Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway

2022 ◽  
Author(s):  
Jiarong Yang ◽  
Haojie Li ◽  
Zijun Hao ◽  
Xiaoyuan Jing ◽  
Yangfei Zhao ◽  
...  
Keyword(s):  
Selenium Nanoparticles ◽  
Stat3 Pathway

HDAC-abhängige Regulation des IL-6/STAT3 pathway bei T-Helferzellaktivierung

2013 ◽  
Vol 51 (08) ◽  
Author(s):  
E Sonnenberg ◽  
R Glauben ◽  
M Wetzel ◽  
P Mascagni ◽  
B Siegmund
Keyword(s):  
Stat3 Pathway

Insight on Ameliorative Role of Selenium Nanoparticles and Niacin in Wound Healing on Adult Female Albino Mice

2020 ◽  
Vol 14 (3) ◽  
pp. 169-186
Author(s):  
Marwa Emam ◽  
Akaber T. Keshta ◽  
Yasser M.A. Mohamed ◽  
Yasser A. Attia
Keyword(s):  
Wound Healing ◽  
Adult Female ◽  
Vascular Endothelial Cell ◽  
Skin Layer ◽  
Positive Control ◽  
Healing Time ◽  
Selenium Nanoparticles ◽  
Tissue Samples ◽  
Liver And Kidney ◽  
Albino Mice

Background: Wound healing is a complex process necessary for repairing damaged tissues and preventing infection. Selenium nanoparticles (Se NPs) were known due to their antioxidant and antimicrobial effects, also niacin has angiogenesis and antioxidant effects that are important in wound healing. Objective: The present study was conducted to investigate the effect of Se NPs and niacin in reducing and accelerating the wound healing time in mice. Methods: A simple wet chemical method has been modified to synthesize Se NPs in order to investigate their effect and niacin on reducing the wound healing in 80 adult female albino mice (250 mm2 full thickness open excision wound) that were divided into eight groups (10 mice/each). After 30-days, the mice were sacrificed, blood and tissue samples were taken for analysis. Results: The results showed that the percentage of wound area had been significantly reduced in Se NPs and niacin treated groups compared to the positive control. The level of Vascular Endothelial cell Growth Factor and Collagenase I in Se NPs and niacin groups significantly exceed those of other groups while Nitric Oxide (NO) was significantly decreased in treated groups. Liver and kidney functions showed the lower toxicity effect of Se NPs and niacin. Skin tissue showed the wound healing effect of Se NPs and niacin by regenerating skin layer compared to the positive group. Conclusion: Se NPs and niacin play an important role in accelerating and reducing the time of wound healing while they were antagonistic to each other.

scholarly journals Antia, a Natural Antioxidant Product, Attenuates Cognitive Dysfunction in Streptozotocin-Induced Mouse Model of Sporadic Alzheimer’s Disease by Targeting the Amyloidogenic, Inflammatory, Autophagy, and Oxidative Stress Pathways

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Nesrine S. El Sayed ◽  
Mamdooh H. Ghoneum
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Protective Effect ◽  
Cognitive Dysfunction ◽  
Protective Role ◽  
Sporadic Alzheimer’S Disease ◽  
Stat3 Pathway ◽  
And Oxidative Stress

Background. Many neurodegenerative diseases such as Alzheimer’s disease are associated with oxidative stress. Therefore, antioxidant therapy has been suggested for the prevention and treatment of neurodegenerative diseases. Objective. We investigated the ability of the antioxidant Antia to exert a protective effect against sporadic Alzheimer’s disease (SAD) induced in mice. Antia is a natural product that is extracted from the edible yamabushitake mushroom, the gotsukora and kothala himbutu plants, diosgenin (an extract from wild yam tubers), and amla (Indian gooseberry) after treatment with MRN-100. Methods. Single intracerebroventricular (ICV) injection of streptozotocin (STZ) (3 mg/kg) was used for induction of SAD in mice. Antia was injected intraperitoneally (i.p.) in 3 doses (25, 50, and 100 mg/kg/day) for 21 days. Neurobehavioral tests were conducted within 24 h after the last day of injection. Afterwards, mice were sacrificed and their hippocampi were rapidly excised, weighed, and homogenized to be used for measuring biochemical parameters. Results. Treatment with Antia significantly improved mice performance in the Morris water maze. In addition, biochemical analysis showed that Antia exerted a protective effect for several compounds, including GSH, MDA, NF-κB, IL-6, TNF-α, and amyloid β. Further studies with western blot showed the protective effect of Antia for the JAK2/STAT3 pathway. Conclusions. Antia exerts a significant protection against cognitive dysfunction induced by ICV-STZ injection. This effect is achieved through targeting of the amyloidogenic, inflammatory, and oxidative stress pathways. The JAK2/STAT3 pathway plays a protective role for neuroinflammatory and neurodegenerative diseases such as SAD.

