scholarly journals Heritability of Age at Menarche in South Korean Female Twins

2019 ◽  
Vol 22 (03) ◽  
pp. 183-186 ◽  
Author(s):  
Yoon-Mi Hur ◽  
Hee-Jeong Jin ◽  
Siwoo Lee
Keyword(s):  
Maximum Likelihood ◽  
Environmental Effects ◽  
Environmental Influences ◽  
Model Fitting ◽  
Total Sample ◽  
Age At Menarche ◽  
South Korean ◽  
Opposite Sex ◽  
The Mean ◽  
Mz Twins

AbstractGenetic and environmental influences on age at menarche (AAM) have rarely been examined in Asian females. This study aimed to investigate the heritability of AAM in South Korean female twins. The AAM data from 1370 female twins (933 monozygotic [MZ] twins, 294 dizygotic [DZ] twins and 160 female members of opposite-sex DZ twins) born between 1988 and 2001 were analyzed. The age of the sample at the time of the assessment ranged from 16 to 28 years with a mean of 19.3 (SD = 2.2) years. The mean AAM in the total sample was 12.49 (SD = 1.41) years. Although the mean AAM decreased with increasing birth years, it levelled off in birth years 2000–2001. Maximum likelihood MZ and DZ twin correlations were 0.72 [95% CI (0.67, 0.76)] and 0.35 [95% CI (0.19, 0.50)], respectively. The results of model-fitting analysis indicated that the additive genetic and individual-specific environmental effects were 72% [95% CI (67%, 76%)] and 28% [95% CI (24%, 33%)], respectively. Neither nonadditive genetic nor shared environmental effects were significant.

scholarly journals Twin Study of the Relationship between Childhood Negative Emotionality and Hyperactivity/Inattention Problems

2021 ◽  
Vol 24 (1) ◽  
pp. 7-13
Author(s):  
Yoon-Mi Hur ◽  
Hoe-Uk Jeong
Keyword(s):  
Genetic Factors ◽  
Environmental Influences ◽  
Model Fitting ◽  
Negative Emotionality ◽  
Phenotypic Correlation ◽  
Environmental Correlation ◽  
South Korean ◽  
Telephone Interviews ◽  
Opposite Sex ◽  
The Relationship

AbstractThe present study aimed to determine the genetic and environmental etiology of the association between childhood negative emotionality (NE) and hyperactivity/inattention problems (HIP) using South Korean elementary school twins (mean age = 10.19 years, SD = 1.79 years). Telephone interviews were given to mothers of 919 twins (229 monozygotic males: 112 pairs and 5 individuals; 148 dizygotic males: 73 pairs and 2 individuals; 180 monozygotic females: 87 pairs and 6 individuals; 103 dizygotic females: 50 pairs and 3 individuals; 259 opposite-sex dizygotic twins: 127 pairs and 5 individuals) to assess their children’s NE and HIP. Consistent with prior studies, the phenotypic correlation between NE and the HIP was moderate (r = .29; 95% CI = .24, .34). Model-fitting analysis revealed that additive genetic and nonshared environmental influences on NE were .45 (95% CI [.34, .54]) and .55 (95% CI [.46, .66]), respectively, and that additive and nonadditive genetic, and nonshared environmental influences on HIP were .08 (95% CI [.03, .26]), .41 (95% CI [.21, .51]) and .51 (95% CI = .42, .61), respectively. In addition, the additive genetic correlation between NE and HIP was 1.0 (95% CI [.52, 1.00]), indicating that additive genetic factors are entirely shared between the two phenotypes. Nonadditive genetic influences were unique to HIP and not responsible for the NE-HIP association. Nonshared environmental correlation was significant but modest (re = .18, 95% CI [.06, .30]).

scholarly journals Heritability of Hwabyung Symptoms in South Korean Adolescent and Young Adult Twins

