Macro and microangiopathy related to retinopathy and choroidopathy in type 2 diabetes

2021 ◽  
pp. 112067212110371
Author(s):  
Francisco de Asís Bartol-Puyal ◽  
Carlos Isanta ◽  
Pilar Calvo ◽  
Beatriz Abadía ◽  
Óscar Ruiz-Moreno ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Medical Records ◽  
Cross Sectional Study ◽  
Peripheral Artery ◽  
Cross Sectional ◽  
Swept Source ◽  
Peripheral Polyneuropathy ◽  
Artery Disease ◽  
The Relationship

Purpose: To describe the relationship between diabetic retinopathy (DR) and choroidal thickness (CT), and systemic macro and microangiopathy in patients with type 2 diabetes (T2D). Methods: Cross-sectional study enrolling 200 eyes (100 T2D naïve patients) without macular edema. DR was graded and swept-source optical coherence tomography Triton DRI (Topcon) was used to measure CT, which gave automatic measurements in ETDRS grid. An endocrinologist examined all the patients and searched in their medical records for data about macro and microangiopathy: ischemic cardiopathy (IC), cerebrovascular accident (CVA), peripheral artery disease (PAD), nephropathy, and peripheral polyneuropathy (PPN). Results: Mean age was 67.38 ± 8.15 years, mean axial length was 23.26 ± 0.09 mm, and mean IOP was 16.75 ± 3.06 mmHg. Sixty eyes had no DR, 46 had mild, 64 had moderate, 20 had severe, and 10 had proliferative DR. IC was correlated with horizontal choroidal zones ( p < 0.05 and η between 0.16 and 0.21) but not with DR ( p = 0.16). CVA was neither correlated with CT ( p > 0.05) nor with DR ( p = 0.39). PAD was not correlated with CT ( p > 0.05) but it was with DR ( p = 0.03). The type of nephropathy was correlated both with CT in vertical sectors ( p < 0.05 and η between 0.15 and 0.27) and DR ( p = 0.01, τ = 0.24). PPN was not correlated with CT ( p > 0.05) but it was with DR ( p = 0.03). Conclusions: DR is correlated with microangiopathy (nephropathy and PPN) but not with macroangiopathy (IC, CVA, and PAD). CT is mildly correlated with nephropathy and IC. Some choroidal regions are more sensitive than others to each diabetic macro and microvascular manifestation.

scholarly journals Carotid arterial wall inflammation in peripheral artery disease is augmented by type 2 diabetes: a cross-sectional study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Sophie J. Bernelot Moens ◽  
Robert M. Stoekenbroek ◽  
Fleur M. van der Valk ◽  
Simone L. Verweij ◽  
Mark J. W. Koelemay ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Artery Disease ◽  
Arterial Wall ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Peripheral Artery ◽  
Cross Sectional ◽  
Artery Disease ◽  
Carotid Arterial

scholarly journals Home-Measured Blood Pressure Is Associated with Handgrip Strength in Patients with Type 2 Diabetes: The KAMOGAWA-HBP Study

2021 ◽  
Vol 10 (9) ◽  
pp. 1913
Author(s):  
Tomonori Kimura ◽  
Emi Ushigome ◽  
Yoshitaka Hashimoto ◽  
Naoko Nakanishi ◽  
Masahide Hamaguchi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Pulse Pressure ◽  
Handgrip Strength ◽  
Cross Sectional Study ◽  
Home Blood Pressure ◽  
Cross Sectional ◽  
The Relationship ◽  
At Home

The association between blood pressure measured at home and handgrip strength in patients with diabetes has not been investigated. Therefore, in this study, we aimed to assess this association among patients with type 2 diabetes. In this cross-sectional study, 157 patients with type 2 diabetes underwent muscle tests and morning and evening blood-pressure measurements at home in triplicate for 14 consecutive days throughout the study period. Univariate and multivariate regression analyses were conducted to analyze the relationship between home blood-pressure parameters and handgrip strength. The average age and hemoglobin A1c of the patients were 70.5 years and 7.1%, respectively. Morning diastolic blood pressure of [β (95% confidence interval; CI): 0.20 (0.03, 0.37)] was associated with handgrip strength in men, while morning systolic blood pressure of [−0.09 (−0.15, −0.04)], morning pulse pressure of [−0.14 (−0.21, −0.08)], and evening pulse pressure of [−0.12 (−0.19, −0.04)] were associated with handgrip strength in women. Home-measured blood pressure was associated with handgrip strength. Sex differences were found in the relationship between home blood-pressure parameters and handgrip strength.

