scholarly journals Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Erfan Dashtimoghadam ◽  
Farahnaz Fahimipour ◽  
Andrew N. Keith ◽  
Foad Vashahi ◽  
Pavel Popryadukhin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Reconstructive Surgery ◽  
Biomedical Applications ◽  
The Body ◽  
Surrounding Tissue ◽  
Curing Time ◽  
Materials Used ◽  
Significant Health

AbstractCurrent materials used in biomedical devices do not match tissue’s mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation.

scholarly journals Injectable Non-leaching Tissue-mimetic Bottlebrush Elastomers: A New Platform for Advancing Reconstructive Surgery

2020 ◽  
Author(s):  
Erfan Dashtimoghadam ◽  
Farahnaz Fahimipour ◽  
Andrew Keith ◽  
Foad Vashahi ◽  
Pavel Popryadukhin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Reconstructive Surgery ◽  
Biomedical Applications ◽  
The Body ◽  
Surrounding Tissue ◽  
Curing Time ◽  
Materials Used ◽  
Significant Health

Abstract Current materials used in biomedical devices do not match tissue’s mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation.

scholarly journals Carbon Nanotubes Reinforced Composites for Biomedical Applications

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Wei Wang ◽  
Yuhe Zhu ◽  
Susan Liao ◽  
Jiajia Li
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Biomedical Applications ◽  
Polymer Matrix Composites ◽  
Ceramic Matrix Composites ◽  
Matrix Composites ◽  
Reinforced Composites ◽  
Reinforced Polymer

This review paper reported carbon nanotubes reinforced composites for biomedical applications. Several studies have found enhancement in the mechanical properties of CNTs-based reinforced composites by the addition of CNTs. CNTs reinforced composites have been intensively investigated for many aspects of life, especially being made for biomedical applications. The review introduced fabrication of CNTs reinforced composites (CNTs reinforced metal matrix composites, CNTs reinforced polymer matrix composites, and CNTs reinforced ceramic matrix composites), their mechanical properties, cell experimentsin vitro, and biocompatibility testsin vivo.

Enhanced Cytocompatibility Properties of Hydroxyapatite Doped with Trivalent Ions

2001 ◽  
Vol 711 ◽  
Author(s):  
Elizabeth A. Massa ◽  
Elliott B. Slamovich ◽  
Thomas J. Webster
Keyword(s):  
Mechanical Properties ◽  
Ionic Radius ◽  
Orthopedic Implants ◽  
The Body ◽  
Surrounding Tissue ◽  
High Solubility ◽  
Ionic Radii ◽  
Osteoblast Adhesion

ABSTRACTHydroxyapatite (HA) is a bone-like ceramic used as a coating for dental and orthopedic implants. It is well known for its good cytocompatibility properties, but is limited in use due to its high solubility within the body and mechanical properties that differ from surrounding tissue and bone. The present in vitro study investigated a variety of dopants as a way to further enhance the good cytocompatibility properties of HA as well as address these problematic properties. The dopants investigated were divalent (magnesium and zinc) and trivalent (yttrium, lanthanum, indium, and bismuth) ions. Of the trivalent ions, yttrium and indium have smaller ionic radii than calcium. The present study showed osteoblast adhesion to be statistically greater (p < 0.1) on yttrium-doped HA and indium-doped HA than on undoped HA. Since yttrium and indium are both trivalent ions of a smaller ionic radius than calcium, and other ions of different size and charge did not show significant changes in osteoblast adhesion, these results suggest that substituting divalent calcium with a trivalent ion of smaller size encourages osteoblast adhesion.

scholarly journals Radiopaque Chitosan Ducts Fabricated by Extrusion-Based 3D Printing to Promote Healing After Pancreaticoenterostomy

2021 ◽  
Vol 9 ◽  
Author(s):  
Maoen Pan ◽  
Chaoqian Zhao ◽  
Zeya Xu ◽  
Yuanyuan Yang ◽  
Tianhong Teng ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Molecular Weight ◽  
Pancreatic Duct ◽  
Silicone Rubber ◽  
The Body ◽  
Molecular Weights ◽  
Pancreatic Duct Stent ◽  
3D Printed

