scholarly journals Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yen-Wei Li ◽  
Tung-Wei Kao ◽  
Pi-Kai Chang ◽  
Wei-Liang Chen ◽  
Li-Wei Wu
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Longitudinal Study ◽  
Age Distribution ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Modern World ◽  
Atherogenic Index Of Plasma ◽  
Gender And Age

AbstractDeeply involved with dyslipidemia, cardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world. Whose correlation with metabolic syndrome (MetS), hypertension and type 2 diabetes mellitus (T2DM) has been well established. We conducted a 9-year longitudinal study to identify the association between easily measured lipid parameters, future MetS, hypertension and T2DM by gender and age distribution. Divided into three groups by age (young age: < 40, middle age: ≥ 40 and < 65 and old age: ≥ 65), 7670 participants, receiving standard medical inspection at Tri-Service General Hospital (TSGH) in Taiwan, had been enrolled in this study. Atherogenic index of plasma (AIP) was a logarithmically transformed ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C). Through multivariate regression analyses, the hazard ratio (HR) of AIP for MetS, hypertension and T2DM were illustrated. AIP revealed significant association with all the aforementioned diseases through the entire three models for both genders. Additionally, AIP revealed significant correlation which remained still after fully adjustment in MetS, hypertension, and T2DM groups for subjects aged 40–64-year-old. Nevertheless, for participants aged above 65-year-old, AIP only demonstrated significant association in MetS group. Our results explore the promising value of AIP to determine the high-risk subjects, especially meddle-aged ones, having MetS, hypertension, and T2DM in the present and the future.

scholarly journals Evaluation of lipid profile pattern and atherogenic index of plasma (AIP) having type-2 diabetes mellitus in Bangladesh

2018 ◽  
Vol 6 (3) ◽  
pp. 776
Author(s):  
Mahfuza Anjum ◽  
Md. Salah Uddin ◽  
Naima Ahmed Tamanna ◽  
Md. Abdullah Al-Zobair ◽  
A. T. M. Mijanur Rahman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Atherogenic Index Of Plasma ◽  
Type 2 Diabetic

Background: Dyslipidemia has been noted to play an integral role in the pathogenesis and progression of micro and macrovascular complications in Diabetes Mellitus (DM) patients. The study was aimed to evaluate the prevalence and pattern of dyslipidemia and atherogenic index of plasma (AIP) in type 2 diabetes mellitus patients as it has not been reported previously in BangladeshMethods: This cross-sectional study was conducted at Armed Forces Institute of pathology, Bangladesh from November 2016 to October 2017. A total number of 300 patients having diabetes in the age group of 30-60 years have been selected using a non-probability method. Fasting plasma glucose (FPG), serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels were estimated by laboratory tests.Results: The prevalence of dyslipidemia in at least one lipid parameter was found in 282 patients (94%), while 18 patients (6%) had no dyslipidemia. High levels of TC, TG and LDL-C were found in 134 (47.3%), 230 (76.7%) and 124 (41.3%) patients, respectively. On the other hand, low levels of HDL-C were found in 180 patients (60%). An increased risk of AIP was found in 298 patients (99.3%), whereas only 2 patients (0.7%) were in low risk. FPG was positively correlated with TC, TG, LDL-C and AIP, while negatively correlated with HDL-C. A significant positive correlation was also observed between FPG and AIP.Conclusions: The Study revealed that dyslipidemia is very common in type 2 diabetic patients and the most common abnormality observed was increased serum triglyceride levels followed by decreased serum HDL-C levels. The AIP is also significantly higher in type 2 diabetic patients.

scholarly journals In Type 2 Diabetes Mellitus Patients, the Atherogenic Index of Plasma as a Marker of Coronary Artery Diseases

2021 ◽  
pp. 263246362110313
Author(s):  
Muhammed Hossam Al-Shaer ◽  
Manar Mostafa Elzaky ◽  
El Sayed Mohamed Farag ◽  
Mostafa Osama Mohamed Saad
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Coronary Artery ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Cvd Risk ◽  
Atherogenic Index Of Plasma

