Outcome in depression (I): why symptomatic remission is not good enough

CNS Spectrums ◽  
2020 ◽  
pp. 1-7
Author(s):  
Koen Demyttenaere ◽  
Glenn Kiekens ◽  
Ronny Bruffaerts ◽  
Philippe Mortier ◽  
Philip Gorwood ◽  
...  
Keyword(s):  
Negative Affect ◽  
Positive Affect ◽  
Cognitive Functioning ◽  
Rating Scale ◽  
Antidepressant Treatment ◽  
Patient Treatment ◽  
Positive And Negative Affect ◽  
Healthy Controls ◽  
Hedonic Tone ◽  
Overall Functioning

Abstract Background. The Leuven Affect and Pleasure Scale (LAPS) is a depression outcome measure aiming to better reflect patient treatment expectations. We investigated the evolution of the LAPS and some comparator scales during antidepressant treatment and compared scores of remitters with scores of healthy controls. Methods. A total of 109 outpatients with Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) major depressive disorder were assessed over 8 weeks of antidepressant treatment. At baseline and after 2, 4, and 8 weeks, the LAPS as well as the Hamilton Depression Rating Scale (HAMD), the Snaith–Hamilton Pleasure Scale (SHAPS), the Positive and Negative Affect Scale (PANAS), and the Sheehan Disability Scale (SDS) were administered. Healthy controls consisted of 38 Italian adults and 111 Belgian students. Results. Correlations between baseline positive and negative affect were only moderate (R between −0.20 and −0.41). LAPS positive affect and hedonic tone showed higher correlations with LAPS cognitive functioning, overall functioning, meaningfulness of life, and happiness than HAMD scores or PANAS negative affect. HAMD remission was associated with normal levels of LAPS negative affect but with significantly lower levels of LAPS positive affect, hedonic tone, cognitive functioning, overall functioning, meaningfulness of life, and happiness. The scores on the latter subscales only reached healthy control scores when the HAMD approached a score of 0 or 1. Conclusions. The standard definition of remission (HAMD cutoff of 7) is probably adequate for remitting negative mood, but not good enough for recovering positive mood, hedonic tone, functioning, or meaningfulness of life.

Outcome in depression (II): beyond the Hamilton Depression Rating Scale

CNS Spectrums ◽  
2020 ◽  
pp. 1-5 ◽  
Author(s):  
Koen Demyttenaere ◽  
Glenn Kiekens ◽  
Ronny Bruffaerts ◽  
Philippe Mortier ◽  
Philip Gorwood ◽  
...  
Keyword(s):  
Negative Affect ◽  
Positive Affect ◽  
Rating Scale ◽  
Antidepressant Treatment ◽  
Present Report ◽  
Added Value ◽  
Patient Treatment ◽  
Hedonic Tone ◽  
Patient Centered ◽  
Hamilton Depression Rating Scale

Abstract Background. The Leuven Affect and Pleasure Scale (LAPS) was developed as an outcome measure in major depressive disorder (MDD) tha treflects patient treatment expectations. The present report investigates whether the LAPS negative affect, the LAPS positive affect, and the LAPS hedonic tone have added value on top of the Hamilton Depression Rating Scale (HAMD) in explaining generic as well as patient-centered outcomes. Methods. A total of 109 outpatients with Diagnostic and Statistical Manual of Mental Disorders, fifth edition, criteria for MDD were assessed over 8 weeks of antidepressant treatment. At baseline and after 2, 4, and 8 weeks, the LAPS, HAMD, Snaith–Hamilton Pleasure Scale (SHAPS), Positive and Negative Affect Scale (PANAS), and Sheehan Disability Scale were administered. The Clinical Global Impression of Improvement (CGI-I) and the Patient Global Impression of Improvement (PGI-I) were also administered at endpoint. Results. Changes in LAPS negative affect, LAPS positive affect, and LAPS hedonic tone explain 14% of the additional variance in CGI-I, 21% in PGI-I, 37% in cognitive functioning, 32% in overall functioning, 31% in “my life is meaningful,” and 45% in “I feel happy.” Compared to standard scales (PANAS and SHAPS), the LAPS negative affect, LAPS positive affect, and LAPS hedonic tone differentiate better between different levels of CGI-I or PGI-I. Conclusions. The LAPS has added value (on top of the HAMD) in explaining changes in both generic outcomes (CGI-I/PGI-I) and patient-centered dimensions. The LAPS negative and positive affects and the LAPS hedonic tone differentiate CGI-I and PGI-I scores better than corresponding scales supposed to cover the same domains.

