scholarly journals An infrared spectral biomarker accurately predicts neurodegenerative disease class in the absence of overt symptoms

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lila Lovergne ◽  
Dhruba Ghosh ◽  
Renaud Schuck ◽  
Aris A. Polyzos ◽  
Andrew D. Chen ◽  
...  
Keyword(s):  
Fourier Transform ◽  
Neurodegenerative Disease ◽  
High Probability ◽  
Behavioral Characteristics ◽  
Brain Pathology ◽  
Disease Class ◽  
The Past ◽  
Infrared Spectral ◽  
New Biomarkers ◽  
Physiological Indicator

AbstractAlthough some neurodegenerative diseases can be identified by behavioral characteristics relatively late in disease progression, we currently lack methods to predict who has developed disease before the onset of symptoms, when onset will occur, or the outcome of therapeutics. New biomarkers are needed. Here we describe spectral phenotyping, a new kind of biomarker that makes disease predictions based on chemical rather than biological endpoints in cells. Spectral phenotyping uses Fourier Transform Infrared (FTIR) spectromicroscopy to produce an absorbance signature as a rapid physiological indicator of disease state. FTIR spectromicroscopy has over the past been used in differential diagnoses of manifest disease. Here, we report that the unique FTIR chemical signature accurately predicts disease class in mouse with high probability in the absence of brain pathology. In human cells, the FTIR biomarker accurately predicts neurodegenerative disease class using fibroblasts as surrogate cells.

FR-IR Molecular Microanalysis System

1990 ◽  
Vol 48 (2) ◽  
pp. 270-271
Author(s):  
John A. Reffner ◽  
William T. Wihlborg
Keyword(s):  
Fourier Transform ◽  
Fourier Transform Infrared ◽  
Integrated System ◽  
Morphological Examination ◽  
Fully Integrated ◽  
Ir Microscopy ◽  
Normal Functions ◽  
Infrared Microspectroscopy ◽  
Infrared Spectral ◽  
Ft Ir

The IRμs™ is the first fully integrated system for Fourier transform infrared (FT-IR) microscopy. FT-IR microscopy combines light microscopy for morphological examination with infrared spectroscopy for chemical identification of microscopic samples or domains. Because the IRμs system is a new tool for molecular microanalysis, its optical, mechanical and system design are described to illustrate the state of development of molecular microanalysis. Applications of infrared microspectroscopy are reviewed by Messerschmidt and Harthcock.Infrared spectral analysis of microscopic samples is not a new idea, it dates back to 1949, with the first commercial instrument being offered by Perkin-Elmer Co. Inc. in 1953. These early efforts showed promise but failed the test of practically. It was not until the advances in computer science were applied did infrared microspectroscopy emerge as a useful technique. Microscopes designed as accessories for Fourier transform infrared spectrometers have been commercially available since 1983. These accessory microscopes provide the best means for analytical spectroscopists to analyze microscopic samples, while not interfering with the FT-IR spectrometer’s normal functions.

scholarly journals Psychosocial and Behavioral Characteristics among Subgroups of Nondaily College Student Smokers

2014 ◽  
Vol 7 ◽  
pp. TUI.S13440 ◽  
Author(s):  
Devan R. Romero ◽  
Kim Pulvers ◽  
Taneisha S. Scheuermann ◽  
Jasjit S. Ahluwalia
Keyword(s):  
Young Adults ◽  
College Student ◽  
Perceived Risk ◽  
Public University ◽  
Behavioral Characteristics ◽  
The Past ◽  
Quit Smoking ◽  
Quit Attempts ◽  
Different Characteristics ◽  
Nondaily Smoking

Nondaily smoking is becoming common in young adults and there appear to be different characteristics associated with past month smoking frequency among nondaily smokers. The present study examines behavioral and psychosocial correlates of smoking among subgroups of nondaily college student smokers ( N = 80; 18–25 years of age) attending a large, public university. Nondaily smokers were categorized based on the frequency of days smoked in the past month and were divided into two subgroups: 1–5 days and 6–29 days. A quarter of nondaily smokers considered themselves as a smoker and significantly more 6–29 nondaily smokers were identified as a smoker and smoked more cigarettes per day (CPD). Almost half (45%) of nondaily smokers have attempted to quit smoking completely and 71% of the 6–29 nondaily smokers reported significantly higher quit attempts. The 6–29 nondaily smokers had significantly higher perceived risk related to smoking. Self-efficacy to abstain from smoking was significantly higher for 1–5 nondaily smokers. These results suggest heterogeneity among subgroups of nondaily college student smokers exists in a number of behavioral and psychosocial factors. Prevention and cessation strategies may be improved by considering frequency of nondaily smoking and targeting subgroups differently.

VISUALIZATION OF SOVIET CHILDHOOD IN DRAWINGS BY EUGENIYA DVOSKINA

2020 ◽  
pp. 96-115
Author(s):  
Zhanna V. Umanskaya ◽  
Keyword(s):  
Everyday Life ◽  
Collective Memory ◽  
Behavioral Characteristics ◽  
Visual Sociology ◽  
Public And Private ◽  
The Past ◽  
The Everyday ◽  
Soviet Ideology ◽  
Almost All ◽  
Artistic Skill

