Steroid hormone analysis of adolescents and young women with polycystic ovarian syndrome and adrenocortical dysfunction using UPC2-MS/MS

Background: Polycystic ovarian syndrome (PCOS) associated with multiple presentation in females although it is common disorder but due to lack of knowledge females often delays in getting confirm diagnosis and treatment. PCOS remains a syndrome and as such no single diagnostic criterion is sufficient for clinical diagnosis. Objective: To assess the knowledge about PCOS in young women.Methods: Cross sectional study was performed on 400 women of age group 18-30 years either studying in Colleges or working in Indore city. Written informed consent was obtained and simple random technique was applied for selection of study participants. Pre-designed, pre-tested, semi-structured questionnaire was used for data collection. The data collected were analyzed through percentages and frequencies using Excel. Relevant statistical test was applied was applied and p value was calculated where ever required and considered statistically significant when it is <0.05.Results: Among 400 participants, only 41% of the women were aware of the term PCOS. 46% of the subjects who were aware about the organ system involved in this disease. Most of the people know about this disorder through friends or relatives. 49% of the women knew about the various signs and symptoms associated with PCOS.Conclusions: The results of present study show that very few of the young women understand what this disease is and what are the earliest symptoms that should alarm them to consult a physician. Discussion with the girls in college authors came to know that most of the people are considering menstrual pain and irregularities as a part of their physiological process and do not consider consulting a doctor.

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Endothelial dysfunction and insulin resistance in young women with polycystic ovarian syndrome

TURKISH JOURNAL OF MEDICAL SCIENCES ◽

10.3906/sag-1401-4 ◽

2014 ◽

Vol 44 ◽

pp. 787-791 ◽

Cited By ~ 7

Author(s):

Mine YAVUZ TAŞLIPINAR ◽

Nedret KILIÇ ◽

Nilüfer BAYRAKTAR ◽

İsmail GÜLER ◽

Yasemin GÜLCAN KURT ◽

...

Keyword(s):

Insulin Resistance ◽

Endothelial Dysfunction ◽

Young Women ◽

Polycystic Ovarian Syndrome ◽

Ovarian Syndrome

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Prevalence of polycystic ovarian syndrome among adolescents and young women in India

Journal of Diabetology ◽

10.4103/jod.jod_105_20 ◽

2021 ◽

Vol 12 (3) ◽

pp. 319

Author(s):

Viswanathan Mohan ◽

ThaharullahShah Mehreen ◽

Harish Ranjani ◽

Rajan Kamalesh ◽

Uma Ram ◽

...

Keyword(s):

Young Women ◽

Polycystic Ovarian Syndrome ◽

Women In India ◽

Ovarian Syndrome

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A cross sectional study of polycystic ovarian syndrome among young women in Bhopal, Central India

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20175603 ◽

2017 ◽

Vol 5 (1) ◽

pp. 95 ◽

Cited By ~ 2

Author(s):

Mahesh Gupta ◽

Daneshwar Singh ◽

Manju Toppo ◽

Angelin Priya ◽

Soumitra Sethia ◽

...

Keyword(s):

Risk Factors ◽

Young Women ◽

Polycystic Ovarian Syndrome ◽

Cross Sectional Study ◽

Reproductive Age ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

Waist Hip Ratio ◽

Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women of reproductive age groups. It is one of the leading causes of poor fertility. Risk factors include obesity, not enough physical exercise, and a family history. Most studies in India report prevalence of PCOS as 9.13% to 36%. Behaviour and life style modifications are important part of treatment for PCOS. A number of cases in the community due to lack of awareness and proper guidance, it remains undiagnosed. Aim of this study was to find the prevalence of PCOS among the young females of Bhopal city. Thus, risk assessment in the form of a survey would be one of the strategies to identify this syndrome early so as to encourage young women to seek timely treatment and prevent its long term complications. Methods: Non comparative cross sectional study for duration of 8 month. Results: The prevalence of PCOS in this study was 8.20%. Among all the risk factors, BMI ≥25 (P value < 0.0001) and waist hip ratio ≥0.85 (<0.0001) were strongly associated with the presence of PCOS and Lack of awareness, there were in girls (78.4%). Conclusions: Women who were having BMI ≥25 and waist hip ratio ≥0.85 should be educated about its complications and should be advised weight loss. Girls who had irregularity of menses and signs of hyperandrogenism should be investigated and must be managed accordingly. Early diagnosis of PCOS and its prompt treatment will help the girls to improve quality of life.