2018 ◽  
Vol 21 (5) ◽  
pp. 378-383 ◽  
Author(s):  
Yoon-Mi Hur ◽  
Eun-ji Choi ◽  
Jong-Woo Kim ◽  
Hee-Jeong Jin ◽  
Siwoo Lee
Keyword(s):  
Young Adult ◽  
Environmental Influences ◽  
Model Fitting ◽  
Adolescent And Young Adult ◽  
Parameter Estimates ◽  
Present Sample ◽  
South Korean ◽  
Opposite Sex ◽  
Estimate Heritability ◽  
Adult Twins

The present study aimed to estimate heritability of Hwabyung (HB) symptoms in adolescent and young adult twins in South Korea. The sample included 1,601 twins consisting of 143 pairs of monozygotic male (MZM), 67 pairs of dizygotic male (DZM), 295 pairs of monozygotic female (MZF), 114 pairs of dizygotic female (DZF), and 117 pairs of opposite-sex dizygotic (OSDZ) twins and 129 twins with non-participating co-twins (mean age = 19.1 ± 3.1 years; range: 12–29 years). An HB symptom questionnaire was given to twins via a telephone interview. Consistent with the literature of HB, the mean level of HB was significantly higher in females than in males. Maximum likelihood twin correlations for HB were 0.31 (95% CI [0.16, 0.45]) for MZM, 0.19 (95% CI [-0.05, 0.41]) for DZM, 0.50 (95% CI [0.41, 0.58]) for MZF, 0.28 (95% CI [0.11, 0.44]) for DZF, and 0.23 (95% CI [0.05, 0.40]) for OSDZ twins. These patterns of twin correlations suggested the presence of additive genetic influences on HB. Model-fitting analysis showed that additive genetic and individual-specific environmental influences on HB were 44% (95% CI [37, 51]) and 56% (95% CI [49, 63]), respectively. Shared environmental influences were not significant. These parameter estimates were not significantly different between two sexes, and did not change significantly with age in the present sample, suggesting that genetic and environmental influences on HB in both sexes are stable across adolescence and young adulthood.

Effects of Chorion Type on Genetic and Environmental Influences on Height, Weight, and Body Mass Index in South Korean Young Twins

2008 ◽  
Vol 11 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Yoon-Mi Hur ◽  
Jung-Sik Shin
Keyword(s):  
Body Mass Index ◽  
Maximum Likelihood ◽  
Body Mass ◽  
Statistical Significance ◽  
Environmental Influences ◽  
Model Fitting ◽  
Twin Design ◽  
South Korean ◽  
Classical Twin Design ◽  
Chorion Type

AbstractThe present study examined the effects of chorionicity of twins on variations of height, weight, and body mass index (BMI) during childhood in the classical twin design. Mothers of 81 pairs of monochorionic monozygotic (MCMZ), 47 pairs of dichorionic monozygotic (DCMZ), and 457 pairs of dizygotic (DZ) twins drawn from the South Korean Twin Registry reported their children's height and weight. Twins' age ranged from 1.9 to 8.7 yrs, with a mean of 4.0 yrs and SD of 1.7 yrs. We computed maximum likelihood twin correlations and performed model-fitting analyses. In correlational and model-fitting analyses, we treated age and sex as covariates to control their main effects. Maximum likelihood MCMZ, DCMZ, and DZ twin correlations were, respectively, .96, .92, and .74, for height, .88, .91, and .57 for weight, and .93, .92, and .61 for BMI. The pattern of these twin correlations suggested very modest chorion effects on body measures. Model-fitting analyses confirmed the observations from twin correlations. Whereas genetic and shared environmental influences were significant for all three body measures, chorion effects attained statistical significance only for height (4%), and those for weight and BMI were zero. These findings indicate that genetic and environmental estimates for height, weight, and BMI during childhood are biased little by the chorion type of MZ twins, supporting the validity of the equal prenatal environment assumption in the classical twin design.

