 3.40–12.17) and 2.66 (95% CI: 1.27–5.57) in age <50 years and ⩾50 years patients, respectively. Neither considerable heterogeneity nor publication bias was observed in the present analysis. Therefore, our present results provided further evidence that hypertension could significantly increase the risks of severity and fatality of SARS-CoV-2 infection.

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A Meta-Analytic Review of Moral Disengagement and Cyberbullying

Frontiers in Psychology ◽

10.3389/fpsyg.2021.681299 ◽

2021 ◽

Vol 12 ◽

Author(s):

Lijun Zhao ◽

Junjian Yu

Keyword(s):

Moral Disengagement ◽

Web Of Science ◽

Meta Analysis ◽

Cultural Background ◽

Inclusion Criteria ◽

Cultural Variables ◽

Analytic Review ◽

Correlate Factor ◽

Online Library ◽

The Relationship

With the development of technology, cyberbullying prevalence rates are increasing worldwide, and a growing body of the literature has begun to document cyberbullying behavior. Moral disengagement is often considered a key correlate factor in cyberbullying. This article aims to conduct a meta-analysis review of the relationship between moral disengagement and cyberbullying and some psychosocial and cultural variables. Based on the PRISMA method, a random-effects meta-analysis is employed in this study to obtain reliable estimates of effect sizes and examine a range of moderators (age, gender, measure method, and cultural background). Relevant studies, published from 2005 to February 30, 2021, were identified through a systematic search of the Web of Science, ScienceDirect, SpringerLink, Pubmed, EBSCO, and Wiley Online Library. Finally, 38 studies (N=38,425) met the inclusion criteria. The meta-analysis conclusion demonstrated that moral disengagement positively correlated medium intensity with cyberbullying (r=0.341). Age, gender, and cultural background had moderated the relationship between moral disengagement and cyberbullying.

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Whether Remdesivir Increases the Risk of Acute Kidney Injury (AKI) in Patients with COVID-19: A Systematic Review and Meta-Analysis

10.21203/rs.3.rs-52615/v1 ◽

2020 ◽

Author(s):

Zhenjian Xu ◽

Ying Tang ◽

Qiuyan Huang ◽

Sha Fu ◽

Xiaomei Li ◽

...

Keyword(s):

Systematic Review ◽

Acute Kidney Injury ◽

Disease Severity ◽

Web Of Science ◽

Meta Analysis ◽

Kidney Injury ◽

Drug Discontinuation ◽

Common Cause ◽

Polymerase Inhibitor

Abstract Background: Acute kidney injury (AKI) occurs among patients with COVID-19, it is also proved to be associated with in-hospital mortality. Remdesivir, an RNA polymerase inhibitor, has shown its antiviral activity in vitro and animal models. The adverse effect of Remdesivir especially AKI is the most common cause which lead to drug discontinuation. Whether Remdesivir increases the risk of AKI in patients with COVID-19 is not clear. We conducted a systematic review and meta-analysis to evaluate the incidence rate of AKI in hospitalized COVID-19 patients and whether Remdesivir increases the risk of AKI. Methods: A thorough search was carried out to find relevant studies in PubMed, medRxiv, and Web of Science from 1 Jan 2020 till 1 June 2020. 15135 COVID-19 patients and 981 COVID-19 patients using Remdesivir were included in our meta-analysis. Results: The pooled estimated incidence of AKI in all hospitalized COVID-19 patients was 12.0% (95% CI:9.0%-15.0%). According to our subgroup study, the incidence of AKI was associated with the age, disease severity and race of patients. The incidence of AKI in hospitalized COVID-19 patients using Remdesivir was 6% (95% CI: 3%-13%) with a total of 5 studies. Comparing with COVID-19 patients without Remdesivir treatment, Remdesivir treatment do not increase the risk of AKI in COVID-19 patients showing OR 0.80(95%CI: 0.44-1.46, P>0.05). Conclusions: We found out that AKI was not rare in hospitalized COVID-19 patients. The incidence of AKI was associated with age, disease severity and race. Remdesivir treatment did not increase the risk of AKI in hospitalized COVID-19 patients. Our meta-analysis may provide an evidence for future study that AKI is associated with the natural cause of COVID-19, not the adverse event after the usage of Remdesivir.

