scholarly journals Relationship of kidney function to immunopathology in chronic serum sickness of rats

1983 ◽  
Vol 24 (2) ◽  
pp. 160-169 ◽  
Author(s):  
Judith B. Van Liew ◽  
Jan R. Brentjens ◽  
Bernice Noble ◽  
B. Noble
Keyword(s):  
Kidney Function ◽  
Serum Sickness ◽  
Relationship Of

Relationship of gender, age, and body mass index to errors in predicted kidney function

2005 ◽  
Vol 20 (9) ◽  
pp. 1791-1798 ◽  
Author(s):  
Massimo Cirillo ◽  
Pietro Anastasio ◽  
Natale G. De Santo
Keyword(s):  
Body Mass Index ◽  
Kidney Function ◽  
Body Mass ◽  
Relationship Of

Sex-specific Relationship of Serum Uric Acid with All-cause Mortality in Adults with Normal Kidney Function: An Observational Study

2017 ◽  
Vol 44 (3) ◽  
pp. 380-387 ◽  
Author(s):  
Eunjeong Kang ◽  
Seung-sik Hwang ◽  
Dong Ki Kim ◽  
Kook-Hwan Oh ◽  
Kwon Wook Joo ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Mortality Rate ◽  
Serum Uric Acid ◽  
Kidney Function ◽  
Reference Group ◽  
Normal Kidney ◽  
Normal Kidney Function ◽  
All Cause Mortality ◽  
Relationship Of

Objective.To explain the clinical effect of serum uric acid (SUA) levels as a risk factor for mortality, considering exclusion of kidney function.Methods.Participants aged over 40 years who underwent health checkups were recruited. Individuals with estimated glomerular filtrations rates < 60 ml/min/1.73 m2 and who received laboratory study and colonoscopy on the same day were excluded.Results.SUA levels were higher in men than in women (5.7 ± 1.2 mg/dl for men and 4.2 ± 0.9 mg/dl for women, p < 0.001). During 12.3 ± 3.6 years of followup, 1402 deaths occurred among 27,490 participants. About 6.9% of men and 3.1% of women died. The overall mortality rate had a U-shaped association with SUA levels, a U-shaped association in men, and no association in women. There was a significant interaction of sex for the SUA-mortality association (p for interaction = 0.049); therefore, survival analysis was conducted by sex. In men, the lower SUA group had a higher mortality rate after adjustment (SUA ≤ 4.0 mg/dl, adjusted HR 1.413, 95% CI 1.158–1.724, p = 0.001) compared with the reference group (SUA 4.1–6.0 mg/dl). A higher SUA contributed to an insignificant increased mortality in men (> 8.0 mg/dl, adjusted HR 1.140, 95% CI 0.794–1.636, p = 0.479). Women failed to show any significant association between SUA and mortality.Conclusion.This study provided novel evidence that SUA-mortality association differed by sex. We demonstrated that a lower SUA was an independent risk factor for all-cause mortality in men with normal kidney function.

scholarly journals Relationship of serum cystatin C to residual kidney function in peritoneal dialysis patients

2011 ◽  
Vol 44 (9) ◽  
pp. 939-944
Author(s):  
Atsushi Saito ◽  
Tsutomu Tabata ◽  
Yoshihiro Tsujimoto ◽  
Yuko Fujiwara ◽  
Yuka Hosomi ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Kidney Function ◽  
Cystatin C ◽  
Dialysis Patients ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Residual Kidney Function ◽  
Relationship Of

scholarly journals Relationship of Proteinuria to Glomerular Basement Membrane Deposits in Serum-Sickness Glomerulonephritis in Rabbits

1977 ◽  
Vol 14 (5) ◽  
pp. 482-489 ◽  
Author(s):  
J. R. Easley ◽  
W. H. Halliwell
Keyword(s):  
Electron Microscopy ◽  
Bovine Serum Albumin ◽  
Basement Membrane ◽  
Light Microscopy ◽  
Glomerular Basement Membrane ◽  
Serum Sickness ◽  
Ultrastructural Changes ◽  
Mesangial Matrix ◽  
Foot Process ◽  
Relationship Of

