scholarly journals The impact of exposure to cafeteria diet during pregnancy or lactation on offspring growth and adiposity before weaning

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Grace George ◽  
Sally A. V. Draycott ◽  
Ronan Muir ◽  
Bethan Clifford ◽  
Matthew J. Elmes ◽  
...  
Keyword(s):  
Maternal Obesity ◽  
Saturated Fat ◽  
Cafeteria Diet ◽  
Postnatal Life ◽  
Chow Diet ◽  
Offspring Growth ◽  
Lower Protein ◽  
Pregnancy And Lactation ◽  
Total Fat ◽  
The Impact

Abstract Exposure to maternal obesity during early-life can have adverse consequences for offspring growth and adiposity. We aimed to assess the relative contributions of exposure to maternal obesity, induced by a highly varied cafeteria diet, during pregnancy and lactation on these measures in rat offspring prior to weaning. Female Wistar rats were fed either a control (C) or cafeteria diet (O) for 8 weeks before mating, throughout pregnancy and lactation. Offspring were cross-fostered at birth to a dam on the same (CC,OO) or alternate diet prior to birth (CO,OC). Feeding a cafeteria diet based on 40 different foods, was associated with a sustained period of elevated energy intake before birth and during lactation (up to 1.7-fold), through increased sugar, total fat and saturated fat intake, and lower protein consumption. Cafeteria fed dams sustained greater weight than animals fed a control chow diet and greater perirenal adiposity by the end of lactation. Exposure to obesity during pregnancy was associated with lower offspring birth weight and body weight in early-postnatal life. In contrast, exposure during lactation alone reduced offspring weight but increased adiposity in male CO offspring before weaning. This research highlights that exposure to maternal obesity during lactation alone can programme adiposity in a sex specific manner.

scholarly journals Impact assessment of the TFA regulation on fatty acid composition of foods in Hungary

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Varga ◽  
E Sarkadi Nagy ◽  
L Zámbó ◽  
É Illés ◽  
M Bakacs ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Trans Fatty Acids ◽  
Saturated Fat ◽  
Portion Size ◽  
World Health ◽  
Food Sources ◽  
Increased Risk ◽  
Total Fat ◽  
The Impact

Abstract Trans fatty acids are formed during the industrial processing of food, and are proven to be harmful for the human body. They have been associated with increased risk of cardiovascular disease, abdominal obesity, diabetes, and certain types of cancer. Decree 71/2013. (XI. 20.) of the Ministry of Human Capacities, which has been in force since 2014, defines the highest permitted amount of trans fats in food products placed on the market in Hungary. The impact of the decree on the industrially produced trans fatty acids (iTFA) availability and population intake was assessed in 2017. Results demonstrated that iTFA were replaced by other fatty acids due to the legislation. In 2019, we investigated food groups which had high measured TFA content before the regulation entered into force and compared the total fat and fatty acid profiles to the same brand or similar products being on the market afterwards. In collaboration with the World Health Organization, this was the first assessment to determine to which extent manufacturers increased saturated fat (SFA) content of foodstuffs to reduce iTFA content. In those product groups, which were identified as significant food sources of iTFA before introducing the regulation (biscuits, coffee creamers and flavorings, sweets, bakery products, confectionary, wafers, margarines) we found no significant changes in the total fat content, while in most foodstuffs the average proportion of SFA was higher after reformulation, as iTFA were mainly substituted with SFA in 61% of the products, with cis-MUFA in 25% and cis-PUFA in 14% of the products, respectively. Evidence from this analysis supports concerns that eliminating iTFA in certain foodstuffs leads to unwanted substitution with saturated fat, hence reducing the possible health benefits. Given the high SFA intake and the unfavourable cardiovascular statistics in Hungary, the consumption frequency and portion size control of these products are advised. Key messages Monitoring the changes of food composition is important in order to evaluate the effect of the regulation. Manufacturers should be encouraged to reduce the SFA content to a technologically feasible level.

scholarly journals Maternal Diet-induced Obesity Programs Cardiovascular Dysfunction in Adult Male Mouse Offspring Independent of Current Body Weight

