Factors that predict epinephrine induced constriction of the persistent arterial duct

1998 ◽  
Vol 8 (2) ◽  
pp. 195-198 ◽  
Author(s):  
Hideshi Tomita ◽  
Shigeto Fuse ◽  
Shunzo Chiba
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
The Body ◽  
Low Birth Weight Infants ◽  
Flow Area ◽  
Arterial Duct ◽  
Significant Difference ◽  
History Of ◽  
Persistent Arterial Duct

SummaryWe studied factors that predict in children catecholamine induced vasoconstriction of the persistent arterial duct. Epinephrine at 2.0–10.0 (4.9 ± 1.3, mean ± standard deviation) μg/kg was injected intravenously into 30 patients with persistent arterial duct whose age ranged from 1 to 91 (27 ± 26) months. In 11 patients aged 10–66 (34 ± 23) months (responders), a continuous murmur had almost completely disappeared on auscultation, and both the diameter and the shunt flow area of the arterial duct had become smaller as shown by Doppler echocardiography. On the other hand, there was no such change in 19 patients aged 1–91 (23 ± 27) months (non-responders). Although there was no significant difference in the age, the body weight, the minimal diameter of the arterial duct, or the doses of epinephrine between responders and non-responders, the gestational age at birth was slightly less (p=0.09) and the birth weight was significantly smaller in responders than in non-responders (p<0.05). The persistent arterial duct of those who had a history of low birth weight always responded to epinephrine. In infants younger than 6 months, the persistent arterial duct was never constricted by epinephrine regardless of the birth weight and gestational age. In low birth weight infants, the vascular smooth muscle of the persistent arterial duct can usually constrict beyond infancy. There may be some age dependent difference in responsiveness to epinephrine until 6 months of age.

NEUROLOGIC MATURATION AND AUDITORY EVOKED RESPONSES IN LOW BIRTH WEIGHT INFANTS

PEDIATRICS ◽  
1968 ◽  
Vol 41 (2) ◽  
pp. 483-494
Author(s):  
Leonard J. Graziani ◽  
Elliot D. Weitzman ◽  
Mutya S. A. Velasco
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Somatic Growth ◽  
Auditory Stimuli ◽  
Neurologic Examination ◽  
Low Birth Weight Infants ◽  
Maternal History ◽  
Auditory Evoked Responses ◽  
Examination Methods

The maturation of the nervous system of two groups of infants of low birth weight was estimated by the results of a standardized clinical neurologic examination and by evaluation of the electroencephalographic responses to auditory stimuli (clicks). Algebraically summed responses to clicks were recorded simultaneously from 10 scalp electrodes, using a standard electroencephalograph, tape recorder, and a computer of average transients. The results obtained by the two methods were compared with the age postconception, estimated from the maternal history. One group consisted of infants whose birth weights were below the 10th percentile for their gestational age (37.1 ± 2.0 weeks); the other group consisted of infants whose birth weights were similar to the first group but were between the 25th and 75th percentile for their gestational age (31.0 ± 2.3 weeks). In the small-for-age infants, the electroencephalographic responses and the neurologic reflexes were more mature than in the infants of similar birth weights who were not small for age. The results of both examination methods correlated well with the estimated postconception age but less well with birth weight, postnatal age, or somatic growth.

Letters to the Editor

PEDIATRICS ◽  
1982 ◽  
Vol 69 (1) ◽  
pp. 130-130
Author(s):  
Evelyn Lipper ◽  
Kwang-sun Lee ◽  
Lawrence M. Gartner ◽  
Bruce Grellong
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Head Circumference ◽  
Low Birth Weight Infants ◽  
Letters To The Editor

All of the infants entered into the study were low-birth-weight infants (&lt;2,500 gm). The majority of infants had a gestational age less than 37 completed weeks, and, of these, some were also small for gestational age. Sixteen infants had a gestational age of ≥37 weeks but were included in the study because their birth weight was below the tenth percentile for their gestational age. We agree with Drs Knobloch and Malone's comment about the interrelationship of all three figures: as gastation advances, birth weight and head circumference increase.

