Benign Brain Tumor Cancer Registries Amendment Act

OBJECTIVESpinal schwannoma remains the third most common intradural spinal tumor following spinal meningioma and ependymoma. The available literature is generally limited to single-institution reports rather than epidemiological investigations. As of 1/1/2004, registration of all benign central nervous system tumors in the United States became mandatory after the Benign Brain Tumor Cancer Registries Amendment Act took action, which provided massive resources for United States population-based epidemiological studies. This article describes the epidemiology of spinal schwannoma in the United States from January 1, 2006, through December 31, 2014.METHODSIn this study, the authors utilized the Central Brain Tumor Registry of the United States, which corresponds to 100% of the American population. The Centers for Disease Control and Prevention’s National Program of Cancer Registries and the National Cancer Institute’s Surveillance Epidemiology and End Results program provide the resource for this data registry. The authors included diagnosis years 2006 to 2014. They used the codes per the International Coding of Diseases for Oncology, 3rd Edition: histology code 9560/0 and site codes C72.0 (spinal cord), C70.1 (spinal meninges), and C72.1 (cauda equina). Rates are per 100,000 persons and are age-adjusted to the 2000 United States standard population. The age-adjusted incidence rates and 95% confidence intervals are calculated by age, sex, race, and ethnicity.RESULTSThere were 6989 spinal schwannoma cases between the years 2006 and 2014. The yearly incidence eminently increased between 2010 and 2014. Total incidence rate was 0.24 (95% CI 0.23–0.24) per 100,000 persons. The peak adjusted incidence rate was seen in patients who ranged in age from 65 to 74 years. Spinal schwannomas were less common in females than they were in males (incidence rate ratio = 0.85; p < 0.001), and they were less common in blacks than they were in whites (IRR = 0.52; p < 0.001) and American Indians/Alaska Natives (IRR = 0.50; p < 0.001) compared to whites. There was no statistically significant difference in incidence rate between whites and Asian or Pacific Islanders (IRR = 0.92; p = 0.16).CONCLUSIONSThe authors’ study results demonstrated a steady increase in the incidence of spinal schwannomas between 2010 and 2014. Male sex and the age range 65–74 years were associated with higher incidence rates of spinal schwannomas, whereas black and American Indian/Alaska Native races were associated with lower incidence rates. The present study represents the most thorough assessment of spinal schwannoma epidemiology in the American population.

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Study of prevalence pattern of neoplastic intracranial tumor in the tribal area of Rajasthan, India

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20170125 ◽

2017 ◽

Vol 4 (1) ◽

pp. 275

Author(s):

Cheeni Jain ◽

Vivek Kumar Jain ◽

N. Mogra

Keyword(s):

Brain Tumor ◽

Brain Tumors ◽

Cancer Registries ◽

Primary Brain Tumor ◽

Full Spectrum ◽

Who Grade ◽

Medical College ◽

Grass Root ◽

Grass Root Level ◽

Set Up

Background: Prevalence estimates available for brain tumors reflect the portion of tumors that are malignant. Just as routine incidence statistics from cancer registries under represent the full spectrum of primary brain tumor cases. Prevalence rates are ideally suited to provide an overall estimate of cancer survivorship and direction for health planning.Methods: A total of 70 cases of CNS tumors were retrieved from the archives of the Department of Pathology, Geetanjali Medical College & hospital, Udaipur from April 2014 to September 2016. The diagnoses in all the cases were made on histological examination of processed tissue.Results: In our study astrocytoma was the most common brain tumor (34.28%), followed by meningioma (32.85%). The third common tumor was oligodendroglioma (11. 42%). However, metastatic brain tumors were seen in only 5.55 % of cases in the present study.Conclusions: Males were at higher risk of developing CNS lesions in comparison to females. WHO Grade I lesions were more common in our institutional set up. Astrocytoma WHO grade IV lesions were more common in comparison to Grade I lesions, indicating need for imaging and neurology consultation at primary grass root level.

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Epidemiology of meningiomas post-Public Law 107-206: The Benign Brain Tumor Cancer Registries Amendment Act

Cancer ◽

10.1002/cncr.29379 ◽

2015 ◽

Vol 121 (14) ◽

pp. 2400-2410 ◽

Cited By ~ 44

Author(s):

Therese A. Dolecek ◽

Emily Van Meter Dressler ◽

Jigisha P. Thakkar ◽

Meng Liu ◽

Abeer Al-Qaisi ◽

...

