scholarly journals Light People: Professor Lin Li

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Hui Wang ◽  
Heng Gu
Keyword(s):  
Climate Change ◽  
Super Resolution ◽  
Development Trend ◽  
Optical Diffraction ◽  
Research Centre ◽  
Resistant Bacteria ◽  
Research Experience ◽  
Laser Material Processing ◽  
Healthy Human ◽  
Research Fields

EditorialHow to deal with climate change, how to mitigate or even reverse it, maybe the hottest scientific topic of the 21st century. Do you know that a Chinese scientist and his team contributed to climate change control by reducing PM2.5 in diesel car exhaust by 35–40%? That scientist is Prof. Lin Li, a Fellow of the Royal Academy of Engineering and founder of the Laser Processing Research Centre at The University of Manchester, United Kingdom. Of course, this is only one example of Professor Li’s scientific achievements. As a pioneer of microsphere super-resolution lens, his team, in collaboration with Singapore colleagues, broke the optical diffraction limit in optical microscopic imaging, making real-time observation of biological viruses without interference possible. He also used lasers to synthesize new nanomaterials which kill drug-resistant bacteria while remaining harmless to healthy human cells, which led to the development and breakthrough of related research fields. We are much honored to have Professor Lin Li for an exclusive interview in which he recalls his years of scientific research experience and talks about the future development trend of laser material processing.

scholarly journals Contributions of Vegetation Greening and Climate Change to Evapotranspiration Trend after Large-Scale Vegetation Restoration on the Loess Plateau, China

Water ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 1755
Author(s):  
Shuo Wang ◽  
Chenfeng Cui ◽  
Qin Dai
Keyword(s):  
Climate Change ◽  
Loess Plateau ◽  
Large Scale ◽  
Vegetation Index ◽  
Normalized Difference Vegetation Index ◽  
Potential Evapotranspiration ◽  
Development Trend ◽  
Future Trend ◽  
Natural Ecosystem ◽  
The Loess Plateau

Since the early 2000s, the vegetation cover of the Loess Plateau (LP) has increased significantly, which has been fully recorded. However, the effects on relevant eco-hydrological processes are still unclear. Here, we made an investigation on the changes of actual evapotranspiration (ETa) during 2000–2018 and connected them with vegetation greening and climate change in the LP, based on the remote sensing data with correlation and attribution analysis. Results identified that the average annual ETa on the LP exhibited an obvious increasing trend with the value of 9.11 mm yr−1, and the annual ETa trend was dominated by the changes of ETa in the third quarter (July, August, and September). The future trend of ETa was predicted by the Hurst exponent. Partial correlation analysis indicated that annual ETa variations in 87.8% regions of the LP were controlled by vegetation greening. Multiple regression analysis suggested that the relative contributions of potential evapotranspiration (ETp), precipitation, and normalized difference vegetation index (NDVI), to the trend of ETa were 5.7%, −26.3%, and 61.4%, separately. Vegetation greening has a close relationship with the Grain for Green (GFG) project and acts as an essential driver for the long-term development trend of water consumption on the LP. In this research, the potential conflicts of water demanding between the natural ecosystem and social-economic system in the LP were highlighted, which were caused by the fast vegetation expansion.

Exploring climate finance for tourism adaptation development: an overview

2016 ◽  
Vol 8 (5) ◽  
pp. 593-605 ◽  
Author(s):  
Daniele Vieira do Nascimento
Keyword(s):  
Climate Change ◽  
Literature Review ◽  
English Language ◽  
Small Island ◽  
Future Research ◽  
Climate Finance ◽  
Content Type ◽  
Main Research ◽  
Research Fields ◽  
New Research