Fifteen rabbits were injected with one dose of 250 milligrams per kilogram of bovine serum albumin intravenously to induce acute serum sickness. The kidneys were removed from groups of five rabbits each at 10, 12 and 14 days after injection and examined by light, electron and immunofluorescent microscopy for evidence of immune complex glomerulonephritis. Urine was examined for protein when rabbits died. Glomerulonephritis was found in eight rabbits by light microscopy and in 10 rabbits by electron microscopy. Only one rabbit had positive immunofluorescence for immunologic components and only two rabbits had proteinuria. Hypercellularity was the primary change seen by light microscopy. Ultrastructural changes were numerous and various, and the major changes recognized were irregularity of the glomerular basement membrane, increased mesangial matrix, hypercellularity, endothelial hypertrophy, mesangial deposits, epithelial foot process fusion and mesangial circumferential interposition. Subepithelial humps were seen in only four rabbits; none of these rabbits had proteinuria. We concluded that increased permeability followed the deposition of immune complexes and development of ultrastructural lesions.

The relationship of intravenous fluid chloride content to kidney function in patients with severe sepsis or septic shock

2015 ◽  
Vol 33 (3) ◽  
pp. 439-443 ◽  
Author(s):  
Faheem W. Guirgis ◽  
Deborah J. Williams ◽  
Matthew Hale ◽  
Abubakr A. Bajwa ◽  
Adil Shujaat ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Kidney Function ◽  
Chloride Content ◽  
Intravenous Fluid ◽  
Relationship Of ◽  
The Relationship

Relationship of several serum folate forms with kidney function and albuminuria: Cross-sectional data from the NHANES 2011-2018

2021 ◽  
pp. 1-33
Author(s):  
Mengyi Liu ◽  
Chun Zhou ◽  
Zhuxian Zhang ◽  
Qinqin Li ◽  
Panpan He ◽  
...  
Keyword(s):  
Kidney Function ◽  
Cross Sectional Study ◽  
Serum Folate ◽  
Creatinine Ratio ◽  
Lower Prevalence ◽  
Cross Sectional ◽  
Health And Nutrition ◽  
Nutritional Guidelines ◽  
Folate Supplement ◽  
Relationship Of

Abstract We aim to examine the relation of several folate forms (5-methyltetrahydrofolate [5-mTHF], unmetabolized folic acid [UMFA], and MeFox) with kidney function and albuminuria, which remained uncertain. The cross-sectional study was conducted in 18,757 participants from National Health and Nutrition Examination Survey 2011–2018. The kidney outcomes were reduced estimated glomerular filtration rate (eGFR) (<60 mL/min/1.73 m2), microalbuminuria (albumin-to-creatinine ratio of 30-299 mg/g), and macroalbuminuria (albumin-to-creatinine ratio ≥ 300 mg/g).Overall, there were significant inverse associations between serum 5-mTHF and kidney outcomes with significant lower prevalence of reduced eGFR (OR, 0.71; 95%CI: 0.57-0.87) and macroalbuminuria (OR, 0.65; 95%CI: 0.46-0.91) in participants in quartile 3-4 (vs. quartile 1-2; ≥34.0 vs. <34.0nmol/L; both P for trend across quartiles <0.05). In contrast, there were significant positive relationship between serum UMFA and kidney outcomes with significant higher prevalence of reduced eGFR in participants in quartile 2-4 (vs. quartile 1; ≥0.5 vs. <0.5nmol/L; OR, 2.12; 95%CI: 1.45-3.12; P for trend <0.001) and higher prevalence of macroalbuminuria in participants in quartile 4 (vs. quartile 1-3; ≥ 1.0 vs. <1.0 nmol/L; OR, 1.46; 95%CI: 1.06-2.01; P for trend <0.001). However, there was no significant associations of 5-mTHF and UMFA with microalbuminuria. In addition, there were significant positive relationships of serum MeFox with reduced eGFR, microalbuminuria and macroalbuminuria (all P for trend <0.01). In conclusion, higher 5-mTHF level, along with lower UMFA and MeFox level, were associated with lower prevalence of kidney outcomes, which may help counsel future clinical trials and nutritional guidelines regarding the folate supplement.

Sign in / Sign up

Export Citation Format

Share Document