scholarly journals Male mice, caged in the International Space Station for 35 days, sire healthy offspring

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Takafumi Matsumura ◽  
Taichi Noda ◽  
Masafumi Muratani ◽  
Risa Okada ◽  
Mutsumi Yamane ◽  
...  
Keyword(s):  
International Space Station ◽  
Outer Space ◽  
Space Station ◽  
Reproductive Organs ◽  
Space Environment ◽  
Male Mice ◽  
International Space ◽  
Significant Difference ◽  
Male Reproductive Organs

Abstract The effect on the reproductive system and fertility of living in a space environment remains unclear. Here, we caged 12 male mice under artificial gravity (≈1 gravity) (AG) or microgravity (MG) in the International Space Station (ISS) for 35 days, and characterized the male reproductive organs (testes, epididymides, and accessory glands) after their return to earth. Mice caged on earth during the 35 days served as a “ground” control (GC). Only a decrease in accessory gland weight was detected in AG and MG males; however, none of the reproductive organs showed any overt microscopic defects or changes in gene expression as determined by RNA-seq. The cauda epididymal spermatozoa from AG and MG mice could fertilize oocytes in vitro at comparable levels as GC males. When the fertilized eggs were transferred into pseudo-pregnant females, there was no significant difference in pups delivered (pups/transferred eggs) among GC, AG, and MG spermatozoa. In addition, the growth rates and fecundity of the obtained pups were comparable among all groups. We conclude that short-term stays in outer space do not cause overt defects in the physiological function of male reproductive organs, sperm function, and offspring viability.

scholarly journals Predicting chromosome damage in astronauts participating in international space station missions

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alan Feiveson ◽  
Kerry George ◽  
Mark Shavers ◽  
Maria Moreno-Villanueva ◽  
Ye Zhang ◽  
...  
Keyword(s):  
International Space Station ◽  
Dose Response ◽  
Ex Vivo ◽  
Space Station ◽  
Space Radiation ◽  
Blood Samples ◽  
International Space ◽  
Significant Difference ◽  
Subject Specific

AbstractSpace radiation consists of energetic protons and other heavier ions. During the International Space Station program, chromosome aberrations in lymphocytes of astronauts have been analyzed to estimate received biological doses of space radiation. More specifically, pre-flight blood samples were exposed ex vivo to varying doses of gamma rays, while post-flight blood samples were collected shortly and several months after landing. Here, in a study of 43 crew-missions, we investigated whether individual radiosensitivity, as determined by the ex vivo dose–response of the pre-flight chromosome aberration rate (CAR), contributes to the prediction of the post-flight CAR incurred from the radiation exposure during missions. Random-effects Poisson regression was used to estimate subject-specific radiosensitivities from the preflight dose–response data, which were in turn used to predict post-flight CAR and subject-specific relative biological effectiveness (RBEs) between space radiation and gamma radiation. Covariates age, gender were also considered. Results indicate that there is predictive value in background CAR as well as radiosensitivity determined preflight for explaining individual differences in post-flight CAR over and above that which could be explained by BFO dose alone. The in vivo RBE for space radiation was estimated to be approximately 3 relative to the ex vivo dose response to gamma irradiation. In addition, pre-flight radiosensitivity tended to be higher for individuals having a higher background CAR, suggesting that individuals with greater radiosensitivity can be more sensitive to other environmental stressors encountered in daily life. We also noted that both background CAR and radiosensitivity tend to increase with age, although both are highly variable. Finally, we observed no significant difference between the observed CAR shortly after mission and at > 6 months post-mission.

Conceptual Design of an Experiment for the International Space Station About Shape Memory Composite in Space Environment

2017 ◽  
Author(s):  
Loredana Santo ◽  
Denise Bellisario ◽  
Giovanni Matteo Tedde ◽  
Fabrizio Quadrini
Keyword(s):  
Shape Memory ◽  
International Space Station ◽  
Space Station ◽  
Sun Exposure ◽  
Aging Effect ◽  
Space Environment ◽  
Aging Effects ◽  
Solar Sails ◽  
International Space ◽  
Shape Memory Composite

Shape memory polymers (SMP) and composites (SMPC) may be used for many applications in Space, from self-deployable structures (such as solar sails, panels, shields, booms and antennas), to grabbing systems for Space debris removal, up to new-concept actuators for telescope mirror tuning. Experiments on the International Space Station are necessary for testing prototypes in relevant environment, above all for the absence of gravity which affects deployment of slender structures but also to evaluate the aging effects of the Space environment. In fact, several aging mechanisms are possible, from polymer cracking to cross-linking and erosion, and different behaviors are expected as well, from consolidating the temporary shape to composite degradation. Evaluating the possibility of shape recovery because of sun exposure is another interesting point. In this study, a possible experiment on the ISS is shown with the aim of evaluating the aging effect of Space on material performances. The sample structure is described as well as the testing strategy.