Endocrinology ◽  
2014 ◽  
Vol 155 (10) ◽  
pp. 3970-3980 ◽  
Author(s):  
Heather L. Blackmore ◽  
Youguo Niu ◽  
Denise S. Fernandez-Twinn ◽  
Jane L. Tarry-Adkins ◽  
Dino A. Giussani ◽  
...  
Keyword(s):  
Body Weight ◽  
Maternal Obesity ◽  
Maternal Diet ◽  
Saturated Fat ◽  
Premature Death ◽  
Causal Link ◽  
Cardiac Contraction ◽  
Diet Induced Obesity ◽  
Increased Risk ◽  
Pregnancy And Lactation

Abstract Obese pregnancies are not only associated with adverse consequences for the mother but also the long-term health of her child. Human studies have shown that individuals from obese mothers are at increased risk of premature death from cardiovascular disease (CVD), but are unable to define causality. This study aimed to determine causality using a mouse model of maternal diet–induced obesity. Obesity was induced in female C57BL/6 mice by feeding a diet rich in simple sugars and saturated fat 6 weeks prior to pregnancy and throughout pregnancy and lactation. Control females were fed laboratory chow. Male offspring from both groups were weaned onto chow and studied at 3, 5, 8, and 12 weeks of age for gross cardiac morphometry using stereology, cardiomyocyte cell area by histology, and cardiac fetal gene expression using qRT-PCR. Cardiac function was assessed by isolated Langendorff technology at 12 weeks of age and hearts were analyzed at the protein level for the expression of the β1 adrenergic receptor, muscarinic type-2 acetylcholine receptor, and proteins involved in cardiac contraction. Offspring from obese mothers develop pathologic cardiac hypertrophy associated with re-expression of cardiac fetal genes. By young adulthood these offspring developed severe systolic and diastolic dysfunction and cardiac sympathetic dominance. Importantly, cardiac dysfunction occurred in the absence of any change in corresponding body weight and despite the offspring eating a healthy low-fat diet. These findings provide a causal link to explain human observations relating maternal obesity with premature death from CVD in her offspring.

The impact of a complex workplace dietary intervention on Irish employees’ off-duty dietary intakes

2019 ◽  
Vol 35 (3) ◽  
pp. 544-554 ◽  
Author(s):  
Sarah Fitzgerald ◽  
Lynn Buckley ◽  
Ivan J Perry ◽  
Fiona Geaney
Keyword(s):  
Nutrition Education ◽  
Dietary Intervention ◽  
Positive Impact ◽  
Saturated Fat ◽  
Dietary Modification ◽  
Dietary Intakes ◽  
Dietary Interventions ◽  
Total Sugars ◽  
Total Fat ◽  
The Impact

Abstract A paucity of evidence exists regarding the impact of workplace dietary interventions on employees’ off-duty dietary intakes. This study assessed the impact of workplace dietary interventions that included nutrition education and environmental dietary modification both alone and in combination on employees’ dietary intakes inside (on-duty) and outside (off-duty) of work. A pre–post study on employees’ on and off-duty dietary intakes was undertaken. Data were obtained from a complex workplace dietary intervention study (Food Choice at Work Trial). Four manufacturing workplaces were allocated to: Control (n = 111), nutrition education (n = 226), environmental dietary modification (n = 113) and nutrition education and environmental dietary modification combined (n = 400) (2013–14). Seven- to nine-month follow-up data were obtained for 517 employees (61% response) [Control (n = 67), Education (n = 107), Environment (n = 71) and Combined (n = 272)]. Dietary intakes were measured using 24-h dietary recalls. Differences between on and off-duty mean dietary intakes were compared and regression analyses adjusted for potential confounders. Significant reductions in on-duty intakes of total fat (−14.2 g/day, p = 0.000), saturated fat (−7 g/day, p = 0.000), salt (−1.4 g/day, p = 0.000) and total sugars (−8.9 g/day, p = 0.003) were observed in the Combined and in the Environment [total fat (−11.4 g/d, p = 0.017) and saturated fat (−8.8 g/day, p = 0.000)]. In the Combined, significant changes were also observed in off-duty intakes of total fat (−10.0 g/day, p = 0.001), saturated fat (−4.2 g/day, p = 0.001), salt (−0.7 g/day, p = 0.020) and total sugars (−8.1 g/day, p = 0.020). Food service can have a positive impact in our everyday environments, including inside and outside of work. Dietary interventions combining nutrition education and environmental dietary modification can improve employees’ on and off-duty dietary intakes.

