The Impact of Trauma History on Pain Anxiety and Sensitivity to the Cold Pressor

2009 ◽  
Author(s):  
Leah Irish ◽  
Douglas Delahanty
Keyword(s):  
Cold Pressor ◽  
Pain Anxiety ◽  
Trauma History ◽  
The Impact

Endothelin Receptor Blockade Blunts the Pressor Response to Acute Stress in Obese Men and Women

2021 ◽  
Author(s):  
Cassandra C. Derella ◽  
Anson M. Blanks ◽  
Xiaoling Wang ◽  
Matthew A. Tucker ◽  
Chase Horsager ◽  
...  
Keyword(s):  
Acute Stress ◽  
Pressor Response ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Normal Weight ◽  
Endothelin Receptor ◽  
Treatment Results ◽  
Endothelin 1 ◽  
Endothelin System ◽  
The Impact

Obesity is associated with dysregulation of the endothelin system. In obese individuals, an exaggerated pressor response to acute stress is accompanied by increased circulating endothelin-1. The impact of combined endothelin A/B receptor (ETA/B) antagonism on the stress-induced pressor response in overweight/obese individuals is unknown. Objective: To test the hypothesis that treatment with an ETA/B antagonist (bosentan) would reduce the stress-induced pressor response and arterial stiffness in overweight/obese compared to normal weight individuals. Methods: 40 participants [Normal weight (NW): n=20, BMI: 21.7 ± 2.4 kg/m2 & Overweight/obese (OB): n=20, BMI: 33.8 ± 8.2 kg/m2] were randomized to placebo or 125 mg of bosentan twice a day (250 mg total) for 3 days. Hemodynamics were assessed before, during, and after a cold pressor test (CPT). Endothelin-1 was assessed at baseline and immediately after CPT. Following a washout period, the same protocol was repeated with the opposite treatment. Results: The change from baseline in mean arterial pressure (MAP) during CPT following bosentan was significantly lower (p=0.039) in the OB group, compared to the NW group (OB: 28±12 vs LN: 34±15 mm Hg). Conclusions: These results suggest that ETA/B antagonism favorably blunts the pressor response to acute stress in overweight/obese individuals.

Teaching human cardiovascular and respiratory physiology with the station method

2002 ◽  
Vol 26 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Barbara E. Goodman ◽  
Douglas S. Martin ◽  
John L. Williams
Keyword(s):  
Cold Pressor ◽  
Respiratory Physiology ◽  
First Year ◽  
Laboratory Design ◽  
Pressor Reflex ◽  
Respiratory Modulation ◽  
Faculty Time ◽  
First Year Medical Students ◽  
The Impact ◽  
Cardiovascular Functions

We have developed a station method to offer combined cardiovascular and respiratory physiology exercises all in one laboratory period during our medical physiology course. This laboratory was designed for first-year medical students in order to minimize equipment costs, maximize efficient use of both student and faculty time, and facilitate integration of basic cardiovascular concepts with those in respiratory physiology. We designed six stations for the students to evaluate: cardiovascular and respiratory responses to dynamic exercise, cold pressor reflex, postural influences and respiratory modulation of cardiovascular functions, forced expiratory maneuvers with inverted bell spirometers, forced expiratory maneuvers and maximal inspiratory maneuvers with electronic spirometers with and without obstruction, and respiratory muscle strength. Students worked in groups of two to four and were assessed by individual laboratory reports. Although we neglected to formally assess the impact on students of changes in laboratory design, students appeared to respond enthusiastically to the laboratory and prepared knowledgeable laboratory reports.

