scholarly journals Trends in clinico-epidemiology profile of surgically operated glioma patients in a tertiary care center over 12 years—through the looking glass!

2021 ◽  
Vol 36 (1) ◽  
Author(s):  
Suyash Singh ◽  
Harsh Deora ◽  
Azfar Neyaz ◽  
Kuntal Kanti Das ◽  
Anant Mehrotra ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Care Center ◽  
Tertiary Care ◽  
Cancer Registries ◽  
Histopathological Diagnosis ◽  
International Studies ◽  
Diffuse Astrocytoma ◽  
Tumor Registry ◽  
Recorded Data ◽  
Looking Glass

Abstract Background Hospital-based cancer registries can provide information on the magnitude and distribution of cancers in a given hospital. Hospital-based brain tumor registry data, focusing on glioma, from a tertiary care rural neurological center is lacking in the scientific literature. This data can be useful in understanding the need for research and funding required for these specific brain tumors. Data of patients operated for glioma, at our institute, was collected between January 2004 and December 2015. Patients’ clinical details and histopathological diagnosis were recorded. Data were analyzed and compared with that of previously published literature, and inferences were drawn on patterns of reporting and epidemiology. Results A total of 1450 cases of glioma, with a mean age of 39.3 (± 17.36 SD) years with males (66.6%) comprising more population as compared to females. Majority of patients 70.8% (n = 1027) belong to the economically active age group of country (18–60 years). Majority of cases (41.4%) were glioblastoma with the next common tumor (22.8%) being diffuse astrocytoma (n = 331) followed by pilocytic astrocytoma (6.2%) and oligodendroglioma (4.5%) in that order. While our data followed similar trends with other Indian data the average age of glioma was a decade younger to what is quoted earlier in Indian and international studies. Conclusion This data for glioma gives a glimpse of the prevalence of this tumor in a primarily rural population and highlights the need for a National Brain Tumor Registry with the need for the development of evidence-based policymaking and enhanced research into this particular ailment.

scholarly journals Epidemiological Profiling and Trends of Primary Intracranial Tumors: A Hospital-Based Brain Tumor Registry from a Tertiary Care Center

2021 ◽  
Vol 12 (01) ◽  
pp. 145-152
Author(s):  
Mukta Meel ◽  
Nikita Choudhary ◽  
Mukesh Kumar ◽  
Kusum Mathur
Keyword(s):  
Brain Tumor ◽  
Care Center ◽  
Tertiary Care ◽  
Germ Cell Tumors ◽  
The United States ◽  
Population Based ◽  
Tertiary Care Center ◽  
Intracranial Tumors ◽  
Pineal Tumors ◽  
Tumor Registry

Abstract Background and Objectives Hospital-based cancer registry is an essential tool for augmentation of the standard of care, administration motive, and resource for population-based cancer registries. Here, we presented hospital-based brain tumor registry (HBBTR) to outline a comprehensive epidemiological data, both clinical and histopathological, as well as trends of central nervous system tumors. In addition, we compare this data with national brain tumor data as well as an international brain tumor registry. Materials and Methods For the generation of this 7-year HBBTR data of all primary intracranial tumors operated, diagnosed, and registered at the Department of Pathology, Sawai ManSingh, between January 1, 2013 and December 31, 2019, was collected, analyzed, and compared with Tata Memorial Hospital, National Institute of Mental Health and Neurosciences, and Central Brain Tumor Registry of the United States. Results A total of 3,526 patients were of primary intracranial tumors. Out of which, male patients were 1,982 (56.2%), while 1,544 (43.8%) were female patients. Maximum proportion of tumors was in fifth decade. Overall, pediatric and adult patients constituted of 15.5 and 84.5% of the cases, respectively. Among all primary intracranial tumors, meningiomas (20%) were most common followed by glioblastoma multiformat (18%) and least common were germ cell tumors (0.1%) followed by pineal tumors (0.3%). In pediatric cohort astrocytic tumors (30.1%) are most common followed by embryonal tumors (20.8%), while in adults meningiomas (23.1%) were most common followed by glioblastomas (20.3%). Our registry showed similar trends of tumors with national data as compared with international data in median age of presentation. Conclusion This HBBTRs provide prevalence of primary intracranial tumors at a tertiary care center and could be a part of population-based registry.

scholarly journals Histopathological spectrum of neoplastic and non-neoplastic breast lesions: A three years study in rural tertiary care center.