The author explores ways to visualize the everyday life of the Brezhnev period’s soviet childhood in a Eugeniya Dvoskina’s drawings cycle «#forthosewhoremember». Comparing the artist’s work with other modern visual nostalgic projects, the significance of the selected source is justified: this cycle allows us to give an idea of the visual environment of the child, typical kinds of the children’s territory, public and private areas in the collective memory of the generation. Based on the methodology of visual sociology (P. Shtompka, O.V. Gavrishina), the author analyzes the reasons for the cycle’s perception of the older generation as uniquely “Soviet” and raises the question about markers of “Soviet childhood”. The universality and heritability of many children’s practices makes them timeless, so the design of the material world and symbols of Soviet ideology are main signs of the historical era. Compositional and graphic solutions of images play an important role for the viewer’s perception. Knowledge of nature and artistic skill allows the artist to create heroes with accurate behavioral characteristics and evokes, in addition to visual, almost all types of sensory memory (tactile, motor, audio). The use of accompaniment text, often in the form of speech formulas, is crucial for this effect. If we consider this cycle in the logic of S.”Boym’s reasoning about nostalgia, drawings about soviet childhood can be attributed to the procedural type of nostalgia, which is characterized by irony and contradictory attitude to the past. Eugeniya Dvoskina’s work provides a complex multi-faceted visualization of the everyday life of Soviet childhood in the 60–80s of the XX century.

Application of Gas Chromatography/Matrix Isolation/Fourier Transform Infrared Spectroscopy to the Identification of Pyrrolizidine Alkaloids from Comfrey Root (Symphytum officinale L.)

1994 ◽  
Vol 77 (5) ◽  
pp. 1167-1174 ◽  
Author(s):  
Magdi M Mossoba ◽  
Hubert S Lin ◽  
Denis Andrzejewski ◽  
James A Sphon ◽  
Joseph M Betz ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Fourier Transform ◽  
Pyrrolizidine Alkaloids ◽  
Matrix Isolation ◽  
Fourier Transform Infrared ◽  
Root Extract ◽  
Spectral Bands ◽  
Infrared Spectral ◽  
Fingerprint Region ◽  
Positive Ion

Abstract This paper demonstrates that pyrrolizidine alkaloids (PAs) extracted from comfrey root grown in Washington State (USA) can be identified by gas chromatography/matrix isolation/Fourier transform infrared (GC/MI/FTIR) spectroscopy. Infrared spectral bands observed in the fingerprint region were unique even for closely related structures. The identities of the 4 major components, intermedine, lycopsamine, 7-acetylintermedine, and 7-acetylly-copsamine, were confirmed by comparison with standards. Confirmation was also obtained by using the established techniques of electron ionization and positive ion chemical ionization gas chro-matography/mass spectrometry. The infrared spectra observed for the components of the root extract were consistent with known structures of specific PAs. The identities of the minor components, sym-phytine and its isomers symlandine and/or sym-viridine, in the same extract were not confirmed.

scholarly journals New Experimental Possibilities and Future Prospects for 1-5μm Infrared Spectroscopy of Interstellar Molecules

1980 ◽  
Vol 87 ◽  
pp. 631-632
Author(s):  
Donald N. B. Hall
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Millimeter Wave ◽  
Molecular Clouds ◽  
Future Prospects ◽  
Interstellar Molecules ◽  
The Past ◽  
Evolved Stars ◽  
Large Numbers ◽  
Fabry Perot

During the past week we have heard a considerable number of papers dealing with spectroscopic observations in the 1-5μm region of the infrared. I predict that as instruments and detectors continue to improve, such observations will play a major role in the study of interstellar molecules in both molecular clouds and circumstellar clouds around evolved stars. Fourier Transform spectrometers and Fabry Perot interferometers have already yielded spectra of such sources with spectral resolution and radial velocity precision fully comparable to millimeter wave observations. The critical need is to improve the limiting magnitude of such observations by 3-5 stellar magnitudes so that one can study large numbers of sources rather than the few brightest in each class.

Properties of Magnetic Features from the Analysis of Near-Infrared Spectral Lines

1994 ◽  
Vol 154 ◽  
pp. 393-405
Author(s):  
Sami K. Solanki
Keyword(s):  
Near Infrared ◽  
Velocity Structure ◽  
Spectral Lines ◽  
The Past ◽  
Diagnostic Potential ◽  
Theoretical Predictions ◽  
Infrared Spectral ◽  
Magnetic Features

An overview is given of the structure and the physics of magnetic features in solar plages, as derived from observations of near-infrared lines. First, the diagnostic potential of near-infrared lines is compared with that of lines in the visible and at 12 μm. Then, the results on the magnetic and velocity structure of magnetic features obtained from 1.5 μm lines are described, discussed and compared with results of observations in the visible and with theoretical predictions. Finally, the past and present achievements of near-infrared investigations of Zeeman-split lines are summarized.

scholarly journals Fourier Transform Infrared Spectral Analysis of Polyisoprene of a Different Microstructure

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Dongmei Chen ◽  
Huafeng Shao ◽  
Wei Yao ◽  
Baochen Huang
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Spectral Analysis ◽  
Fourier Transform ◽  
Magnetic Resonance ◽  
Detailed Analysis ◽  
Fourier Transform Infrared ◽  
Ftir Spectra ◽  
H Nmr ◽  
Infrared Spectral

Some polyisoprene samples of different microstructure contents were studied by Fourier transform infrared (FTIR) and1H Nuclear magnetic resonance (1H NMR). On the basis of detailed analysis of FTIR spectra of polyisoprene, the shift of absorption peaks caused by microstructure content’s variation was discussed. The contents of the polyisoprene samples’ microstructure which was determined by the1H NMR was used as the standard. Through the choice, calculation, and comparison with the corresponding absorption peaks of FTIR, a method based on the results of the analysis has been developed for the determination of the microstructure contents of polyisoprene by FTIR.

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