scholarly journals Prevalence of elevated serum fatty acid synthase in chronic limb-threatening ischemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shirli Tay ◽  
Gayan S. De Silva ◽  
Connor M. Engel ◽  
Nikolai Harroun ◽  
Amanda S. Penrose ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Elevated Serum ◽  
Cross Sectional Study ◽  
Serum Samples ◽  
Serum Fatty Acid ◽  
Cross Sectional ◽  
Vascular Intervention ◽  
Artery Disease

AbstractThere are currently no serum-based evaluations that can corroborate the severity of peripheral artery disease (PAD). In this cross-sectional study, we assessed the prevalence of elevated serum fatty acid synthase (cFAS) in patients with chronic limb-threatening ischemia (CLTI) and evaluated the accuracy of its use in detecting this condition. Preoperative fasting serum samples from 87 patients undergoing vascular intervention were collected between October 2014 and September 2016. Median age was 62 years, with 56 (64%) men, and 32 (37%) with CLTI. We found that elevated cFAS content (OR 1.17; 95% CI 1.04–1.31), type 2 diabetes (T2D; OR 5.22; 95% CI 1.77–15.4), and smoking (OR 3.53; 95% CI 1.19–10.5) were independently associated with CLTI and could detect the presence of CLTI with 83% accuracy (95% CI 0.74–0.92). Furthermore, serum FAS content was positively correlated with FAS content in femoral artery plaque in patients with severe PAD ($${R}^{2}$$ R 2 = 0.22; P =  0.023). Finally, significantly higher co-localization of FAS and ApoB were observed within lower extremity arterial media (P < .001). Our findings indicate that serum FAS content is a marker for disease severity in patients with PAD, independent of concomitant T2D and smoking, and may play a key role in FAS and ApoB peripheral plaque progression.

scholarly journals Essential fatty acid intake and serum fatty acid composition among adolescent girls in central Mozambique

2015 ◽  
Vol 113 (7) ◽  
pp. 1086-1095 ◽  
Author(s):  
Riitta Freese ◽  
Liisa Korkalo ◽  
Bengt Vessby ◽  
Siv Tengblad ◽  
Elina M. Vaara ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Essential Fatty Acid ◽  
Adolescent Girls ◽  
Rural Areas ◽  
Nutrition Transition ◽  
Cross Sectional Study ◽  
Fat Intake ◽  
Serum Samples ◽  
Serum Fatty Acid ◽  
Cross Sectional

Many African diets are low in fat but are currently changing because of nutrition transition. We studied fat and fatty acid (FA) intake and the essential fatty acid (EFA) status of adolescent girls (aged 14–19 years, n 262) in Zambezia Province, central Mozambique. A cross-sectional study was carried out in a city as well as in the towns and rural villages of a coastal and an inland district. Dietary intake and FA sources were studied in a 24 h dietary recall. FA compositions of cholesteryl esters and phospholipids of non-fasting serum samples were analysed by GLC. Fat intake was low (13–18 % of energy) in all areas. Coconut and palm oil were the main sources of fat, and soyabean oil and maize were the main sources of PUFA. Compared to Food and Agriculture Organization/WHO 2010 recommendations, intake of linoleic acid (LA, 18 : 2n-6) was inadequate in the coastal district, and intakes of n-3 PUFA were inadequate in all areas. FA compositions of serum lipids differed between areas. The proportions of LA tended to be highest in the city and lowest in the rural areas. The phospholipid mead (20 : 3n-9):arachidonic acid (20 : 4n-6) ratio did not indicate EFA insufficiency. LA proportions in phospholipids were low, but those of long-chain n-6 and n-3 PUFA were high in comparison with Western adolescents. To conclude, fat sources, FA intake and EFA status differed between adolescent girls living in different types of communities. Fat intake was low, but EFA insufficiency was not indicated.

