scholarly journals Cognitive insights from tertiary sulci in prefrontal cortex

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Willa I. Voorhies ◽  
Jacob A. Miller ◽  
Jewelia K. Yao ◽  
Silvia A. Bunge ◽  
Kevin S. Weiner

AbstractThe lateral prefrontal cortex (LPFC) is disproportionately expanded in humans compared to non-human primates, although the relationship between LPFC brain structures and uniquely human cognitive skills is largely unknown. Here, we test the relationship between variability in LPFC tertiary sulcal morphology and reasoning scores in a cohort of children and adolescents. Using a data-driven approach in independent discovery and replication samples, we show that the depth of specific LPFC tertiary sulci is associated with individual differences in reasoning scores beyond age. To expedite discoveries in future neuroanatomical-behavioral studies, we share tertiary sulcal definitions with the field. These findings support a classic but largely untested theory linking the protracted development of tertiary sulci to late-developing cognitive processes.

2020 ◽  
Author(s):  
Willa I. Voorhies ◽  
Jacob A. Miller ◽  
Jewelia K. Yao ◽  
Silvia A. Bunge ◽  
Kevin S. Weiner

ABSTRACTWhile the disproportionate expansion of lateral prefrontal cortex (LPFC) throughout evolution is commonly accepted, the relationship between evolutionarily new LPFC brain structures and uniquely human cognitive skills is largely unknown. Here, we tested the relationship between variability in evolutionarily new LPFC tertiary sulci and reasoning skills in a pediatric cohort. A novel data-driven approach in independent discovery and replication samples revealed that the depth of specific LPFC tertiary sulci predicts individual differences in reasoning skills beyond age. These findings support a classic, yet untested, theory linking the protracted development of tertiary sulci to late-developing cognitive processes. We conclude by proposing a mechanistic hypothesis relating the depth of LPFC tertiary sulci to anatomical connections. We suggest that deeper LPFC tertiary sulci reflect reduced short-range connections in white matter, which in turn, improve the efficiency of local neural signals underlying cognitive skills such as reasoning that are central to human cognitive development.


2021 ◽  
Vol 11 (1) ◽  
pp. 81
Author(s):  
Kristina C. Backer ◽  
Heather Bortfeld

A debate over the past decade has focused on the so-called bilingual advantage—the idea that bilingual and multilingual individuals have enhanced domain-general executive functions, relative to monolinguals, due to competition-induced monitoring of both processing and representation from the task-irrelevant language(s). In this commentary, we consider a recent study by Pot, Keijzer, and de Bot (2018), which focused on the relationship between individual differences in language usage and performance on an executive function task among multilingual older adults. We discuss their approach and findings in light of a more general movement towards embracing complexity in this domain of research, including individuals’ sociocultural context and position in the lifespan. The field increasingly considers interactions between bilingualism/multilingualism and cognition, employing measures of language use well beyond the early dichotomous perspectives on language background. Moreover, new measures of bilingualism and analytical approaches are helping researchers interrogate the complexities of specific processing issues. Indeed, our review of the bilingualism/multilingualism literature confirms the increased appreciation researchers have for the range of factors—beyond whether someone speaks one, two, or more languages—that impact specific cognitive processes. Here, we highlight some of the most salient of these, and incorporate suggestions for a way forward that likewise encompasses neural perspectives on the topic.


2020 ◽  
Vol 22 (5) ◽  
pp. 942-957
Author(s):  
Lilun Du ◽  
Qing Li

Problem definition: Service providers often recruit a large number people over a short period of time, a practice known as high-volume recruitment. In this study, we describe a data-driven approach that can be used to streamline the recruitment process and aid decision making. The recruitment process consists of two stages: screening and interview. All candidates are evaluated in the screening stage, but only those with sufficiently high screening scores are short-listed for an interview. After the interview stage, offers are made based on the screening and interview scores. We define the error rate as the probability that a candidate who is rejected during either stage might have had a higher job performance than the median job performance of the candidates recruited had he or she been accepted. To ensure the error rate is no higher than a certain level, how many candidates should be short-listed, and, after the interview, how should candidates be ranked based on the two scores? Academic/practical relevance: High-volume recruitment is challenging because decisions have to be made for many people, under tight time constraints, and under uncertainty. Our approach does not require knowledge about the cost of evaluating candidates and the utility of selecting candidates; hence, it is easier to implement in practice. We apply the approach to the process of recruiting students for a postgraduate business program. Methodology: We use stochastic modeling and regression. Results: We provide a procedure for estimating the error rate as a function of the percentage of candidates short-listed for interviews. We show that the estimated error rate is asymptotically unbiased and converges to the true error rate in probability. We then run a linear regression analysis to estimate the relationship between job performance and the screening and interview scores. In a case study involving a postgraduate business program, the job performance measure we adopt is the grade point average in the program, observable only for the students enrolled in the program. We find that the interview score is statistically significant, but the screening score is not. Managerial implications: For the postgraduate program, our study demonstrates that the time-intensive interview process has substantial value. We should increase, rather than reduce, as suggested by the program administrators before our study, the weight assigned to the interview score and the time spent on the interview process. Knowing the relationship between the error rate and the percentage of candidates short-listed for interviews, the program administrators can determine the appropriate percentage for any given error rate deemed acceptable and improve the ranking of candidates. Our approach is general and can be applied to other high-volume recruiters.