2020 ◽  
Vol 7 (01) ◽  
pp. 4721-4725
Author(s):  
Dr. Sanjeev Kumar Singh ◽  
Dr. Geeta Maurya ◽  
Dr. Pinki Pandey ◽  
Dr. Rashmi
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Care Center ◽  
Benign Lesion ◽  
Tertiary Care ◽  
Age Distribution ◽  
Morbidity And Mortality ◽  
Histopathological Diagnosis ◽  
Breast Lesions ◽  
Neoplastic Lesions

Background: Breast tumours are very common cause of morbidity and mortality worldwide specially in developing countries. Breast lesions show broad spectrum of disease patterns in respect to benign, malignant, and non-neoplastic. Breast cancer is one of the most frequently occurring cancer among women. Objective: To study the frequency, age distribution, clinical and histological patterns of neoplastic and non-neoplastic lesions of breast in this rural population. Material and methods: This observational study was conducted over a duration of three years. In which we studied 210 cases of breast lesions. Specimens were received in department of pathology. Grossing, tissue processing, staining done according to standard protocol. Haematoxylin and eosin (H&E) stained sections were examined under microscope to categorise different type of lesions in the form of non-neoplastic and neoplastic. Results:  Out of 210 breast lesions, fibroadenoma was the commonest (114 cases) benign lesion. While invasive ductal carcinoma (70 cases) was commonest in malignant category. Non neoplastic lesions stand on third place, study showed 6 cases out of 210 total cases, in which acute mastitis (4 cases) was most common. Benign tumours were mostly seen in 2nd and 3rd decade and malignant tumour mainly in 5th and 6th decade Conclusion: Early histopathological diagnosis of breast lesions is very important to differentiate between benign and malignant lesions. Large number of cases of invasive ductal carcinoma (>33% of all cases) were seen in our study, which is a serious concern. So, generation of awareness among women is need of time to reduce the morbidity and mortality specially in Indian rural setup

scholarly journals Conjunctival Lesions: A 5-Year Basic Demographic Data and Clinicopathological Review in a Tertiary Eye Care Hospital

2021 ◽  
Author(s):  
Hind M. Alkatan ◽  
Khalid M. Alshomar ◽  
Hala A. Helmi ◽  
Wajda M. Alhothali ◽  
Abdulaziz M. Alshalan
Keyword(s):  
Wide Spectrum ◽  
Care Center ◽  
Demographic Data ◽  
Tertiary Care ◽  
Malignant Lesion ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Adult Males ◽  
Duration Of Symptoms ◽  
Malignant Lesions

Abstract Background Conjunctival lesions are common with a wide spectrum of benign, premalignant, and malignant lesions. Few histopathological studies have been conducted on conjunctival lesions with variable designs and results. Our aim in this study is to provide information on common conjunctival lesions seen in an ophthalmology tertiary care center in Saudi Arabia. Methods A retrospective, observational study of all consecutive conjunctival tissue specimens sent for histopathological assessment to the pathology department from 2015 to 2019 were analyzed. Clinical data were collected from medical records, and the histopathological slides were reviewed by a single pathologist. Results A total of 110 conjunctival specimens from 108 patients were included (mean age: 53 years, 67 males and 43 females). Bilateral involvement was mostly found in inflammatory lesions (40%). Most lesions were benign (91%), with a significantly longer duration of symptoms in malignant lesions (p = 0.036*). The clinical diagnosis matched the final histopathological diagnosis in 75.5% of the total specimens. The most frequent category of benign lesions was fibrodegenerative and proliferative lesions (53.6%), with a significantly higher prevalence among adult males (p < 0.001). Melanocytic lesions were more common in children (33.3%) than adults (9.8%), and the mean age of children was significantly lower (p = 0.013). The most frequent malignant lesion was ocular surface squamous neoplasia (50%), with equal prevalence among males and females. The overall outcome was favorable in 89.4% and unfavorable in 10.6%, mostly due to surgical complications, further progression of the lesion, or recurrence. Conclusion This study shows variability in the frequency of conjunctival lesions based on gender, age, geographical, racial, and environmental factors. There has been a shift in the gender-based prevalence of ocular squamous neoplasia over the last three decades, probably due to a change in lifestyle.