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Prevalence of Frailty in the Middle East: Systematic Review and Meta-Analysis

Healthcare ◽

10.3390/healthcare10010108 ◽

2022 ◽

Vol 10 (1) ◽

pp. 108

Author(s):

Bader A. Alqahtani ◽

Mohammed M. Alshehri ◽

Ragab K. Elnaggar ◽

Saad M. Alsaad ◽

Ahmed A. Alsayer ◽

...

Keyword(s):

Publication Bias ◽

Web Of Science ◽

Meta Analysis ◽

Middle Eastern ◽

Community Dwelling ◽

Point Estimate ◽

Inclusion Criteria ◽

Pooled Prevalence ◽

Regression Test ◽

Community Dwelling Older Adults

(1) We aimed to systematically search available data on the prevalence of frailty among community-dwelling elders in Middle Eastern countries. The results from available studies are cumulated to provide comprehensive evidence for the prevalence of frailty. (2) Methods: A meta-analysis was done. A literature search was carried out using PRISMA guidelines in PubMed, Web of Science, and SCOPUS websites for studies up to 2020. Inclusion criteria entailed all primary studies conducted in Middle Eastern countries on frailty in community-dwelling older adults aged 60 years and older. (3) Results: A total of 10 studies were selected for this study. Random-effects meta-analysis of nine studies indicated there was a pooled prevalence rate of 0.3924 with a standard error of 0.037. This pooled prevalence point estimate of 0.3924 was statistically significant (p < 0.001). The Egger’s regression test and the trim-fill method for detecting publication bias did not detect any evidence of publication bias in the sample of included studies. The Egger’s regression test was not statistically significant. The trim-fill method indicated zero studies were missing on either side; (4) Conclusions: The study’s findings indicate that the prevalence of frailty is higher in Middle Eastern nations. Despite indications that many of these nations’ populations are rapidly ageing, we presently lack information on the incidence of frailty in these populations; this information is essential to health, policymakers, and social care planning.

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Correlation between gastrointestinal symptoms and disease severity in patients with COVID-19: a systematic review and meta-analysis

BMJ Open Gastroenterology ◽

10.1136/bmjgast-2020-000437 ◽

2020 ◽

Vol 7 (1) ◽

pp. e000437 ◽

Cited By ~ 1

Author(s):

Jing Liu ◽

Min Cui ◽

Tao Yang ◽

Ping Yao

Keyword(s):

Systematic Review ◽

Publication Bias ◽

Disease Severity ◽

Meta Analysis ◽

Severe Disease ◽

Gastrointestinal Symptoms ◽

Exclusion Criteria ◽

Funnel Plot ◽

Gi Symptoms ◽

Significant Difference

ObjectiveTo study the correlation between gastrointestinal (GI) symptoms and disease severity in patients with COVID-19.DesignWe searched six databases including three Chinese and three English databases for all the published articles on COVID-19. Studies were screened according to inclusion and exclusion criteria. The relevant data were extracted and all the statistical analyses were performed using Revman5.3.ResultIn a meta-analysis of 9 studies, comprising 3022 patients, 479 patients (13.7%, 95% CI 0.125 to 0.149) had severe disease and 624 patients (14.7%, 95% CI 0.136 to 0.159) had GI symptoms. Of 624 patients with GI symptoms, 118 patients had severe disease (20.5%, 95% CI 0.133 to 0.276) and of 2397 cases without GI symptoms, 361 patients had severe disease (18.2%, 95% CI 0.129 to 0.235). Comparing disease severity of patients with and without GI symptoms, the results indicated: I²=62%, OR=1.21, 95% CI 0.94 to 1.56, p=0.13; there was no statistically significant difference between the two groups. The funnel plot was symmetrical with no publication bias.ConclusionCurrent results are not sufficient to demonstrate a significant correlation between GI symptoms and disease severity in patients with COVID-19.

