Aqueous Suspensions of Cellulose Oligomer Nanoribbons for Growth and Natural Filtration-Based Separation of Cancer Spheroids

Langmuir ◽  
2020 ◽  
Vol 36 (46) ◽  
pp. 13890-13898
Author(s):  
Takeshi Serizawa ◽  
Tohru Maeda ◽  
Saeko Yamaguchi ◽  
Toshiki Sawada
Keyword(s):  
Aqueous Suspensions ◽  
Natural Filtration ◽  
Cancer Spheroids

Coagulation-condensation structure formation in aqueous suspensions of mixtures of sulfur and gypsum

2013 ◽  
Vol 0 (1) ◽  
pp. 122
Author(s):  
K. Toshtay ◽  
Kuanyshbek Mussabekov ◽  
S. Kumargaliyeva ◽  
С. Turganbay ◽  
Inal Bakhytkyzy
Keyword(s):  
Structure Formation ◽  
Aqueous Suspensions ◽  
Condensation Structure

scholarly journals Optimization of Sintering Process of Alumina Ceramics Using Response Surface Methodology

2021 ◽  
Vol 13 (12) ◽  
pp. 6739
Author(s):  
Darko Landek ◽  
Lidija Ćurković ◽  
Ivana Gabelica ◽  
Mihone Kerolli Mustafa ◽  
Irena Žmak
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Heating Rate ◽  
Sintering Temperature ◽  
Nonlinear Models ◽  
Slip Casting ◽  
Holding Time ◽  
Alumina Ceramics ◽  
Aqueous Suspensions ◽  
Temperature Heating

In this work, alumina (Al2O3) ceramics were prepared using an environmentally friendly slip casting method. To this end, highly concentrated (70 wt.%) aqueous suspensions of alumina (Al2O3) were prepared with different amounts of the ammonium salt of a polycarboxylic acid, Dolapix CE 64, as an electrosteric dispersant. The stability of highly concentrated Al2O3 aqueous suspensions was monitored by viscosity measurements. Green bodies (ceramics before sintering) were obtained by pouring the stable Al2O3 aqueous suspensions into dry porous plaster molds. The obtained Al2O3 ceramic green bodies were sintered in the electric furnace. Analysis of the effect of three sintering parameters (sintering temperature, heating rate and holding time) on the density of alumina ceramics was performed using the response surface methodology (RSM), based on experimental data obtained according to Box–Behnken experimental design, using the software Design-Expert. From the statistical analysis, linear and nonlinear models with added first-order interaction were developed for prediction and optimization of density-dependent variables: sintering temperature, heating rate and holding time.

scholarly journals Path homology theory of edge-colored graphs

2021 ◽  
Vol 19 (1) ◽  
pp. 706-723
Author(s):  
Yuri V. Muranov ◽  
Anna Szczepkowska
Keyword(s):  
Spectral Sequence ◽  
Edge Coloring ◽  
Homology Theory ◽  
Homotopy Category ◽  
Homology Groups ◽  
Colored Graphs ◽  
Natural Filtration ◽  
Definition Of ◽  
Exact Sequences

Abstract In this paper, we introduce the category and the homotopy category of edge-colored digraphs and construct the functorial homology theory on the foundation of the path homology theory provided by Grigoryan, Muranov, and Shing-Tung Yau. We give the construction of the path homology theory for edge-colored graphs that follows immediately from the consideration of natural functor from the category of graphs to the subcategory of symmetrical digraphs. We describe the natural filtration of path homology groups of any digraph equipped with edge coloring, provide the definition of the corresponding spectral sequence, and obtain commutative diagrams and braids of exact sequences.

scholarly journals Extracellular vesicles derived from ascitic fluid enhance growth and migration of ovarian cancer cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aparna Mitra ◽  
Kyoko Yoshida-Court ◽  
Travis N. Solley ◽  
Megan Mikkelson ◽  
Chi Lam Au Yeung ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Extracellular Vesicles ◽  
Ovarian Cancer Cells ◽  
High Grade ◽  
Serous Ovarian Carcinoma ◽  
Advanced Stages ◽  
And Migration ◽  
Cancer Spheroids ◽  
Omental Fat ◽  
Low Expression

AbstractOvarian cancer is associated with a high mortality rate due to diagnosis at advanced stages. Dissemination often occurs intraperitoneally within the ascites fluid. The microenvironment can support dissemination through several mechanisms. One potential ascites factor which may mediate dissemination are EVs or extracellular vesicles that can carry information in the form of miRNAs, proteins, lipids, and act as mediators of cellular communication. We present our observations on EVs isolated from ascitic supernatants from patients diagnosed with high grade serous ovarian carcinoma in augmenting motility, growth, and migration towards omental fat. MicroRNA profiling of EVs from malignant ascitic supernatant demonstrates high expression of miR 200c-3p, miR18a-5p, miR1246, and miR1290 and low expression of miR 100- 5p as compared to EVs isolated from benign ascitic supernatant. The migration of ovarian cancer spheroids towards omental fat is enhanced in the presence of malignant ascitic EVs. Gene expression of these cells showed increased expression of ZBED2, ZBTB20, ABCC3, UHMK1, and low expression of Transgelin and MARCKS. We present evidence that ovarian ascitic EVs increase the growth of ovarian cancer spheroids through miRNAs.

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