Perceived Stress and Chronic Inflammation

2009 ◽  
Author(s):  
Virginia E. Ferent ◽  
Celestina Barbosa-Leiker ◽  
Bruce Wright
Keyword(s):  
Chronic Inflammation ◽  
Perceived Stress

Chronic inflammation in hepatitis C patients is associated with increased perceived stress and abnormal connectivity between insula and basal ganglia

2019 ◽  
Vol 29 ◽  
pp. S163-S164
Author(s):  
G. Oriolo ◽  
R. Navines ◽  
L. Blanco ◽  
D. Martín-Hernández ◽  
Z. Mariño ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Basal Ganglia ◽  
Chronic Inflammation ◽  
Perceived Stress

scholarly journals Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients

2019 ◽  
Vol 80 ◽  
pp. 204-218 ◽  
Author(s):  
Giovanni Oriolo ◽  
Laura Blanco-Hinojo ◽  
Ricard Navines ◽  
Zoe Mariño ◽  
David Martín-Hernández ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Functional Connectivity ◽  
Chronic Inflammation ◽  
Perceived Stress ◽  
Brain Areas

Acetaminophen: Macula densa hypersecretory activity by induced hepatotoxicity

1987 ◽  
Vol 45 ◽  
pp. 934-935
Author(s):  
S.S. Poolsawat ◽  
C.A. Huerta ◽  
S.TY. Lae ◽  
G.A. Miranda
Keyword(s):  
Cell Proliferation ◽  
Liver Function ◽  
Chronic Inflammation ◽  
Foam Cell ◽  
Term Effect ◽  
Short Term ◽  
Drug Induced ◽  
Experimental Induction ◽  
Tissue Alterations ◽  
Toxic Responses

Introduction. Experimental induction of altered histology by chemical toxins is of particular importance if its outcome resembles histopathological phenomena. Hepatotoxic drugs and chemicals are agents that can be converted by the liver into various metabolites which consequently evoke toxic responses. Very often, these drugs are intentionally administered to resolve an illness unrelated to liver function. Because of hepatic detoxification, the resulting metabolites are suggested to be integrated into the macromolecular processes of liver function and cause an array of cellular and tissue alterations, such as increased cytoplasmic lysis, centrilobular and localized necroses, chronic inflammation and “foam cell” proliferation of the hepatic sinusoids (1-4).Most experimentally drug-induced toxicity studies have concentrated primarily on the hepatic response, frequently overlooking other physiological phenomena which are directly related to liver function. Categorically, many studies have been short-term effect investigations which seldom have followed up the complications to other tissues and organs when the liver has failed to function normally.

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

Anforderungen, Entscheidungsfreiräume und Stress im Studium

Diagnostica ◽  
2019 ◽  
Vol 65 (2) ◽  
pp. 63-74 ◽  
Author(s):  
Laura I. Schmidt ◽  
Fabian Scheiter ◽  
Andreas Neubauer ◽  
Monika Sieverding
Keyword(s):  
Perceived Stress ◽  
Soziale Arbeit ◽  
Stress Index ◽  
Job Content Questionnaire ◽  
Reliabilität Und Validität ◽  
Körperliche Beschwerden ◽  
Job Content ◽  
Demand Control

Zusammenfassung. Mit dem Demand-Control-Modell und dem dazugehörigen Job Content Questionnaire (JCQ) existiert im Arbeitsumfeld ein bewährtes Modell zur Vorhersage physischer und psychischer Gesundheitsrisiken. Um diese auch unter Studierenden theoriegeleitet vorhersagen zu können, passten wir den JCQ auf den Hochschulkontext an und untersuchten mittels unseres Fragebogens zu strukturellen Belastungen und Ressourcen im Studium (StrukStud) den Erklärungsbeitrag hinsichtlich Stresserleben und Wohlbefinden. In 4 Studien mit insgesamt 732 Studierenden (Psychologie, Lehramt, Soziale Arbeit, Wirtschaftsrecht und Erziehung & Bildung) wurden die Demand-Control-Dimensionen (StrukStud), Stresserleben (Heidelberger Stress-Index HEI-STRESS & Perceived Stress Questionnaire) und weitere Referenzkonstrukte wie Studienzufriedenheit und körperliche Beschwerden erfasst. Befunde zur Reliabilität und Validität werden vorgestellt. Die Ergebnisse belegen die psychometrische Qualität des StrukStud sowie dessen Potenzial zur Erklärung von Stress im Studium. Mit dem StrukStud liegt für den deutschsprachigen Raum erstmals ein ökonomisches Selbsteinschätzungsinstrument zur Erfassung von psychologischen Anforderungen und Entscheidungsfreiräumen im Studium vor.

The Buffering Effect of Character Strengths on Depression

2019 ◽  
Vol 26 (3) ◽  
pp. 101-109
Author(s):  
Beatrice Lee ◽  
Cahit Kaya ◽  
Xiangli Chen ◽  
Jia-Rung Wu ◽  
Kanako Iwanaga ◽  
...  
Keyword(s):  
College Students ◽  
Perceived Stress ◽  
Attributional Style ◽  
Mental Health Problems ◽  
Character Strengths ◽  
Empirically Supported ◽  
High School To College ◽  
Transition From High School ◽  
Adjustment Issues ◽  
Negative Attributional Style

Abstract. The transition from high school to college can be very stressful for Turkish students because they may experience value conflicts and adjustment issues, which can trigger the development of mental health problems. Character strengths can serve as a buffer against psychopathology. The aim of the study was to examine perceived stress and negative attributional style as mediating factors between character strengths and depression among Turkish college students. Bootstrap testing approach was implemented to compute direct and indirect effects and total effect in the mediation analysis. Altogether 235 students from two Turkish universities participated in the study. The results showed that character strengths were associated with lower levels of depression and it was negatively associated with perceived stress and negative attributional style. The results also indicated that perceived stress and negative attribution style completely mediated the relationship between character strengths and depression among Turkish college students. These findings suggested the need to develop empirically supported interventions that can promote character strengths toward reducing stress, negative attributions, and depression in this population.

Guilty Pleasure No More

2017 ◽  
Vol 29 (3) ◽  
pp. 126-136 ◽  
Author(s):  
Robin L. Nabi ◽  
Debora Pérez Torres ◽  
Abby Prestin
Keyword(s):  
Stress Management ◽  
Perceived Stress ◽  
Media Use ◽  
Well Being ◽  
Breast Cancer Patients ◽  
Positive Role ◽  
Individual Difference Variables ◽  
Relative Value ◽  
Management Techniques ◽  
Managing Stress

Abstract. Despite the substantial attention paid to stress management in the extant coping literature, media use has been surprisingly overlooked as a strategy worthy of close examination. Although media scholars have suggested media use may be driven by a need to relax, related research has been sporadic and, until recently, disconnected from the larger conversation about stress management. The present research aimed to determine the relative value of media use within the broader range of coping strategies. Based on surveys of both students and breast cancer patients, media use emerged as one of the most frequently selected strategies for managing stress across a range of personality and individual difference variables. Further, heavier television consumers and those with higher perceived stress were also more likely to use media for coping purposes. Finally, those who choose media for stress management reported it to be an effective tool, although perhaps not as effective as other popular strategies. This research not only documents the centrality of media use in the corpus of stress management techniques, thus highlighting the value of academic inquiry into media-based coping, but it also offers evidence supporting the positive role media use can play in promoting psychological well-being.

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