scholarly journals Adult Empathy: Possible Gender Differences in Gene-Environment Architecture for Cognitive and Emotional Components in a Large Italian Twin Sample

2018 ◽  
Vol 21 (3) ◽  
pp. 214-226 ◽  
Author(s):  
Virgilia Toccaceli ◽  
Corrado Fagnani ◽  
Nancy Eisenberg ◽  
Guido Alessandri ◽  
Augusto Vitale ◽  
...  
Keyword(s):  
Gender Differences ◽  
Environmental Effects ◽  
Genetic Model ◽  
Statistical Significance ◽  
Environmental Influences ◽  
Model Fitting ◽  
Gene Environment ◽  
Empathy Quotient ◽  
Empathy Scale ◽  
Study Participants

Empathy plays a central role in prosocial behavior and human cooperation. Very few twin researchers have investigated innate and environmental effects in adult empathy, and twin research on gender differences in these effects is sparse. The goal of this study was to examine innate and environmental influences on three components of an empathy scale frequently used with adults — the expression of cognitive (CE), emotional (EE), and social skills (SS) empathy — and to explore gender differences in the influences. Study participants were ~1,700 twins (18–65 years) enrolled in the Italian Twin Registry. Empathy was assessed with the Italian version of the Empathy Quotient (EQ), for which the three-factor structure (i.e., CE, EE, and SS) was confirmed. Twin correlations in monozygotic and dizygotic pairs, and males and females were estimated for the total EQ and subscale scores, and univariate genetic model fitting was carried out. Women's empathy (i.e., total EQ as well as CE and EE subdimensions) was predominantly driven by genetic factors and individual experiences, whereas for males, no genetic contribution or important shared and individual environmental effects emerged. Although of large magnitude, the gender differences did not reach statistical significance. Age did not moderate empathy heritability in adulthood. Only for the SS subscale were genetic and environmental proportions of variance similar for men and women. This study suggests possible gender-specific innate and environmental influences on empathy and its cognitive and emotional components that need to be confirmed in future studies.

scholarly journals Common Genetic Influences on Age at Pubertal Voice Change and BMI in Male Twins

2020 ◽  
Vol 23 (4) ◽  
pp. 235-240 ◽  
Author(s):  
Yoon-Mi Hur
Keyword(s):  
Pubertal Timing ◽  
Twin Studies ◽  
Total Sample ◽  
Genetic Influences ◽  
Phenotypic Correlation ◽  
Birth Cohorts ◽  
Voice Change ◽  
Bivariate Model ◽  
South Korean ◽  
The Mean

AbstractThe present study aimed to explore secular trends in age at voice change (AVC), estimate heritability of AVC and investigate to what extent common genes influence the association between AVC and body mass index (BMI) in South Korean males. The sample of 955 male twins consisted of 241 pairs and 118 co-twin missing monozygotic (MZ) twins, 82 pairs and 50 co-twin missing dizygotic (DZ) twins and 141 male members of opposite-sex DZ twins who participated in telephone surveys in the South Korean Twin Registry. AVC was asked of twins during the surveys. The mean (SD) age of the sample was 18.92 (2.42) years (range: 16.00–29.25 years). The birth years of the twins were divided into two groups (1988–1993, 1994–2001). Kaplan–Meyer survival analyses were conducted to compute the mean age of AVC in the total sample as well as to test mean differences between the two birth cohorts. Maximum likelihood twin correlations and univariate and bivariate model-fitting analyses were performed. The mean AVC in the total sample was 14.19 (95% CI [14.09, 14.29]) years. The mean AVC significantly declined from 14.38 to 14.02 years from 1988 to 2001, confirming downward trends in AVC in recent years. Heritability for AVC was .59 (95% CI [.50, .67]), which was within the range reported in most Western twin studies. Although the phenotypic correlation between AVC and BMI was modest (r = −.14; 95% CI [−.07, −.21]), it was entirely mediated by common genes, similar to what has been found in females in prior twin studies. In conclusion, the present twin study underscores the importance of genetic influences on pubertal timing and its association with BMI in South Korean males.