Abdominal aortic calcification is associated with morbidity of cardiovascular disease and Fib-4 index in type 2 diabetes: a retrospective cross-sectional study

2020 ◽  
Author(s):  
Yu Togashi ◽  
Jun Shirakawa ◽  
Daisuke Miyashita ◽  
Mayu Kyohara ◽  
Tomoko Okuyama ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Cross Sectional Study ◽  
Abdominal Aortic Calcification ◽  
Cross Sectional ◽  
Abdominal Aortic ◽  
Artery Disease

Abstract Background: Little is known about the association between abdominal aortic calcification (AAC) and the risk of cardiovascular disease (CVD) among patients with diabetes. This study evaluated the cross-sectional association between AAC and CVD morbidity in patients with type 2 diabetes. Methods: This retrospective cross-sectional study enrolled 285 inpatients with type 2 diabetes. The lateral view of an abdominal X-ray image obtained while each subject was in a standing position was examined, and the AAC score and AAC length, corresponding to the area of calcific deposits in the anterior and posterior aortic wall for the L1-4 and L1-5 regions, respectively, were measured. The associations between the AAC scores and lengths and the presence of coronary artery disease (CAD), cerebral infarction (CI), and peripheral artery disease (PAD) were then assessed. The correlation between the AAC grades and other clinical factors were also evaluated. Results: The degree of AAC was significantly correlated with a higher prevalence of CAD and CI but not PAD after adjustments for cardiovascular risk factors. The AAC score was inversely correlated with BMI, and both the AAC score and the AAC length were correlated with the Fib-4 index; these correlations persisted after adjustments for cardiovascular risk factors and BMI, although AAC was not associated with ultrasonography-diagnosed fatty liver. Conclusion: AAC is associated with CAD and CI morbidity in patients with type 2 diabetes. AAC grading also predicts the Fib-4 index, a hepatic fibrosis marker, suggesting a novel potential predictor of liver disease that is independent of cardiovascular risk factors and obesity.

scholarly journals Nutrient intakes and dysglycaemia in populations of West African origin

2011 ◽  
Vol 105 (2) ◽  
pp. 297-306 ◽  
Author(s):  
Simon G. Anderson ◽  
Novie Younger ◽  
Adrian H. Heald ◽  
Marshall K. Tulloch-Reid ◽  
Wiyumile P. Simukonda ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Intake ◽  
Tolerance Test ◽  
Cross Sectional Study ◽  
Dietary Factors ◽  
Oral Glucose ◽  
African Origin ◽  
Cross Sectional ◽  
The Relationship

Examining the relationship between glucose intolerance and dietary intake in genetically similar populations with different dietary patterns and rates of type 2 diabetes may provide important insights into the role of diet in the pathogenesis of this disease. The objective of the present study was to assess the relationship between dietary variables and dysglycaemia/type 2 diabetes among three populations of African origin. The study design consists of a cross-sectional study of men and women of African descent aged 24–74 years from Cameroon (n 1790), Jamaica (n 857) and Manchester, UK (n 258) who were not known to have diabetes. Each participant had anthropometric measurements and underwent a 2 h 75 g oral glucose tolerance test. Habitual dietary intake was estimated with quantitative FFQ, developed specifically for each country. The age-adjusted prevalence of undiagnosed type 2 diabetes in Cameroon was low (1·1 %), but it was higher in Jamaica (11·6 %) and the UK (12·6 %). Adjusted generalised linear and latent mixed models used to obtain OR indicated that each 1·0 % increment in energy from protein, total fat and saturated fats significantly increased the odds of type 2 diabetes by 9 (95 % CI 1·02, 1·16) %, 5 (95 % CI, 1·01, 1·08) % and 16 (95 % CI 1·08, 1·25) %, respectively. A 1 % increase in energy from carbohydrates and a 0·1 unit increment in the PUFA:SFA ratio were associated with significantly reduced odds of type 2 diabetes. The results show independent effects of dietary factors on hyperglycaemia in African origin populations. Whether modifying intake of specific macronutrients helps diabetes prevention needs testing in randomised trials.