scholarly journals The impact of food industry reformulation, innovation and consumer preference on dietary intakes in Ireland: a probabilistic intake model

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Maeve Cushen ◽  
Noel Rogers ◽  
Rebecca Barron ◽  
Jasmin Wonik ◽  
Beata Stanek ◽  
...  
Keyword(s):  
Food Industry ◽  
Consumer Preferences ◽  
Saturated Fat ◽  
Consumer Preference ◽  
Rank Test ◽  
Dietary Intakes ◽  
Nutrient Intakes ◽  
Increased Risk ◽  
Total Fat ◽  
The Impact

AbstractStrong evidence exists linking poor diet to increased risk of overweight, obesity and non-communicable diseases. Reformulation initiatives, whereby the food industry gradually reduces energy, sodium, sugar, fat and saturated fat content of their products, are identified as important strategies to improve dietary intakes. The analysis aimed to examine the impact of voluntary reformulation, changes to products on the market and changes in consumer preferences on dietary intakes in Ireland from 2005 to 2017. Data on composition and volume sales (kg/ year) of products available on the market in 2005 and 2017 were collected from 15 Food Drink Ireland (FDI) member companies via online templates. These products were assigned to appropriate food and beverage groups identified in four Irish University Nutrition Alliance (IUNA) surveys of preschool children (1–4 years), children (5–12 years), teenagers (13–17 years) and adults (18–90 years). Assignment of FDI products to IUNA foods and beverages was carried out using weighted distributions for a given group of foods. The weightings were taken from the sales volumes of similar products relative to one another in a given category in a given year. Monte Carlo simulations were used to run the IUNA survey consumption data with both sets of weighted composition data from 2005 and 2017. The Creme Global intake model was used to estimate daily energy and nutrient intakes for all four populations during 2005 and 2017. The Wilcoxon-signed rank test was used to test for differences between the two years. Changes in both the products available on the market and market share of these products were observed from 2005 to 2017. The nutrient with the greatest intake reduction between the two years for all ages was sugar. Children and teens were the most affected, where total sugar intakes reduced by 3.2g/d and 2.7g/d, respectively. This reduction was primarily driven by the beverage category. There were modest saturated fat intake reductions observed for teens and adults (0.2g/d and 0.5g/d, respectively). Energy, total fat and sodium intakes for all ages remained relatively stable between the two years. This analysis highlights the impact of not only food industry efforts but also consumer choices on nutrient intakes in Ireland. It is worth noting that the data collected predates the sugar tax on sugar-sweetened beverages in Ireland. Reductions in sugar intakes were not compensated by total fat or energy increases.

scholarly journals Investigating the impact of the HSE Healthier Vending Policy on unit sales of snack items

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Marco McVey ◽  
Isobel Stanley ◽  
Agatha Lawless ◽  
Sarah O'Brien ◽  
Celine Murrin
Keyword(s):  
Saturated Fat ◽  
Easy Access ◽  
Post Intervention ◽  
Nutrition Environment ◽  
Vending Machines ◽  
Total Unit ◽  
Dried Fruit ◽  
Total Fat ◽  
The Republic ◽  
The Impact

AbstractVending machines provide quick and easy access to snacks and, in general, provide few healthy options to consumers. Given this high availability of unhealthy foods in vending machines, consumers are likely to purchase and consume a less healthy option. The aim of this study was to investigate the impact of a Healthier Vending policy in all Health Service Executive (HSE) premises across the Republic of Ireland on unit sales of vending machine snacks. Under the policy, the contents of vending machines were altered so that healthier, Better Choice (BC), snacks would constitute a majority of the vending machine stock (minimum 60%) in comparison to the less healthy, Other Choice (OC), snacks. Snacks were defined as BC if they contained: ≤ 150kcals/packet, ≤ 20g/100 g total fat, ≤ 5g/100 g saturated fat, ≤ 15g/100 g sugar, and ≤ 1.5g/100 g salt/sodium. Products stocked as OC should be ≤ 250kcals/packet. BC snacks were placed in prime slots and at eye-level in order to prompt the consumer towards buying a BC snack, with OC snacks being placed to incentivise the choice of BC snacks. Consumers were also incentivised to purchase BC snacks through written cues that appear on the vending machines. Sales data was provided by vending companies for 2015 (baseline) and 2016 (year 1). Unit sales of all snack types increased between the two time points, with the exception of dried fruit and nuts. The proportion of OC products purchased relative to total unit sales decreased following the intervention, as did the proportion of gum and mints and dried fruit and nuts sales. While the proportion of BC crisps purchased relative to total unit sales increased post-intervention, an increase in the proportion of OC bars purchased relative to total unit sales was also seen. Sales of both BC and OC dried fruit/nuts relative to total unit sales decreased. Our results indicate that policies aiming to improve the nutrition environment in health care settings, through increasing the availability of healthy products in vending machines and promoting their purchase, could be an effective method of reducing the amount of unhealthy products purchased overall. These policies can alter consumers’ purchasing patterns and prompt consumers towards purchasing a healthier/unhealthier version of the same product, as seen with crisps and bars in this study.

