Porous Gold Nanocages: High Atom Utilization for Thiolated Aptamer Immobilization to Well Balance the Simplicity, Sensitivity, and Cost of Disposable Aptasensors

Laser-deposited gold immobilization layers having different porosities were incorporated into love wave surface acoustic wave sensors (LW-SAWs). Variation of pulsed laser deposition parameters allows good control of the gold film morphology. Biosensors with various gold film porosities were tested using the biotin–avidin reaction. Control of the Au layer morphology is important since the biotin and avidin layer morphologies closely follow that of the gold. The response of the sensors to biotin/avidin, which is a good indicator of biosensor performance, is improved when the gold layer has increased porosity. Given the sizes of the proteins, the laser-deposited porous gold interfaces have optimal pore dimensions to ensure protein stability.

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Correction to: A DM1-doped porous gold nanoshell system for NIR accelerated redox-responsive release and triple modal imaging guided photothermal synergistic chemotherapy

Journal of Nanobiotechnology ◽

10.1186/s12951-021-00844-1 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Pengcheng Xu ◽

Ru Wang ◽

Wenqian Yang ◽

Yanyan Liu ◽

Dongsheng He ◽

...

Keyword(s):

Gold Nanoshell ◽

Porous Gold ◽

Redox Responsive

An amendment to this paper has been published and can be accessed via the original article.

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Correction to Inducing Cancer Cell Death by Targeting Its Nucleus: Solid Gold Nanospheres versus Hollow Gold Nanocages

Bioconjugate Chemistry ◽

10.1021/bc400299q ◽

2013 ◽

Vol 24 (8) ◽

pp. 1414-1414 ◽

Cited By ~ 1

Author(s):

Megan A. Mackey ◽

Farhat Saira ◽

Mahmoud A. Mahmoud ◽

Mostafa A. El-Sayed

Keyword(s):

Cell Death ◽

Cancer Cell ◽

Gold Nanospheres ◽

Solid Gold ◽

Cancer Cell Death ◽

Gold Nanocages

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Fabrication of a surface-enhanced Raman spectroscopy-based analytical method consisting of multifunctional DNA three-way junction-conjugated porous gold nanoparticles and Au-Te nanoworm for C-reactive protein detection

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-021-03559-2 ◽

2021 ◽

Author(s):

Soo Min Kim ◽

Jinmyeong Kim ◽

Gyeonghye Yim ◽

Ho Jung Ahn ◽

Myoungro Lee ◽

...

Keyword(s):

Gold Nanoparticles ◽

Raman Spectroscopy ◽

Analytical Method ◽

Protein Detection ◽

Surface Enhanced Raman Spectroscopy ◽

C Reactive Protein ◽

Reactive Protein ◽

Porous Gold ◽

Surface Enhanced ◽

Surface Enhanced Raman

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Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation

Pharmaceutics ◽

10.3390/pharmaceutics11030143 ◽

2019 ◽

Vol 11 (3) ◽

pp. 143 ◽

Cited By ~ 4

Author(s):

Jingnan Zhao

Keyword(s):

Hyaluronic Acid ◽

Inflammatory Cells ◽

Oxygen Species ◽

Necrosis Factor Alpha ◽

Tnf Α ◽

Nanogold Particles ◽

Gold Nanocages ◽

Factor Alpha ◽

Anti Inflammatory ◽

Necrosis Factor

Gold nanocages (AuNCs) are biocompatible and porous nanogold particles that have been widely used in biomedical fields. In this study, hyaluronic acid (HA) and peptide- modified gold nanocages (HA-AuNCs/T/P) loaded with 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1) were prepared to investigate their potential for combating inflammation. TPCA-1 was released from AuNCs, intracellularly when HA was hydrolyzed by hyaluronidase. HA-AuNCs/T/P show a much higher intracellular uptake than AuNCs/T/P, and exhibit a much higher efficacy on the suppression of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) than free TPCA-1, suggesting great improvement to the anti-inflammatory efficacy of TPCA-1 through the application of AuNCs. HA-AuNCs/T/P can also reduce the production of reactive oxygen species in inflammatory cells. This study suggests that HA-AuNCs/T/P may be potential agents for anti-inflammatory treatment, and are worthy of further investigation.

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Comparative effect of thermo/pH-responsive polymer-coated gold nanocages and hollow nanostars on chemo-photothermal therapy of breast cancer cells

Cancer Nanotechnology ◽

10.1186/s12645-021-00091-x ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Asrin Pakravan ◽

Mehdi Azizi ◽

Fariborz Rahimi ◽

Farhad Bani ◽

Farideh Mahmoudzadeh ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Mtt Assay ◽

Photothermal Therapy ◽

Breast Cancer Cells ◽

Covalent Attachment ◽

Mcf7 Cells ◽

Dapi Staining ◽

Hemolysis Assay ◽

Gold Nanocages

Abstract Background Combination chemo-photothermal therapy appears to be one of the next generations of cancer treatment. In this study hollow gold nanostars (HGNSs) and gold nanocages (GNCs) were synthesized and stabilized with thermo-pH-sensitive thiol-end capped ABC triblock copolymer poly(acrylic acid)-b-poly(N isopropylacrylamide)-b-poly (e-caprolactone)-SH; PAA-b-PNIPAAm-b-PCL-SH (GNSs@Pol). Doxorubicin (Dox) was conjugated to the GNSs@Pol nanostructures via ionic interaction, covalent attachment and hydrogen bonding (GNSs@Dox-Pol). The physicochemical characteristics of prepared GNSs@Pol and GNSs were assessed using dynamic light scattering (DLS), transmission electron microscopy (TEM) and zeta potential techniques. Cytocompatibility of the GNSs@Pol was studied by hemolysis assay and MTT assay. The chemo-photothermal therapy (PTT) potential of GNSs@Dox-Pol was compared on MCF7 cells using MTT assay, cell cycle, DAPI staining and Annexin-V apoptosis assay techniques. Results Cell internalization results showed an almost complete uptake of GNSs@Pol by MCF-7 cells in the first 3 h of treatment. The heat generation measurement results showed that both of GNSs have a potential for light to heat conversion (∆T = 23–27 ºC) and HGNSs demonstrated better efficiency than GNCs after 10-min exposure to NIR irradiation. Following chemo-photothermal treatment, the highest cell mortality (90%) and apoptotic effects (97% apoptosis) were observed in HGNSs@Dox-Pol received laser irradiation treatment group. Conclusions This work highlights the potential application of designed GNSs@Dox-Pol in a combinational chemo-PTT to treat breast cancer cells. Graphic abstract

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Laser-induced fabrication of porous gold nanoshells

Nanoscale ◽

10.1039/c8nr04617d ◽

2018 ◽

Vol 10 (43) ◽

pp. 20108-20112 ◽

Cited By ~ 12

Author(s):

Tae-Hyeon Park ◽

Du-Jeon Jang

Keyword(s):

Raman Scattering ◽

Laser Irradiation ◽

High Surface ◽

Gold Nanoshells ◽

Nanosecond Laser ◽

Scattering Efficiency ◽

Porous Gold ◽

Surface Enhanced ◽

Surface Enhanced Raman ◽

Enhanced Raman Scattering

Hollow and porous gold nanoshells with high surface-enhanced Raman scattering efficiency have been fabricated through utilizing nanosecond laser irradiation.

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