scholarly journals Photodynamic and Contact Killing Polymeric Fabric Coating for Bacteria and SARS-CoV-2

Author(s):  
Taylor Wright ◽  
Marli Vlok ◽  
Tirosh Shapira ◽  
Andrea D. Olmstead ◽  
François Jean ◽  
...  
Keyword(s):  

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 137
Author(s):  
Xinzhen Fan ◽  
L’Hocine Yahia ◽  
Edward Sacher

Microbes, including bacteria and fungi, easily form stable biofilms on many surfaces. Such biofilms have high resistance to antibiotics, and cause nosocomial and postoperative infections. The antimicrobial and antiviral behaviors of Ag and Cu nanoparticles (NPs) are well known, and possible mechanisms for their actions, such as released ions, reactive oxygen species (ROS), contact killing, the immunostimulatory effect, and others have been proposed. Ag and Cu NPs, and their derivative NPs, have different antimicrobial capacities and cytotoxicities. Factors, such as size, shape and surface treatment, influence their antimicrobial activities. The biomedical application of antimicrobial Ag and Cu NPs involves coating onto substrates, including textiles, polymers, ceramics, and metals. Because Ag and Cu are immiscible, synthetic AgCu nanoalloys have different microstructures, which impact their antimicrobial effects. When mixed, the combination of Ag and Cu NPs act synergistically, offering substantially enhanced antimicrobial behavior. However, when alloyed in Ag–Cu NPs, the antimicrobial behavior is even more enhanced. The reason for this enhancement is unclear. Here, we discuss these results and the possible behavior mechanisms that underlie them.



2020 ◽  
Vol 04 (Supp01) ◽  
pp. 1-6
Author(s):  
Tan Yee Lin

The development of cross infections arising from bacteria transmission on frequently touched facilities has led to an urgent need to promptly disinfect these surfaces, such as hand railings, door handles and elevator buttons. Conventional antimicrobial disinfectants are not ideal as they contribute to the growing antimicrobial resistance crisis. In recent years, the discovery that the wings of insects such as the Clanger cicada (Psaltoda claripennis) possess naturally occurring antimicrobial properties has led to a growing interest to synthetically recreate these surfaces. The use of a physical contact killing mechanism on such nanotextured surfaces is a promising strategy for curbing the proliferation of bacteria, as it is unlikely to contribute to the formation of antimicrobial resistance. Here, I highlight the key advantages of using these antimicrobial nanotextured materials and how they could play a role in safeguarding public health security, especially during the current COVID-19 pandemic.



2018 ◽  
Vol 9 (23) ◽  
pp. 3195-3198 ◽  
Author(s):  
Chao Peng ◽  
Apoorva Vishwakarma ◽  
Zhuoran Li ◽  
Toshikazu Miyoshi ◽  
Hazel A. Barton ◽  
...  

Tecoflex-NH3+ exhibited a contact-killing mechanism and showed excellent anti-biofilm properties against E. coli even after 5 days.



RSC Advances ◽  
2019 ◽  
Vol 9 (23) ◽  
pp. 13159-13167
Author(s):  
Kaimei Peng ◽  
Jianqing Hu ◽  
Xuexin Dai ◽  
Zaibo Yang ◽  
Runping Wang ◽  
...  

A new self-stratified contact-killing antimicrobial polyurethane was synthesized via efficient and orthogonal click-chemistry.



2020 ◽  
Vol 491 ◽  
pp. 107983 ◽  
Author(s):  
Aatrayee Das ◽  
Sonia Kundu ◽  
Sumanta Kumar Ghosh ◽  
Aalok Basu ◽  
Mradu Gupta ◽  
...  




2020 ◽  
Vol 114 ◽  
pp. 117-132 ◽  
Author(s):  
Liheng Gao ◽  
Yiwei Wang ◽  
Yimeng Li ◽  
Mingxi Xu ◽  
Gang Sun ◽  
...  


2020 ◽  
Vol 7 (3) ◽  
pp. 83 ◽  
Author(s):  
Heba Mitwalli ◽  
Rashed Alsahafi ◽  
Abdulrahman A. Balhaddad ◽  
Michael D. Weir ◽  
Hockin H. K. Xu ◽  
...  

Polymeric materials are the first choice for restoring tooth cavities, bonding tooth-colored fillings, sealing root canal systems, and many other dental restorative applications. However, polymeric materials are highly susceptible to bacterial attachment and colonization, leading to dental diseases. Many approaches have been investigated to minimize the formation of biofilms over polymeric restorative materials and at the tooth/material interfaces. Among them, contact-killing compounds have shown promising results to inhibit dental biofilms. Contact-killing compounds can be immobilized within the polymer structure, delivering a long-lasting effect with no leaching or release, thus providing advantages compared to release-based materials. This review discusses cutting-edge research on the development of contact-killing compounds in dental restorative materials to target oral pathogens. Contact-killing compounds in resin composite restorations, dental adhesives, root canal sealers, denture-based materials, and crown cements have all demonstrated promising antibacterial properties. Contact-killing restorative materials have been found to effectively inhibit the growth and activities of several oral pathogens related to dental caries, periodontal diseases, endodontic, and fungal infections. Further laboratory optimization and clinical trials using translational models are needed to confirm the clinical applicability of this new generation of contact-killing dental restorative materials.



Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1678
Author(s):  
Artemis Tsagdi ◽  
Denisa Druvari ◽  
Dionisios Panagiotaras ◽  
Pavlos Avramidis ◽  
Vlasoula Bekiari ◽  
...  

Crosslinked polymeric materials based on a quaternary trimethylammonium compound were developed and evaluated as potential antifouling coatings. For this purpose, two water-soluble random copolymers, poly(4-vinylbenzyltrimethylammonium chloride-co-acrylic acid) P(VBCTMAM-co-AAx) and poly(N,N-dimethylacrylamide-co-glycidylmethacrylate) P(DMAm-co-GMAx), were synthesized via free radical polymerization. A water based approach for the synthesis of P(VBCTMAM-co-AAx) copolymer was used. Coatings of the complementary reactive copolymers in different compositions were obtained by curing at 120 °C for one day and were used to coat aquaculture nets. These nets were evaluated in respect to their release rate using Total Organic Carbon (TOC) and Total Nitrogen (TN) measurements. Finally, the antifouling efficacy of these newly-composed durable coatings was investigated for 14 days in accelerated conditions. The results showed that this novel polymeric material provides contact-killing antifouling activity for a short time period, whereas it functions efficiently in biofouling removal after high-pressure cleaning.





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