scholarly journals Penurunan Kecemasan Ibu dan Perbaikan Status Bangun-Tidur BBLR melalui Perawatan Metode Kanguru

2011 ◽  
Vol 14 (3) ◽  
pp. 193-198 ◽  
Author(s):  
Qori’Ila Saidah ◽  
Yeni Rustina ◽  
Nani Nurhaeni
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Kangaroo Mother Care ◽  
Maternal Anxiety ◽  
Friedman Test ◽  
Low Birth Weight Infants ◽  
Kangaroo Care ◽  
Consecutive Sampling ◽  
Significant Difference ◽  
Wake State

AbstrakKondisi klinis dan perawatan di ruang rawat intensif pada Bayi Berat Lahir Rendah (BBLR) mempengaruhi status banguntidurnyadan menyebabkan kecemasan pada ibu. Tujuan penelitian ini mengidentifikasi pengaruh perawatan metode kanguruterhadap kecemasan ibu dan status bangun-tidur BBLR. Rancangan penelitian one group pretest posttest design dengan sampel16 ibu dan BBLR di sebuah rumah sakit Surabaya secara consecutive sampling. Kecemasan ibu diukur dengan PSS: NICU danstatus bangun tidur dengan modifikasi skala Brazelton oleh Priya. Hasil analisis uji statistik menggunakan Wilcoxon Sign RankTest dan uji Friedman menunjukkan ada perbedaan bermakna (p= 0,000; α= 0,05). PMK mempunyai pengaruh signifikanterhadap perubahan kecemasan ibu dan status bangun-tidur BBLR. Tenaga kesehatan disarankan mengembangkan PMK untukpeningkatan status kesehatan ibu, juga tumbuh kembang bayi yang optimal.Kata kunci: kecemasan ibu, perawatan metode kangguru, status bangun-tidur BBLR.AbstractClinical condition and treatment at Low Birth Weight Infants (LBW) in the intensive care unit affects sleep-wake status andcauses anxiety for the mother. The aims of this study is to identify the influence of methods of kangaroo care on maternalanxiety and sleep-wake status of LBW. The design of this study was one group pretest posttest design with sample of 16 mothersand low birth weight in a hospital in Surabaya by consecutive sampling. Maternal anxiety was measured with the PSS: NICUand sleep-wake status with Brazelton scale modified by Priya. The result of statistical analysis test using Wilcoxon Sign RankTest and Friedman test showed there are significant difference (p= 0.000; α= 0.05). KMC has a significant influence onchanges in maternal anxiety and sleep-wake status of LBW. Health care provider are recommended to develop KMC forimprovement of maternal health status, as well as the optimal infant growth and development.Keywords: maternal anxiety, kangaroo mother care, sleep-wake state in low birth weight baby

scholarly journals The Effectiveness of Auditory Stimuli from Murottal Quran to Improve Comfort and Weight in Low Birth Weight Infants: Randomized Controlled Trial

Jurnal NERS ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 111
Author(s):  
Desriati Devi ◽  
Yeni Rustina ◽  
Defi Efendi
Keyword(s):  
Randomized Controlled Trial ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Controlled Trial ◽  
Auditory Stimuli ◽  
Control Groups ◽  
Low Birth Weight Infants ◽  
Randomized Controlled ◽  
Significant Difference ◽  
And Control

