scholarly journals Mechanisms of Cerebrovascular Dilation by Ether in Monkeys

1987 ◽  
Vol 7 (2) ◽  
pp. 230-236
Author(s):  
Yoo Goo Kang ◽  
Edwin M. Nemoto ◽  
Achiel L. Bleyaert ◽  
Peter M. Winter ◽  
Benjamin H. Eidelman ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Cerebral Metabolism ◽  
Plasma Catecholamines ◽  
The Other ◽  
Plasma Epinephrine ◽  
Ether Anesthesia ◽  
Cerebrovascular Resistance ◽  
Cerebral Metabolic Rate ◽  
Before And After ◽  
Stimulation Of

We hypothesized that when the depth of ether anesthesia is increased from 2 to 5%, cerebral vessels dilate secondary to circulating catecholamine stimulation of cerebral metabolism. Cerebral blood flow (CBF) by 133Xe clearance and cerebral metabolic rate for oxygen (CMRO2) were measured on 2% and then 5% ether in air in two groups of seven monkeys each during mechanical ventilation. Propranolol, 0.5 mg/kg i. v., was infused over 5 min in one group, and the other received saline. All measurements were repeated on 5% and 2% ether. Cerebrovascular resistance (CVR) fell by 30%, from 2.28 2± 0.61 (mean ± SD) to 1.51± 0.28 mm Hg ml−1 100 g−1 min−1 (p < 0.01), with the increase in ether from 2 to 5%. CBF and CMRO2 were unaltered from values of about 45 ml 100 g−1 min−1 and 2.3 ml 100 g−1 min−1, respectively. During 5% ether anesthesia, propranolol had no effect on CBF, CMRO2, or CVR. On 2% ether, it increased CVR twofold, from 1.5 ± 0.30 to 3.0 ± 1.0 mm Hg ml−1 100 g−1 min−1, and decreased CBF by 33%, from 48 ± 8 to 32 ± 10 ml 100 g−1 min−1. Plasma epinephrine was twofold higher on 2% compared to 5% ether, both before and after saline or propranolol infusion. In monkeys, cerebrovascular dilation by ether at 5% compared to 2% is not secondary to catecholamine stimulation of CMRO2. It may result from a direct effect of either plasma catecholamines or ether on the cerebrovasculature.

scholarly journals Stimulating Emotional Intelligence in Seniors: The Peci-Pm Program

2014 ◽  
Vol 4 (3) ◽  
pp. 329-339
Author(s):  
Mª del Carmen Pérez-Fuentes ◽  
Mª del Mar Molero ◽  
José J. Gázquez ◽  
Francisco J. Soler
Keyword(s):  
Emotional Intelligence ◽  
Older People ◽  
Senior Citizens ◽  
Cognitive Stimulation ◽  
The Other ◽  
Before And After ◽  
Interpersonal Dimension ◽  
Emotional Intelligence Inventory ◽  
Stimulation Of

The Cognitive Stimulation and Emotional Intelligence for Seniors Program (PECI-PM), combines cognitive stimulation with intervention and stimulation of aspects related to emotional intelligence. The purpose of this study was to analyze the emotional intelligence results of the first stage of PECI-PM implementation. A sample of 28 program users who had completed 20 sessions and participated in the two evaluations (pre-post) was employed for this. Emotional Intelligence was evaluated before and after intervention using the Inventario Breve de Inteligencia Emocional para Mayores [Brief Emotional Intelligence Inventory for Senior Citizens] (EQ-i-M20). After intervention with the PECI-PM, improvement was observed in most of the emotional intelligence dimensions (Intrapersonal, Interpersonal, Adaptability and Mood). In the Stress Management dimension, there was no change in scores after intervention, which leads us to reconsider the weight of this emotional intelligence dimension in the older population. On the other hand, the role of the Interpersonal dimension, which correlates significantly with other emotional intelligence factors (Intrapersonal and Adaptability) in older people, should be emphasized.