Purpose The purpose of this paper is to provide an overview of the links between climate finance and tourism adaptation development. Besides increasing adaptation and mitigation efforts to limit greenhouse gas emissions, climate change remains a major challenge in the twenty-first century and beyond especially for tourism which is highly climate sensitive. Hence, it is necessary for tourism to adapt to survive. The aim of the study is to provide a systematic overview of the topic to offer a foundation for better understanding different ways of integrating climate finance initiatives with tourism. Design/methodology/approach The research focused on the top-ranked, peer reviewed journals of each of the two selected research fields. To address this topic, an in-depth systematic literature review in the fields of climate change finance and tourism adaptation development was conducted. Furthermore, because it is a relatively new research topic, conference proceedings were also explored. To guarantee wide coverage of the literature, a query of the following scholarly databases was considered: Elsevier, ScienceDirect and Web of Science. Findings Based on the analyses of the literature available on the topic, the paper highlights the main research trends and conclusions. It is argued that there is imbalance of knowledge on climate change finance as it relates to tourism. To date, there have been relatively few published articles on this topic in the context of tourism. Based on the findings, promising areas for future research were identified, and in particular for small island communities and recommendations for future research are outlined. Research limitations/implications The paper is limited by the scope of the literature review accessed by the researcher. The results of this review may vary according to the databases used. Originality/value Currently, there is no extensive review of articles on climate finance and tourism adaptation. This paper aims at reviewing climate finance studies published in English language to explore knowledge gaps in tourism adaptation. Sets of themes being advanced are also highlighted. Recommendations for future research are provided.

Future options in landscape ecology: development and research

2009 ◽  
Vol 33 (1) ◽  
pp. 31-48 ◽  
Author(s):  
Xiuzhen Li ◽  
Ülo Mander
Keyword(s):  
Climate Change ◽  
Landscape Ecology ◽  
Global Climate Change ◽  
Landscape Metrics ◽  
Global Climate ◽  
Anthropogenic Factors ◽  
Landscape Development ◽  
Spatial And Temporal Scales ◽  
Research Fields ◽  
Interdisciplinary Field

The aim of this brief overview is to highlight some new and promising research fields in landscape ecology, which is essentially an interdisciplinary field of study. We also analyse the development of some classical branches of landscape ecology regarding pattern and process relationships at broad spatial and temporal scales, such as landscape metrics, the influence of anthropogenic factors and global climate change on landscape development, the fragmentation of ecosystems and disturbances of populations, and material and energy cycling in and between ecosystems.

scholarly journals How Computational Chemistry and Drug Delivery Techniques Can Support the Development of New Anticancer Drugs

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1756 ◽  
Author(s):  
Mariangela Garofalo ◽  
Giovanni Grazioso ◽  
Andrea Cavalli ◽  
Jacopo Sgrignani
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Rational Design ◽  
Significant Contribution ◽  
Research Experience ◽  
Computer Aided Drug Design ◽  
Target Drug Delivery ◽  
Research Fields ◽  
Target Drug ◽  
New Anticancer Drugs

The early and late development of new anticancer drugs, small molecules or peptides can be slowed down by some issues such as poor selectivity for the target or poor ADME properties. Computer-aided drug design (CADD) and target drug delivery (TDD) techniques, although apparently far from each other, are two research fields that can give a significant contribution to overcome these problems. Their combination may provide mechanistic understanding resulting in a synergy that makes possible the rational design of novel anticancer based therapies. Herein, we aim to discuss selected applications, some also from our research experience, in the fields of anticancer small organic drugs and peptides.

A Preliminary Study on the Relationship between Vegetation Cover and Regional Climate Change in Jiangsu Area of China

2013 ◽  
Vol 448-453 ◽  
pp. 916-922
Author(s):  
Yan Rong Yang ◽  
Zhe Kong ◽  
Chun Ming Liu
Keyword(s):  
Climate Change ◽  
Vegetation Cover ◽  
Vegetation Index ◽  
Climate Model ◽  
Regional Climate ◽  
Precipitation Amount ◽  
Regional Climate Change ◽  
Research Field ◽  
Research Fields ◽  
The Relationship

The relationship between vegetation cover and climate change is one of the most important research fields in global change. Herein Jiangsu province and thereabout in China is chosen to be the research field. Under the support of observations from normalized differential vegetation index (NDVI) during years from 1998 to 2008 and corresponding benchmark weather stations, the relationship between vegetation and climate change had been analyzed combined with simulations from regional climate model RegCM3, in perspectives of point vegetation cover amount and area vegetation cover type respectively. Conclusions are: (1) Points observations showed that NDVI had positive correlation with annual total precipitation and negative correlation with annual average temperature. (2) Area simulations showed that two different vegetation types in south and north Jiangsu almost had same 8warming value, but the incremental annual precipitation amount is more significant in south Jiangsu.