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The prevalence of neuropathy among type 1 diabetic adolescents in Iran: a systematic review and meta-analysis

International Journal of Adolescent Medicine and Health ◽

10.1515/ijamh-2018-0223 ◽

2019 ◽

Vol 0 (0) ◽

Cited By ~ 4

Author(s):

Aminolah Vasigh ◽

Alireza Abdi ◽

Milad Borji ◽

Asma Tarjoman

Keyword(s):

Systematic Review ◽

Web Of Science ◽

Meta Analysis ◽

Analysis Data ◽

Diabetic Patients ◽

Meta Regression ◽

Meta Regression Analysis ◽

Online Library ◽

Type 1 Diabetic Patients

Abstract Introduction Neuropathy is one of the most common complications of diabetes, which causes many problems for diabetic patients. Thus, the aim of the present study was to investigate the prevalence of neuropathy among type 1 diabetic adolescents by systematic review and meta-analysis. Materials and methods This study is a systematic review and meta-analysis, which reviewed articles published from 2001 to September 1, 2018. The search process was carried out in the Google Scholar search engine and domestic and international databases such as Magiran, SID, Iranmedex, IranDoc, Medlib, PubMed, Scopus, Science Direct, Springer, Wiley Online Library, Web of Science, Ebsco and Cochrane using Persian and English keywords based on MESH conformity. All the research steps were carried out by two members of the research team who were familiar with systematic reviews and meta-analysis data, using the software CMA. Analysis of meta-regression and the use of a random effects model were introduced and analyzed. Findings When a systematic search was carried out on the reviewed articles, five of them were included in the meta-analysis phase. The sample size was 484, and the prevalence of diabetic peripheral neuropathy (DPN) in type 1 diabetic patients was 28.2% [confidence interval (CI) = 19.5–39.1]. The findings of the meta-regression analysis showed that the DPN prevalence rate decreased with increasing age (Q = 5.77 p = 0.016), and the results of more recent studies showed an increase in the DPN incidence rate (Q = 20.62, p < 0.001). Conclusion The findings of the present study revealed that although the prevalence of neuropathy in diabetic adolescents was not high, the prevalence was significant. Considering the increasing prevalence of diabetes and its impact on the health status of patients, appropriate interventions should be conducted to prevent diabetes and subsequent diabetic neuropathy.

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The effects of job satisfaction on nurses' professional status: A meta analysisHemşirelerde çalışma statüsünün iş doyumuna etkisi: Bir meta analiz çalışması

Journal of Human Sciences ◽

10.14687/jhs.v13i3.3967 ◽

2016 ◽

Vol 13 (3) ◽

pp. 4268 ◽

Cited By ~ 3

Author(s):

Filiz Kantek ◽

Handan Kartal

Keyword(s):

Job Satisfaction ◽

Sample Size ◽

Publication Bias ◽

Nurse Managers ◽

Web Of Science ◽

Meta Analysis ◽

Total Sample ◽

Clinical Nurses ◽

Working Status ◽

Ebsco Host

Job satisfaction is a prerequisite for employees to be more successful, satisfied, and productive at work as well as for institutions to attain their organizational objectives. The aim of this paper is to analyze the effects of job status on the job satisfaction of nurses. In this meta-analysis, we reviewed Turkish Medical Index, Google scholar, Council of Higher Education Thesis Center, Pubmed, EBSCO Host and Web of Science databases. A set of keyterms such as “job satisfaction”, “nurse”, “nurses”, keywords were searched both in Turkish and English. 9 studies for general satisfaction and 7 studies for both internal and external satisfaction were identified to be appropriate for inclusion criteria. Data were analyzed by CMA statistical software. In our study the total sample size for the overall satisfaction were 2314, 326 nurse managers and 1988 clinical nurses. The total sample size for both internal and external satisfaction were 1629, 246 nurse managers and 1383 clinical nurses. As a result of heterogeneity test, examined studies showed dimensions of overall, internal and external satisfaction were homogeneous. Publication bias test result showed no publication bias. According to fixed effects model impact of the working status on the job satisfaction as 95% degree of importance was calculated 0.55 for overall job satisfaction, 0.53 for internal satisfaction and 0.47 for external satisfaction. Result of this study revealed impact of the working status in favor of the nurse managers is moderate insignificant on overall, internal and external job satisfaction. Özetİş doyumu hem çalışanların başarılı, mutlu ve üretken olabilmeleri hem de kurumların amaçlarına ulaşabilmesi için önemli gereklerden biridir. Bu çalışmanın amacı çalışma statüsünün hemşirelerin iş doyumlarına etkisini analiz etmektir. Çalışmada meta analiz yöntemi kullanıldı. İş doyumu ile ilgili çalışmalara ulaşmak için Türk Tıp Dizini, Google Akademik, YÖK tez merkezi, Pubmed, EBSCO Host, Web of Science veri tabanları tarandı. Taramada “iş doyumu”, “iş tatmini”, “hemşire” “hemşireler” anahtar sözcükleri Türkçe ve İngilizce olarak kullanıldı. Genel doyum için 9 çalışma, içsel ve dışsal doyum için 7 çalışma dahil edilme kriterlerine uygundu. Verilerin analizinde CMA (The Comprehensive Meta–Analysis software) istatistik programı kullanıldı. Araştırmada genel doyum için toplam örneklem büyüklüğü 2314 olup, 326‘sı yönetici hemşire ve 1988’i klinik hemşireydi. İçsel ve dışsal doyum için toplam örneklem sayısı 1629 olup, 246‘si yönetici hemşire ve 1383’ü klinik hemşireydi. Heterojenlik testi sonucunda genel, içsel ve dışsal doyum için çalışmaların homojen özellik gösterdiği belirlendi. Yayın yanlılığı testi sonucunda yayın yanlılığı olmadığı belirlendi. Sabit etkiler modeline göre % 95 önem derecesinde çalışma statüsünün iş doyumuna olan ortalama etki büyüklüğü genel doyum için 0.55, içsel doyum için 0.53 ve dışsal doyum için 0.47 olarak hesaplandı. Bu çalışmanın sonuçları çalışma statüsünün genel, içsel ve dışsal doyuma etkisinin yönetici hemşireler lehine orta düzeyde olduğunu ortaya koydu.

