scholarly journals Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Samuel Furse ◽  
Adam J. Watkins ◽  
Nima Hojat ◽  
James Smith ◽  
Huw E. L. Williams ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Analytical Approach ◽  
Fat Metabolism ◽  
Traffic Analysis ◽  
Carbohydrate Intake ◽  
Analysis Tool ◽  
Computational Tool ◽  
The Impact ◽  
Insight Into

AbstractIn this paper we present an investigation of parental-diet-driven metabolic programming in offspring using a novel computational network analysis tool. The impact of high paternal carbohydrate intake on offsprings’ phospholipid and triglyceride metabolism in F1 and F2 generations is described. Detailed lipid profiles were acquired from F1 neonate (3 weeks), F1 adult (16 weeks) and F2 neonate offspring in serum, liver, brain, heart and abdominal adipose tissues by MS and NMR. Using a purpose-built computational tool for analysing both phospholipid and fat metabolism as a network, we characterised the number, type and abundance of lipid variables in and between tissues (Lipid Traffic Analysis), finding a variety of reprogrammings associated with paternal diet. These results are important because they describe the long-term metabolic result of dietary intake by fathers. This analytical approach is important because it offers unparalleled insight into possible mechanisms for alterations in lipid metabolism throughout organisms.

scholarly journals Exploring the effects of long-term anti-social behaviour victimisation

2020 ◽  
pp. 026975802096197
Author(s):  
Vicky Heap
Keyword(s):  
Qualitative Research ◽  
Social Behaviour ◽  
Empirical Work ◽  
Criminal Behaviour ◽  
Structured Interviews ◽  
Different Types ◽  
The Impact ◽  
Mental And Physical Health ◽  
Insight Into

Despite victimological interest in the impacts of different types of criminal victimisation, there is little empirical work that examines the effects of sub-criminal behaviour on victims. This article begins to redress the balance by reporting the findings from a qualitative research project in England that investigated the effects of long-term anti-social behaviour victimisation. Semi-structured interviews explored victims’ accounts of the long-term anti-social behaviour they experienced and the resultant effects it had on their lives. The research uncovered that victims experience a range of mental and physical health effects as well as behavioural changes and has provided the first in-depth insight into the impact of this type of victimisation. The findings suggest the cumulative harms associated with anti-social behaviour need to be better acknowledged, understood and addressed, with greater support made available to victims.

scholarly journals A genome-wide association study to identify candidate genes for metabolic disorders in offspring by in vitro fertilization

2021 ◽  
Author(s):  
Lihong Liu ◽  
Siyao Ha ◽  
Zhiling Li ◽  
MingQing Li
Keyword(s):  
Lipid Metabolism ◽  
In Vitro Fertilization ◽  
Health Risks ◽  
Genome Wide Association Study ◽  
Vitro Fertilization ◽  
A Genome ◽  
Offspring Health ◽  
The Impact

Abstract In vitro fertilization (IVF) processes increase offspring's short-term and long-term health risks, but their mechanisms remain unclear. We conducted a bibliometric analysis to determine the landscape of IVF offspring health. Subsequently, a bioinformatics method was utilized to identify the co-genes properties and biological function mechanisms of IVF and type 2 diabetes mellitus (T2DM). Finally, we predicted compounds against key targets and performed multiple validations of the mechanisms underlying IVF offspring health risks. We identified 15 genes associated with T2DM, and their biological functions are primarily associated with lipid metabolism. We also identified the properties of co-genes, modified characteristics, confirmed a conserved motif, identified 3 SNPs sites, and determined the three core genes, APOA1, APOB, and APOE, which were mainly correlated with metabolic and cardiovascular diseases. In addition, we predicted drugs that may improve metabolic abnormalities in IVF offspring. The impact of aberrant lipid metabolism in offspring after IVF therapy warrants additional investigation, particularly in terms of long-term health consequences and possible mechanisms.

