scholarly journals Model Studies To Access the [6,7,5,5]-Core of Ineleganolide Using Tandem Translactonization–Cope or Cyclopropanation–Cope Rearrangements as Key Steps

2017 ◽  
Vol 82 (24) ◽  
pp. 13051-13067 ◽  
Author(s):  
Jennifer L. Roizen ◽  
Amanda C. Jones ◽  
Russell C. Smith ◽  
Scott C. Virgil ◽  
Brian M. Stoltz
Keyword(s):  
Model Studies ◽  
Cope Rearrangements ◽  
Key Steps

Preparation of (4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide. A synthetic approach to olguine: further model studies

1987 ◽  
Vol 65 (2) ◽  
pp. 332-338 ◽  
Author(s):  
Serafin Valverde ◽  
Bernardo Herradon ◽  
Rosa M. Rabanal ◽  
Manuel Martin-Lomas
Keyword(s):  
Tartaric Acid ◽  
Title Compound ◽  
Synthetic Approach ◽  
Enantiomerically Pure ◽  
Model Studies ◽  
Phosphonium Iodide ◽  
Key Steps

The enantiomerically pure title compound ((4R,5S)-(5-methyl-2,2-dimethyl-1,3-dioxolane-4-ylmethyl)-phosphonium iodide) has been synthesized starting from (R,R)-(+)-tartaric acid. The synthesis of an olguine analog has been carried out. Attempts have been made to improve the stereoselectivity and yield of key steps.

Novel Synthesis of 4-Fluoropyridines Based on 2-Fluoroallylic Alcohols by Succeeding Ireland-Claisen and Aza-Cope Rearrangements as Key Steps

Synthesis ◽  
2006 ◽  
Vol 2006 (13) ◽  
pp. 2085-2096 ◽  
Author(s):  
Günter Haufe ◽  
Ulrich Wittmann ◽  
Frank Tranel ◽  
Roland Fröhlich
Keyword(s):  
Novel Synthesis ◽  
Cope Rearrangements ◽  
Key Steps

Reflections on the Cognitive Interviewing Reporting Framework

Methodology ◽  
2013 ◽  
Vol 9 (3) ◽  
pp. 123-128 ◽  
Author(s):  
Gordon Willis ◽  
Hennie Boeije
Keyword(s):  
Research Design ◽  
Cognitive Testing ◽  
Level Of Detail ◽  
Cognitive Interviewing ◽  
Research Groups ◽  
Research Project ◽  
Reporting Framework ◽  
Full Explanation ◽  
Key Steps

Based on the experiences of three research groups using and evaluating the Cognitive Interviewing Reporting Framework (CIRF), we draw conclusions about the utility of the CIRF as a guide to creating cognitive testing reports. Authors generally found the CIRF checklist to be usable, and that it led to a more complete description of key steps involved. However, despite the explicit direction by the CIRF to include a full explanation of major steps and features (e.g., research objectives and research design), the three cognitive testing reports tended to simply state what was done, without further justification. Authors varied in their judgments concerning whether the CIRF requires the appropriate level of detail. Overall, we believe that current cognitive interviewing practice will benefit from including, within cognitive testing reports, the 10 categories of information specified by the CIRF. Future use of the CIRF may serve to direct the overall research project from the start, and to further the goal of evaluation of specific cognitive interviewing procedures.

“In vitro” and in Animal Model Studies on a Double Virus- Inactivated Factor VIII Concentrate

1995 ◽  
Vol 74 (03) ◽  
pp. 868-873 ◽  
Author(s):  
Silvana Arrighi ◽  
Roberta Rossi ◽  
Maria Giuseppina Borri ◽  
Vladimir Lesnikov ◽  
Marina Lesnikov ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Animal Model ◽  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Virus Inactivation ◽  
Enveloped Viruses ◽  
Model Studies ◽  
Heat Treated

SummaryTo improve the safety of plasma derived factor VIII (FVIII) concentrate, we introduced a final super heat treatment (100° C for 30 min) as additional virus inactivation step applied to a lyophilized, highly purified FVIII concentrate (100 IU/mg of proteins) already virus inactivated using the solvent/detergent (SID) method during the manufacturing process.The efficiency of the super heat treatment was demonstrated in inactivating two non-lipid enveloped viruses (Hepatitis A virus and Poliovirus 1). The loss of FVIII procoagulant activity during the super heat treatment was of about 15%, estimated both by clotting and chromogenic assays. No substantial changes were observed in physical, biochemical and immunological characteristics of the heat treated FVIII concentrate in comparison with those of the FVIII before heat treatment.

The Nature of Mining-Induced Horizontal Displacement of Surface on the Example of Several Coal Mines

2014 ◽  
Vol 59 (4) ◽  
pp. 971-986 ◽  
Author(s):  
Krzysztof Tajduś
Keyword(s):  
Underground Mining ◽  
Mining Industry ◽  
Horizontal Displacement ◽  
Surface Slope ◽  
Proportionality Coefficient ◽  
Model Studies ◽  
Displacement Vectors ◽  
Mining Conditions ◽  
Design Projects ◽  
Academy Of Sciences

Abstract The paper presents the analysis of the phenomenon of horizontal displacement of surface induced by underground mining exploitation. In the initial part, the basic theories describing horizontal displacement are discussed, followed by three illustrative examples of underground exploitation in varied mining conditions. It is argued that center of gravity (COG) method presented in the paper, hypothesis of Awierszyn and model studies carried out in Strata Mechanics Research Institute of the Polish Academy of Sciences indicate the proportionality between vectors of horizontal displacement and the vector of surface slope. The differences practically relate to the value of proportionality coefficient B, whose estimated values in currently realized design projects for mining industry range between 0.23r to 0.42r for deep exploitations, whereas in the present article the values of 0.33r and 0.47r were obtained for two instances of shallow exploitation. Furthermore, observations on changes of horizontal displacement vectors with face advancement indicated the possibility of existence of COG zones above the mined-out field, which proved the conclusions of hitherto carried out research studies (Tajduś 2013).

The development of alternative energy sources: Prospects in Russia and the world

2020 ◽  
Vol 16 (5) ◽  
pp. 885-904
Author(s):  
M.E. Frai
Keyword(s):  
Alternative Energy ◽  
Systems Approach ◽  
Energy Resource ◽  
Current Situation ◽  
Energy Sources ◽  
The Sustainable Development ◽  
Energy Complex ◽  
Alternative Energy Sources ◽  
Governmental Institutions ◽  
Key Steps

Subject. The article discusses limited sources of energy nowadays and an ongoing survey of new ones. I focus on fuel and energy complexes worldwide and in Russia. Objectives. The study is to analyze the future use of alternative energy sources in the fuel and energy complex nationwide and worldwide. I review the existing energy sources of the fuel and energy complex in the global and regional markets, specifically the alternative ones. Methods. The study relies upon methods of statistics, analysis and systems approach. Results. The article demonstrates that the fuel and energy complex strongly depends on the current situation in the energy resource market, which is difficult to forecast. If we continue relying on traditional energy resources, we get exposed to some risks affecting the sustainable development of the economy. Russia should diversify the power engineering sector by developing alternative energy sources. The article sets forth the economic rationale for alternative sources and key steps Russia shall make. Conclusions and Relevance. Considering the current situation in the energy balance, alternative energy is what any advanced society seeks for, being supported by manufacturers, governmental institutions, and researchers, though low profitability and high infrastructure costs impede its development. In Russia, these challenges are even more palpable. However, even now Russia is able to find alternative energy solutions. In addition to advantages of alternative energy, which is globally proclaimed, they will also help Russia diversify and update the economic system.

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