Is there enough “interest in and pleasure in” the concept of depression? The development of the Leuven Affect and Pleasure Scale (LAPS)

CNS Spectrums ◽  
2017 ◽  
Vol 24 (02) ◽  
pp. 265-274 ◽  
Author(s):  
Koen Demyttenaere ◽  
Philippe Mortier ◽  
Glenn Kiekens ◽  
Ronny Bruffaerts
Keyword(s):  
College Students ◽  
Negative Affect ◽  
Positive Affect ◽  
Rating Scale ◽  
Positive Mood ◽  
Hedonic Tone ◽  
Meaningful Life ◽  
Independent Variables ◽  
Depressed College Students ◽  
Overall Functioning

ObjectivePresence of negative mood (depressed mood) and anhedonia (lack of interest and pleasure) are considered core symptoms of depression, while absence of positive mood is not taken into account. It is therefore remarkable that the depression scales routinely used to assess changes during antidepressant treatment (Hamilton Depression Rating Scale [HDRS], Montgomery–Åsberg Depression Rating Scale [MADRS]) do not really take into account anhedonia. Several scales were developed to assess positive mood and hedonic tone, but they only partially cover the multidimensional concept. Therefore we developed a new 16-item questionnaire, the Leuven Affect and Pleasure Scale (LAPS), to assess negative affect, positive affect, and hedonic tone.MethodsThis first article on the LAPS questionnaire reports on the correlations between the different items, on the factor analysis, and on the differences found in 3 groups of subjects : healthy college students (N=138), depressed but still functioning college students (N=27), and severely depressed inpatients (N=38). These differences were calculated using univariate general linear models with Bonferroni post-hoc testing, and effect sizes were expressed in η2.ResultsNegative and positive affect were only moderately correlated, and the 4 independent variables (cognitive functioning, overall functioning, meaningful life, and happiness) had stronger correlations with positive affect than with negative affect. The major difference in negative affect was between healthy college students and depressed college students, positive affect was different between the 3 groups, and the major difference for hedonic tone was between depressed college students and depressed inpatients. Affiliative positive affect and the affiliative hedonic function were well preserved, even in depressed inpatients.ConclusionsThis preliminary report suggests that the LAPS offers a comprehensive assessment of negative and positive affect, of hedonic tone, and of independent variables (cognitive functioning, overall functioning, meaningful life, and happiness). Clinically relevant differences in subscores were found in 3 groups of subjects with variable levels of depression (healthy subjects, mildly depressed subjects, and severely depressed inpatients).

scholarly journals Association of Affect and Gait Performance in Dual-Task Walking in Non-Demented Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 287-287
Author(s):  
Deepan Guharajan ◽  
Roee Holtzer
Keyword(s):  
Older Adults ◽  
Negative Affect ◽  
Positive Affect ◽  
Dual Task ◽  
Task Demands ◽  
Gait Velocity ◽  
Positive And Negative Affect ◽  
Increased Risk ◽  
Aging Populations ◽  
Task Conditions