The struggle for good care: moral challenges during the COVID-19 lockdown of Dutch elderly care facilities

2022 ◽  
Author(s):  
Wendy van der Geugten ◽  
Gaby Jacobs ◽  
Anne Goossensen
Keyword(s):  
Moral Distress ◽  
Elderly Care ◽  
Term Care ◽  
Care Facilities ◽  
The Impact ◽  
Personal Ethics ◽  
Depth Interviews ◽  
Insight Into

The COVID-19 lockdown of Dutch long-term care facilities between March and May 2020 affected the quality of lives of residents and opposed professional and personal ethics of care. This article, based on 25 in-depth interviews with healthcare chaplains, gives insight into what moral challenges appeared for care professionals. Moral challenges were related to: ‘family ruptures’, ‘residents’ loneliness and despair’, ‘cold-hearted deaths’ and ‘response and responsibilities’. The findings illuminate the complexity of providing care during the lockdown and show variation in the impact of these ethical experiences, in which both moral distress and moral resilience occurred.

scholarly journals Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression

2017 ◽  
Vol 215 (2) ◽  
pp. 627-644 ◽  
Author(s):  
Jung-Mi Lee ◽  
Vinothini Govindarajah ◽  
Bryan Goddard ◽  
Ashwini Hinge ◽  
David E. Muench ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Cell Compartment ◽  
Hematopoietic Stem ◽  
Stem Cell Compartment ◽  
Normal Environment ◽  
Key Driver ◽  
The Impact ◽  
Insight Into

Obesity is a chronic organismal stress that disrupts multiple systemic and tissue-specific functions. In this study, we describe the impact of obesity on the activity of the hematopoietic stem cell (HSC) compartment. We show that obesity alters the composition of the HSC compartment and its activity in response to hematopoietic stress. The impact of obesity on HSC function is progressively acquired but persists after weight loss or transplantation into a normal environment. Mechanistically, we establish that the oxidative stress induced by obesity dysregulates the expression of the transcription factor Gfi1 and that increased Gfi1 expression is required for the abnormal HSC function induced by obesity. These results demonstrate that obesity produces durable changes in HSC function and phenotype and that elevation of Gfi1 expression in response to the oxidative environment is a key driver of the altered HSC properties observed in obesity. Altogether, these data provide phenotypic and mechanistic insight into durable hematopoietic dysregulations resulting from obesity.

scholarly journals Measuring and publishing quality improvement

2021 ◽  
pp. rapm-2020-102201
Author(s):  
Greg Ogrinc
Keyword(s):  
Quality Improvement ◽  
Case Vignette ◽  
Analysis Tool ◽  
Statistical Process ◽  
Measurement And Analysis ◽  
System Functioning ◽  
External Forces ◽  
Ongoing Assessment ◽  
The Impact ◽  
Insight Into

Misalignment of measures, measurement and analysis with the goals and methods of quality improvement efforts in healthcare may create confusion and decrease effectiveness. In healthcare, measurement is used for accountability, research, and quality improvement, so distinguishing between these is an important first step. Using a case vignette, this paper focuses on using measurement for improvement to gain insight into the dynamic nature of healthcare systems and to assess the impact of interventions. This involves an understanding of the variation in the data over time. Statistical process control (SPC) charting is an effective and powerful analysis tool for this. SPC provides ongoing assessment of system functioning and enables an improvement team to assess the impact of its own interventions and external forces on the system. Once improvement work is completed, the Standards for Quality Improvement Reporting Excellence (SQUIRE) guidelines is a valuable tool to describe the rationale, context, and study of the interventions. SQUIRE can be used to plan improvement work as well as structure a manuscript for publication in peer-reviewed journals.

scholarly journals The Effect of Speed Humps on Instantaneous Traffic Emissions

2020 ◽  
Vol 10 (5) ◽  
pp. 1592 ◽  
Author(s):  
Julio César Pérez-Sansalvador ◽  
Noureddine Lakouari ◽  
Jesus Garcia-Diaz ◽  
Saúl E. Pomares Hernández
Keyword(s):  
Air Quality ◽  
Traffic Emissions ◽  
Traffic Density ◽  
Traffic Calming ◽  
Specialized Equipment ◽  
Planning Strategies ◽  
The Impact ◽  
Insight Into ◽  
Speed Humps

Bad air quality due to free pollutants such as particulate matter (PM), carbon dioxide (CO 2 ), nitrogen oxides (NO x ) and volatile organic components (VOC) increases the risk of long- term health diseases. The impact of traffic-calming measures on air quality has been studied using specialized equipment at control sites or mounted on cars to monitor pollutants levels. However, this approach suffers from a large number of variables on the experiments such as vehicles types, number of monitored vehicles, driver’s behavior, traffic density, time of the day, elapsed monitoring time, road conditions and weather. In this work, we use a cellular automata and an instantaneous traffic emissions model to capture the effect of speed humps on traffic flow and on the generation of CO 2 , NO x , VOC and PM pollutants. This approach allows us to study and characterize the effect of many speed humps on a single lane. We found that speed humps significantly promote the generation of pollutants when the number of vehicles on a lane is low. Our results may provide insight into urban planning strategies to reduce the generation of traffic emissions and lower the risk of long-term health diseases.