USG versus Histopathological Diagnosis of Ovarian Masses at Tertiary Care Center

2017 ◽  
Vol 5 (1) ◽  
pp. 31-37
Author(s):  
Amruta Ahirrao ◽  
◽  
Alka Patil ◽  
Anamika Arun ◽  
◽  
...  
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Histopathological Diagnosis ◽  
Tertiary Care Center ◽  
Ovarian Masses

scholarly journals COMPARATIVE STUDY OF CT-SCAN FINDINGS WITH BIOPSY IN LIVER MASSES DONE AT A TERTIARY CARE CENTER

2020 ◽  
pp. 1-2
Author(s):  
Bhanupriya Singh ◽  
Khushal N Pawar ◽  
Suhas S Ghule ◽  
Dilip L Lakhkar
Keyword(s):  
Ct Scan ◽  
Predictive Value ◽  
Care Center ◽  
Tertiary Care ◽  
Malignant Lesion ◽  
Normal Liver ◽  
Liver Lesion ◽  
Cross Sectional Study ◽  
Histopathological Diagnosis ◽  
Cross Sectional

Background: More than 80% of all primary hepatic malignancies are hepatocellular carcinoma. Identification of a liver lesion depends on the attenuation difference between normal liver and the lesion. CT helps in detecting tumors and their size in liver quiet successfully. Accurate detection of liver mass is crucial for the deciding the treatment regimens. Objective: The study was undertaken to compare the results of CT-scan to histopathology findings. Methodology: This cross-sectional study was carried out in the Department of Radiodiagnosis and Imaging, Dr. Vitthalrao Vikhe Patil Foundation’s Medical College, Ahmednagar in association with Department of pathology of the concerned institute for histopathological diagnosis from 01-03-2014 to 28-02-2015 for a period of one year. Patients having hepatic mass of any sex or age presenting in the hospital were included in the study. The exclusion criteria were as patients refusing consent, or CT-scan and/or biopsy, known adverse reaction to contrast agent. CT scan and histopathology were done in all the subjects. Result: 50 subjects were studied in this study. Mean age of all subjects was 52.88 ± 16.03 years with a range of 18 year to 85 years. 40 cases were male in the study group. Maximum number of cases were in the age group 40-59 years. Out of 28 confirmed malignant cases by histopathology, 27 cases were diagnosed as malignant by CT scan too. Sensitivity of CT to diagnose malignant lesion was 96.4%, specificity 86.4%, accuracy 92%, positive predictive value 90% and negative predictive value 95%. Conclusion: CT scan can be used as a tool for the detecting of malignant liver masses.

scholarly journals Clinicopathological study of breast lesions over a period of one year in a tertiary care center

2018 ◽  
Vol 6 (10) ◽  
pp. 3397
Author(s):  
Divyasree Neeli ◽  
Bhagyalakshmi Atla ◽  
Satish Kumar Seeram ◽  
Lavanya Latchupatula ◽  
Srikanth Reddy Kamireddy
Keyword(s):  
Breast Carcinoma ◽  
Care Center ◽  
Tertiary Care ◽  
Duct Cell ◽  
Histopathological Diagnosis ◽  
Breast Lesions ◽  
Adequate Treatment ◽  
Molecular Features ◽  
Number Of Patients ◽  
One Year