Abstract Aging populations are at increased risk to experience mobility disability, which is associated with falls, frailty, and mortality. Previous studies have not examined the concurrent associations of both positive and negative affect with gait velocity. We examined whether individual differences in positive and negative affect predicted dual-task performance decrements in velocity in a dual-task (DT) paradigm in non-demented older adults. We hypothesize that positive affect would be associated with lower DT costs, and negative affect would be associated with higher DT costs. Participants (N = 403; mean age, = 76.22 (6.55); females = 56%) completed the Positive and Negative Affect Schedule (PANAS) and a DT paradigm that involved three task conditions: Single-Task-Walk (STW), Alpha (cognitive interference requiring participants to recite alternate letters of the alphabet), and Dual-Task-Walk (DTW) requiring participant to perform the two single tasks concurrently. Gait velocity was assessed via an instrumented walkway. As expected, results of a linear mixed effects model (LME) showed a significant decline in gait velocity (cm/s) from STW to DTW (estimate = -11.79; 95%CI = -12.82 to -10.77). LME results further revealed that negative affect was associated with greater decline in gait velocity from STW to DTW (ie., worse DT cost) (estimate = -0.38; 95%CI = -0.73 to -0.03). Positive affect did not, however, predict DT costs in gait velocity (estimate = -0.09; 95%CI = -0.23 to 0.05). These findings suggest that increased negative affect interferes with the allocation of attentional resources to competing task demands inherent in the DT paradigm.

Grandparent-child cohesion, friendship quality, and left-behind children’s positive/negative affect in rural China

2021 ◽  
pp. 135910532110499
Author(s):  
Jingxin Zhao ◽  
Jing Ge ◽  
Qianyu Li
Keyword(s):  
Negative Affect ◽  
Positive Affect ◽  
Rural China ◽  
Friendship Quality ◽  
Interaction Effects ◽  
Positive And Negative Affect ◽  
Left Behind ◽  
Emotional Adaptation ◽  
Reinforcement Model ◽  
Intimate Exchange

This study examined the roles of grandparent-child cohesion and friendship quality in left-behind children’s positive and negative affect compared with non-left-behind children. Data from 557 participants indicated that grandparent-child cohesion and friendship quality predicted children’s emotional adaptation. Friend trust and support and intimate exchange had a stronger predictive effect on positive affect among non-left-behind children. Moreover, the interaction effects between grandparent-child cohesion and friendship quality on children’s positive affect supported the reinforcement model, while the interaction effects on negative affect supported the reinforcement model among left-behind children but supported the compensation model among non-left-behind children.

A Multilevel Investigation of the Effects of Daily Work–Family Interaction on Daily Affect During the COVID-19 Pandemic

2021 ◽  
pp. 0192513X2110444
Author(s):  
Mehmet Çetin ◽  
Bayram Dede ◽  
Özgür Kökalan ◽  
Ezgi Dede
Keyword(s):  
Negative Affect ◽  
Positive Affect ◽  
Family Conflict ◽  
Positive And Negative Affect ◽  
Work Family Conflict ◽  
Daily Work ◽  
Level Data ◽  
Work Family ◽  
Work Family Enrichment ◽  
Family Enrichment

This research aimed to examine the effects of daily work–family conflict and work–family enrichment on daily positive and negative affect levels of employees during the first phases of the COVID-19 pandemic in Turkey. The multilevel structure of the research design makes this study original. 730 day-level data were collected from 146 respondents during five consecutive workdays. One week later, a larger survey was delivered for assessing the person-level variables. The results indicated that both forms of work–family conflict significantly decreased positive affect and increased negative affect. Both types of work–family enrichment significantly increased positive affect; but only daily work to family enrichment significantly decreased daily negative affect. Findings also revealed that positive affect levels of respondents increase while negative affect levels decrease with time. On the days employees worked from distance, lower levels of positive and negative affect were experienced.