Abdominal aortic calcification is associated with morbidity of cardiovascular disease and Fib-4 index in type 2 diabetes: a retrospective cross-sectional study

2020 ◽  
Author(s):  
Yu Togashi ◽  
Jun Shirakawa ◽  
Daisuke Miyashita ◽  
Mayu Kyohara ◽  
Tomoko Okuyama ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Cross Sectional Study ◽  
Abdominal Aortic Calcification ◽  
Cross Sectional ◽  
Abdominal Aortic ◽  
Artery Disease

Abstract Background: Little is known about the association between abdominal aortic calcification (AAC) and the risk of cardiovascular disease (CVD) among patients with diabetes. This study evaluated the cross-sectional association between AAC and CVD morbidity in patients with type 2 diabetes. Methods: This retrospective cross-sectional study enrolled 285 inpatients with type 2 diabetes. The lateral view of an abdominal X-ray image obtained while each subject was in a standing position was examined, and the AAC score and AAC length, corresponding to the area of calcific deposits in the anterior and posterior aortic wall for the L1-4 and L1-5 regions, respectively, were measured. The associations between the AAC scores and lengths and the presence of coronary artery disease (CAD), cerebral infarction (CI), and peripheral artery disease (PAD) were then assessed. The correlation between the AAC grades and other clinical factors were also evaluated. Results: The degree of AAC was significantly correlated with a higher prevalence of CAD and CI but not PAD after adjustments for cardiovascular risk factors. The AAC score was inversely correlated with BMI, and both the AAC score and the AAC length were correlated with the Fib-4 index; these correlations persisted after adjustments for cardiovascular risk factors and BMI, although AAC was not associated with ultrasonography-diagnosed fatty liver. Conclusion: AAC is associated with CAD and CI morbidity in patients with type 2 diabetes. AAC grading also predicts the Fib-4 index, a hepatic fibrosis marker, suggesting a novel potential predictor of liver disease that is independent of cardiovascular risk factors and obesity.

Macro and microangiopathy related to retinopathy and choroidopathy in type 2 diabetes

2021 ◽  
pp. 112067212110371
Author(s):  
Francisco de Asís Bartol-Puyal ◽  
Carlos Isanta ◽  
Pilar Calvo ◽  
Beatriz Abadía ◽  
Óscar Ruiz-Moreno ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Medical Records ◽  
Cross Sectional Study ◽  
Peripheral Artery ◽  
Cross Sectional ◽  
Swept Source ◽  
Peripheral Polyneuropathy ◽  
Artery Disease ◽  
The Relationship

Purpose: To describe the relationship between diabetic retinopathy (DR) and choroidal thickness (CT), and systemic macro and microangiopathy in patients with type 2 diabetes (T2D). Methods: Cross-sectional study enrolling 200 eyes (100 T2D naïve patients) without macular edema. DR was graded and swept-source optical coherence tomography Triton DRI (Topcon) was used to measure CT, which gave automatic measurements in ETDRS grid. An endocrinologist examined all the patients and searched in their medical records for data about macro and microangiopathy: ischemic cardiopathy (IC), cerebrovascular accident (CVA), peripheral artery disease (PAD), nephropathy, and peripheral polyneuropathy (PPN). Results: Mean age was 67.38 ± 8.15 years, mean axial length was 23.26 ± 0.09 mm, and mean IOP was 16.75 ± 3.06 mmHg. Sixty eyes had no DR, 46 had mild, 64 had moderate, 20 had severe, and 10 had proliferative DR. IC was correlated with horizontal choroidal zones ( p < 0.05 and η between 0.16 and 0.21) but not with DR ( p = 0.16). CVA was neither correlated with CT ( p > 0.05) nor with DR ( p = 0.39). PAD was not correlated with CT ( p > 0.05) but it was with DR ( p = 0.03). The type of nephropathy was correlated both with CT in vertical sectors ( p < 0.05 and η between 0.15 and 0.27) and DR ( p = 0.01, τ = 0.24). PPN was not correlated with CT ( p > 0.05) but it was with DR ( p = 0.03). Conclusions: DR is correlated with microangiopathy (nephropathy and PPN) but not with macroangiopathy (IC, CVA, and PAD). CT is mildly correlated with nephropathy and IC. Some choroidal regions are more sensitive than others to each diabetic macro and microvascular manifestation.

scholarly journals Elevated Serum Total Bilirubin Concentrations Are Negatively Associated with Diabetic Retinopathy among the Chinese Northeastern Population

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Dan Zhang ◽  
Wei Zhang ◽  
Shi Jin ◽  
Wei Wang ◽  
Dan Guo ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Total Bilirubin ◽  
Elevated Serum ◽  
Cross Sectional Study ◽  
Continuous Variable ◽  
Serum Total Bilirubin ◽  
Cross Sectional ◽  
Total Bilirubin Concentration ◽  
The Mean

