Body weight gain rather than body weight variability associated with increased risk of nonalcoholic fatty liver disease

AbstractWeight loss, the most established therapy for nonalcoholic fatty liver disease (NAFLD), is frequently followed by weight regain and fluctuation. The aim of this study was to investigate whether body weight change and variability were independent risk factors for incident NAFLD. We conducted a longitudinal cohort study. Among the 1907 participants, incident NAFLD occurred in 420 (22.0%) cases during median follow-up of 5.6 years. In the multivariate analysis, there was no significant association between weight variability and the risk of incident NAFLD. The risk of incident NAFLD was significantly higher in subjects with weight gain ≥ 10% and 7% < gain ≤ 10% [hazard ratios (HR), 2.43; 95% confidence intervals (CI), 1.65–3.58 and HR, 1.73; 95% CI, 1.26–2.39, respectively], while the risk of incident NAFLD was significantly lower in those with −7% < weight loss ≤ -−3% (HR, 0.33; 95% CI, 0.22–0.51). Overall body weight gain rather than bodyweight variability was independently associated with the risk of incident NAFLD. Understanding the association between body weight variability and incident NAFLD may have future clinical implications for the quantification of weight loss as a treatment for patients with NAFLD.

Download Full-text

Impact of Body Weight Gain on the Incidence of Nonalcoholic Fatty Liver Disease in Nonobese Japanese Individuals

The American Journal of Gastroenterology ◽

10.14309/ajg.0000000000001030 ◽

2020 ◽

Vol Publish Ahead of Print ◽

Author(s):

Gen Yamada ◽

Yasuhiro Hagiwara ◽

Takeshi Kimura ◽

Yoshinori Takeuchi ◽

Koji Oba ◽

...

Keyword(s):

Body Weight ◽

Liver Disease ◽

Weight Gain ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Body Weight Gain ◽

Nonalcoholic Fatty Liver

Download Full-text

The impact of body weight gain on nonalcoholic fatty liver disease and metabolic syndrome during earlier and later adulthood

Diabetes Research and Clinical Practice ◽

10.1016/j.diabres.2016.04.047 ◽

2016 ◽

Vol 116 ◽

pp. 183-191 ◽

Cited By ~ 13

Author(s):

Shanshan Du ◽

Cheng Wang ◽

Wei Jiang ◽

Chunlong Li ◽

Yanchuan Li ◽

...

Keyword(s):

Metabolic Syndrome ◽

Body Weight ◽

Liver Disease ◽

Weight Gain ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Body Weight Gain ◽

Nonalcoholic Fatty Liver ◽

The Impact

Download Full-text

Influence of increased physical activity without body weight loss on hepatic inflammation in patients with nonalcoholic fatty liver disease

Environmental Health and Preventive Medicine ◽

10.1186/s12199-020-00857-6 ◽

2020 ◽

Vol 25 (1) ◽

Author(s):

Fuminari Asada ◽

Takuo Nomura ◽

Atsushi Hosui ◽

Masashi Kubota

Keyword(s):

Physical Activity ◽

Weight Loss ◽

Body Weight ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Body Weight Loss ◽

Hepatic Inflammation ◽

Nonalcoholic Fatty Liver

Download Full-text

Onset of Ulcerative Colitis in a Patient with Nonalcoholic Fatty Liver Disease (NAFLD): Dramatic Effect of Plant-based Diet for NAFLD

Inflammatory Bowel Diseases ◽

10.1093/ibd/izz208 ◽

2019 ◽

Vol 25 (11) ◽

pp. e146-e147 ◽

Cited By ~ 2

Author(s):

Mitsuro Chiba ◽

Kunio Nakane ◽

Hitoshi Abe ◽

Masafumi Komatsu ◽

Haruhiko Tozawa

Keyword(s):

Ulcerative Colitis ◽

Metabolic Syndrome ◽

Weight Loss ◽

Body Weight ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver ◽

Normal Ranges

Abstract Nonalcoholic fatty liver disease (NAFLD) develops in ulcerative colitis (UC) and Crohn’s disease. However, there is scarce reporting on the onset of UC in patients with NAFLD. A 44-year-old man was diagnosed with UC and referred to us in 2019. His height was 166.0 cm, and body weight was 86.3 kg. The waist circumference was 93.7 cm (normal range <85) and triglyceride was 751 mg/dL. These findings, in addition to hypertension, resulted in a diagnosis of metabolic syndrome. HbA1c was normal. Ultrasonography disclosed severe fatty liver. Nonalcoholic fatty liver disease was diagnosed. He underwent 12 days of educational hospitalization for UC. A lacto-ovo-semi-vegetarian diet (1400 kcal/day), a kind of plant-based diet (PBD), was provided. He lost 4 kg, which was 4.6% of his base body weight. Triglyceride and total cholesterol decreased to the normal ranges. Transaminases and γ-glutamyl transpeptidase also decreased. His body weight decreased further after discharge. Follow-up ultrasonography indicated an improvement in hepatic enlargement. The shear wave velocity decreased from 1.11 to 0.88 m/s. His soft stool became normal stool by 2 months after discharge. Records of his health checkups revealed the presence of metabolic syndrome and abnormal liver function tests already in 2015. Thus, it was concluded that UC developed in a patient with NAFLD in this case. Plant-based diet has already been shown to be effective in inflammatory bowel disease (IBD). In the present case, NAFLD parameters were dramatically improved by PBD. Whether the improvement was due to weight loss per se or due to weight loss with PBD is to be clarified.

Download Full-text

L‐citrulline inhibits body weight gain and hepatic fat accumulation by improving lipid metabolism in a rat nonalcoholic fatty liver disease model

Food Science & Nutrition ◽

10.1002/fsn3.2439 ◽

2021 ◽

Author(s):

Maya Kudo ◽

Yoshie Yamagishi ◽

Shiori Suguro ◽

Masaaki Nishihara ◽

Hisae Yoshitomi ◽

...