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Prenatal androgen exposure alters KNDy neurons and their afferent network in a model of polycystic ovarian syndrome

Endocrinology ◽

10.1210/endocr/bqab158 ◽

2021 ◽

Author(s):

Aleisha M Moore ◽

Dayanara B Lohr ◽

Lique M Coolen ◽

Michael N Lehman

Keyword(s):

Gene Expression ◽

Negative Feedback ◽

Polycystic Ovarian Syndrome ◽

Pulse Generator ◽

Steroid Hormone ◽

Receptor Gene ◽

Hypothalamic Area ◽

Kndy Neurons ◽

Prenatal Androgen ◽

Ovarian Syndrome

Abstract Polycystic ovarian syndrome (PCOS), the most common endocrinopathy affecting women worldwide, is characterized by elevated luteinizing hormone (LH) pulse frequency due to the impaired suppression of gonadotrophin-releasing hormone (GnRH) release by steroid hormone negative feedback. Although neurons that co-express kisspeptin, neurokinin B and dynorphin (KNDy cells) were recently defined as the GnRH/LH pulse generator, little is understood about their role in the pathogenesis of PCOS. We used a prenatal androgen-treated (PNA) mouse model of PCOS to determine whether changes in KNDy neurons or their afferent network underlie altered negative feedback. First, we identified elevated androgen receptor gene expression in KNDy cells of PNA mice, whereas progesterone receptor and dynorphin gene expression was significantly reduced, suggesting elevated androgens in PCOS disrupt progesterone negative feedback via direct actions upon KNDy cells. Second, we discovered GABAergic and glutamatergic synaptic input to KNDy neurons was reduced in PNA mice. Retrograde monosynaptic tract-tracing revealed a dramatic reduction in input originates from sexually dimorphic afferents in the preoptic area, anteroventral periventricular nucleus, anterior hypothalamic area and lateral hypothalamus. These results reveal two sites of neuronal alterations potentially responsible for defects in negative feedback in PCOS: changes in gene expression within KNDy neurons, and changes in synaptic inputs from steroid hormone-responsive hypothalamic regions. How each of these changes contribute to the neuroendocrine phenotype seen in in PCOS, and the role of specific sets of upstream KNDy afferents in the process, remains to be determined.

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Hochu-Ekki-to Treatment Improves Reproductive and Immune Modulation in the Stress-Induced Rat Model of Polycystic Ovarian Syndrome

10.20944/preprints201705.0073.v1 ◽

2017 ◽

Author(s):

Eunkuk Park ◽

Chun Whan Choi ◽

Soo Jeong Kim ◽

Yong-In Kim ◽

Samkee Sin ◽

...

Keyword(s):

Polycystic Ovarian Syndrome ◽

Hormone Receptors ◽

Steroid Hormone ◽

Reproductive Hormones ◽

Steroid Hormone Receptors ◽

Clinical Effects ◽

Immune Functions ◽

Cold Temperatures ◽

Hsp 90 ◽

Ovarian Syndrome

The traditional herbal medicine, Hochu-ekki-to, has been shown to have preventive effects on viral infection and stress. This study aimed to evaluate the clinical effects of Hochu-ekki-to on two stress-related rat models of polycystic ovarian syndrome. Female Sprague-Dawley rats were divided into control and treatment groups, the latter of which were subjected to stress induced by exposure to adrenocorticotropic hormone (ACTH) or cold temperatures. After these stress inductions, rats were orally treated with dissolved Hochu-ekki-to once per day for 7 days. Rats subjected to the two different stressors exhibited upregulation of steroid hormone receptors (in ovaries) and reproductive hormones (in blood), and consequent stimulation of abnormal follicle development accompanied by elevation of Hsp 90 expression (in ovaries). Treatment with Hochu-ekki-to for 7 days after stress induction increased immune functions, reduced the stress-induced activation of Hsp 90, and normalized the levels of the tested steroid hormone receptors and reproductive hormones. Our findings suggest that stress stimulations may promote the activation of Hsp 90 via the dysregulation of steroid hormone receptors and reproductive hormones, but that post-stress treatment with Hochu-ekki-to improves reproductive and immune functions in the ovaries of stressed rats.

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Polycystic Ovarian Syndrome management with Ayurvedic prospective

Ayurline: International Journal of Research in Indian Medicine ◽

10.52482/ayurline.v5i04.537 ◽

2021 ◽

Vol 5 (04) ◽

Author(s):

Monika Luharia

Keyword(s):

Body Mass Index ◽

Side Effects ◽

Young Women ◽

Polycystic Ovarian Syndrome ◽

Disease Incidence ◽

Modern Science ◽

Root Cause ◽

Day By Day ◽

Index Disease ◽

Ovarian Syndrome

Polycystic Ovarian Syndrome is one of the most serious medical conditions associated with pregnant women, particularly young women, and It is linked to miscarriage, erratic menstrual cycle, and a disturbed body mass index. Disease incidence increases mostly day by day because of undisciplined living style, diet, depression, etc. This leads to both physical and mental disorders of the patient and, if not cared for and treated, can also lead to miscarriage or frequent abortion. PCOD is one of that condition which typically affects second or third decade of life in females. It is important to know thoroughly about this disease as modern science has no root cause cure to treat it even the treatment of modern science implicated leads to severe side effects and dependence on the drugs. PCOD is diagnosed in Ayurveda according to its presentation in so many ways like hetu, lakshana, dosha- dushya, samprapti, associated features of PCOS are closely resembling with vandhya yonivyapada, artava-vahastrotas- viddha lakshana, nastartava and ksheena- artava described by acharya Sushruta and pushpaghni jatharini and vikruta jatharini mentioned by acharya Kashyap.

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