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Diagnostic accuracy of the LAMP assay for Neisseria meningitidis

10.21203/rs.2.13073/v2 ◽

2020 ◽

Author(s):

Shu- Jin Fan ◽

Xu-Guang Guo ◽

Hong-kun Tan ◽

Yu-cheng Xu ◽

Yuan-zhi Chen ◽

...

Keyword(s):

Bacterial Meningitis ◽

Diagnostic Accuracy ◽

Neisseria Meningitidis ◽

Publication Bias ◽

Operating Characteristic ◽

Web Of Science ◽

Meta Analysis ◽

Lamp Assay ◽

High Sensitivity ◽

Summary Receiver Operating Characteristic

Abstract Background Neisseria meningitidis is a major cause of bacterial meningitis, and these infections are associated with a high mortality rate. Rapid and reliable diagnosis of bacterial meningitis is critical in clinical practice. However, this disease often occurs in economically depressed areas, so an inexpensive, easy to use, and accurate technology is needed. We performed a meta-analysis to assess the potential of the recently developed loop-mediated isothermal amplification (LAMP) assay for detection of meningococcus. Methods Pubmed, Embase, and Web of Science were searched to identify original studies that used the LAMP assay to detect meningococcus. After pooling of data, the sensitivity and specificity were calculated, a summary receiver operating characteristic (SROC) curve was determined, and the area under the SROC curve was computed to determine diagnostic accuracy. Publication bias was assessed using Deek's funnel plot. Results We examined 14 studies within 6 publications. The LAMP assay had high sensitivity (94%) and specificity (100%) in the detection of meningococcus in all studies. The area under the SROC curve (0.980) indicated high overall accuracy of the LAMP assay. There was no evidence of publication bias. Conclusion The LAMP assay has accuracy comparable to bacterial culture and PCR for detection of meningococcus, but is less expensive and easier to use. We suggest adoption of the LAMP assay for detect meningococcus, especially in economically depressed areas.

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Diagnostic accuracy of the LAMP assay for Neisseria meningitidis

10.21203/rs.2.13073/v1 ◽

2019 ◽

Author(s):

Shu- Jin Fan ◽

Xu-Guang Guo ◽

Hong-kun Tan ◽

Yu-cheng Xu ◽

Yuan-zhi Chen ◽

...