One-third of all deaths globally are caused by cardiovascular disease (CVD), and this percentage is predicted to climb as CVD risk factors become more widespread. Primary prevention of risk factors is the most fundamental duty in dealing with the CVD epidemic. The link between atherogenic index of plasma (AIP) and other CVD risks among university workers was investigated among study participants in order to demonstrate that AIP, not lipid profile, is a better predictor of CVDs. They discovered a link between AIP and CVD risk variables (body mass index, visceral fat, body fat, total cholesterol, low density lipoprotein cholesterol, triglyceride, glucose, and high density lipoprotein cholesterol) in people with type 2 diabetes. This comparative study was carried out in Cardiology Department, Zagazig University Hospitals. This study included 140 type 2 diabetes mellitus patients. They were classified into 2 main groups: Group 1: 70 patients with type 2 diabetes who had coronary artery disease (CAD). Group (2): 70 type 2 diabetes individuals with no indicators of CAD (admitted complaining of symptoms of angina or CA showing no significant stenotic lesions). Regarding study explained it has showed that AIP outperforms standard lipid indicators in predicting the likelihood ofdeveloping CADs in people with type 2 diabetes. In addition, the value of AIP in diabetic and prediabetic patients for predicting future CVD is being investigated. They came to the conclusion that AIP is an excellent predictor of future CVD in those with diabetes and those who are prediabetic.

Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Hadi Bazyar ◽  
Seyed Ahmad Hosseini ◽  
Sirous Saradar ◽  
Delsa Mombaini ◽  
Mohammad Allivand ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Atherogenic Index ◽  
Control Group ◽  
Atherogenic Index Of Plasma ◽  
The Mean

Abstract Background In patients with type 2 diabetes mellitus (T2DM) the inflammatory and metabolic responses to epigallocatechin-3-gallate (EGCG) are unknown. Objectives Evaluate the impacts of EGCG on metabolic factors and some biomarkers of stress oxidative in patients with T2DM. Methods In this randomized, double-blind, placebo-controlled trial, 50 patients with T2DM consumed either 2 tablets (300 mg) EGCG (n=25) or wheat flour as placebo (n=25) for 2 months. The total antioxidant capacity (TAC), interleukin-6 (IL-6), lipid profile, mean arterial pressure (MAP), atherogenic index of plasma (AIP) were evaluated before and after the intervention. Results The finding of present study exhibited a significant increase in the serum levels of TAC after the EGCG supplementation (p=0.001). Also, in compare with control group, the mean changes of TAC were significantly higher in supplement group (p=0.01). In intervention group, a significant decrease was observed in the mean levels of triglyceride, total cholesterol, diastolic blood pressure (DBP), AIP, and MAP (p<0.05). Taking EGCG resulted in the mean changes of total cholesterol, MAP and DBP were significantly lower in compare with control group (p<0.05). Conclusions This study recommended that EGCG supplementation may be improved blood pressure, lipid profile, AIP, and oxidative status in patients with T2DM.

scholarly journals Prognostic impact of the atherogenic index of plasma in type 2 diabetes mellitus patients with acute coronary syndrome undergoing percutaneous coronary intervention

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaoteng Ma ◽  
Yan Sun ◽  
Yujing Cheng ◽  
Hua Shen ◽  
Fei Gao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Percutaneous Coronary Intervention ◽  
Cardiovascular Events ◽  
Coronary Intervention ◽  
Atherogenic Index ◽  
Atherogenic Index Of Plasma ◽  
Coronary Syndrome ◽  
Percutaneous Coronary

Abstract Background The association of the atherogenic index of plasma (AIP), an emerging lipid index that can predict the risk for cardiovascular disease, with adverse outcomes in type 2 diabetes mellitus (T2DM) patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) has not been determined. Therefore, the aim of this study was to investigate whether the AIP could independently predict adverse cardiovascular events in T2DM patients with ACS undergoing PCI. Methods This study was a retrospective analysis of a single-centre prospective registry involving 826 consecutive T2DM patients who underwent primary or elective PCI for ACS from June 2016 to November 2017. This study ultimately included 798 patients (age, 61 ± 10 years; male, 72.7%). The AIP was calculated as the base 10 logarithm of the ratio of the plasma concentration of triglycerides to high-density lipoprotein-cholesterol (HDL-C). All the patients were divided into 4 groups based on the AIP quartiles. The primary endpoint was a composite of death from any cause, non-fatal spontaneous myocardial infarction (MI), non-fatal ischaemic stroke, and unplanned repeat revascularization. The key secondary endpoint was a composite of cardiovascular death, non-fatal MI, and non-fatal ischaemic stroke. Results During a median follow-up period of 927 days, 198 patients developed at least one event. An unadjusted Kaplan-Meier analysis showed that the incidence of the primary endpoint increased gradually with rising AIP quartiles (log-rank test, P = 0.001). A multivariate Cox proportional hazards analysis revealed that compared with the lowest AIP quartile, the top AIP quartile was associated with significantly increased risk for the primary and key secondary endpoints (hazard ratio [HR]: 2.249, 95% confidence interval [CI]: 1.438 to 3.517, P < 0.001; and HR: 2.571, 95% CI: 1.027 to 6.440, P = 0.044, respectively). Conclusions A higher AIP value on admission was independently and strongly associated with adverse cardiovascular events in T2DM patients with ACS undergoing PCI.

