scholarly journals Maternal circulating Vitamin D3 levels during pregnancy and behaviour across childhood

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mónica López-Vicente ◽  
Jordi Sunyer ◽  
Nerea Lertxundi ◽  
Llúcia González ◽  
Cristina Rodríguez-Dehli ◽  
...  
Keyword(s):  
Vitamin D ◽  
Social Competence ◽  
Population Based ◽  
Autism Spectrum ◽  
Behavioural Problems ◽  
Plasma Vitamin ◽  
Critical Periods ◽  
Neurodevelopmental Outcomes ◽  
Maternal Vitamin ◽  
Vitamin D Levels

Abstract Vitamin D deficiency during critical periods of development could lead to persistent brain alterations. We aimed to assess the association between maternal vitamin D3, the major circulatory form of vitamin D, at pregnancy and neurodevelopmental outcomes during childhood, namely: behavioural problems, Attention Deficit and Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) symptoms, and social competence. This study included 2,107 mother-child pairs of a Spanish population-based birth cohort. Maternal plasma vitamin D3 was measured in pregnancy. The outcomes were measured through questionnaires at 5, 8, 14, and 18 years old. We ran multivariate regression models adjusted for potential confounding variables. We found that per each 10 ng/mL increment of maternal vitamin D3, children obtained higher social competence scores (coefficient = 0.77; 95% CI = 0.19, 1.35) at 5 years old. However, we observed null associations between maternal vitamin D3 and total behavioural problems and ADHD and ASD symptoms in children from 5 to 18 years old. Further studies carried out in countries where the population is exposed to lower vitamin D levels are needed.

scholarly journals Maternal vitamin D deficiency and the risk of autism spectrum disorders: population-based study

BJPsych Open ◽  
2016 ◽  
Vol 2 (2) ◽  
pp. 170-172 ◽  
Author(s):  
Cecilia Magnusson ◽  
Kyriaki Kosidou ◽  
Christina Dalman ◽  
Michael Lundberg ◽  
Brian K. Lee ◽  
...  
Keyword(s):  
Vitamin D ◽  
Intellectual Disability ◽  
Vitamin D Deficiency ◽  
Population Based ◽  
Autism Spectrum ◽  
Population Based Study ◽  
Maternal Vitamin ◽  
Increase Risk ◽  
Spectrum Disorders ◽  
The Relationship

BackgroundMaternal vitamin D deficiency may increase risk of autism spectrum disorder (ASD), but direct evidence is lacking.AimsTo clarify the relationship between maternal vitamin D deficiency and offspring risk of ASD with and without intellectual disability.MethodUsing a register-based total population study (N=509 639), we calculated adjusted odds ratios (aORs) and 95% confidence intervals (CIS) of ASD with and without intellectual disability in relation to lifetime diagnoses of maternal vitamin D deficiency. Although rare, such deficiency was associated with offspring risk of ASD with, but not without, intellectual disability (aORs 2.51, 95% CI 1.22–5.16 and 1.28, 0.68–2.42). Relationships were stronger in non-immigrant children.ConclusionsIf reflecting associations for prenatal hypovitaminosis, these findings imply gestational vitamin D substitution as a means of ASD prevention.

Maternal vitamin D levels during pregnancy and offspring autism spectrum disorder

2021 ◽  
Author(s):  
Andre Sourander ◽  
Subina Upadhyaya ◽  
Heljä-Marja Surcel ◽  
Susanna Hinkka-Yli-Salomäki ◽  
Keely Cheslack-Postava ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Maternal Vitamin ◽  
Vitamin D Levels

scholarly journals Genetic Contributions to Maternal and Neonatal Vitamin D Levels

Genetics ◽  
2020 ◽  
Vol 214 (4) ◽  
pp. 1091-1102
Author(s):  
Michela Traglia ◽  
Gayle C. Windham ◽  
Michelle Pearl ◽  
Victor Poon ◽  
Darryl Eyles ◽  
...  
Keyword(s):  
Vitamin D ◽  
Association Studies ◽  
Genetic Regulation ◽  
Autism Spectrum ◽  
Adverse Outcomes ◽  
Genome Wide Association Studies ◽  
Maternal Vitamin ◽  
Maternal Genotype ◽  
Vitamin D Levels ◽  
In Pregnancy