Super-resolution imaging of self-assembly of amphiphilic photoswitchable macrocycles

2017 ◽  
Vol 53 (18) ◽  
pp. 2669-2672 ◽  
Author(s):  
Qiong-Xin Hua ◽  
Bo Xin ◽  
Zu-Jing Xiong ◽  
Wen-Liang Gong ◽  
Chong Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Super Resolution ◽  
Fluorescence Microscope ◽  
Optical Diffraction ◽  
Tetraethylene Glycol ◽  
Resolution Imaging ◽  
Diffraction Limitation

Self-assembly of an amphiphilic photoswitchable fluorescent macrocycle methoxy-tetraethylene glycol-substituted hexaarylbiimidazole-borondipyrromethene can be observed directly under a super-resolution fluorescence microscope, with the nanoscale resolution beyond the optical diffraction limitation.

scholarly journals Characterizing Locus Specific Chromatin Structure and Dynamics with Correlative Conventional and Super Resolution imaging in living cells

2021 ◽  
Author(s):  
Dushyant Mehra ◽  
Santosh Adhikari ◽  
Chiranjib Banerjee ◽  
Elias M. Puchner
Keyword(s):  
Single Molecule ◽  
Chromatin Structure ◽  
Spatial Organization ◽  
Super Resolution ◽  
Living Cells ◽  
Diffraction Limit ◽  
Optical Diffraction ◽  
Acquisition Time ◽  
Structure And Dynamics ◽  
Chromatin Structure And Dynamics

The dynamic rearrangement of chromatin is critical for gene regulation, but mapping both the spatial organization of chromatin and its dynamics remains a challenge. Many structural conformations are too small to be resolved via conventional fluorescence microscopy and the long acquisition time of super-resolution PALM imaging precludes the structural characterization of chromatin below the optical diffraction limit in living cells due to chromatin motion. Here we develop a correlative conventional fluorescence and PALM imaging approach to quantitatively map time-averaged chromatin structure and dynamics below the optical diffraction limit in living cells. By assigning localizations to a locus as it moves, we reliably discriminate between bound and searching dCas9 molecules, whose mobility overlap. Our approach accounts for changes in DNA mobility and relates local chromatin motion to larger scale domain movement. In our experimental system, we show that compacted telomeres have a higher density of bound dCas9 molecules, but the relative motion of those molecules is more restricted than in less compacted telomeres. Correlative conventional and PALM imaging therefore improves the ability to analyze the mobility and time-averaged nanoscopic structural features of locus specific chromatin with single molecule precision and yields unprecedented insights across length and time scales.

scholarly journals Resolving the Effects of Nanoscale Membrane Curvature on Lipid Mobility

2017 ◽  
Author(s):  
Abir Maarouf Kabbani ◽  
Xinxin Woodward ◽  
Christopher V. Kelly
Keyword(s):  
Lipid Bilayers ◽  
Super Resolution ◽  
Membrane Curvature ◽  
Single Particle Tracking ◽  
Correlation Spectroscopy ◽  
Optical Diffraction ◽  
Membrane Behavior ◽  
Lipid Mobility ◽  
Experimental Resolution ◽  
Membrane Budding

The biophysical consequences of nanoscale curvature have been challenging to resolve due to size-dependent membrane behavior and the experimental resolution limits imposed by optical diffraction. Recent advances in nanoengineering and super-resolution techniques have enabled new capabilities for creating and observing curvature. In particular, draping supported lipid bilayers over lithographically patterned substrates provides a model system for endocytic pits. The experiments and simulations presented below describe the possible detection of membrane curvature through fluorescence recovery after photobleaching (FRAP), fluorescence correlation spectroscopy (FCS), single particle tracking (SPT), and polarized localization microscopy (PLM). FRAP and FCS depend on diffraction-limited illumination and detection. In particular, a simulation of FRAP shows no effects on lipids diffusion due to a 50 nm diameter membrane bud at any stage in the budding process. Simulated FCS demonstrated small effects due to a 50 nm radius membrane bud that was amplified with curvature-dependent lipid mobility changes. However, PLM and SPT achieve sub-diffraction-limited resolution of membrane budding and lipid mobility through the identification of the single-lipid positions with ≤15 nm spatial and ≤20 ms temporal resolution. By mapping the single-lipid step lengths to locations on the membrane, the effects of curvature on lipid behavior have been resolved.

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