scholarly journals Association Between Pulse Index and Metabolic syndrome in Individuals with Type 2 Diabetes Mellitus: Outcome of a Twelve-Weeks Therapeutic Exercise

2009 ◽  
pp. 10-15
Author(s):  
Ade Fatai Adeniyi ◽  
Arinola O Sanya ◽  
A A Fasanmade ◽  
B Tijjani ◽  
A E Uloko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Type 2 Diabetes Mellitus ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cardiovascular Fitness ◽  
Therapeutic Exercises

Background and Objective: Metabolic syndrome (MS) is an entity with clustering of cardiovascular risk factors and is associated with Type 2 Diabetes Mellitus (T2DM). Low level cardiovascular fitness is also associated with risk of T2DM. An association between Pulse Index (PI) and MS requires further description. This study sought to determine the association between PI and components of MS. Methods: Seventy-seven participants/subjects aged 48.6±6.52 years with T2DM were enrolled into the study at Aminu-Kano Teaching Hospital, Kano, Nigeria. PI and components of MS including Fasting Blood Glucose (FBG), Glycosylated Haemoglobin (HBAlc), High-Density Lipoprotein (HDL-CHOL), Triglycerides (TRIG.), Blood Pressure (BP) and obesity were assessed before and after twelve-week therapeutic exercises. Results: Inverse correlations were obtained for PI and each ofFBG (r=-0.45), HBAlc (r=-0.52), TRIG (r=-0.26), BP(r=-0.43/-0.32), Waist Circumference (r=-0.53), BMI (r=-0.79), blood pressure (r=-0.43/-0.32) except HDL-CHOL (r= 0.67), (P< 0.05 for all the subjects/participants). Conclusions: Low-levels of PI were associated with poor glycaemia, hypertension, obesity and dyslipidaemia. Therapeutic exercises aimed at improving cardiovascular fitness may have significant improvement on MS. which in turn aids the prevention of both T2DM and cardiovascular diseases. Keywords: Type 2 Diabetes Mellitus, Cardiovascular fitness, aerobic exercises, Pulse Index'

scholarly journals Atherogenic index of plasma is associated with major adverse cardiovascular events in patients with type 2 diabetes mellitus

2021 ◽  
Author(s):  
Liyao Fu ◽  
Ying Zhou ◽  
Jiaxing Sun ◽  
Zhaowei Zhu ◽  
Zhenhua Xing ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiovascular Events ◽  
Atherogenic Index ◽  
Confounding Factors ◽  
Atherogenic Index Of Plasma ◽  
All Cause Mortality ◽  
Study Population

Abstract Background Previous studies have reported the prognostic value of the atherogenic index of plasma (AIP) in the course of atherosclerosis and other cardiovascular diseases (CVDs). However, the utility of the AIP for prediction is unknown among patients with type 2 diabetes mellitus (T2DM). Methods This was a secondary analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study which randomized 10,251 patients with long-lasting T2DM. ROC curve analysis was used to determine an optimal threshold for AIP and the study population was divided into high and low AIP groups. Univariate and multivariate Cox proportional hazards regression analyses were used to find the association between AIP and primary (MACEs) and second outcomes (all-cause mortality). Stratified analyses were performed to control the confounding factors. Results AIP was an independent risk factor for the prognosis of T2DM (HR = 1.309; 95% CI, 1.084–1.581; P = 0.005). The threshold for AIP was determined to be 0.34 among the study population. After adjustments for confounding factors, multivariate analysis showed that AIP was associated with the risk of MACEs (Model 1: HR = 1.333, 95%CI: 1.205–1.474, P༜0.001; Model 2: HR = 1.171, 95%CI: 1.030–1.333, P = 0.016; Model 3: HR = 1.194, 95%CI: 1.049–1.360, P = 0.007) and all-cause mortality (Model 1: HR = 1.184, 95%CI: 1.077–1.303, P༜0.001), especially cardiovascular deaths (Model 1: HR = 1.422, 95%CI: 1.201–1.683, P༜0.001; Model 3: HR = 1.264, 95%CI: 1.015–1.573, P = 0.036) and nonfatal myocardial infarction (Model 1: HR = 1.447, 95%CI: 1.255–1.669, P༜0.001; Model 2: HR = 1.252, 95%CI: 1.045–1.499, P = 0.015; Model 3: HR = 1.284, 95%CI: 1.071–1.539, P = 0.007). Subgroup stratified analyses showed that AIP might interact with gender, a classical risk factor of cardiovascular events. Conclusions Our study showed that AIP might be a strong biomarker that could be used to predict the risk of cardiovascular events in patients with T2DM.