Vitamin D is essential for several physiological functions and biological processes. Increasing levels of maternal vitamin D are required throughout pregnancy as a unique source of vitamin D for the fetus, and consequently maternal vitamin D deficiency may result in several adverse outcomes in newborns. However, the genetic regulation of vitamin D in pregnancy and at birth is not yet well understood. We performed genome-wide association studies of maternal midgestational serum-derived and neonatal blood-spot-derived total 25-hydroxyvitamin D from a case-control study of autism spectrum disorder (ASD). We identified one fetal locus (rs4588) significantly associated with neonatal vitamin D levels in the GC gene, encoding the binding protein for the transport and function of vitamin D. We also found suggestive cross-associated loci for neonatal and maternal vitamin D near immune genes, such as CXCL6-IL8 and ACKR1. We found no interactions with ASD. However, when including a set of cases with intellectual disability but not ASD (N = 179), we observed a suggestive interaction between decreased levels of neonatal vitamin D and a specific maternal genotype near the PKN2 gene. Our results suggest that genetic variation influences total vitamin D levels during pregnancy and at birth via proteins in the vitamin D pathway, but also potentially via distinct mechanisms involving loci with known roles in immune function that might be involved in vitamin D pathophysiology in pregnancy.

scholarly journals Maternal Vitamin D Status and Children’s Asthma or Wheezing: A Narrative Review Article

2021 ◽  
Vol 9 (1) ◽  
pp. 1-8
Author(s):  
Zeinab Nazari ◽  
◽  
Javad Ghaffari ◽  
Abbas Dabaghzadeh ◽  
Negar Ghaffari ◽  
...  
Keyword(s):  
Vitamin D ◽  
English Language ◽  
Review Article ◽  
Plasma Vitamin ◽  
Respiratory Disorder ◽  
Serum Samples ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
Study Results ◽  
Allergic Disorders

Context: Asthma is a chronic inflammatory respiratory disorder, and nutritional conditions affect allergic diseases such as asthma. This study aims to find the relationship between maternal gestational vitamin D levels and asthma progression and wheezing in children later in life. Objectives: Allergic disorders are common everywhere in the world. Asthma is the most chronic inflammatory respiratory disorder among children. It causes significant morbidity and mortality in children as well as adults. Vitamin D deficiency or insufficiency, is a global problem. Vitamin D has immunological effects, and it may prevent autoimmune diseases. Maternal plasma vitamin D during pregnancy has a different impact on children’s allergic disorders. Evidence Acquisition: This is a review article. We searched databases, including Google Scholar, PubMed, SID, IranDoc, Scopus, until now. The keywords for the search included maternal vitamin D, asthma, wheezing, children, and pediatric. We searched in the mentioned databases until March 2020. Full-text articles in the English language were included in this study. Results: A few articles were found in our search. All of them were cohort studies. They evaluated maternal vitamin D and its outcomes in their children’s asthma and wheezing using questionnaire data and serum samples. After assessing the articles (more than 100), 15 papers were included in our review. Six and four articles showed that higher maternal vitamin D levels reduce children’s asthma and or wheezing, respectively. In contrast, 7 articles showed no association between maternal vitamin D and children’s asthma or wheezing. Vitamin D does not have any serious side effects. Because the articles were heterogenic, a meta-analysis could not be done. Conclusions: Administering vitamin D supplements or food enriched vitamin D during pregnancy has different effects on the prevalence of wheezing and or asthma in children.

scholarly journals Vitamin D levels during pregnancy and associations with birth weight and body composition of the newborn: a longitudinal multiethnic population-based study

2017 ◽  
Vol 117 (7) ◽  
pp. 985-993 ◽  
Author(s):  
Åse R. Eggemoen ◽  
Anne K. Jenum ◽  
Ibrahimu Mdala ◽  
Kirsten V. Knutsen ◽  
Per Lagerløv ◽  
...  
Keyword(s):  
Vitamin D ◽  
Birth Weight ◽  
Pregnant Women ◽  
Head Circumference ◽  
Population Based ◽  
Abdominal Circumference ◽  
Anthropometric Measures ◽  
Maternal Vitamin ◽  
Multiethnic Cohort ◽  
Vitamin D Levels