Playing for God’s Team: The Influence of Belief in the Supernatural on Perceptions of Religious, Spiritual, and Natural Cues

2016 ◽  
Vol 16 (3-4) ◽  
pp. 215-244
Author(s):  
Virginia A. Periss ◽  
David F. Bjorklund
Keyword(s):  
Negative Affect ◽  
Positive Affect ◽  
Social Exchange ◽  
Religious Belief ◽  
Large Scale ◽  
Positive And Negative Affect ◽  
Positive Bias ◽  
Evolutionary Perspective ◽  
Supernatural Beliefs ◽  
Supernatural Explanations

Adherence to religious belief may serve to promote group cohesion and cooperation by decreasing the costs associated with social exchange. Consistent with this, organized religious ideologies, unlike secular or spiritual based ideologies, have been argued to facilitate cooperation among individuals living in large-scale societies. In the current study, we examined whether hypothetical adults’ explanations of natural events focused on religious ideologies were more effective at eliciting positive-affect compared to spiritual or natural explanations. Results revealed that religious cues were more effective than spiritual cues in eliciting perceptions of positive-affect, but only when participant religiosity was taken into account. Participants high in religiosity favored the religious cues over the spiritual and natural cues, whereas participants high in spirituality showed no preferences. Conversely, participants low in religious belief demonstrated not only a positive bias towards the natural explanations, but also rated the adults expressing the supernatural explanations, in particular the religious explanations, as having greater negative-affect. From an evolutionary perspective, we interpreted the results as providing support that some forms of supernatural thinking, typical of organized religion, are more effective at eliciting feelings of positive and negative affect compared to supernatural beliefs not rooted in organized religion.

Relations among Positive Affect, Negative Affect, and Somatic Symptoms in a Medically Ill Patient Sample

2000 ◽  
Vol 87 (1) ◽  
pp. 227-233 ◽  
Author(s):  
Steven A. Kvaal ◽  
Shobhana Patodia
Keyword(s):  
Psychological Distress ◽  
Negative Affect ◽  
Positive Affect ◽  
Pain Intensity ◽  
Somatic Symptoms ◽  
Somatic Complaints ◽  
Positive And Negative Affect ◽  
Medical Patients ◽  
Medically Ill ◽  
Different Populations

The Positive and Negative Affect Scale (PANAS), a brief measure of Positive and Negative Affect, may be useful in assessing mood of medical patients because it does not include somatic items frequently confounded with medical conditions. In previous research Positive and Negative Affect have been independent and uncorrelated, and Negative Affect but not Positive Affect has been positively correlated with somatic symptoms. However, relationships between variables may vary in different populations, and there is relatively little information on Positive and Negative Affect in medical patients. In the current study, the PANAS was used to assess the relationships among Positive Affect, Negative Affect, and somatic symptoms and pain in a medically ill hospital population. Positive and Negative Affect scores were positively correlated and for patients reporting pain, Positive Affect scores were positively correlated with pain intensity. Results from this and other studies indicate that Positive and Negative Affect are independent but in some populations may be correlated; positive affects such as hopefulness may co-occur with both somatic complaints and psychological distress.

Neuroticism, alexithymia, negative affect and positive affect as predictors of medically unexplained symptoms in primary care

2002 ◽  
Vol 14 (4) ◽  
pp. 181-185 ◽  
Author(s):  
V. De Gucht
Keyword(s):  
Primary Care ◽  
Negative Affect ◽  
Positive Affect ◽  
Personality Traits ◽  
Affective State ◽  
Medically Unexplained Symptoms ◽  
Positive And Negative Affect ◽  
Medically Unexplained ◽  
Unexplained Symptoms

Background:Somatization has been defined in a number of ways. Despite their differences, these definitions have one element in common, namely the presence of somatic symptoms that cannot be explained (adequately) by organic findings.Objective:The primary objectives of the dissertation were to gain a better insight into the concept of somatization, and to study (prospectively) the relationship between neuroticism and alexithymia, two personality traits that have been shown to be related to somatization, the affective state dimensions positive and negative affect (or psychological distress) and medically unexplained symptoms.Method:A selective review was conducted regarding conceptual and methodological issues related to somatization. A total number of 318 patients, presenting to their primary care physician with medically unexplained symptoms, participated in the prospective study. Both at baseline and at 6-month follow-up a number of measures were filled out with respect to somatization, neuroticism, alexithymia, negative and positive affect, anxiety and depression.Results:The concept of somatization was clarified, thereby making use of the distinction between presenting and functional somatization. The personality traits neuroticism and alexithymia were found to have an indirect influence on symptom reports. Both the cross-sectional and follow-up data pointed to the importance of positive and negative affect as determinants of (changes in) number of symptoms (over time). Negative affect, together with the alexithymia dimension measuring difficulty identifying feelings, predicted symptom persistence.Conclusions:The theoretical as well as therapeutic implications of the present paper may give an impetus to new research in the domain of somatization.