“COMPARISON OF ATHEROGENIC INDEX OF PLASMA AND CHOLESTEROL/HDL RATIO AMONG TYPE 2 DIABETES MELLITUS PATIENTS IN A TERTIARY CARE HOSPITAL”

2021 ◽  
pp. 52-54
Author(s):  
Amrita Karmakar ◽  
Dipa Mandal ◽  
Soma Gupta
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Group ◽  
Atherogenic Index ◽  
P Value ◽  
Atherogenic Index Of Plasma ◽  
Lipid Ratios ◽  
Cardio Vascular

Lipid prole though is a well established parameter to predict cardio vascular risk in patients suffering from type 2 diabetes mellitus(T2DM), at present lipid ratios are replacing these age old parameters. Among the lipid ratios Atherogenic index of plasma(AIP) and cholesterol/HDL(Chol/HDL) are found to be of great signicance. This cross-sectional study aimed to compare the predictive value of two lipid ratios, "Atherogenic index of plasma" (AIP) and "Cholesterol/HDL ratio" on basis of insulin resistance (IR) among 55 newly diagnosed cases with Type 2 Diabetes Mellitus (T2DM) and 50 control subjects. HOMA –IR (p value <0.0001), AIP (<0.001) and Cholesterol/HDL ratio (<0.001) were signicantly raised among case group in comparison to controls. Both AIP(r- 0.305, p-0.002) and Chol/HDL ratio(r- 0.23, p value- 0.018) was signicantly correlated with HOMA-IR. ROC curve of AIP and Chol/HDL ratio was plotted for identifying IR. There is no signicant difference between areas under curve (AUC) of AIP (AUC-0.656) and Chol/HDL ratio(AUC-0.630) (p value- 0.49). AIP was found to be correlated better with Insulin resistance than CHOL/HDL ratio. AUC in AIP was found to be slightly higher and overall sensitivity and specicity of AIP was found to be 66% and 69%, of Chol/HDL ratio was 46% and 76% to identify moderate to high-risk group: whereas it is 69%&47% of AIP and 87% and 32% of Chol/HDL ratio to identify low risk group. Both lipid ratios have some signicance in predicting cardio vascular risk in T2DM

The Atherogenic Index of Plasma: A Powerful and Reliable Predictor for Coronary Artery Disease in Patients With Type 2 Diabetes

Angiology ◽  
2021 ◽  
pp. 000331972110121
Author(s):  
Kuo Zhou ◽  
Zheng Qin ◽  
Jinfan Tian ◽  
Kongyong Cui ◽  
Yunfeng Yan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Atherogenic Index ◽  
Atherogenic Index Of Plasma ◽  
Artery Disease ◽  
Cad Risk

We evaluated the predictive power of the atherogenic index of plasma (AIP) for coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). A total of 3278 patients who underwent coronary angiography were consecutively enrolled, including 2052 patients with CAD and 1226 patients with T2DM but without CAD. Patients in the CAD group had higher levels of triglyceride (TG), total cholesterol, low-density lipoprotein cholesterol, AIP and a lower level of high-density lipoprotein cholesterol (HDL-C). In correlation analyses, AIP correlated positively with body mass index, log (homeostasis model assessment of insulin resistance), TG, remnant lipoprotein cholesterol, non–HDL-C, but negatively with age and HDL-C. Multivariate logistic regression analyses demonstrated that AIP was an independent risk factor for CAD in diabetic patients and was validated by multiple models. Furthermore, the ORs for CAD risk were raised with increasing AIP quartiles; ORs of AIP quartiles Q2–Q4 compared with Q1 were 1.56, 1.70, and 2.22, respectively ( Ps < .001), which suggested AIP was the lipid parameter that most strongly associated with incident CAD. In conclusion, AIP is a powerful and reliable biomarker for predicting CAD risk beyond individual lipid profiles in patients with T2DM.

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