AbstractWe investigated associations between serum 25-hydroxyvitamin D (25(OH)D) in pregnancy and birth weight and other neonatal anthropometric measures. The present study was a population-based, multiethnic cohort study of 719 pregnant women (59 % ethnic minorities) in Oslo, Norway, delivering a singleton neonate at term and with birth weight measurements. In a representative sample, anthropometric measurements were taken. Maternal 25(OH)D was measured at gestational weeks 15 and 28. Women with 25(OH)D <37 nmol/l were recommended vitamin D3 supplementation. Separate linear regression analyses were performed to model the associations between 25(OH)D and each of the outcomes: birth weight, crown–heel length, head circumference, abdominal circumference, sum of skinfolds, mid-upper arm circumference and ponderal index. In early pregnancy, 51 % of the women were vitamin D deficient (25(OH)D<50 nmol/l). In univariate analyses and in models adjusting for maternal age, parity, education, prepregnancy BMI, season, gestational age and neonate sex, maternal 25(OH)D was significantly associated with birth weight, head circumference, abdominal circumference and ponderal index (P<0·05 for all), when used as a continuous variable and categorised (consistently low, consistently high, increasing and decreasing level). However, after adjusting for ethnicity, 25(OH)D was no longer associated with any of the outcomes. Sex-specific associations for abdominal circumference and sum of skinfolds were found (Pfor interaction<0·05). In conclusion, in a multiethnic cohort of pregnant women with high prevalence of vitamin D deficiency, we found no independent relation between maternal vitamin D levels and any of the neonatal anthropometric measures, and the strong association between ethnicity and neonatal outcomes was not affected by maternal vitamin D status.

Lower Vitamin D Level as a Risk Factor for Late Onset Neonatal Sepsis: An Observational Case–Control Study

2021 ◽  
Author(s):  
Shaimaa Reda Abdelmaksoud ◽  
Mostafa Abdel-Azim Mostafa ◽  
Rana Atef khashaba ◽  
Effat Assar
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Late Onset ◽  
Case Control ◽  
Sepsis Group ◽  
Term Neonates ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
Control Study

Objective The aim of the study is to investigate the relation of neonatal and maternal vitamin D and late-onset sepsis (LOS) Study Design One-hundred twenty term neonates along with their mothers were enrolled in this case–control study. Sixty neonates who were admitted in the neonatal intensive care unit by LOS and had not been previously admitted for last 48 hours and did not receive antibiotics or vitamin D were enrolled as cases (sepsis) group. On the other hand, 60 healthy term neonates were referred as control group. Maternal and neonatal serum 25-OH vitamin D levels were assessed in both the cohorts. Results Maternal and neonatal 25-OH vitamin D levels in cases (17.2 and 16.1 ng/mL, respectively) were significantly lower than in controls (22.7 and 21 ng/mL, respectively) p = 0.001. In the study group, the neonatal 25-OH vitamin D was negatively correlated with C-reactive protein and length of hospital stay (r = −0.616 and −0.596, respectively) p <0.001 for both. With a cut-off value of 12.9 ng/mL, the specificity and positive predictive value of neonatal vitamin D were 83.3 and 74.4%, respectively. The odds ratio was 1.088 (95% CI = 1.034–1.144)) for LOS in vitamin D-deficient neonates. Conclusion Neonates with higher vitamin D level are at lower risk of LOS than those with vitamin D deficiency. Maternal vitamin D correlates with neonatal vitamin D. These data suggest that maternal vitamin supplementation during pregnancy may lower the risk of LOS. Key Points

scholarly journals Association of Plasma Vitamin D Levels with Adiposity in Hispanic and African Americans

2009 ◽  
Vol 94 (9) ◽  
pp. 3306-3313 ◽  
Author(s):  
Kendra A. Young ◽  
Corinne D. Engelman ◽  
Carl D. Langefeld ◽  
Kristen G. Hairston ◽  
Steven M. Haffner ◽  
...  
Keyword(s):  
Vitamin D ◽  
African Americans ◽  
Plasma Vitamin ◽  
Vitamin D Levels
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