2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1 ◽  
Author(s):  
Willa I. Voorhies ◽  
Jacob A. Miller ◽  
Jewelia Yao ◽  
Ishana Raghuram ◽  
Silvia A. Bunge ◽  
...  

2020 ◽  
Vol 29 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Anna-Lena Schubert ◽  
Gidon T. Frischkorn

More intelligent individuals typically show faster reaction times. However, individual differences in reaction times do not represent individual differences in a single cognitive process but in multiple cognitive processes. Thus, it is unclear whether the association between mental speed and intelligence reflects advantages in a specific cognitive process or in general processing speed. In this article, we present a neurocognitive-psychometrics account of mental speed that decomposes the relationship between mental speed and intelligence. We summarize research employing mathematical models of cognition and chronometric analyses of neural processing to identify distinct stages of information processing strongly related to intelligence differences. Evidence from both approaches suggests that the speed of higher-order processing is greater in smarter individuals, which may reflect advantages in the structural and functional organization of brain networks. Adopting a similar neurocognitive-psychometrics approach for other cognitive processes associated with intelligence (e.g., working memory or executive control) may refine our understanding of the basic cognitive processes of intelligence.


2016 ◽  
Vol 23 (3) ◽  
pp. 275-286 ◽  
Author(s):  
Ifat Levy

Individuals vary substantially in their tendency to take risks. In the past two decades, a large number of neuroimaging studies in humans have explored the neural mechanisms of several cognitive processes that contribute to risk taking. In this article, I focus on functional and structural MRI studies that investigated uncertainty processing, one of the main features of risk behavior. Using decision-making and learning paradigms, these studies implicated a network of brain areas, including posterior parietal cortex, anterior insula, anterior cingulate cortex, and ventrolateral prefrontal cortex, in various aspects of uncertainty processing. Individual differences in behavior under uncertainty are reflected in the function and structure of some of these areas and are integrated into value representations in ventromedial prefrontal cortex and ventral striatum, reinforcing the potential contribution of all of these brain structures to individual tendencies to take risks.


Aries ◽  
2021 ◽  
pp. 1-37
Author(s):  
Gwen Grant

Abstract This study uncovers a link between sound patterns and ritualistic language in Charles Williams’ novels through an analysis of the relationship between type of sound and content. The study focuses on War in Heaven with a view to conducting a preliminary exploration into this link, and establishing possibilities for future research. Like Williams’ other novels, War in Heaven is saturated with the symbolism and ritual practices he learned in The Fellowship of the Rosy Cross and, potentially, the Hermetic Order of the Golden Dawn. Williams’ experimentation with sound to convey his experience of ritual is explored through the framework of Roman Jakobson’s “Poetic Function”, to establish how Williams may have intended sound to contribute to the experience of the reader. Using a data driven approach, the study explores how sound patterns work with ritualistic content across War in Heaven, discovering a link between fricative sounds and ritualistic events.


2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Michael L. Mack ◽  
Alison R. Preston ◽  
Bradley C. Love

AbstractPrefrontal cortex (PFC) is thought to support the ability to focus on goal-relevant information by filtering out irrelevant information, a process akin to dimensionality reduction. Here, we test this dimensionality reduction hypothesis by relating a data-driven approach to characterizing the complexity of neural representation with a theoretically-supported computational model of learning. We find evidence of goal-directed dimensionality reduction within human ventromedial PFC during learning. Importantly, by using computational predictions of each participant’s attentional strategies during learning, we find that that the degree of neural compression predicts an individual’s ability to selectively attend to concept-specific information. These findings suggest a domain-general mechanism of learning through compression in ventromedial PFC.


Author(s):  
Senxu Lu ◽  
Xiangyu Ding ◽  
Yuanhe Wang ◽  
Xiaoyun Hu ◽  
Tong Sun ◽  
...  

Recent accumulating researches implicate that non-coding RNAs (ncRNAs) including microRNA (miRNA), circular RNA (circRNA), and long non-coding RNA (lncRNAs) play crucial roles in colorectal cancer (CRC) initiation and development. Notably, N6-methyladenosine (m6A) methylation, the critical posttranscriptional modulators, exerts various functions in ncRNA metabolism such as stability and degradation. However, the interaction regulation network among ncRNAs and the interplay with m6A-related regulators has not been well documented, particularly in CRC. Here, we summarize the interaction networks and sub-networks of ncRNAs in CRC based on a data-driven approach from the publications (IF > 6) in the last quinquennium (2016–2021). Further, we extend the regulatory pattern between the core m6A regulators and m6A-related ncRNAs in the context of CRC metastasis and progression. Thus, our review will highlight the clinical potential of ncRNAs and m6A modifiers as promising biomarkers and therapeutic targets for improving the diagnostic precision and treatment of CRC.


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