Keyword(s):

Body Weight ◽

Lipid Metabolism ◽

Liver Disease ◽

Weight Gain ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Body Weight Gain ◽

Disease Model ◽

Nonalcoholic Fatty Liver ◽

Hepatic Fat

Download Full-text

The Effect of Weight Loss on Pediatric Nonalcoholic Fatty Liver Disease

ISRN Gastroenterology ◽

10.1155/2013/398297 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8

Author(s):

David E. St-Jules ◽

Corilee A. Watters ◽

Ken Nagamori ◽

Jeremy King

Keyword(s):

Weight Loss ◽

Body Weight ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Alanine Aminotransferase ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver ◽

One Year

This study evaluated the effect of weight loss on pediatric nonalcoholic fatty liver disease (NAFLD). Subjects included 81 overweight NAFLD patients referred to two pediatric gastroenterologists from 2000 to 2010. Data on subjects were obtained from review of medical charts. The effect of weight loss was assessed at 1–4 months, 5–8 months, 9–12 months, and beyond one year as the change in weight, BMI -score (for age-and-sex), and alanine aminotransferase and the relationship between the change in body weight and BMI -score, and the change in alanine aminotransferase. Subjects were mostly obese (99%), male (86%), and Asian (63%) and had median age of 14.1 (11.2–16.2) years and alanine aminotransferase of 105 (78–153) U/L at referral. Alanine aminotransferase decreased 32 ± 66 (), 30 ± 65 (), 37 ± 75 (), and 45 ± 69 () for subjects with follow-up data at 1–4 months (), 5–8 months (), 9–12 months (), and beyond one year (), respectively. During these time periods, neither was body weight (−0.2 to +7.1 kg) or BMI -score (−0.12 to −0.05) significantly reduced, nor were changes in these variables associated with the change in alanine aminotransferase. These findings suggest that weight and BMI -score may not be sufficient indicators of treatment response in pediatric NAFLD patients.

Download Full-text

Body weight variability and the risk of cardiovascular outcomes in patients with nonalcoholic fatty liver disease

Scientific Reports ◽

10.1038/s41598-021-88733-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Mi Na Kim ◽

Kyungdo Han ◽

Juhwan Yoo ◽

Yeonjung Ha ◽

Young Eun Chon ◽

...

Keyword(s):

Body Weight ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Large Scale ◽

Health Examination ◽

Nonalcoholic Fatty Liver ◽

Increased Risk ◽

All Cause Mortality

AbstractWe investigated the association between body weight variability and the risks of cardiovascular disease and mortality in patients with nonalcoholic fatty liver disease (NAFLD) using large-scale, nationwide cohort data. We included 726,736 individuals with NAFLD who underwent a health examination between 2009 and 2010. NAFLD was defined as a fatty liver index ≥ 60, after excluding significant alcohol intake, viral hepatitis, and liver cirrhosis. Body weight variability was assessed using four indices, including variability independent of the mean (VIM). During a median 8.1-year follow-up, we documented 11,358, 14,714, and 22,164 cases of myocardial infarction (MI), stroke, and all-cause mortality, respectively. Body weight variability was associated with an increased risk of MI, stroke, and mortality after adjusting for confounding variables. The hazard ratios (HRs) (95% confidence intervals) for the highest quartile, compared with the lowest quartile, of VIM for body weight were 1.15 (1.10–1.20), 1.22 (1.18–1.26), and 1.56 (1.53–1.62) for MI, stroke, and all-cause mortality, respectively. Body weight variability was associated with increased risks of MI, stroke, and all-cause mortality in NAFLD patients. Appropriate interventions to maintain a stable weight could positively affect health outcomes in NAFLD patients.

Download Full-text

Nonalcoholic fatty liver disease and the risk of atrial fibrillation stratified by body mass index: a nationwide population-based study

Scientific Reports ◽

10.1038/s41598-021-83367-x ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

So-Ryoung Lee ◽

Kyung-Do Han ◽

Eue-Keun Choi ◽

Seil Oh ◽

Gregory Y. H. Lip

Keyword(s):

Atrial Fibrillation ◽

Body Mass Index ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Body Mass ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver ◽

Increased Risk ◽

The Impact

AbstractWe evaluated the association between nonalcoholic fatty liver disease (NAFLD) and incident atrial fibrillation (AF) and analyzed the impact of NAFLD on AF risk in relation to body mass index (BMI). A total of 8,048,055 subjects without significant liver disease who were available fatty liver index (FLI) values were included. Subjects were categorized into 3 groups based on FLI: < 30, 30 to < 60, and ≥ 60. During a median 8-year of follow-up, 534,442 subjects were newly diagnosed as AF (8.27 per 1000 person-years). Higher FLI was associated with an increased risk of AF (hazard ratio [HR] 1.053, 95% confidence interval [CI] 1.046–1.060 in 30 ≤ FLI < 60, and HR 1.115, 95% CI 1.106–1.125 in FLI ≥ 60). In underweight subjects (BMI < 18.5 kg/m2), higher FLI raised the risk of AF (by 1.6-fold in 30 ≤ FLI < 60 and by twofold in FLI ≥ 60). In normal- and overweight subjects, higher FLI was associated with an increased risk of AF, but the HRs were attenuated. In obese subjects, higher FLI was not associated with higher risk of AF. NAFLD as assessed by FLI was independently associated with an increased risk of AF in nonobese subjects with BMI < 25 kg/m2. The impact of NAFLD on AF risk was accentuated in lean subjects with underweight.

Download Full-text