DIET LIBERALISATION IN OLDER AUSTRALIANS DECREASES FRAILTY WITHOUT INCREASING THE RISK OF DEVELOPING CHRONIC DISEASE

2012 ◽  
pp. 1-9
Author(s):  
L. BAULDERSTONE ◽  
A. YAXLEY ◽  
M. LUSZCZ ◽  
M. MILLER
Keyword(s):  
Chronic Disease ◽  
Saturated Fat ◽  
Dietary Exposure ◽  
Binary Logistic Regression ◽  
The Elderly ◽  
Total Fat ◽  
Definition Of ◽  
The Impact ◽  
Saturated Fat Intake

Background:Successful ageing relies on the prevention of frailty and chronic disease, many of whichhave a strong link with diet. Despite evidence suggesting diet is important in the management of frailty, there islittle evidence investigating the impact of a liberal diet on the prevention of frailty and development of chronicdiseases in the elderly. Objectives:To determine the impact of a liberal diet on the development of frailty andwhether this affects the incidence of obesity, diabetes, hypertension and hyperlipidaemia. Design:Secondary dataanalysis of the Australian Longitudinal Study of Ageing, 1992 to 2000. Setting:Random selection of older adultsfrom the South Australian electoral roll. Participants:1298 older Australians (629 women, 669 men), mean age77 years. Measurements:A validated food frequency questionnaire was used to measure the dietary exposure;liberal diet defined as: energy >10% estimated requirements; sodium >1600mg; total fat >35% energy; saturatedfat >10%; refined sugar >10%; fibre <38g males and <28g females. Frailty was determined using the Friedphenotype in combination with Cesari’s biological definition of frailty. Chronic disease outcomes were measuredby medication usage and obesity defined as BMI >30kg/m². Binary logistic regression was performed usingparticipants free of chronic disease at baseline to determine the impact of each dietary exposure independently,and combined, on the development of frailty and the incidence of chronic disease over the subsequent eight years.Results:Incidence of frailty after 8 years of follow up was 14%. The incidence of diabetes after 8 years of followup was 5.3%, hypertension 39%, hyperlipidaemia 15% and obesity 6%. A liberal energy intake adjusted for ageand sex, significantly reduced the risk of developing frailty eight years post baseline (OR 0.48, 95% CI 0.30,0.77). After adjustment for age, sex and body weight, a liberal saturated fat intake (>10% of energy) increasedthe risk of hyperlipidaemia (OR 2.11, 95% CI 1.27, 3.54). A liberal intake of sodium, total fat, refined sugar andfibre did not increase the risk of diabetes, hypertension, hyperlipidaemia or obesity. Conclusions:This studysuggests that a liberal intake of energy may decrease the risk of developing frailty in the elderly withoutincreasing the risk of developing obesity, diabetes, hypertension or hyperlipidaemia. Caution should remainhowever in the prescription of diets high in saturated fat as the link established with hyperlipidaemia in youngadults appears to be consistent in the elderly. Further research is required to explore the optimal sources of energyfor a liberalised diet and the effect of a liberalised diet on other diet related health conditions.

Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring

2009 ◽  
Vol 297 (4) ◽  
pp. R1049-R1057 ◽  
Author(s):  
Kathleen C. Page ◽  
Raleigh E. Malik ◽  
Joshua A. Ripple ◽  
Endla K. Anday
Keyword(s):  
Body Weight ◽  
High Fat Diet ◽  
Saturated Fat ◽  
Male Offspring ◽  
Regulatory Subunit ◽  
Cytokine Signaling ◽  
Chow Diet ◽  
Metabolic Dysfunction ◽  
High Fat ◽  
Pregnancy And Lactation

Epidemiological data and results from animal studies indicate that imbalances in maternal nutrition impact the expression of metabolic disorders in the offspring. We tested the hypothesis that consumption of excess saturated fats during pregnancy and lactation contributes to adult metabolic dysfunction and that these disturbances can be further influenced by the postweaning diet. Adult male offspring from chow-fed dams were compared with males from dams fed a diet high in saturated fat (45 kcal/100 kcal) before mating, pregnancy, and lactation. Offspring were weaned to a standard chow diet or high fat diet. Animals were killed at 120 days after a 24-h fast. Body weight, energy intake, fat deposition, serum leptin, and insulin were significantly higher in offspring from control or high-fat dams if fed a high-fat diet from weaning to adulthood. Only fat-fed offspring from fat-fed dams were hyperglycemic. Leptin receptor, proopiomelanocortin, and neuropeptide Y (NPY) were also significantly increased in offspring exposed to excess saturated fat during gestation and into adulthood, whereas NPY1 receptor was downregulated. Signal transducer and activator of transcription 3 mRNA level was significantly higher in offspring from high-fat-fed dams compared with controls; however, no change was detected in cocaine and amphetamine-regulated transcript or suppressor of cytokine signaling 3. An increase in agouti-related protein expression did not reach significance. A significant reduction in phosphatidylinositol 3-kinase regulatory subunit (p85α) coupled to an upregulation of protein kinase B was observed in offspring from high-fat-fed dams transitioned to chow food, whereas p85α expression was significantly increased in high-fat offspring weaned to the high-fat diet. These data support the hypothesis that early life exposure to excess fat is associated with changes in hypothalamic regulation of body weight and energy homeostasis and that postweaning diet influences development of metabolic dysfunction and obesity.

Impact of Leuconostoc SD23 intake in obese pregnant rats: benefits for maternal metabolism

2020 ◽  
Vol 11 (5) ◽  
pp. 533-539 ◽  
Author(s):  
Diana C. Castro-Rodríguez ◽  
Gimena Juárez-Pilares ◽  
Luz Cano-Cano ◽  
Mariana Pérez-Sánchez ◽  
Carlos A. Ibáñez ◽  
...  
Keyword(s):  
Small Intestine ◽  
Maternal Obesity ◽  
High Energy ◽  
Model Assessment ◽  
Maternal Weight ◽  
Pregnant Rats ◽  
Control Female ◽  
Maternal Metabolism ◽  
Pregnancy And Lactation ◽  
The Impact

AbstractMaternal obesity (MO) during pregnancy and lactation leads to maternal and offspring metabolic dysfunction. Recent research has suggested that probiotics might be a novel approach to counteract these unwanted MO effects. The aim of this research was to analyze the impact of Leuconostoc SD23, a probiotic isolated from aguamiel (traditional Mexican drink), on MO metabolism in rats at the end of lactation (21 days). From weaning through lactation, control female Wistar rats (C) ate chow (5% fat) or high-energy obesogenic diet (MO; 25% fat). Half the C and MO mothers received a daily dose (1 × 1010 CFU/ml) of probiotic orally, control with probiotic (CP) and MO with probiotic (MOP), 1 month before mating and through pregnancy and lactation. Histological analyses of the liver, white adipose tissue and small intestine, body composition, glucose, insulin, triglycerides, and leptin were determined in mothers at the end of lactation. Maternal weight during pregnancy was greater in MO than C mothers, but similar at the end of lactation. Probiotic intervention had no effect on maternal weight. However, at the end of lactation, percentage of body fat was higher in MO than C, CP, and MOP. Serum glucose, homeostasis model assessment of insulin resistance, and triglycerides were higher in MO versus C, CP, and MOP. MO small intestine villus height was higher versus MOP, C, and CP. Leuconostoc SD23 did not present adverse effects in C. Conclusions: maternal administration of Leuconostoc SD23 has beneficial effects on maternal metabolism, which holds possibilities for preventing adverse offspring metabolic programming.