scholarly journals Effect of esomeprazole on lipid profile in patients with peptic ulcer

Pharmacia ◽  
2021 ◽  
Vol 68 (3) ◽  
pp. 613-617
Author(s):  
Eman Abdullah ◽  
Sarraa Dhiaa ◽  
Khalaf Saleh ◽  
Marwan Merkhan
Keyword(s):  
Peptic Ulcer ◽  
Lipid Metabolism ◽  
Side Effects ◽  
Lipid Profile ◽  
Total Cholesterol Level ◽  
Healthcare Providers ◽  
Pharmacokinetic Profile ◽  
Healthy Individuals ◽  
The Impact

Esomeprazole; a newly introduced PPI has been widely prescribed by healthcare providers due to its improved pharmacokinetic profile. Most users could have other diseases and the PPIs are indicated as acid-suppressor to minimize gastric side effects of polypharmacy. A high percentage of users could suffer from cardiovascular diseases and lipid dysmetabolism. Hence, this study was designed to determine the impact of long-term use of esomeprazole on lipid profile in a normal subject other than having peptic ulcer for which esomeprazole has been indicated. Results confirmed that esomeprazole reduced triglyceride and HDL levels and elevated total cholesterol level and correspondingly LDL level was elevated, however, no effect was noticed with VLDL. To sum up, esomeprazole impaired lipid metabolism in apparently normal healthy individuals apart from having peptic ulcer for which the esomeprazole was indicated, this finding rise a caution during prescribing esomeprazole for the patient with multiple diseases and polypharmacy including cardiovascular ailments.

scholarly journals The Discerning Ear: Cardiac Auscultation in the Era of Artificial Intelligence and Telemedicine

2021 ◽  
Author(s):  
Vivek Jani ◽  
David A Danford ◽  
W Reid Thompson ◽  
Andreas Schuster ◽  
Cedric Manlhiot ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Computer Assisted ◽  
Cardiac Auscultation ◽  
Cardiac Murmur ◽  
New Era ◽  
History Of ◽  
The Impact ◽  
Paradigm Shifting ◽  
Insight Into

Abstract Heart murmur, a thoracic auscultatory finding of cardiovascular origin, is extremely common in childhood and can appear at any age from premature newborn to late adolescence. The objective of this review is to provide a modern examination and update of cardiac murmur auscultation in this new era of artificial intelligence and telemedicine. First, we provide a comprehensive review of the causes and differential diagnosis, clinical features, evaluation, and long-term management of pediatric heart murmurs. Next, we provide a brief history of computer-assisted auscultation and murmur analysis, along with insight into the engineering design of the digital stethoscope. We conclude with a discussion of the paradigm shifting impact of deep learning on murmur analysis, artificial intelligence assisted auscultation, and the implications of these technologies on telemedicine in pediatric cardiology. It is our hope that this article provides an updated perspective on the impact of artificial intelligence on cardiac auscultation for the modern pediatric cardiologist.

scholarly journals A Genome-Wide Association Study To Identify Candidate Genes for Metabolic Disorders in Offspring by In Vitro Fertilization

2021 ◽  
Author(s):  
Lihong Liu ◽  
Siyao Ha ◽  
Zhiling Li ◽  
MingQing Li
Keyword(s):  
Lipid Metabolism ◽  
In Vitro Fertilization ◽  
Health Risks ◽  
Genome Wide Association Study ◽  
Vitro Fertilization ◽  
A Genome ◽  
Offspring Health ◽  
The Impact

Abstract In vitro fertilization (IVF) processes increase offspring's short-term and long-term health risks, but their mechanisms remain unclear. We conducted a bibliometric analysis to determine the landscape of IVF offspring health. Subsequently, a bioinformatics method was utilized to identify the co-genes properties and biological function mechanisms of IVF and type 2 diabetes mellitus (T2DM). Finally, we predicted compounds against key targets and performed multiple validations of the mechanisms underlying IVF offspring health risks. We identified 15 genes associated with T2DM, and their biological functions are primarily associated with lipid metabolism. We also identified the properties of co-genes, modified characteristics, confirmed a conserved motif, identified 3 SNPs sites, and determined the three core genes, APOA1, APOB, and APOE, which were mainly correlated with metabolic and cardiovascular diseases. In addition, we predicted drugs that may improve metabolic abnormalities in IVF offspring. The impact of aberrant lipid metabolism in offspring after IVF therapy warrants additional investigation, particularly in terms of long-term health consequences and possible mechanisms.

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