scholarly journals Melatonin-selenium nanoparticles protects liver against immunological injury induced by bacillus Calmette-Guérin and lipopolysaccharide

2005 ◽  
Vol 26 (6) ◽  
pp. 745-752 ◽  
Author(s):  
Hua WANG ◽  
Wei WEI ◽  
Sheng-yi ZHANG ◽  
Yu-xian SHEN ◽  
Ni-ping WANG ◽  
...  
Keyword(s):  
Selenium Nanoparticles ◽  
Bacillus Calmette Guerin

M1959 Helicobacter pylori cagA Tyrosine Phosphorylation Triggers the Interleukin-11/STAT3 Pathway in Gastric Epithelial Cells

2010 ◽  
Vol 138 (5) ◽  
pp. S-448
Author(s):  
Kai Syin Lee ◽  
Anastasia Kalantzis ◽  
Naoko Murata-Kamiya ◽  
Masanori Hatakeyama ◽  
Andrew S. Giraud ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Tyrosine Phosphorylation ◽  
Gastric Epithelial Cells ◽  
Stat3 Pathway ◽  
Interleukin 11

scholarly journals Biogenic synthesis of selenium nanoparticles by Shewanella sp. HN-41 using modified bioelectrochemical system

2021 ◽  
Author(s):  
Cuong Tu Ho ◽  
Thi-Hanh Nguyen ◽  
Thuong-Thuong Lam ◽  
Dang-Quang Le ◽  
Canh Xuan Nguyen ◽  
...  
Keyword(s):  
Selenium Nanoparticles ◽  
Bioelectrochemical System ◽  
Biogenic Synthesis

Selenite bioreduction and biosynthesis of selenium nanoparticles by Bacillus paramycoides SP3 isolated from coal mine overburden leachate

2021 ◽  
pp. 117519
Author(s):  
Siddhartha Narayan Borah ◽  
Lalit Goswami ◽  
Suparna Sen ◽  
Deepa Sachan ◽  
Hemen Sarma ◽  
...  
Keyword(s):  
Coal Mine ◽  
Selenium Nanoparticles

scholarly journals The Antimicrobial, Antioxidant, and Anticancer Activity of Greenly Synthesized Selenium and Zinc Composite Nanoparticles Using Ephedra aphylla Extract

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 470
Author(s):  
Mustafa Mohsen El-Zayat ◽  
Mostafa M. Eraqi ◽  
Hani Alrefai ◽  
Ayman Y. El-Khateeb ◽  
Marwan A. Ibrahim ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Anticancer Agents ◽  
Antimicrobial Agents ◽  
Selenium Nanoparticles ◽  
Normal Lung ◽  
Zinc Nanoparticles ◽  
Antioxidant Agents ◽  
Hct 116 ◽  
Phytochemical Constituents ◽  
Hct 116 Cells

The current work aimed to synthesize selenium and zinc nanoparticles using the aqueous extract of Ephedra aphylla as a valuable medicinal plant. The prepared nanoparticles were characterized by TEM, zeta potential, and changes in the phytochemical constituents. Hence, the phenolic, flavonoid, and tannin contents were reduced in the case of the prepared samples of nanoparticles than the original values in the aqueous extract. The prepared extract of Ephedra aphylla and its selenium and zinc nanoparticles showed high potency as antioxidant agents as a result of the DPPH• assay. The samples were assessed as anticancer agents against six tumor cells and a normal lung fibroblast (WI-38) cell line. The selenium nanoparticles of Ephedra aphylla extract revealed very strong cytotoxicity against HePG-2 cells (inhibitory concentration (IC50) = 7.56 ± 0.6 µg/mL), HCT-116 cells (IC50 = 10.02 ± 0.9 µg/mL), and HeLa cells (IC50 = 9.23 ± 0.8 µg/mL). The samples were evaluated as antimicrobial agents against bacterial and fungal strains. Thus, selenium nanoparticles showed potent activities against Gram-negative strains (Salmonella typhimurium, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli), Gram-positive strains (Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus, and Staphylococcus epidermidis), and the fungal strain Candida albicans. In conclusion, the preparation of nanoparticles of either selenium or zinc is crucial for improved biological characteristics.

Toxicity and deleterious impacts of selenium nanoparticles at supranutritional and imbalance levels on male goldfish (Carassius auratus) sperm

2021 ◽  
Vol 66 ◽  
pp. 126758
Author(s):  
Javad Seyedi ◽  
Mohammad Reza Kalbassi ◽  
Milad Esmaeilbeigi ◽  
Mohammad Behzadi Tayemeh ◽  
Jamshid Amiri Moghadam
Keyword(s):  
Carassius Auratus ◽  
Selenium Nanoparticles ◽  
Goldfish Carassius Auratus
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