Introduction: Low birth weight (LBW) infants who have been hospitalized are exposed to various conditions that provoke discomfort, which could trigger a stress response and growth disorders. This study aimed to identify the effects of auditory stimuli from Murottal Quran when it comes to the comfort and weight of LBW infants.Methods: This study used a clinical randomized controlled trial design involving 52 low birth weight infants. The infants were randomly assigned to either the intervention group (n=26) or the control (n=26). The intervention of Murottal Quran was given using a speaker 4 times a day for 20 minutes every 3 hours. This intervention was conducted for three days.Results: The results of this study show that there is a significant difference in the comfort of  low birth weight infants after Murottal Qur’an on the first, second, and third days between the intervention and control groups (p=0.014; <0.001; <0.001). There was no significant difference in the weight between the intervention and control groups in the first, second, and third days (p=0.481; 0.481; 0.464).Conclusion: The auditory stimuli of Murottal Quran can help to improve the comfort level of low birth weight infants during hospitalization. It can therefore be used as a supportive therapy to facilitate low birth weight infant and premature infant development.

INSENSIBLE WATER LOSS IN LOW BIRTH WEIGHT INFANTS

PEDIATRICS ◽  
1972 ◽  
Vol 50 (2) ◽  
pp. 236-245 ◽  
Author(s):  
Avroy A. Fanaroff ◽  
Michael Wald ◽  
Howard S. Gruber ◽  
Marshall H. Klaus
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Water Loss ◽  
Thermal Environment ◽  
Heat Shield ◽  
Low Birth Weight Infants ◽  
Water Losses ◽  
Large Water

Insensible water loss (IWL) was determined from measurements of insensible weight loss during the first 7 weeks of life on 30 immature and nine small-for-gestational age, low birth weight infants. Under standard conditions (single-walled incubator, infant nude, gavage feeding), 10 infants with birth weights less than 1,250 gm, gestational age &lt; 230 days (32 weeks) and postnatal age &lt;10 days lost &gt;2.5 gm/kg/hr (equivalent to 60-120 ml/kg/day), considerably higher than previously reported. Studies following the insertion of a plastic heat shield revealed a 25% reduction in IWL. The heat shield facilitates achievement of neutral thermal environment and reduced water losses in low birth weight infants. IWL measurements in infants with birth weights &gt;1,500 gm and those small-for-gestational age were similar to previously reported studies. Because of the known limited ability of small immature infants to increase metabolic rate, these extremely high losses are believed to represent disproportionately larger water losses from skin. Skin factors predisposing to large water loss in immature infants include thinner epidermis, increased water content, and increased permeability.

Serum Thymic Hormone Activity and Cell-Mediated Immunity in Healthy Neonates, Preterm Infants, and Small-for-Gestational Age Infants

PEDIATRICS ◽  
1981 ◽  
Vol 67 (3) ◽  
pp. 407-411
Author(s):  
R. K. Chandra
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Lymphocyte Stimulation ◽  
Cell Mediated Immunity ◽  
Low Birth Weight Infants ◽  
Thymic Hormone ◽  
Appropriate For Gestational Age

Groups of healthy, small-for-gestational age (SGA) and preterm appropriate-for-gestational age (AGA) infants were studied at birth, 1 month, 3 months, and 12 months of age. Serum thymic hormone (TH) activity was assayed, the number of T lymphocytes in the peripheral blood was counted, and in vitro lymphocyte stimulation responses to phytohemagglutinin (PHA) were evaluated. TH activity was decreased in 1-month-old SGA infants. T cells were reduced in all low birth weight infants; the number reverted to normal by 3 months of age in preterm AGA infants, whereas it remained low for at least 12 months in the SGA group. Lymphocyte stimulation response was decreased in low birth weight infants; the extent of depression paralleled reduction in T lymphocyte number. These observations indicate that cell-mediated immunity is impaired in low birth weight newborns and reduced TH activity may be one of the pathogenetic factors involved. Persistent depression of immunocompetence may underlie the increased susceptibility of SGA infants to infection-related morbidity and mortality.

scholarly journals Hospital Regimens Including Probiotics Guide the Individual Development of the Gut Microbiome of Very Low Birth Weight Infants in the First Two Weeks of Life