scholarly journals A MICROLONGITUDINAL APPROACH TO STUDYING GRANDMOTHER-GRANDCHILD DAILY INTERACTIONS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S281-S282
Author(s):  
Shelbie Turner ◽  
Shannon T Mejia ◽  
Robert S Stawski ◽  
Karen Hooker
Keyword(s):  
Negative Affect ◽  
Positive Affect ◽  
Social Experiences ◽  
Intraindividual Variability ◽  
Positive And Negative Affect ◽  
Daily Interactions ◽  
Multi Level ◽  
Using Data ◽  
Over Time

Abstract Research suggests that grandparent-grandchild dyads shift in degree of solidarity over extended periods of time (e.g. Moorman & Stokes, 2016), but no work has considered grandparent-grandchild interactions microlongitudinally. This study utilized microlongitudinal data with an emphasis on intraindividual variability to examine the daily processes associated with relational aspects of grandparenting. Using data from 24 grandmothers in the Personal Understandings of Life and Social Experiences (PULSE) project, we explored how grandmother-reported satisfaction with grandchild interactions impacted grandmothers’ same-day positive and negative affect over 100 days. We first justified the need for microlongitudinal analyses by assessing the degree to which there were within-person shifts in interaction satisfaction over time. Intra-class correlations indicated 86% of the variation in interaction satisfaction was within-persons, warranting an intraindividual variability approach. As such, we then employed multi-level models to examine the within-person and between-person effects of interaction satisfaction predicting same day positive and negative affect. At the within-person level, on days when grandmothers reported higher than their average interaction satisfaction, they reported more positive affect (Estimate = 0.09, SE = 0.03, p = 0.009) and lower negative affect overall that day (Estimate = -0.08, SE = 0.02, p = 0.005). At the between-person level, grandmothers who had, on average, higher interaction satisfaction had more positive affect (Estimate = 0.63, SE = 0.09, p<.0001) and lower negative affect on average (Estimate = -0.53, SE = 0.11, p<.0001).

The Association of Positive and Negative Affect and Exercise Self-Efficacy in Older Adults

2003 ◽  
Vol 11 (2) ◽  
pp. 265-274 ◽  
Author(s):  
Glenn V. Ostir ◽  
Jiska Cohen-Mansfield ◽  
Suzanne Leveille ◽  
Stefano Volpato ◽  
Jack M. Guralnik
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Muscle Strength ◽  
Negative Affect ◽  
Positive Affect ◽  
Aerobic Exercise ◽  
Self Efficacy ◽  
Odds Ratio ◽  
Positive And Negative Affect ◽  
Independent Association

This study investigated whether positive or negative affect has an independent association with exercise self-efficacy. Participants (N= 324) age 75-85 were classified as high or at-risk performers, and three exercise-self-efficacy items (scored 1-10) were assessed. For at-risk performers, positive affect was significantly associated with confidence in the ability to perform strength and flexibility (b= 0.83,SE= 0.23,p= .001) and aerobic exercise (b= 0.59,SE= 0.28,p= .04) and with the perception that exercise would not worsen preexisting symptoms (b= 0.73,SE= 0.24,p= .001). Among high performers, nonsignificant associations were found for positive and negative affect and exercise-self-efficacy. For at-risk performers, higher positive affect was associated with an increased odds ratio of 2.72 for scoring 10 on the muscle strength and flexibility item, 4.08 on the aerobic item, and 2.94 on the item assessing preexisting symptoms. The results suggest that improving at-risk older adults’ positive affect might increase their participation in exercise.

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