Effect of ether on control of rate and depth of breathing in newborn rabbits

1976 ◽  
Vol 40 (3) ◽  
pp. 281-286 ◽  
Author(s):  
B. T. Thach ◽  
I. Wyszogrodski ◽  
J. Milic-Emili
Keyword(s):  
Airway Pressure ◽  
Contractile Force ◽  
The Other ◽  
Ether Anesthesia ◽  
Newborn Rabbit ◽  
Elastic Load ◽  
Inspiratory Muscles ◽  
Before And After ◽  
The Central Nervous System ◽  
Vagal Influence

The effect of ether anesthesia on Hering-Breuer inflation reflexes of newborn rabbit pups was investigated. Studies were done at a level of anesthesia at which an apneustic pattern of respiration is seen in vagotomized animals. The hypothesis that increase in vagal influence on respiratory frequency is accompanied by increase in influence on contractile force of the inspiratory muscles was tested. Two aspects of the Hering-Breuer reflex, breath duration and airway pressure developed with an elastic load, were evaluated simultaneously. This was done by performing airway occlusions at FRC--the results expressed as percent slowing on occlusion and as effective elastance (E'rs). The animals were studied with and without anesthesia, before and after vagotomy. Anesthesia resulted in a marked increase in vagal influence on inspiratory duration (34% increase) and on total breath duration (36% increase). In contrast E'rs was decreased (20%) after anesthesia whereas passive elastance was slightly increased. The vagal contribution to E'rs was essentially the same before and after anesthesia (36–38%). Thus ether anesthesia increases one aspect of the Hering-Breuer reflex without changing the other. These findings are likely due to depression of the central nervous system rather than due to peripheral effects of ether.

scholarly journals Stimulating Emotional Intelligence in Seniors: The Peci-Pm Program

2014 ◽  
Vol 4 (3) ◽  
pp. 329-339
Author(s):  
Mª del Carmen Pérez-Fuentes ◽  
Mª del Mar Molero ◽  
José J. Gázquez ◽  
Francisco J. Soler
Keyword(s):  
Emotional Intelligence ◽  
Older People ◽  
Senior Citizens ◽  
Cognitive Stimulation ◽  
The Other ◽  
Before And After ◽  
Interpersonal Dimension ◽  
Emotional Intelligence Inventory ◽  
Stimulation Of

The Cognitive Stimulation and Emotional Intelligence for Seniors Program (PECI-PM), combines cognitive stimulation with intervention and stimulation of aspects related to emotional intelligence. The purpose of this study was to analyze the emotional intelligence results of the first stage of PECI-PM implementation. A sample of 28 program users who had completed 20 sessions and participated in the two evaluations (pre-post) was employed for this. Emotional Intelligence was evaluated before and after intervention using the Inventario Breve de Inteligencia Emocional para Mayores [Brief Emotional Intelligence Inventory for Senior Citizens] (EQ-i-M20). After intervention with the PECI-PM, improvement was observed in most of the emotional intelligence dimensions (Intrapersonal, Interpersonal, Adaptability and Mood). In the Stress Management dimension, there was no change in scores after intervention, which leads us to reconsider the weight of this emotional intelligence dimension in the older population. On the other hand, the role of the Interpersonal dimension, which correlates significantly with other emotional intelligence factors (Intrapersonal and Adaptability) in older people, should be emphasized.

Antiparasitic Treatment of Patients with P. falciparum Malaria Reduces the Ability of Patient Serum to Induce Tissue Factor by Decreasing NF-κB Activation

1995 ◽  
Vol 73 (01) ◽  
pp. 039-048 ◽  
Author(s):  
A Bierhaus ◽  
Ch J Hemmer ◽  
N Mackman ◽  
R Kutob ◽  
R Ziegler ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Falciparum Malaria ◽  
De Novo ◽  
Neutralizing Antibody ◽  
Mobility Shift ◽  
Before And After ◽  
Tf Gene ◽  
Electrophoretic Mobility Shift Assays ◽  
Antiparasitic Treatment ◽  
Stimulation Of