scholarly journals Type 2 diabetes mellitus in glucose-6-phosphate dehydrogenase deficient individuals in a Ghanaian population

2020 ◽  
Vol 8 (12) ◽  
pp. 4348
Author(s):  
Perez Quartey ◽  
Bright Afriyie Owusu ◽  
Daniel Taylor ◽  
Eliza-Bertha Adomaka
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
G6pd Deficiency ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Chi Square Analysis ◽  
The Relationship

Background: Studies in different populations have shown an association between diabetes mellitus and G6PD deficiency. This association has not been investigated in the Ghanaian population. We conducted a cross-sectional study to investigate the relationship between G6PD deficiency and type 2 diabetes mellitus in a Ghanaian population.Methods: The cross-sectional study involved 125 registered type 2 diabetes mellitus clients and 125 non-diabetic individuals. Chi-square analysis was used to assess the association between G6PD status and type 2 diabetes mellitus with statistical significance pegged at p-value<0.05.Results: The prevalence of G6PD deficiency in the study population was 24.0% and 13.6% for the diabetics and non-diabetics respectively. In terms of gender, 29.5% of the diabetic males were G6PD deficient whiles G6PD deficiency was observed in 11.1% of the non-diabetic males. Additionally, 21.0% of the diabetic females were also G6PD deficient with 15.3% of the non-diabetic females being G6PD deficient. The results showed that the overall G6PD deficiency was significantly associated with type 2 diabetes mellitus as compared to the non-diabetics. In terms of gender differences, G6PD deficiency was significantly associated with type 2 diabetes in males but, there was no significant association in females.Conclusions: The study reports the first findings of the relationship between G6PD deficiencies among type 2 diabetes patients in Ghana. The study revealed that G6PD deficiency is more prevalent among type 2 diabetics than non-diabetics. Type 2 diabetes mellitus is independently associated with G6PD deficiency in males but not females.

scholarly journals A Pilot Study on the Effect of Anti-Thrombopoietin Antibody on Platelet Count in Patients with Type 2 Diabetes

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1667
Author(s):  
Takuya Fukuda ◽  
Masahide Hamaguchi ◽  
Takafumi Osaka ◽  
Yoshitaka Hashimoto ◽  
Emi Ushigome ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Platelet Count ◽  
Cross Sectional Study ◽  
Regression Analyses ◽  
Sectional Study ◽  
Cross Sectional ◽  
Platelet Production ◽  
The Relationship

Thrombopoietin (THPO) is a circulatory cytokine that plays an important role in platelet production. The presence of anti-THPO antibody relates to thrombocytopenia and is rarely seen in hematopoietic and autoimmune diseases. To date, there had been no reports that focused on the anti-THPO antibody in patients with type 2 diabetes mellitus (T2DM). To evaluate prevalence of the anti-THPO antibody in patients with T2DM and the relationship between anti-THPO antibody and platelet count, a cross-sectional study was performed on 82 patients with T2DM. The anti-THPO antibody was measured by ELISA using preserved sera and detected in 13 patients. The average platelet count was significantly lower in patients with the anti-THPO antibody than in those without the anti-THPO antibody. Multivariate linear regression analyses showed a significant relationship between the anti-THPO antibody and platelet count, after adjusting for other variables. To our best knowledge, this was the first report on the effect of the anti-THPO antibody on platelet count in patients with T2DM. Further investigation is needed to validate the prevalence and pathological significance of the anti-THPO antibody in patients with T2DM.

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