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1256 ◽  
Author(s):  
Stefan Kurath-Koller ◽  
Charlotte Neumann ◽  
Christine Moissl-Eichinger ◽  
Raimund Kraschl ◽  
Claudia Kanduth ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Bacterial Load ◽  
Oxygen Demand ◽  
Individual Development ◽  
Low Birth Weight Infants ◽  
Multicenter Cohort Study ◽  
Fecal Microbiome ◽  
Significant Difference

Background: It is unknown to what extent the microbiome of preterm infants is influenced by hospital regimens including the use of different probiotics when it comes to the prevention of necrotizing enterocolitis (NEC). Methods: Prospective controlled multicenter cohort study including very low birth weight infants from three neonatal intensive care units (NICUs) between October 2015 and March 2017. During this time span, stool was sampled every other day during the first two weeks and samples were subjected to amplicon-based microbiome analyses. Out of these, seventeen negative controls were processed (German Registry of Clinical Trials (No.: DRKS00009290)). Results: The groups (3 × 18 infants) showed no statistically significant difference regarding gestational age, birth weight, APGAR scores and oxygen demand. 2029 different taxa were detected, including Enterococcus and Staphylococcus, as well as the probiotic genera Lactobacillus and Bifidobacterium predominating. The bacterial load was found to increase earlier on when probiotics were used. Without probiotics administration, Lactobacillus and Bifidobacterium contributed only marginally to the fecal microbiome. Some infants did not respond to probiotic administration. The samples from all centers participating reached a very similar diversity after two weeks while the microbiome samples from all three centers clustered significantly yet varied from each other. Conclusion: Probiotics proved to be safe and initiated an earlier increase of bacterial load (with marked individual divergences), which might play a crucial role in the prevention of neonatal morbidities. Meconium was found not to be free of bacterial DNA, and oral antibiotics did not influence the fecal microbiome development negatively, and hospital regimes led to a center-specific, distinct cluster formation.

Pre-discharge growth pattern of very low birth weight infants (VLBW): A 5 year single center experience

2020 ◽  
pp. 1-6
Author(s):  
S.H. Elbeely ◽  
M.A. AlQurashi
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Growth Pattern ◽  
Very Low Birth Weight ◽  
Single Center ◽  
Low Birth Weight Infants ◽  
Cross Sectional ◽  
Vlbw Infants ◽  
The Mean

BACKGROUND: Very low birth weight infants born prematurely are at greater risk for growth delays that lead to Ex-utero Growth Restriction (EUGR) during vulnerable periods of organ structural and functional development. There is considerable evidence that early growth failure has adverse effects on long term neurodevelopment in children which often persists into adulthood. METHODS: This is a single-center cross-sectional study on live newborn infants with birth weight ranges from 500 to 1500 grams (VLBW) and gestational age (GA) between 24–32 weeks who were admitted to NICU at KAMC-Jeddah over a 5 year period (2009–2013). This study aims to evaluate predischarge growth pattern of VLBW infants in terms of weight, head circumference (HC) and length and to identify important variables that have influenced such growth pattern. RESULTS: Of the 135 infants included in the final analysis, 68 (50.4%) were male and 67 (49.6%) were female and the mean gestational age was 28.83±2.064 weeks and the mean birth weight 1166.74±256 grams. Ninety-two infants (68%) had discharge weight at ≤10th percentile and forty four (32%) had their weight >10th percentile. HC was the lowest affected among the anthropometric measurements with 42% ≤10th percentile. In terms of linear growth, 62% had their length ≤10th percentile. Amongst infants born ≤750 grams, 71% and 70% had HC and height at ≤10th percentile respectively, at the time of discharge. BPD was significantly associated with EUGR (p = 0.026). CONCLUSIONS: This study demonstrates that almost 2/3rd of VLBW infants born at KAMC-Jeddah with birth weight ≤750 grams were discharged home with EUGR as demonstrated by their weight, length, and HC ≤10th percentile. BPD was found to be significantly associated with EUGR amongst post-natal factors influencing EUGR.

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