scholarly journals Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells

Oncogene ◽  
2002 ◽  
Vol 21 (51) ◽  
pp. 7817-7823 ◽  
Author(s):  
Regina Hampton ◽  
Mignon Walker ◽  
John Marshall ◽  
Hartmut Juhl
Keyword(s):  
Colon Cancer ◽  
Healthy Volunteers ◽  
Carcinoembryonic Antigen ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Differential Expression ◽  
Whole Blood ◽  
Splice Variants ◽  
Colon Cancer Cells

scholarly journals Tumour‐suppressive effect of oestrogen receptor β in colorectal cancer patients, colon cancer cells, and a zebrafish model

2020 ◽  
Vol 251 (3) ◽  
pp. 297-309
Author(s):  
Geriolda Topi ◽  
Shakti Ranjan Satapathy ◽  
Pujarini Dash ◽  
Syrina Fred Mehrabi ◽  
Roy Ehrnström ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Oestrogen Receptor ◽  
Suppressive Effect ◽  
Colon Cancer Cells ◽  
Zebrafish Model ◽  
Colorectal Cancer Patients

scholarly journals Metabolism-Based Molecular Sub-Phenotyping Predict Ketogenic Diet Responses in Colorectal Cancer

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 356-356
Author(s):  
Meng Tang ◽  
Qi Zhang ◽  
Kangping Zhang ◽  
Xi Zhang ◽  
Hanping Shi
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Ketogenic Diet ◽  
Theoretical Basis ◽  
Nutritional Stress ◽  
Metabolic Reprogramming ◽  
Metabolic Phenotype ◽  
Colon Cancer Cells ◽  
Metabolic Heterogeneity

Abstract Objectives Current studies have confirmed that the sensitivity of the ketogenic diet (KD) therapy for cancer depends on the low expression of ketolytic enzymes. However, increasing evidence showed that heterogeneity of tumor metabolism leads to inconsistent efficacies of KD therapy, which broke the illusion of the possibility of cancer treatment. Our study aims to construct colon cancer metabolism-related molecular subtyping. Furthermore, to explore the metabolic heterogeneity in diverse colon cancer cells and illuminate the mechanisms of mitochondrial metabolic reprogramming. Thus, providing a theoretical basis for clinical nutritional therapy and combined intervention measures based on metabolic molecular phenotyping. Methods We selected 19 genes associated with glucose and the keto-body metabolic pathway, then constructed a prognostic gene signature by LASSO and KM curve.  Based on the screened metabolic molecules, we further explored the nutrition metabolic heterogeneity and illuminate our understanding of mitochondrial metabolic reprogramming under nutritional stress in vivo. Results Through the integration of patients’ transcriptomics data,  we stratified colon cancer patients into three significant phenotypes with distinct glycolytic and ketolytic characteristics. We identified glycolysis + subtype with either GLUT1 or PFKFB3 overexpression, and ketolysis + subtype with either OXCT1 or ACAT1 deficiency.  In general, combining glycolysis+/ketolysis-phenotype demonstrated the worst prognosis. Furthermore, we discovered the metabolic heterogeneity through western blot and energy metabolic phenotype analysis which also confirmed that these different colon cancer cells showed great significance in metabolic reprogramming under nutritional stress. Conclusions The multi-target combination of metabolic phenotyping proved to be a foundation for individualized molecular stratified treatment which plays an essential role in predicting effectiveness of nutritional modulation therapy among colon cancer patients. It provided a theoretical basis for the clinical trial of KD therapy for patients with specific metabolic subtypes of colon cancer. Funding Sources The National Key Research and Development Program: The key technology of palliative care and nursing for cancer patients.

scholarly journals The role of coagulation and platelets in colon cancer-associated thrombosis

2019 ◽  
Vol 316 (2) ◽  
pp. C264-C273 ◽  
Author(s):  
Annachiara Mitrugno ◽  
Samuel Tassi Yunga ◽  
Joanna L. Sylman ◽  
Jevgenia Zilberman-Rudenko ◽  
Toshiaki Shirai ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Cancer Cell ◽  
Platelet Activation ◽  
Molecular Mechanisms ◽  
Cell Interactions ◽  
Coagulation Cascade ◽  
Colon Cancer Cells ◽  
Cancer Associated Thrombosis

Cancer-associated thrombosis is a common first presenting sign of malignancy and is currently the second leading cause of death in cancer patients after their malignancy. However, the molecular mechanisms underlying cancer-associated thrombosis remain undefined. In this study, we aimed to develop a better understanding of how cancer cells affect the coagulation cascade and platelet activation to induce a prothrombotic phenotype. Our results show that colon cancer cells trigger platelet activation in a manner dependent on cancer cell tissue factor (TF) expression, thrombin generation, activation of the protease-activated receptor 4 (PAR4) on platelets and consequent release of ADP and thromboxane A2. Platelet-colon cancer cell interactions potentiated the release of platelet-derived extracellular vesicles (EVs) rather than cancer cell-derived EVs. Our data show that single colon cancer cells were capable of recruiting and activating platelets and generating fibrin in plasma under shear flow. Finally, in a retrospective analysis of colon cancer patients, we found that the number of venous thromboembolism events was 4.5 times higher in colon cancer patients than in a control population. In conclusion, our data suggest that platelet-cancer cell interactions and perhaps platelet procoagulant EVs may contribute to the prothrombotic phenotype of colon cancer patients. Our work may provide rationale for targeting platelet-cancer cell interactions with PAR4 antagonists together with aspirin and/or ADP receptor antagonists as a potential intervention to limit cancer-associated thrombosis, balancing safety with efficacy.

scholarly journals Carcinoembryonic Antigen Cell Adhesion Molecule 1 long isoform modulates malignancy of poorly differentiated colon cancer cells

Gut ◽  
2015 ◽  
Vol 65 (5) ◽  
pp. 821-829 ◽  
Author(s):  
Azadeh Arabzadeh ◽  
Jeremy Dupaul-Chicoine ◽  
Valérie Breton ◽  
Sina Haftchenary ◽  
Sara Yumeen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Adhesion ◽  
Carcinoembryonic Antigen ◽  
Cancer Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Colon Cancer Cells ◽  
Poorly Differentiated ◽  
Cell Adhesion Molecule 1

Differential expression of nanog1 and nanogp8 in colon cancer cells

2012 ◽  
Vol 418 (2) ◽  
pp. 199-204 ◽  
Author(s):  
Tatsuya Ishiguro ◽  
Ai Sato ◽  
Hirokazu Ohata ◽  
Hiroaki Sakai ◽  
Hitoshi Nakagama ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Differential Expression ◽  
Colon Cancer Cells
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