Keyword(s):

Bacterial Meningitis ◽

Diagnostic Accuracy ◽

Neisseria Meningitidis ◽

Publication Bias ◽

Operating Characteristic ◽

Web Of Science ◽

Meta Analysis ◽

Lamp Assay ◽

High Sensitivity ◽

Summary Receiver Operating Characteristic

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Oral Manifestations of COVID-19: Updated Systematic Review With Meta-Analysis

Frontiers in Medicine ◽

10.3389/fmed.2021.726753 ◽

2021 ◽

Vol 8 ◽

Author(s):

Javier Aragoneses ◽

Ana Suárez ◽

Juan Algar ◽

Cinthia Rodríguez ◽

Nansi López-Valverde ◽

...

Keyword(s):

Systematic Review ◽

Observational Studies ◽

Web Of Science ◽

Opportunistic Infections ◽

Meta Analysis ◽

Oral Lesions ◽

Oral Manifestations ◽

Prevalence Data ◽

Considerable Heterogeneity ◽

Pooled Prevalence

There is increasing evidence for oral lesions and manifestations of COVID-19. The aim of this meta-analysis was to investigate the types of oral manifestations of COVID-19 and their prevalence. PubMed/Medline, Scopus, Web of Science, and Google Scholar databases were used to search for publications on oral manifestations in patients with PCR-confirmed COVID-19. A total of 310 records were selected, and 74 were included. Oral lesions in COVID-19 were classified according to their etiologies, including iatrogenic lesions caused by intubation and opportunistic infections. Of the included studies, 35 reported oral lesions probably caused by severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) infection. Meta-analysis of prevalence data on oral manifestations and aphthous lesions indicated high heterogeneity, while meta-analysis of xerostomia prevalence data revealed a pooled prevalence, with considerable heterogeneity. In conclusion, the meta-analysis yielded high heterogeneity between studies: oral lesions yielded a prevalence of 0.33 (95% CI 0.11–0.60), xerostomia lesions a prevalence of 0.44 (95% CI 0.36–0.52) and aphthous lesions 0.10 (95% CI 0.01–0.24). In addition, a gap in the evidence regarding the prevalence of oral lesions in COVID-19 was identified and the need for further observational studies focusing on this issue and on the causal relationships between oral lesions and COVID-19 was highlighted.

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ASSOCIATIONS OF IL-6 -174G>C AND IL-10 -1082A>G POLYMORPHISMS WITH SUSCEPTIBILITY TO CELIAC DISEASE: EVIDENCE FROM A META-ANALYSIS AND LITERATURE REVIEW

Arquivos de Gastroenterologia ◽

10.1590/s0004-2803.201900000-60 ◽

2019 ◽

Vol 56 (3) ◽

pp. 323-328 ◽

Cited By ~ 1

Author(s):

Majid AFLATOONIAN ◽

Gholamreza SIVANDZADEH ◽

Majid MOROVATI-SHARIFABAD ◽

Seyed Reza MIRJALILI ◽

Mohammad Javad AKBARIAN-BAFGHI ◽

...

Keyword(s):

Celiac Disease ◽

Literature Review ◽

Publication Bias ◽

Web Of Science ◽

Disease Risk ◽

Meta Analysis ◽

Case Control ◽

Case Control Studies ◽

Potential Association ◽

Increased Risk

ABSTRACT BACKGROUND: There has been little evidence to suggest that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms are significantly associated with susceptibility to celiac disease. Thus, we performed the present meta-analysis to explore the potential association between these polymorphisms and celiac disease risk. METHODS: Eligible studies were searched in PubMed, Medline, Embase, Web of Science and CNKI database up to April 20, 2019. Odds ratios with 95% confidence interval were calculated to assess the potential associations. Moreover, we performed the heterogeneity, sensitivity, and publication bias tests to clarify and validate the pooled results. RESULTS: Overall, nine case-control studies involving five studies with 737 cases and 1,338 control on IL-6 -174G>C polymorphism and four studies with 923 cases and 864 controls on IL-10 -1082A>G polymorphism were selected. The pooled ORs showed that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms were not significantly associated with increased risk of celiac disease under all five genetic models. There was no publication bias. CONCLUSION: To the best of our knowledge, this is the first meta-analysis summarizing all of the available studies on the association of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with celiac disease. Our results suggest that the IL-6 -174G>C and IL-10 -1082A>G polymorphisms may not be associated with increased risk of celiac disease. Moreover, large and well-designed studies are needed to fully describe the association of IL-6 -174G>C and IL-10 -1082A>G polymorphisms with celiac disease.

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