SummarySerum from patients with P. falciparum malaria at day 1 (pretherapy) induces tissue factor (TF) in cultured endothelial cells. TF induction depends on de novo transcription as shown in Nuclear Run On assays. Electrophoretic mobility shift assays demonstrated binding of AP-1 and NF- κB/Rel proteins to their recognition sites in the TF promotor. After therapy (day 28), stimulation of TF antigen by patient serum is reduced by 70%. When serum obtained before and after therapy was compared, a decrease of NF-κB activation was evident. Activation of NF-κB-like proteins was in part dependent on TNFα in patient serum, since a TNFα neutralizing antibody reduced induction of TF transcription and translation and induction of NF-κB-like proteins. Induction of TF activity was suppressed by pDTC, an inhibitor of NF-κB activation. When different promotor constructs of the TF gene were tested, induction was dependent upon the presence of the intact NF-κB-like binding site in the TF promotor. A mutant with deleted NF-κB, but intact AP-1 sites was not inducible. Mutation of the AP-1 sites did not prevent induction, but reduced inducibility by pretherapy serum. Therefore, NF-κB/Rel proteins are responsible for induction of TF transcription by pretherapy serum, but AP-1 is needed for highest inducibility. The effect of antiparasitic therapy on the induction of TF by serum from patients with complicated P. falciparum malaria is dependent on a therapy-mediated loss of activation of NF-κB-like proteins in post-treatment patient serum.

EFFECT OF ACTINOMYCIN D ON TSH-INDUCED STIMULATION OF THYROIDAL PROTEIN SYNTHESIS IN THE RAT

1974 ◽  
Vol 77 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Gustav Wägar
Keyword(s):  
Protein Synthesis ◽  
Actinomycin D ◽  
The Other ◽  
Leucine Incorporation ◽  
Short Term ◽  
Other Hand ◽  
Thyroid Glands ◽  
Translational Level ◽  
Stimulation Of

ABSTRACT Whether the short-term regulation of thyroidal protein synthesis by TSH occurs at the transcriptional or the translational level was tested by measuring the effect of actinomycin D (act D) on the TSH-induced stimulation of L-14C-leucine incorporation into the thyroidal proteins of rats. TSH was injected 6 h before the rats were killed. The thyroid glands were then removed and incubated in vitro in the presence of L-14C-leucine for 2 h. The pronounced stimulation of leucine incorporation in the TSH-treated animals was depressed as compared with controls but still significant even when the animals had been pre-treated with 100 μg act D 24 and 7 h before sacrifice. On the other hand, act D strongly decreased incorporation of 3H-uridine into RNA. Short-term regulation of thyroidal protein synthesis by TSH appears to be partly but not wholly dependent on neosynthesis of RNA. Hence regulation may partly occur at the translation level of protein synthesis.

Arthroscopy in Arthrosis: Is It Worth it? A case Presentation

2018 ◽  
Vol 69 (8) ◽  
pp. 2232-2235
Author(s):  
Marius Moga ◽  
Mark Edward Pogarasteanu ◽  
Antoine Edu
Keyword(s):  
Clinical Status ◽  
Loose Body ◽  
Point Of View ◽  
The Other ◽  
Joint Range Of Motion ◽  
Objective Evidence ◽  
Before And After ◽  
Total Knee ◽  
Joint Range

The role of arthroscopy in incipient and mild arthrosis, even combined with proximal tibial ostetomy, is well known and well documented. On the other hand, its role in the treatment of advanced arthrosis of the large joints, especially the knee, is a subject of controversy. The proponents of the use of arthroscopy in advanced arthrosis claim that meniscectomy, synovectomy, ostophytectomy, chondral lesion stabilization, arthroscopic release, plica and loose body removal greatly improve the quality of life for most patients, especially if followed by the use of viscoelastic injection, by diminishing pain and improving joint range of motion. The opponents claim that, even though the advantages are clear in the cases that refuse arthroplasty, in all the other cases the surgical indication should be total knee arthroplasty, as the clinical relief is temporary, but with all the risks of a surgical intervention. We have conducted an overview of the recent literature, in order to find objective evidence to sustain either point of view. We focused on articles published that included an objective measurement of before and after clinical status through clinical scores and objective measurements. We also focused on the follow-up period and on the evolution of the pathology after arthroscopy.