Long-term placement of non-degradable silicone rubber pancreatic duct stents in the body is likely to cause inflammation and injury. Therefore, it is necessary to develop degradable and biocompatible stents to replace silicone rubber tubes as pancreatic duct stents. The purpose of our research was to verify the feasibility and biological safety of extrusion-based 3D printed radiopaque chitosan (CS) ducts for pancreaticojejunostomy. Chitosan-barium sulfate (CS-Ba) ducts with different molecular weights (low-, medium-, and high-molecular weight CS-Ba: LCS-Ba, MCS-Ba, and HCS-Ba, respectively) were soaked in vitro in simulated pancreatic juice (SPJ) (pH 8.0) with or without pancreatin for 16 weeks. Changes in their weight, water absorption rate and mechanical properties were tested regularly. The biocompatibility, degradation and radiopaque performance were verified by in vivo and in vitro experiments. The results showed that CS-Ba ducts prepared by this method had regular compact structures and good molding effects. In addition, the lower the molecular weight of the CS-Ba ducts was, the faster the degradation rate was. Extrusion-based 3D-printed CS-Ba ducts have mechanical properties that match those of soft tissue, good biocompatibility and radioopacity. In vitro studies have also shown that CS-Ba ducts can promote the growth of fibroblasts. These stents have great potential for use in pancreatic duct stent applications in the future.

scholarly journals Diamond thin films: giving biomedical applications a new shine

2017 ◽  
Vol 14 (134) ◽  
pp. 20170382 ◽  
Author(s):  
P. A. Nistor ◽  
P. W. May
Keyword(s):  
Thin Films ◽  
Biomedical Applications ◽  
Large Body ◽  
Chemical Vapour ◽  
The Body ◽  
First Century ◽  
Diamond Thin Films ◽  
Deposition Technology

Progress made in the last two decades in chemical vapour deposition technology has enabled the production of inexpensive, high-quality coatings made from diamond to become a scientific and commercial reality. Two properties of diamond make it a highly desirable candidate material for biomedical applications: first, it is bioinert, meaning that there is minimal immune response when diamond is implanted into the body, and second, its electrical conductivity can be altered in a controlled manner, from insulating to near-metallic. In vitro, diamond can be used as a substrate upon which a range of biological cells can be cultured. In vivo , diamond thin films have been proposed as coatings for implants and prostheses. Here, we review a large body of data regarding the use of diamond substrates for in vitro cell culture. We also detail more recent work exploring diamond-coated implants with the main targets being bone and neural tissue. We conclude that diamond emerges as one of the major new biomaterials of the twenty-first century that could shape the way medical treatment will be performed, especially when invasive procedures are required.

In vivo n.m.r. imaging in medicine: the Aberdeen approach, both physical and biological

1980 ◽  
Vol 289 (1037) ◽  
pp. 519-533 ◽  
Keyword(s):  
Pulse Sequence ◽  
The Body ◽  
Spin Lattice Relaxation ◽  
Surrounding Tissue ◽  
Whole Body ◽  
Spin Concentration ◽  
Stage Of Development ◽  
Wide Range

A novel magnetic field and radio frequency (1.7 MHz) pulse sequence is described for a whole body n.m.r. imaging machine under construction. Selective excitation is used to obtain signals from successive lines of proton spins (water) across the body to build up an image of a transverse section. The images display spin concentration and spin-lattice relaxation time, T 1 , separately. For a 50 % change in T 1 to be discerned in the human trunk, a spatial resolution of 2 cm 3 is expected for a 2 min scan and 0.5 cm 3 for a 30 min scan. Very preliminary images at the present incomplete stage of development show the geometrical accuracy and T 1 discrimination: an in vivo image demonstrates some of the difficulties to be overcome. In vitro measurements of normal rabbit tissue samples have been made at 24 MHz to map the T 1 distributions that can be expected from normal subjects. The transposition of this information from rabbit to man, and from 24 MHz to 2.5 MHz have been checked and the comparison shown to be meaningful. Of pathological samples, human breast tumour and human liver metastases offer a good contrast to their surrounding tissue, and an experimental investigation has shown that tissue immediately surrounding a tumour also has an elevated T 1 value. A wide range of abnormalities that are associated with abnormal fluid formation in the body may be amenable to imaging by the n.m.r. technique. Potential hazards are believed to be small in the present generation of equipment.

scholarly journals The Role of Probiotics in Chronic Rhinosinusitis Treatment: An Update of the Current Literature

Healthcare ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1715
Author(s):  
Maria Rita Bianco ◽  
Massimo Ralli ◽  
Domenico Michele Modica ◽  
Marta Amata ◽  
Salvatore Poma ◽  
...  
Keyword(s):  
General Population ◽  
Environmental Factors ◽  
Medical Treatment ◽  
Chronic Rhinosinusitis ◽  
General Condition ◽  
The Body ◽  
Significant Health