scholarly journals Genetic and Environmental Overlaps Among Sasang Constitution Types: A Multivariate Twin Study

2018 ◽  
Vol 21 (6) ◽  
pp. 518-526 ◽  
Author(s):  
Yoon-Mi Hur ◽  
Siwoo Lee ◽  
Hee-Jeong Jin
Keyword(s):  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Environmental Influences ◽  
Model Fitting ◽  
Multivariate Model ◽  
Environmental Correlations ◽  
Sasang Constitution ◽  
Organ Systems ◽  
Opposite Sex ◽  
Complementary And Alternative

According to the Sasang theory, humans can be categorized into one of the four Sasang constitution (SC) types. The four SC types are Tae-Yang (TY), Tae-Eum (TE), So-Yang (SY), and So-Eum (SE), which are determined mainly on the basis of anthropometric characteristics, personality, and the balance of the physiological functions of the major organ systems. There is a growing recognition in the complementary and alternative medicine area that SC types have the potential to be a useful scientific tool for the prevention, diagnosis, and treatment of diseases (Cooper, Evidence Based Complementary and Alternative Medicine, Vol. 6 (Suppl. 1), 2009, pp. 1–3). The main purposes of the present study are to estimate genetic and environmental influences on SC types, and to explore genetic and environmental correlations that affect phenotypic associations among the SC types. In total, 1,742 (365 monozygotic male, 173 dizygotic male, 675 monozygotic female, 271 dizygotic female, and 258 opposite-sex dizygotic) twins (mean age = 19.1 ± 3.1 year) completed a Sasang questionnaire. Univariate and multivariate model-fitting analyses were performed. Total (additive and non-additive) genetic influences were 71% for males and 81% for females in TE, 70% for males and 71% for females in SE, and 47% for both sexes in SY. Non-additive genetic effects were substantial, and shared environmental influences were negligible in most SC types. Multivariate model-fitting analysis revealed that non-additive genetic and individual-specific environmental correlations between TE and SE were -0.92 (95% CI [-0.89, -0.93]) and -0.62 (95% CI [-0.57, -0.68]), respectively. The corresponding estimates were -0.55 (95% CI [-0.48, -0.61]) and -0.44 (95% CI [-0.37, -0.51]) between TE and SY and 0.19 (95% CI [0.09, 0.29]) and -0.40 (95% CI [-0.32, -0.47]) between SE and SY. These results suggest that the phenotypic associations among SC types may be mediated by pleiotropic mechanism of genes.

Age does not necessarily influence latency of event-related potentials

2014 ◽  
Vol 33 (10) ◽  
pp. 723-727
Author(s):  
M. Westermann ◽  
I. W. Husstedt ◽  
A. Okegwo ◽  
S. Evers
Keyword(s):  
Normal Values ◽  
Rank Correlation ◽  
Event Related Potentials ◽  
Intrinsic Property ◽  
Total Sample ◽  
Oddball Paradigm ◽  
Age Dependent ◽  
Related Potentials ◽  
The Mean ◽  
P3 Component

SummaryEvent-related potentials (ERP) are regarded as age dependent. However, it is not known whether this is an intrinsic property of ERP or an extrinsic factor. We designed a setting in which ERP were evoked using a modified oddball paradigm with highly differentiable and detectable target and non-target stimuli. A total of 98 probands were enrolled in this study. We evaluated the latency and amplitude of the P3 component of visually evoked ERP. The mean P3 latency was 294 ± 28 ms and was not related to age (r = –0.089; p = 0.382; Spearman-rank-correlation). The P3 amplitude was related to age in the total sample (r = –0.323; p = 0.001; Spearmanrank-correlation) but not in the probands under the age of 60 years. There were no significant differences regarding sex. Our findings suggest that ERP are not age dependent if highly differentiable and detectable stimuli are used. This should be considered when normal values of ERP are created for clinical use.