Antimicrobial Effect of 940 nm Diode Laser based on Photolysis of Hydrogen Peroxide in the Treatment of Periodontal Disease

2018 ◽  
Vol 69 (8) ◽  
pp. 2081-2088 ◽  
Author(s):  
Alin Alexandru Odor ◽  
Edwin Sever Bechir ◽  
Deborah Violant ◽  
Victoria Badea
Keyword(s):  
Hydrogen Peroxide ◽  
Laser Therapy ◽  
Diode Laser ◽  
Antimicrobial Effect ◽  
The Other ◽  
Control Group ◽  
Group 4 ◽  
Periodontal Bacteria ◽  
Severe Periodontitis ◽  
Before And After

Moderate and severe periodontitis represents a challenge in the non-surgical periodontal therapy. Due to the lack of evidence regarding the antimicrobial effectiveness of 940 nm diode laser in periodontal treatment, this study aimed to evaluate the antimicrobial effect of hydrogen peroxide (H2O2) photolysis performed with 940 nm diode laser in the treatment of moderate and severe periodontitis. Twenty-five patients with 100 teeth were selected for this pilot study. The test teeth were randomly assigned to one of the four treatment groups: Group 1: scaling and root planning (SRP) (control group); and the following experimental groups: Group 2: H2O2; Group 3: 940 nm diode laser therapy; Group 4: 940 nm diode laser therapy and H2O2. Clinical examinations, like probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were performed before and after the treatment. The microbiological evaluation, effectuated before and after the treatment, included nine periodontal bacteria species and investigated by means of real-time PCR assay. The clinical and bacterial differences in the tested groups, was assessed between control group and the other three experimental groups, as well as between the experimental groups. The total bacteria load was reduced for all four studied groups. Group 4 (diode laser + H2O2) showed significant bacterial reduction of the major periodontal bacteria like Pg., Tf., Td., Pi., Pm., Fn (p[0.001) than the other 3 groups (p]0.001). Also the periodontal clinical parameters, like PD, CAL and BOP showed a significant reduction after the photolysis of H2O2 with the 940 nm diode laser (p[0.001). Differences between tested groups showed a significant beneficial results in regard to Group 4.It is suggested that the photoactivation of H2O2 with the 940 nm diode laser can be used successfully in adjunctive to the non-surgical periodontal treatment as a bactericidal tool.

scholarly journals Receptor-operated Ca2+ channels in gastric parietal cells: gastrin and carbachol induce Ca2+ influx in depleting intracellular Ca2+ stores

1993 ◽  
Vol 289 (1) ◽  
pp. 117-124 ◽  
Author(s):  
S Roche ◽  
J P Bali ◽  
R Magous
Keyword(s):  
Steady State ◽  
Receptor Activation ◽  
Parietal Cells ◽  
The Other ◽  
Bivalent Cation ◽  
Gtp Binding ◽  
Gastric Parietal Cells ◽  
Type Receptor ◽  
Ca2 Channels ◽  
Stimulation Of