Objective. To evaluate the association between serum total bilirubin concentration (STBC) and diabetic retinopathy (DR) among the Chinese northeastern population. Methods. A cross-sectional study was conducted in Liaoning between January 2015 and May 2017. Results. A total of 742 subjects (419 men and 323 women) with type 2 diabetes mellitus (DM) who visited an ophthalmic clinic were included in this study. The mean age of the subjects was 59.55 ± 10.63 years, and 43.5% of the subjects were women. The mean of DM duration was 11.01 ± 7.35 years. STBC were negatively correlated with DM duration, urea nitrogen, serum creatinine, uric acid, and urine microalbumin. After adjusting for confounding factors, as a continuous variable, STBC was inversely associated with the risk of DR in total subjects (OR: 0.95, 95% CI: 0.93–0.99). When STBC was used as a tertiary variable, compared with the first tertile, the OR in the third tertile was 0.37 (95% CI: 0.22–0.64) in total subjects. Conclusion. Our results demonstrate that a significant negative association was found between STBC and DR. STBC might be an early clinical marker for predicting the occurrence of DR.

scholarly journals Distribution of Helicobacter pylori infection and abnormal body- mass index (BMI) in a developing country

2018 ◽  
Vol 12 (05) ◽  
pp. 342-346 ◽  
Author(s):  
Basit Siddiqui ◽  
Javed Yakoob ◽  
Zaigham Abbas ◽  
Rabeea Azmat ◽  
Syeda Sadia Fatima ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Helicobacter Pylori ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Comorbid Conditions ◽  
Cross Sectional ◽  
Artery Disease ◽  
H Pylori

Introduction: Helicobacter pylori is prevalent in developing nations. We determined the prevalence of H. pylori infection in relation to body-mass index (BMI) of dyspeptic patients and related comorbid conditions. Methodology: In a cross-sectional study, dyspeptic patients were enrolled and tested for H. pylori infection. “Underweight” was defined as BMI lower than 18.4; “Healthy” 18.5 to 23; “Overweight” 23.1-27.9; and “Obese” greater than 28. Results: Six hundred and ninety-eight patients were included, with a mean age of 44 ± 16 years. Males were 373/698, 53%. H. pylori was positive in 399/698, 57%. Underweight were 36 (5%); BMI-healthy 168 (24%); overweight 236 (34%) and obese 258 (37%). H. pylori infection was present in 65/273 BMI-healthy patients ; 24% compared to obese 208/273; 76% (P < 0.001). In the H. pylori- positive with a “healthy” BMI, dyslipidemia was seen in 6/65; 8% compared to obese 53/208; 25% (P = 0.005); type 2 diabetes in 8/65; 12% with a “healthy” BMI compared to obese 54/208; 26% (P = 0.022) and coronary artery disease in 4/65; 6% of BMI-healthy compared to obese 38/208; 18% patients (P = 0.018). Multivariate analysis showed that age 31-50 years (OR 1.77, 95% CI 1.13-2.77), BMI > 23.1 (OR 2.91, 95% CI infection. 2.01-4.20), and type 2 diabetes (OR 2.41, 95% CI 1.43-4.06) were risk factors for H. pylori Conclusions: H. pylori infection was prevalent in the 31-50-year age group. Abnormal BMI was associated with H. pylori infection.

scholarly journals Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Qin-Fen Chen ◽  
Dan Cao ◽  
Ting-Ting Ye ◽  
Hui-Hui Deng ◽  
Hong Zhu
Keyword(s):  
Type 2 Diabetes ◽  
Arterial Disease ◽  
Cross Sectional Study ◽  
Fibrinogen Concentration ◽  
Sectional Study ◽  
Cross Sectional ◽  
Noninvasive Measurements ◽  
Artery Disease ◽  
Peripheral Arterial

Background. The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography. Methods. We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females). The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly. Furthermore, the univariate and multiple logistic analyses were performed to explore the correlation between PAD and fibrinogen levels, individual components in the cross-sectional study. Results. Finally, 887 (80.9%) T2DM patients meet the diagnostic criteria of PAD and these patients had considerably higher serum fibrinogen concentration than non-PAD group (P<0.001). Multiple logistic analyses revealed that higher fibrinogen quartiles were positively related with the development of PAD in the adjusted model. After adjusting for known confounding parameters, the ORs for PAD were 1.993 (95% CI: 1.322-3.005, P<0.001), 2.469 (95% CI: 1.591-3.831, P<0.001), and 2.942 (95% CI, 1.838-4.711, P<0.001) for Q2, Q3, and Q4, respectively (all P values <0.05). Conclusions. Our results suggest that serum fibrinogen concentration can be considered as an independent risk factor for PAD in T2DM patients.

Sign in / Sign up

Export Citation Format

Share Document