Chronic rhinosinusitis (CRS) is a significant health problem. It affects 5–12% of the general population. The causes that underlie the onset of CRS are not yet well known. However, many factors may contribute to its onset, such as environmental factors and the host’s general condition. Medical treatment mainly uses local corticosteroids, nasal irrigation, and antibiotics. In recent years, a new therapeutic approach that employs the use of probiotics emerged. Probiotics have been extensively studied as a therapy for dysbiosis and inflammatory pathologies of various parts of the body. We aimed to examine the studies in vivo and in vitro and clinicals reports in the existing literature to update probiotics’ role in rhinosinusitis chronic medical treatment.

scholarly journals Biomedical applications of copper-free click chemistry: in vitro, in vivo, and ex vivo

2019 ◽  
Vol 10 (34) ◽  
pp. 7835-7851 ◽  
Author(s):  
Eunha Kim ◽  
Heebeom Koo
Keyword(s):  
Click Chemistry ◽  
Chemical Reactions ◽  
Biomedical Applications ◽  
Ex Vivo ◽  
The Body ◽  
Cell Surfaces ◽  
Cell Cytosol ◽  
Biomedical Fields

Copper-free click chemistry has resulted in a change of paradigm, showing that artificial chemical reactions can occur on cell surfaces, in cell cytosol, or within the body. It has emerged as a valuable tool in biomedical fields.

Additively manufactured titanium alloys and effect of hydroxyapatite coating for biomedical applications: A review

2020 ◽  
Vol 234 (11) ◽  
pp. 1450-1460
Author(s):  
Franklin Anene ◽  
Jaafar Aiza ◽  
Ismail Zainol ◽  
Azmah Hanim ◽  
Mohd Tahir Suraya
Keyword(s):  
Mechanical Properties ◽  
Additive Manufacturing ◽  
Titanium Alloys ◽  
Biomedical Applications ◽  
Hydroxyapatite Coating ◽  
In Vivo Studies ◽  
Processing Technologies ◽  
Treatment Processes

Metallic implants are extensively used to treat a spectrum of orthopaedic related disorders. Among the metals, titanium and its alloys are considered most excellent and indispensable material for the production of orthopaedic implants regarding their sterling mechanical properties and exceptional biocompatibility. Recently, rapid progress in developing non-toxic titanium-based alloys with modulus similar to that of human bone has inspired researchers globally. Thus, many studies have focused on titanium alloys, their heat treatment processes and several processing technologies. Additive manufacturing has been designed to enhance their mechanical properties tailored towards biomedical applications. Inarguably, the need to further improve on the implant’s biocompatibility with bodily environment for optimum service life is of great importance. Hence, hydroxyapatite coating provides an improvement as demonstrated by in vitro as well as in vivo studies. The present article critically reviews, based on recent scientific literatures, the progress made thus far in the development of titanium-based alloys, additive manufacturing processes and their heat and surface treatments tailored towards biomedical applications.

In Vivo Mechanical Characterization of Micro-Specimens Using a Novel Micro-Electro-Mechanical System

2011 ◽  
Author(s):  
Leila Ladani ◽  
Daniel Preston
Keyword(s):  
Mechanical Properties ◽  
Biological Tissues ◽  
Micro Electro Mechanical System ◽  
The Body ◽  
Mechanical Degradation ◽  
Element Analysis ◽  
Rigid Frame

Mechanical probing, stimulation and characterization of tissues are of the most challenging areas of engineering due to limitations of working with bio specimens. Understanding the bio-mechanics of tissues could potentially help to understand mechanical degradation of biological tissues due to disease or change in physiological condition of the body. Biomechanical processes at the microscopic level have become increasingly recognized as an important factor in different biological conditions. In many of these conditions analyzing biomechanics of tissues at microscale in vivo or in vitro will provide invaluable information on microenvironment and physiological parameters that affect the microenvironment and mechanical properties. To address the issue of measuring mechanical properties at microscale, an electroactive-based micro-electromechanical machine is designed. The device is comprised of two electroactive (piezoelectric) micro-elements mounted on a rigid frame. Electrical activation of one of the elements causes it to expand and induce a stress in the intervening micro-specimen. The response of the microspecimen to the stress is measured by the deformation and thereby voltage/resistance induced in the second electro-active element. Figure 1 shows the device design and architecture. Analytical analysis and multiphysics finite element analysis (FEA) are used to prove the concept. A summary of the results are shown in the next sections.

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