An inverse relationship between the growth rate of human melanoma xenografts and their response to some cytostatic drugs

Centrioles are highly structured organelles whose size is remarkably consistent within any given cell type. New centrioles are born when Polo-like kinase 4 (Plk4) recruits Ana2/STIL and Sas-6 to the side of an existing “mother” centriole. These two proteins then assemble into a cartwheel, which grows outwards to form the structural core of a new daughter. Here, we show that in early Drosophila melanogaster embryos, daughter centrioles grow at a linear rate during early S-phase and abruptly stop growing when they reach their correct size in mid- to late S-phase. Unexpectedly, the cartwheel grows from its proximal end, and Plk4 determines both the rate and period of centriole growth: the more active the centriolar Plk4, the faster centrioles grow, but the faster centriolar Plk4 is inactivated and growth ceases. Thus, Plk4 functions as a homeostatic clock, establishing an inverse relationship between growth rate and period to ensure that daughter centrioles grow to the correct size.

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Regulation of respiratory activity by oxygen in Arthrobacter fluorescens ammonium-limited chemostat culture

Canadian Journal of Microbiology ◽

10.1139/m85-168 ◽

1985 ◽

Vol 31 (10) ◽

pp. 896-899 ◽

Cited By ~ 3

Author(s):

I. Cacciari ◽

D. Lippi ◽

S. Ippoliti ◽

T. Pietrosanti ◽

W. Pietrosanti

Keyword(s):

Growth Rate ◽

Dissolved Oxygen ◽

Respiratory Rate ◽

Oxygen Concentration ◽

Respiration Rate ◽

Inverse Relationship ◽

Respiratory Activity ◽

Chemostat Culture ◽

Oxygen Limitation ◽

Dissolved Oxygen Concentration

The effect of a sudden imposition of either oxygen limitation or over oxygenation on an Arthrobacter sp. ammonium-limited chemostat culture was studied at growth rate of 0.03 h−1. Growth and respiratory activity of the cultures were examined during the transition periods and at both steady-states. Arthrobacter fluorescens responded to oxygen limitation by increasing respiratory rate and degrading polysaccharide content. In contrast, an increase in dissolved oxygen concentration caused a decrease in respiration rate and an increase in biosynthesis of endogenous polysaccharides. Under both conditions an inverse relationship seemed to occur between respiration rate and yield coefficients.

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The State of Litter of Pigs in the Conditions of the Complex

E3S Web of Conferences ◽

10.1051/e3sconf/202020301008 ◽

2020 ◽

Vol 203 ◽

pp. 01008

Author(s):

Romazan Siraziev ◽

Olesia Gruzdova

Keyword(s):

Growth Rate ◽

Corpus Luteum ◽

Inverse Relationship ◽

The State ◽

Embryonic Mortality ◽

Large White ◽

Small Weight ◽

Positive Correlation ◽

Early Timing

The state of litter of large white pigs in industrial conditions was studied. Embryonic mortality is higher during the first 30 days of littering (21.6%) – in the period of histotrophic feeding of fetuses – before the beginning of placental connection formation. whereas during the whole period of pregnancy it is 38.4%. In a number of sows at different periods of littering. the number of corpus luteum and the number of fetuses from the side of the corresponding fertile horn do not coincide. that which indicates the migration of embryos into contralateral horn in the early timing of pregnancy. Fetuses growth rate is higher by the 45-days pregnancy. In the litter of pigs there are normotrophic (full-fledged. large-fetused). hypotrophic (small-weight) and stillborn pigs. There is close inverse relationship (r = -0.98 between fertility and full-fledgeness of piglets в гнездеin the nest. wherein the number of hypotrophic and stillborn ones as the number of newborns in the litter increases has direct positive correlation (r = + 0.98). The more piglets in the litter. the fewer full-fledged ones. and on the contrary. the number of hypotrophic and stillborns is increasing.

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The value of experimental models as preclinical screens for cytostatic drugs against human melanoma

Melanoma Research ◽

10.1097/00008390-199303000-00255 ◽

1993 ◽

Vol 3 (1) ◽

pp. 70

Author(s):

W. Tilgen ◽

B. Hennes ◽

M. Weigand ◽

D. Haag

Keyword(s):

Experimental Models ◽

Human Melanoma ◽

Cytostatic Drugs

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The relationship between the growth rate and the lifetime in carbon nanotube synthesis

Nanoscale ◽

10.1039/c5nr01125f ◽

2015 ◽

Vol 7 (19) ◽

pp. 8873-8878 ◽

Cited By ~ 25

Author(s):

Guohai Chen ◽

Robert C. Davis ◽

Hiroe Kimura ◽

Shunsuke Sakurai ◽

Motoo Yumura ◽

...

Keyword(s):

Growth Rate ◽

Carbon Nanotube ◽

Growth Kinetics ◽

Growth Temperature ◽

Carbon Concentration ◽

Inverse Relationship ◽

Carbon Nanotube Synthesis ◽

The Relationship ◽

Catalyst Lifetime

We report an inverse relationship between the carbon nanotube (CNT) growth rate and the catalyst lifetime by investigating the dependence of growth kinetics for ∼330 CNT forests on the carbon feedstock, carbon concentration, and growth temperature.

