Grewia abutilifolia (Tiliaceae) tree is known for its uses in traditional medicine due to its various degrees of ethno-pharmacological activities. In this study, Grewia abutilifolia was evaluated for its in vitro antioxidant activities; further, flavonoids, flavonols, total phenolic content and proanthocyanidins content were determined to justify its uses against various oxidative stresses.We evaluated antioxidant activity by determining total antioxidant, Fe3+ reducing power, DPPH (2,2-diphenyl-1-picrylhydrazyl) and hydroxyl radical scavenging, and lipid peroxidation inhibition activity. Aqueous fraction (AQF) contained highest total phenolic content (238.56 mg of gallic acid equivalent/g). Crude methanolic extract (CHE) contained maximum flavonoid (211.54 mg) and flavonols (380.25 mg) content equivalent to quercetin which showed significant reducing activity. Proanthocyanidins content was highest in petroleum ether fraction (PEF), 45.89 mg of catechin equivalent per gram. PEF showed maximum activity in DPPH scavenging assay (IC50 = 3.82 ± 0.055 μg/ml) and in hydroxyl radical scavenging assay (IC50, concentration required to inhibit the process by half, of 6.45 ± 1.297 μg/ml). Lipid peroxidation inhibition activity was also performed in the test chloroform fraction (CLF), which showed the highest inhibition (IC50 = 15.62 ± 1.31 μg/ml). These results suggested its potentiality against various diseases related to oxidative stress.