scholarly journals A Novel Personalized Systems Nutrition Program Improves Dietary Patterns, Lifestyle Behaviors and Health-Related Outcomes: Results from the Habit Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1763
Author(s):  
Iris M. de Hoogh ◽  
Barbara L. Winters ◽  
Kristin M. Nieman ◽  
Sabina Bijlsma ◽  
Tanja Krone ◽  
...  
Keyword(s):  
Behavior Change ◽  
Saturated Fat ◽  
Population Based ◽  
Health Improvement ◽  
Phenotypic Flexibility ◽  
Lifestyle Behaviors ◽  
Systems Nutrition ◽  
Health Related ◽  
Total Fat ◽  
The Impact

Personalized nutrition may be more effective in changing lifestyle behaviors compared to population-based guidelines. This single-arm exploratory study evaluated the impact of a 10-week personalized systems nutrition (PSN) program on lifestyle behavior and health outcomes. Healthy men and women (n = 82) completed the trial. Individuals were grouped into seven diet types, for which phenotypic, genotypic and behavioral data were used to generate personalized recommendations. Behavior change guidance was also provided. The intervention reduced the intake of calories (−256.2 kcal; p < 0.0001), carbohydrates (−22.1 g; p < 0.0039), sugar (−13.0 g; p < 0.0001), total fat (−17.3 g; p < 0.0001), saturated fat (−5.9 g; p = 0.0003) and PUFA (−2.5 g; p = 0.0065). Additionally, BMI (−0.6 kg/m2; p < 0.0001), body fat (−1.2%; p = 0.0192) and hip circumference (−5.8 cm; p < 0.0001) were decreased after the intervention. In the subgroup with the lowest phenotypic flexibility, a measure of the body’s ability to adapt to environmental stressors, LDL (−0.44 mmol/L; p = 0.002) and total cholesterol (−0.49 mmol/L; p < 0.0001) were reduced after the intervention. This study shows that a PSN program in a workforce improves lifestyle habits and reduces body weight, BMI and other health-related outcomes. Health improvement was most pronounced in the compromised phenotypic flexibility subgroup, which indicates that a PSN program may be effective in targeting behavior change in health-compromised target groups.

scholarly journals Omega-6:Omega-3 Fatty Acid Ratio and Total Fat Content of the Maternal Diet Alter Offspring Growth and Fat Deposition in the Rat

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2505 ◽  
Author(s):  
Sally A. V. Draycott ◽  
Matthew J. Elmes ◽  
Beverly S. Muhlhausler ◽  
Simon Langley-Evans
Keyword(s):  
Maternal Diet ◽  
Female Offspring ◽  
Fat Content ◽  
Fat Deposition ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Adult Rats ◽  
Offspring Growth ◽  
Pregnancy And Lactation ◽  
Total Fat

Omega-3 long-chain polyunsaturated fatty acids (LCPUFA) have been shown to inhibit lipogenesis and adipogenesis in adult rats. Their possible early life effects on offspring fat deposition, however, remain to be established. To investigate this, female Wistar rats (n = 6–9 per group) were fed either a 9:1 ratio of linoleic acid (LA) to alpha-linolenic acid (ALA) or a lower 1:1.5 ratio during pregnancy and lactation. Each ratio was fed at two total fat levels (18% vs. 36% fat w/w) and offspring were weaned onto standard laboratory chow. Offspring exposed to a 36% fat diet, irrespective of maternal dietary LA:ALA ratio, were lighter (male, 27 g lighter; female 19 g lighter; p < 0.0001) than those exposed to an 18% fat diet between 3 and 8 weeks of age. Offspring exposed to a low LA (18% fat) diet had higher proportions of circulating omega-3 LCPUFA and increased gonadal fat mass at 4 weeks of age (p < 0.05). Reduced Srebf1 mRNA expression of hepatic (p < 0.01), gonadal fat (p < 0.05) and retroperitoneal fat (p < 0.05) tissue was observed at 4 weeks of age in male and female offspring exposed to a 36% fat diet, and hepatic Srebf1 mRNA was also reduced in male offspring at 8 weeks of age (p < 0.05). Thus, while offspring fat deposition appeared to be sensitive to both maternal dietary LA:ALA ratio and total fat content, offspring growth and lipogenic capacity of tissues appeared to be more sensitive to maternal dietary fat content.

Sign in / Sign up

Export Citation Format

Share Document