Background: Breast carcinoma is no longer seen as a single disease but rather a multifaceted disease comprised of distinct biological subtypes with varied natural history, presenting a diverse spectrum of clinico-pathological and molecular features with different therapeutic and prognostic implications. The present study was designed to evaluate the frequency, age, gender and histopathological features of breast carcinoma in a tertiary care hospital.Methods: The present study is a hospital based retrospective study for a period of one year from January 2015 to December 2015, conducted in the Department of Pathology, Andhra Medical College, Visakhapatnam.The clinical details were recorded as per the proforma. Tissue for H&E sections were fixed in 10% formalin and subjected to routine paraffin embedded processing and stained with Hematoxylin and Eosin.Results: Out of the total 185 cases of breast lesions, 151 cases (81.62%) were diagnosed as non-malignant and 34 cases were malignant (18.37%). Maximum number of patients, 106 cases (57.2%), were between 21 - 40 years. Out of 34 malignant breast lesions, 27 were diagnosed as Infiltrative duct cell carcinoma (79.41%), followed by medullary carcinoma 4 cases (11.76%).Conclusions: The pattern of breast lesions provides valuable information concerning clinicopathological profile of breast lesions. The clinical diagnosis of a breast lump must be correlated with histopathological diagnosis for correct and adequate treatment of patient.

scholarly journals Institutional-based tumor registry of hematopoietic malignancies: A 4 years’ preliminary report from Karachi

2018 ◽  
Vol 10 (02) ◽  
pp. 168-172
Author(s):  
Sadia Sultan ◽  
Syed Mohammed Irfan ◽  
Navaira Ali ◽  
Neesha Nawaz
Keyword(s):  
Myeloid Leukemia ◽  
Lymphoblastic Leukemia ◽  
Health Planning ◽  
Care Center ◽  
Demographic Data ◽  
Tertiary Care ◽  
Future Health ◽  
Female Ratio ◽  
Tumor Registry ◽  
Hematological Cancers

ABSTRACT BACKGROUND: Pakistan has a population of over 198 million making it the world’s sixth populous country. However, operational population-based cancer registries in Pakistan are lacking. Limited data are available based on institutional or Karachi Cancer Registry from Karachi; however, no exclusive registry for hematological malignancies is established till date. Hence, we decided to conduct a database analysis to determine the frequencies of various hematological cancers in our tertiary care center in Karachi. PATIENTS AND METHODS: Retrospective assessment of 366 patients presented to Hematology Department, Liaquat National Hospital and Medical College from May 2012 to May 2016 with confirmed diagnosis of hematological cancers was performed. Data were retrieved from hospital-based tumor registry. All pro forma was filled by qualified medical research officer, which included demographic data as age, gender, history, disease type, and its stage at presentation. RESULTS: Male gender was predominant and accounted for 69.9% (n = 256) and female accounted for 30.0% (n = 110) of the total cases with the male-to-female ratio of ~2:1. The mean ages of female and male patients were 42.9 ± 20.7 and 49.7 ± 18.1 years with the median age of 45 and 51.5 years, respectively. In males, the three most frequent malignancies were chronic myeloid leukemia (CML) (16%), acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML) (12.8% of each). In females, AML was the most common cancer accounting for 21.8% followed by CML (18.1%) and ALL (10%). CONCLUSIONS: Our institution-based tumor registry indicates CML and AML were the most common cancers in males and females, respectively, followed by ALL. Chronic lymphoid leukemia, unlike in the West, is seen infrequently in our population. National and provisional hematological tumor registry will be beneficial for future health planning and research.

scholarly journals Discordance of Histo-pathological Diagnosis of Patients with Soft Tissue Sarcoma Referred to Tertiary Care Center

2019 ◽  
Vol 4 (4) ◽  
pp. 119-123
Author(s):  
Sameer Rastogi ◽  
Aditi Aggarwal ◽  
Sorun Shishak ◽  
Adarsh Barwad ◽  
Ekta Dhamija ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Treatment Plan ◽  
Care Center ◽  
Univariate Analysis ◽  
Tertiary Care ◽  
Soft Tissue Sarcomas ◽  
Pathological Diagnosis ◽  
Histopathological Diagnosis ◽  
Histopathologic Diagnosis ◽  
Major Discrepancy