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Effect of testosterone on antler growth in yearling male reindeer

Rangifer ◽

10.7557/2.3.2.475 ◽

1983 ◽

Vol 3 (2) ◽

pp. 6 ◽

Cited By ~ 4

Author(s):

Morten Ryg

Keyword(s):

Growth Rate ◽

Body Weight ◽

Food Intake ◽

Inverse Relationship ◽

Rangifer Tarandus ◽

Testosterone Levels ◽

Rangifer Tarandus Tarandus ◽

Antler Growth ◽

Effect Of Treatment

1. The effect of exogenous testosterone on ander growth in yearling male reindeer (Rangifer tarandus tarandus) was tested. 2. Testosterone (33 mg/kg) inhibited antler growth, and in one animal induced cleaning and subsequent casting of the antlers. This animal grew a new set of antlers, which were cleaned at the normal time. 3. During treatment, there was an inverse relationship between peak testosterone levels and antler growth rate. 4. There was no effect of treatment on body weight or food intake. 5. It is concluded that the effects of testosterone on antler growth are qualitatively the same in reindeer as in other deer. However, because high testosterone doses were necessary to produce effects, it is questionable whether this hormone normally is responsible for the cessation of antler growth in reindeer.Virkningen av testosteron på gevirvekst hos ettårige reinbukker.Abstract in Norwegian / Sammendrag: 1. Virkningen av testosteron på gevirvekst hos ett-årige reinbukker (Rangifer tarandus tarandus) ble undersøkt. 2. Testosteron (33 mg/kg) hemmet gevirveksten, og hos ett dyr førte behandlingen til at geviret ble feiet og deretter felt. Deretter vokste det ut ett nytt gevir, som ble feiet til vanlig tid. 3. Det var en negativ korrelasjon mellom maksimale testosteronnivåer og gevirvekst under behandlingen. 4. Det var ingen effekt på forinntak eller vektutvikling. 5. Det blir konkludert med at virkningen av testosteron på gevirvekst er kvalitativt den samme hos rein som hos andre hjortedyr. Det er likevel tvilsomt om testosteron normalt er ansvarlig for avslutningen av gevirvekst hos rein, fordi store testosterondoser måtte til for å få noen virkning.Testosteronin vaikutus vuodenikåisten urosporojen sarvien kasvuun.Abstract in Finnish / Tiivistelmä: 1. Tutkimuksessa seurattiin ruiskeena annetun testosteronin vaikutusta vuodenikåisten urosporojen (Rangifer tarandus tarandus) sarvien kasvuun. 2. Testosteron! (33 mg/kg) hidasti sarvien kasvua, aiheuttaen yhdesså elåimesså sarvien kelomisen ja pudottamisen. Talle elåimelle kasvoi uudestaan sarvet, jotka se keloi normaaliin aikaan. 3. Testosteronin huipputaso veresså oli kåsittelyaikana kååntåen verrannollinen sarvien kasvunopeuteen. 4. Kåsittely ei vaikuttanut elåinten ruumiinpainoon eikå niiden ruokahaluun. 5. Voidaan pååtellå testosteronin vaikutuksien sarvien kasvuun olevan porossa laadullisesti yhtålåiset kuin muissakin hirvielåimisså. Koska vaikutuksen aikaansaamiseksi vaadittiin korkeita testosteroniannoksia, voidaan kuitenkin pitåå kyseenalaisena, onko kyseinen hormoni normaalisti vastuussa poronsarven kasvun keskeytymisestå.

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EFECTOS DEL DESEMPLEO SOBRE LOS DETERMINANTES DEL CONSUMO AGREGADO. EVIDENCIA EMPÍRICA PARA EL CASO ECUATORIANO

REVISTA CIENCIAS PEDAGÓGICAS E INNOVACIÓN ◽

10.26423/rcpi.v4i1.126 ◽

2016 ◽

Vol 4 (1) ◽

Author(s):

Wendy Wasbrum Tinoco ◽

Margarita Palma Samaniego ◽

Gloria Valencia Vivas ◽

Flor Garcés

Keyword(s):

Growth Rate ◽

Financial Crisis ◽

Unemployment Rate ◽

Inverse Relationship ◽

Permanent Income ◽

Disposable Income ◽

Population Migration ◽

Consumption Growth ◽

Palabras Clave ◽

Year 2000

En el Ecuador, la tasa de desempleo en el año 2000 fue del 12%, teniendo fluctuaciones positivas de dos a tres puntos porcentuales en los siguientes cinco años, provocando una migración representativa en la población ecuatoriana, hacia Europa y EEU, repercutiendo en la inestabilidad económica y crisis financiera del Ecuador. En el presente estudio se analiza la tasa de desempleo del Ecuador para el periodo 2000-2015 y los determinantes del consumo como son: el ingreso permanente, tasa de crecimiento del consumo y el nivel de ahorro precautorio de los ecuatorianos a nivel nacional; obteniendo como resultados de la investigación la relacion inversa entre la tasa de desempleo y la tasa de crecimiento del consumo, cumpliéndose este supuesto macroeconómico básico en la economía del Ecuador. Palabras Clave: Tasa de desempleo, tasa de crecimiento del consumo, ingreso disponible y ahorro precautorio ABSTRACT Ecuador’s unemployment rate of year 2000 was 12% with positive fluctuations of two to three points on the following five years resulting on a fraction of its population migration towards Europe and USA. It was an impact of economic instability that resulted in a general financial crisis. Unemployment rate of Ecuador for the period 2000 - 2015 and determinants of consumption were analyzed in this study as well as permanent income, consumption growth rate and preventative national savings level. A basic macroeconomic scenario for Ecuador is confirmed by analyzing the inverse relationship between unemployment and consumption growth rate. Keywords: unemployment rate, consumption growth rate, disposable income and preventative savings Recibido: diciembre de 2015Aprobado: mayo 2016

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