Thermoelectric Applications as Related to Biomedical Engineering for Nasa Johnson Space Center

1997 ◽  
Vol 478 ◽  
Author(s):  
C. D. Kramer ◽  
P.E.
Keyword(s):  
International Space Station ◽  
Space Station ◽  
Space Environment ◽  
Space Applications ◽  
International Space ◽  
Future Technology ◽  
Technological Developments ◽  
Environment Noise ◽  
Scientific Value

AbstractThis paper presents current NASA biomedical developments and applications using thermoelectrics. Discussion will include future technology enhancements that would be most beneficial to the application of thermoelectric technology.A great deal of thermoelectric applications have focused on electronic cooling. As with all technological developments within NASA, if the application cannot be related to the average consumer, the technology will not be mass-produced and widely available to the public (a key to research and development expenditures and thermoelectric companies). Included are discussions of thermoelectric applications to cool astronauts during launch and reentry. The earth-based applications, or spin-offs, include such innovations as tank and race car driver cooling, to cooling infants with high temperatures, as well as, the prevention of hair loss during chemotherapy. In order to preserve the scientific value of metabolic samples during long-term space missions, cooling is required to enable scientific studies. Results of one such study should provide a better understanding of osteoporosis and may lead to a possible cure for the disease.In the space environment, noise has to be kept to a minimum. In long-term space applications such as the International Space Station, thermoelectric technology provides the acoustic relief and the reliability for food, as well as, scientific refrigeration/freezers. Applications and future needs are discussed as NASA moves closer to a continued space presence in Mir, International Space Station, and Lunar-Mars Exploration.

The International Space Station

2019 ◽  
pp. 79-95
Author(s):  
Chris Nie
Keyword(s):  
International Space Station ◽  
Outer Space ◽  
Space Station ◽  
The United States ◽  
The Moon ◽  
New Era ◽  
International Space ◽  
Space Race ◽  
Future Space ◽  
Technical Details

A new era of spaceflight dawned following the conclusion of the United States and Russian space race. This new era has been marked by the design, assembly, and operation of one of the greatest engineering feats mankind has accomplished, the International Space Station (ISS). The ISS is comprised of hundreds of thousands of kilograms of material built on the ground and transported to space for assembly. It houses an artificial atmosphere to sustain life in outer space and has been continually inhabited for over 15 years. This chapter describes the technical complexity of the ISS, the background of how it was assembled, its major systems, details of crew life onboard, commercial usage of the resource, and examples of mishaps that have occurred during the ISS's operation. The technical details of the ISS provide a glimpse into what future space stations that might orbit the Moon and Mars will resemble.

Making Space for Islam: Religion, Science, and Politics in Contemporary Malaysia

2010 ◽  
Vol 69 (4) ◽  
pp. 1143-1166 ◽  
Author(s):  
Darren C. Zook
Keyword(s):  
International Space Station ◽  
International Politics ◽  
Outer Space ◽  
Space Station ◽  
Religious Practice ◽  
Space Mission ◽  
International Space ◽  
Science And Politics ◽  
Cooperative Venture

In October 2007, Malaysia celebrated sending its first astronaut into space, as part of a cooperative venture on board a Russian space mission. As Malaysia's first astronaut was a Muslim, the Malaysian government commissioned, through its Department of Islamic Development, a project to create a definitive set of guidelines for the practice of Islam in outer space, specifically on board the International Space Station. What may on the surface appear to be a practical exercise in clarifying religious practice reveals upon closer examination to be a complex restructuring of Malaysia's domestic and international politics, with the role of Islam as the catalytic and somewhat controversial centerpiece.

The Constrained Vapor Bubble Experiment: Results From the International Space Station

2011 ◽  
Author(s):  
Arya Chatterjee ◽  
Joel L. Plawsky ◽  
Peter C. Wayner ◽  
David F. Chao ◽  
Ronald J. Sicker ◽  
...  
Keyword(s):  
Heat Pipe ◽  
International Space Station ◽  
Vapor Bubble ◽  
Space Station ◽  
Optical Measurements ◽  
Space Environment ◽  
Working Fluid ◽  
Operating Characteristics ◽  
International Space ◽  
Constrained Vapor Bubble

The constrained vapor bubble (CVB) experiment is an experiment in thermal fluid science currently operating on the International Space Station. Flown as the first experiment on the Fluids Integrated Rack on the Destiny module of the US part of the space station, the experiment promises to provide new and exciting insights into the working of a wickless micro heat pipe in the micro-gravity environment. The CVB consists of a relatively simple setup — a quartz cuvette with sharp corners partially filled with pentane as the working fluid. Along with temperature and pressure measurements, the curvature of the pentane menisci formed at the corners of the cuvette can be determined using optical measurements. This is the first time the data collected in space environment is being presented to the public. The data shows that, while the performance of the CVB heat pipe is enhanced due to increased fluid flow, the loss of convection as a heat loss mechanism in the space environment, leads to some interesting consequences. We present some significant differences in the operating characteristics of the heat pipe between the space and Earth’s gravity environments and show that this has important ramifications in designing effective radiators for the space environment.

Passive Space-Environment-Effect Measurement on the International Space Station

2009 ◽  
Vol 46 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Yugo Kimoto ◽  
Keiichi Yano ◽  
Junichiro Ishizawa ◽  
Eiji Miyazaki ◽  
Ichiro Yamagata
Keyword(s):  
International Space Station ◽  
Space Station ◽  
Space Environment ◽  
Effect Measurement ◽  
Environment Effect ◽  
International Space

Art in the Space Age: Exploring the Relationship between Outer Space and Earth Space

Leonardo ◽  
2004 ◽  
Vol 37 (4) ◽  
pp. 273-276
Author(s):  
Takuro Osaka
Keyword(s):  
International Space Station ◽  
Outer Space ◽  
Parabolic Flight ◽  
Space Station ◽  
International Space ◽  
Earth Space ◽  
Space Art ◽  
Effective Use ◽  
The Relationship ◽  
Micro Gravity

The author's interest in Space Art has taken several forms, including project proposals for the effective use of the International Space Station, research on the theme of the possibility of art in outer space, and conducting interviews with astronauts. He has also performed experiments in a micro-gravity environment generated by parabolic flight. This article provides an account of his plans and the results of these experiments.

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