Background: Reaching the correct histo-pathological diagnosis of soft tissue sarcomas (STS) is a great challenge and is cornerstone for treatment planning. Need of expertise for diagnosis is limited due to the lack of dedicated expert sarcoma pathologists and oncologists in India. In this study we highlight the pattern of pathological diagnosis and its accuracy outside specialist centre. Methods: We performed retrospective analysis of all patients referred to us with a clinical or histopathologic diagnosis of STS over the period January 2016 to December 2017. According to the protocol, all patients had a review of histopathology diagnosis from our institute. The tissue blocks if available were reviewed and a fresh biopsy was performed when required. The histopathologic diagnosis was also reviewed in the joint clinic, giving clinico-radiological inputs to sarcoma pathologists. For the patients with outside diagnosis and discordant report, we divided them into major discrepancy (including change of diagnosis of sarcoma to benign or other histological entity that could potentially change the treatment plan) or minor discrepancy (like mild change in grade or histopathological diagnosis not affecting the treatment plan). Statistical analysis was done by SPSS ver 23.Results: There were 149 patients with median age of 36 years (range 14-77 years), and 93 patients (62.4%) were males. About 57% (85 cases) of patients had localized disease. Most common subtypes were synovial sarcoma (16%), liposarcoma (9%), soft tissue ewings sarcoma (9%), MPNST (9%), leiomyosarcoma (8%), and undifferentiated pleomorphic sarcoma (8%). Of 149 patients, 47 (31.5%) had not been worked up outside by immunohistochemistry or other molecular studies and thus comparison was not possible; while 4 patients couldn’t retrieve blocks and repeat biopsy could not be performed. Of 97 patients (biopsy = 84, FNAC = 13) who had diagnosis from outside, 37% had major discrepancy and 24% had minor discrepancy as compared with our diagnosis from the sarcoma specialists. Univariate analysis revealed that the major discrepancy was more in non-extremity than extremity STS (p = 0.003).Conclusion: Histopathologic diagnosis in more than half of patients referred from outside centers was discordant with respect to the diagnosis of our centre with major implications on 37% of cases. We believe this is due to the lack of sarcoma pathology experts, and they are virtually non-existent in the multidisciplinary clinic set up outside the tertiary care centres.  

scholarly journals Patients’ Preference to Bedside Teaching Encounters in Four Major Wards in a Tertiary Care Centre

2019 ◽  
Vol 57 (220) ◽  
Author(s):  
Calvin Ghimire ◽  
Sajan Acharya ◽  
Abhiskar Thapa ◽  
Asha Shrestha ◽  
Deep Basnet ◽  
...  
Keyword(s):  
Medical Students ◽  
Confidence Interval ◽  
Binary Data ◽  
Care Center ◽  
Tertiary Care ◽  
Point Estimate ◽  
International Studies ◽  
Bedside Teaching ◽  
Care Centre ◽  
Tertiary Care Centre

Introduction: Patient interaction is a vital aspect of medical education. Bedside teaching encounters involve clinicians, medical students, and patients, and comprise a formative and focused activity. Patients' willingness to cooperate and contribute to the education and training of medical students provide better teaching opportunities. The study aims to find the patients’ preference to bedside teaching encounters in four major wards in a tertiary care center in Nepal. Methods: This descriptive cross-sectional study was performed in four major wards in a tertary care centre from June 3, 2015 to July 3, 2015 after receiving ethical approval. Convenient sampling was done. Data was collected in Microsoft Excel and analyzed in Statistical Package for Social Sciences 13.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Subgroup analysis was done on the basis of demographic variables. Results: Seventy-eight (77.2%) patients preferred bedside teaching encounters among 101 participants (77.12-77.28 at 95% Confidence Interval). Among which, females, age ranging from 16 to 32 years, education below secondary school and with hospital stay<4 days were most common. Conclusions: The results showed that most of the patients preferred bedside teaching encounters which was congruent with the other national and international studies.

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