Keyword(s):

Brain Tumor ◽

Cancer Registries ◽

Public Law

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Cancer collection efforts in the United States provide clinically relevant data on all primary brain and other CNS tumors

Neuro-Oncology Practice ◽

10.1093/nop/npz029 ◽

2019 ◽

Vol 6 (5) ◽

pp. 330-339 ◽

Cited By ~ 1

Author(s):

Carol Kruchko ◽

Haley Gittleman ◽

Jennifer Ruhl ◽

Jim Hofferkamp ◽

Elizabeth M Ward ◽

...

Keyword(s):

United States ◽

Brain Tumor ◽

Cancer Registries ◽

The United States ◽

Cancer Surveillance ◽

Cns Tumors ◽

Cancer Registration ◽

Clinical Practices ◽

Tumor Registry ◽

Central Brain

Abstract Cancer surveillance is critical for monitoring the burden of cancer and the progress in cancer control. The accuracy of these data is important for decision makers and others who determine resource allocation for cancer prevention and research. In the United States, cancer registration is conducted according to uniform data standards, which are updated and maintained by the North American Association of Central Cancer Registries. Underlying cancer registration efforts is a firm commitment to ensure that data are accurate, complete, and reflective of current clinical practices. Cancer registries ultimately depend on medical records that are generated for individual patients by clinicians to record newly diagnosed cases. For the cancer registration of brain and other CNS tumors, the Central Brain Tumor Registry of the United States is the self-appointed guardian of these data. In 2017, the Central Brain Tumor Registry of the United States took the initiative to promote the inclusion of molecular markers found in the 2016 WHO Classification of Tumours of the Central Nervous System into information collected by cancer registries. The complexities of executing this latest objective are presented according to the cancer registry standard-setting organizations whose collection practices for CNS tumors are directly affected.

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EPID-23. THE PAKISTAN BRAIN TUMOR EPIDEMIOLOGY STUDY: PAVING THE WAY FOR A NATIONAL BRAIN TUMOR REGISTRY

Neuro-Oncology ◽

10.1093/neuonc/noab196.356 ◽

2021 ◽

Vol 23 (Supplement_6) ◽

pp. vi90-vi91

Author(s):

Mashal Shah ◽

Erum Baig ◽

Mohammad Hamza Bajwa ◽

Altaf Ali Laghari ◽

Saad Bin-Anis ◽

...

Keyword(s):

Brain Tumor ◽

Data Collection ◽

Brain Tumors ◽

Private Sector ◽

Cancer Registries ◽

Cross Sectional Study ◽

Tumor Patients ◽

Cross Sectional ◽

Pineal Tumors ◽

The Public

Abstract INTRODUCTION In Pakistan, brain tumor epidemiology has been examined in single-centre studies or as part of general cancer registries, which are limited by catchment area, age group, or are not specific to brain tumors. The Pakistan Society of Neuro-Oncology conducted a nationwide study to assess the distribution of brain tumor distribution and associated risk factors. This unfunded study explores data from across Pakistan and serves as a potential model for LMICs to emulate. METHODS A cross-sectional study was designed to include patients diagnosed with brain tumors in major neurosurgical centers in Pakistan retrospectively from January-December 2019. Patients, both alive and deceased, with a radiological diagnosis of a brain tumor were included. Data were recorded on a comprehensive online form from 35 centers, encompassing an estimated 85% of all the brain tumor patients seeking initial treatment by a neurosurgeon from the public and private sectors. Data collection was split into three regions: Sindh and Balochistan; Punjab; and Khyber Pakhtunkhwa and Islamabad. Data collection occurred between August 2020 and January 2021. RESULTS A total of 2750 brain tumor cases were recorded of which 1897 (69%) were diagnosed in the private sector hospitals. MRIs were a more common radiological study compared to CT scans. 2666 surgeries were performed, 174 individuals underwent chemotherapy and 479 underwent radiation therapy; approximately two-thirds of the patients that require adjuvant treatment are not able to receive it. Gliomas were the most common tumor, while pineal tumors were the least common. Findings indicate a low metastasis frequency and few females seeking care. CONCLUSION The study shows that brain tumors are mostly diagnosed and operated on in the private sector; the public sector should be more engaged. The study also highlights that despite inconsistencies in hospital records for brain tumor patients, reliable information can be collected in LMIC settings.

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Trends in clinico-epidemiology profile of surgically operated glioma patients in a tertiary care center over 12 years—through the looking glass!