scholarly journals High Adherence to the Mediterranean Diet Is Associated with a Reduced Risk of Obesity among Adults in Gulf Countries

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 995
Author(s):  
Israa M. Shatwan ◽  
Eiman A. Alhinai ◽  
Balqees Alawadhi ◽  
Shelini Surendran ◽  
Najlaa M. Aljefree ◽  
...  
Keyword(s):  
Mediterranean Diet ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Inverse Association ◽  
Protective Effects ◽  
Hip Circumference ◽  
Cross Sectional ◽  
Gulf Countries ◽  
The Mean ◽  
The Mediterranean

The Mediterranean diet (MedDiet) is considered as a good example of a healthy dietary pattern that has protective effects on obesity. The aim of the present study was to assess the adherence of adults from three Gulf countries (Saudi Arabia, Oman, and Kuwait) to the MedDiet and its association with obesity risk. A cross-sectional study was conducted on 961 men and women (75.7%) aged 20–55 years old. Waist circumference (WC), and hip circumference (HC) were measured waist/hip ratio (WHR) and body mass index (BMI) were calculated. A validated 14-item Questionnaire was used to measure adherence to MedDiet. The mean of the adherence to MedDiet score was 5.9 ± 2.03 for the total sample. An inverse association was observed between the adherence to MedDiet and BMI after adjusting for potential confounders (p = 0.0003 in total participants, and p = 0.001 in women only). A protective effect was seen with a higher adherence to the MedDiet on HC, suggesting that a greater adherence to the MedDiet was associated with a decreased HC (p = 0.04 in total participants, and p = 0.01 in women only). In conclusion, low adherence to the MedDiet among participants from three gulf countries was associated with increased obesity indicators, BMI, and HC.

Influence of Age, Sex, and Anthropometric Determinants on the Foot Posture Index in a Pediatric Population

2017 ◽  
Vol 107 (2) ◽  
pp. 124-129 ◽  
Author(s):  
Ana María Jimenez-Cebrian ◽  
María Francisca Morente-Bernal ◽  
Pedro Daniel Román-Bravo ◽  
Juan Francisco Saucedo-Badía ◽  
Juan Antonio Alonso-Ríos ◽  
...  
Keyword(s):  
Pediatric Population ◽  
Quantitative Result ◽  
Total Sample ◽  
Clinical Tool ◽  
Foot Posture Index ◽  
Posture Index ◽  
Asymptomatic Children ◽  
Foot Posture ◽  
The Mean ◽  
Foot Position

Background: The Foot Posture Index (FPI) is a clinical tool for diagnosis that aims to quantify the grade of a foot position as neutral, pronated, or supinated. Its purpose is to develop a simple six-factor method for rating foot posture with an easy and quantitative result. We evaluated possible differences in the FPI by sex and the influences of age, weight, height, foot size, and body mass index (BMI) on foot posture. Methods: In 150 asymptomatic children (79 boys and 71 girls) aged 8 to 13 years, we determined weight, height, BMI, and FPI in the bipedal, static, and relaxed position. The FPI was obtained as the sum of the scores (–2, –1, 0, 1, 2) given to each of the six criteria. Results: The mean ± SD FPI value for the total sample was 5.1 ± 2.1 (boys: 5.1 ± 2.2; girls: 5.2 ± 2.0), so there were no significant differences between the sexes (P = .636). Of the 150 feet examined, none had FPI values of very supinated or highly pronated, two were supinated (1.3%), 76 neutral (50.7%), and 72 pronated (48.0%). Of the total FPI values, 7.7% can be explained by anthropometric variables: height, weight, and foot size (r2 = 0.077; P < .010). Conclusions: The most frequent foot postures in the sample were neutral and pronated. Neither age nor BMI explained variations in the FPI.

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