The impact of pain anxiety on chronic pain among elders

2011 ◽  
Vol 26 (S2) ◽  
pp. 1006-1006 ◽  
Author(s):  
M. Tsatali ◽  
M. Gouva
Keyword(s):  
Chronic Pain ◽  
Pain Intensity ◽  
Statistical Significance ◽  
Well Being ◽  
Linear Regression Method ◽  
Pain Anxiety ◽  
Education Levels ◽  
Geriatric Pain ◽  
Pain Anxiety Symptoms Scale ◽  
The Impact

IntroductionPain is a complex and multifacial phenomenon, which interferes in almost every person's life, while in case it turns into chronic, can cause a significant disturbance in individual's physical, psychological and social sphere. That means the intense communication and interaction between ache biome, living conditions and state of health. Cognitive factors play a significant role on the recurrent dysphoria levels, while cognitive functions participate actively in pain intensity, sense of disability and medicine response.AimEstimate the possible significance between pain anxiety and pain intensity.Materials and methodsEighty six elders suffering from various types of chronic pain were examined by the Pass-20 (Pain Anxiety Symptoms Scale) scale, and GPM (Geriatric Pain Measure), while the results were assessed by SPSS 14 and specifically the Linear Regression method.ResultsIt was found statistical significance between the four sub-scales and the presence and existence of chronic pain among participants. Specifically the first subcale (avoidance of pain) was linked with the intensity of pain (p = ,00), the second scale (fearfull thinking) was associated with the prevalence of pain and the gender (p = ,014), the third scale (cognitive anxiety) showed a statistic significance with GPM results and education levels (p = ,00) and the forth scale (psychological responses) was found to affect the pain sense, while it was depended by gender (p = ,0015).DiscussionAmong elders pain anxiety can deteriorate the pain sense affecting the general well-being. For that reason non-pharmacological interventions can be very helpful both for the patient and clinician.

scholarly journals Microneurography and sympathetic nerve activity: a decade-by-decade journey across 50 years

2019 ◽  
Vol 121 (4) ◽  
pp. 1183-1194 ◽  
Author(s):  
Jason R. Carter
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Lower Body Negative Pressure ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Isometric Handgrip ◽  
Nerve Activity ◽  
The Past ◽  
Thomson Reuters ◽  
The Impact

The technique of microneurography has advanced the field of neuroscience for the past 50 years. While there have been a number of reviews on microneurography, this paper takes an objective approach to exploring the impact of microneurography studies. Briefly, Web of Science (Thomson Reuters) was used to identify the highest citation articles over the past 50 years, and key findings are presented in a decade-by-decade highlight. This includes the establishment of microneurography in the 1960s, the acceleration of the technique by Gunnar Wallin in the 1970s, the international collaborations of the 1980s and 1990s, and finally the highest impact studies from 2000 to present. This journey through 50 years of microneurographic research related to peripheral sympathetic nerve activity includes a historical context for several of the laboratory interventions commonly used today (e.g., cold pressor test, mental stress, lower body negative pressure, isometric handgrip, etc.) and how these interventions and experimental approaches have advanced our knowledge of cardiovascular, cardiometabolic, and other human diseases and conditions.

scholarly journals Veterans Team Recovery Integrative Immersion Process (Vet TRIIP): A Qualitative Evaluation of Participation and Impact

2020 ◽  
Vol 185 (7-8) ◽  
pp. e1284-e1289
Author(s):  
Dondee Maddox ◽  
Bob Deschner ◽  
Dottie Goodsun ◽  
M Danet Lapiz-Bluhm
Keyword(s):  
Quality Of Life ◽  
Qualitative Evaluation ◽  
Psychological Needs ◽  
Post Traumatic Stress ◽  
Daily Lives ◽  
Non Profit ◽  
Pain Anxiety ◽  
Eye Opening ◽  
The Impact