Egyptian Journal of Neurosurgery ◽

10.1186/s41984-021-00118-w ◽

2021 ◽

Vol 36 (1) ◽

Author(s):

Suyash Singh ◽

Harsh Deora ◽

Azfar Neyaz ◽

Kuntal Kanti Das ◽

Anant Mehrotra ◽

...

Keyword(s):

Brain Tumor ◽

Care Center ◽

Tertiary Care ◽

Cancer Registries ◽

Histopathological Diagnosis ◽

International Studies ◽

Diffuse Astrocytoma ◽

Tumor Registry ◽

Recorded Data ◽

Looking Glass

Abstract Background Hospital-based cancer registries can provide information on the magnitude and distribution of cancers in a given hospital. Hospital-based brain tumor registry data, focusing on glioma, from a tertiary care rural neurological center is lacking in the scientific literature. This data can be useful in understanding the need for research and funding required for these specific brain tumors. Data of patients operated for glioma, at our institute, was collected between January 2004 and December 2015. Patients’ clinical details and histopathological diagnosis were recorded. Data were analyzed and compared with that of previously published literature, and inferences were drawn on patterns of reporting and epidemiology. Results A total of 1450 cases of glioma, with a mean age of 39.3 (± 17.36 SD) years with males (66.6%) comprising more population as compared to females. Majority of patients 70.8% (n = 1027) belong to the economically active age group of country (18–60 years). Majority of cases (41.4%) were glioblastoma with the next common tumor (22.8%) being diffuse astrocytoma (n = 331) followed by pilocytic astrocytoma (6.2%) and oligodendroglioma (4.5%) in that order. While our data followed similar trends with other Indian data the average age of glioma was a decade younger to what is quoted earlier in Indian and international studies. Conclusion This data for glioma gives a glimpse of the prevalence of this tumor in a primarily rural population and highlights the need for a National Brain Tumor Registry with the need for the development of evidence-based policymaking and enhanced research into this particular ailment.

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EPID-29. CAUSES OF DEATH FOR PRIMARY BRAIN AND CNS TUMOR PATIENTS IN THE UNITED STATES (2001 – 2016): A POPULATION BASED STUDY

Neuro-Oncology ◽

10.1093/neuonc/noaa215.347 ◽

2020 ◽

Vol 22 (Supplement_2) ◽

pp. ii84-ii85

Author(s):

Maria Penuela ◽

Nirav Patil ◽

Gino Cioffi ◽

Carol Kruchko ◽

Jill S Barnholtz-Sloan

Keyword(s):

Brain Tumor ◽

Cause Of Death ◽

Causes Of Death ◽

Malignant Tumors ◽

Cancer Registries ◽

Population Based ◽

Cns Tumors ◽

Tumor Patients ◽

Factors Associated ◽

Specific Mortality

Abstract BACKGROUND Population-based data on the various causes of death among Primary Brain and CNS tumor patients are lacking. We evaluated the causes of death for all eligible patients using the National Program of Cancer Registries (NPCR) data. METHODS The population-based cancer survival data collected by the Centers for Disease Control and Prevention’s National Program of Cancer Registries (NPCR) were used to analyze the causes of death for patients of all ages with primary brain and CNS tumors diagnosed between 2001 and 2016. Patients for whom the cause of death was not listed on the death certificate or whose state death certificate was not available were excluded. Additional analyses to identify factors associated with brain tumor-specific mortality for the most common malignant (Glioblastoma) and non-malignant (Meningioma) were performed using univariable and multivariable logistic regression analysis. RESULTS Major cause of death for patients with malignant tumors was death due to brain and other CNS tumors (49.29%), and for non-malignant tumors were other benign and malignant tumors (31.5%) and heart disease (17.9%). Overall mortality was 36.4% (n=331,953) in patients with Primary Brain and CNS Tumors during the study period. Specifically, 163,621 (49.29%) patients died due to brain and other CNS tumors. A significant proportion of patients with malignant tumors had brain tumor-specific mortality compared to non-malignant tumors (75.4% in malignant vs 4.2% in non-malignant). The factors associated with brain specific mortality in Glioblastoma patients were Age (p< 0.001), Race (p< 0.001) and Primary Site (p< 0.001). Further, the factors associated with brain specific mortality in Non-malignant Meningioma patients were Age (p< 0.001), Sex (p< 0.001), Race (p< 0.001) and Primary Site (P< 0.001). CONCLUSION Cause of death attributed to the brain tumor was significantly higher in malignant brain tumors compared to non-malignant brain tumors.

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