The mechanism whereby gastrin-type receptor and muscarinic M3-type receptor regulate free intracellular Ca2+ concentration ([Ca2+]i) was studied in rabbit gastric parietal cells stimulated by either gastrin or carbachol. Both agonists induced a biphasic [Ca2+]i response: a transient [Ca2+]i rise, followed by a sustained steady state depending on extracellular Ca2+. Gastrin and carbachol also caused a rapid and transient increase in Mn2+ influx (a tracer for bivalent-cation entry). Pre-stimulation of cells with one agonist drastically decreased both [Ca2+]i increase and Mn2+ influx induced by the other. Neither diltiazem nor pertussistoxin treatment had any effect on agonist-stimulated Mn2+ entry. Thapsigargin, a Ca(2+)-pump inhibitor, induced a biphasic [Ca2+]i increase, and enhanced the rate of Mn2+ entry. Preincubation of cells with thapsigargin inhibits the [Ca2+]i increase as well as Mn2+ entry stimulated by gastrin or by carbachol. Thapsigargin induced a weak but significant increase in Ins(1,4,5)P3 content, but this agent had no effect on the agonist-evoked Ins(1,4,5)P3 response. In permeabilized parietal cells, Ins(1,4,5)P3 and caffeine caused an immediate Ca2+ release from intracellular pools, followed by a reloading of Ca2+ pools which can be prevented in the presence of thapsigargin. We conclude that (i) gastrin and carbachol mobilize common Ca2+ intracellular stores, (ii) Ca2+ permeability secondary to receptor activation involves neither a voltage-sensitive Ca2+ channel nor a GTP-binding protein from the G1 family, and (iii) agonists regulate common Ca2+ channels in depleting intracellular Ca2+ stores.

scholarly journals Management of chronic periodontitis: an interdisciplinary approach

2016 ◽  
Vol 4 (2) ◽  
pp. 65
Author(s):  
Sneha Dani ◽  
Savitha A.N ◽  
Kenneth Tan ◽  
Anand Naik ◽  
Charan Chhatrala ◽  
...  
Keyword(s):  
Public Interest ◽  
Orthodontic Treatment ◽  
Interdisciplinary Approach ◽  
Primary Objective ◽  
Periodontal Therapy ◽  
The Other ◽  
Periodontal Health ◽  
Orthodontic Therapy ◽  
Single Tooth ◽  
Before And After

Objective: In recent years, advances in technique as well as a growing public interest in developing and maintaining a healthy and attractive smile, has resulted in a greater understanding of the interrelationships between periodontics and orthodontics. The primary objective of periodontal therapy is to restore and maintain the health and integrity of the attachment apparatus of teeth. In adults, the loss of teeth or periodontal support can result in pathological teeth migration involving either a single tooth or a group of teeth. This may result in the development of a diastema, incisal proclination, rotation with collapse of the posterior occlusion.Materials and methods: This case report is of a 32 year old female patient who reported with swollen gums, generalized spacing between the teeth and extruded upper anterior tooth. Periodontal therapy followed by fixed orthodontic therapy was planned.Results: At the end of 2 years a stable healthy periodontium was established that was both functional and esthetic.Conclusion: Adjunctive orthodontic therapy is often necessary for successful restoration of periodontal health. On the other hand, successful orthodontic treatment will depend on the periodontal preparation before and after treatment and the maintenance of periodontal health throughout all phases of mechano-therapy.

On Research and Other Matters

1922 ◽  
Vol 26 (140) ◽  
pp. 325-330
Author(s):  
S. Heckstall Smith
Keyword(s):  
British Empire ◽  
Air Force ◽  
The Other ◽  
Other Hand ◽  
Secretary Of State ◽  
The Press ◽  
The Subject ◽  
Stimulation Of

If the thought of another war troubles you, then don't read this article. If you would rather say to yourself as the Secretary of State said to the Air Conference, “ There won't be another war for ten years, so why worry? ” then no doubt you will think with him that it is better to let other nations have alk the bother and expense of trying to advance; after all, we are jolly fine fellows and can soon pick up. If, on the other hand, you have imagination which gives you a nasty queasy sensation when you think of what might be, then perhaps the following notes, albeit disjointed and mostly stale, may at least conjure up in you thoughts of your own on the subject. This is all that is needed to help, our advancement in the air–the stimulation of spoken and written thoughts by the British nation, for if every taxpayer in the British Empire says “ Air Force,” then the Press and Parliament will say it too.

Sign in / Sign up

Export Citation Format

Share Document