Abstract Introduction The Veterans Team Recovery Integrative Immersion Process (Vet TRIIP) is a short-term multi-modality complementary, integrative immersion program for veterans with chronic pain, post-traumatic stress, and related symptoms. Geared toward Veterans, active duty servicemembers, family members, and caregivers, Vet TRIIP aims to honor and empower them to create healthy, happy, and productive civilian lives. This study evaluates the program to determine its impact on the quality of life and ways to improve and develop Vet TRIIP. Materials and Methods In total, 14 clients participated in the qualitative review of the Vet TRIIP program in San Antonio. The participants were interviewed related to their reason for participating, their most bothersome symptoms and the effects of Vet TRIIP on those symptoms, service provided that is most and least appreciated, suggestions for improvement, and things learned from Vet TRIIP that helped them daily. Responses were analyzed for emerging themes. Results The main reasons for participating were physiological and psychological needs, social support, and curiosity to address their reported symptoms such as pain, stress/anxiety, and depression. Vet TRIIP reportedly improved their quality of life and decreased stress. The participants liked most the support of the Vet TRIIP staff and the interventions such as reiki and massage. Other participants did not like acupuncture. Participants suggested the addition of professional psychological services could be helpful. They reported that emotional freedom technique (EFT/tapping) and guided breathing were most useful in their daily lives. Each participant reported that Vet TRIIP was a positive experience that helped with their pain, anxiety, and stress management, providing an improvement in their quality of life. It also imparted an eye-opening experience to nontraditional non-pharmacological interventions for pain, anxiety, and stress. Conclusions Evaluative studies on organizations that support Veterans are useful to gauge the effectiveness and impact. Through this study, Veterans expressed perceived strengths and weaknesses of the program so further development and appropriate services will be provided. Similar studies on the impact of non-profit organizations are encouraged. Vet TRIIP significantly impacts the lives of many through stress and pain reduction, potentially preventing suicide.

scholarly journals Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans

2020 ◽  
Vol 319 (3) ◽  
pp. R288-R295
Author(s):  
M. L. Keller-Ross ◽  
H. A. Cunningham ◽  
J. R. Carter
Keyword(s):  
Sympathetic Nerve Activity ◽  
Muscle Sympathetic Nerve Activity ◽  
Cold Pressor Test ◽  
Cold Pressor ◽  
Pressor Test ◽  
Initial Rise ◽  
Group Time ◽  
The Impact ◽  
Finger Plethysmography ◽  
Age And Sex

Prior longitudinal work suggests that blood pressure (BP) reactivity to the cold pressor test (CPT) helps predict hypertension; yet the impact of age and sex on hemodynamic and neural responsiveness to CPT remains equivocal. Forty-three young (21 ± 1yr, means ± SE) men (YM, n = 20) and women (YW, n = 23) and 16 older (60 ± 1yr) men (OM, n = 9) and women (OW, n = 7) participated in an experimental visit where continuous BP (finger plethysmography) and muscle sympathetic nerve activity (MSNA; microneurography) were recorded during a 3- to 5-min baseline and 2-min CPT. Baseline mean arterial pressure (MAP) was greater in OM than in YM (92 ± 4 vs. 77 ± 1 mmHg, P < 0.01), but similar in women ( P = 0.12). Baseline MSNA incidence was greater in OM [69 ± 6 bursts/100 heartbeats (hb)] than in OW (44 ± 7 bursts/100 hb, P = 0.02) and lower in young adults (YM: 17 ± 3 vs. YW: 16 ± 2 bursts/100 hb, P < 0.01), but similar across the sexes ( P = 0.83). However, when exposed to the CPT, MSNA increased more rapidly in OW (Δ43 ± 6 bursts/100 hb; group × time, P = 0.01) compared with OM (Δ15 ± 3 bursts/100 hb) but was not different between YW (Δ30 ± 3 bursts/100 hb) and YM (Δ33 ± 4 bursts/100 hb, P = 1.0). There were no differences in MAP with CPT between groups (group × time, P = 0.33). These findings suggest that OW demonstrate a more rapid initial rise in MSNA responsiveness to a CPT compared with OM. This greater sympathetic reactivity in OW may be a contributing mechanism to the increased hypertension risk in postmenopausal women.

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